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Cover Story 10 Indian Non-Profit YRGCARE Selects NetSuite to 18
Dear friends and readers, I hope you would have enjoyed reading our previous issue.
Once again, I am delighted to bring to you the January 2020 edition of the Microbioz Support its Mission to Save More Live
India Health edition, supported by the cover story entitled “Purification and
YRGCARE, an Indian non-profit that provides clinical care to
Maintenance of Cardiomyocytes” an editorial submitted by AMSBIO.AMSBIO has
introduced human recombinant iMatrix Laminin 211 fragment for the purification and individuals diagnosed with HIV and other infectious diseases,
maintenance of cardiomyocytes in culture. has selected Oracle NetSuite to support its mission to save more
Featured article 16 lives.
Added to this, the current edition has a special featured guest article entitled Zeiss Introduces Four Axiocam Models for Light 28
“Effectiveness of healing with Beej Mantra” authored by Dr Arti & Dr Gaurav Shukla
along with Dr. Tarini and Dr. Neelam Vats. Beej Mantra is the shortest form of a Mantra
Microscopy Applications
just like a Beej (seed) which when sown grows into a tree. When recited together these Zeiss, Oberkochen, Germany, has introduced four new high-
Beej Mantras give humans lot of positive energy. They are the vibrations, and represent quality complementary metal oxide semiconductor (CMOS)
the "call" of the soul. It is a belief that when the universe was created then the sounds cameras to support digital imaging in light microscopy.
produced during the cosmic evolution were basically the Beej mantras.
FDA Clears Lumipulse G Whole PTH Assay 28
Product Launches 28 Fujirebio Diagnostics, Malvern, Pa, has received FDA
The edition also covers recent Healthcare news articles and product launches collected clearance for use of its new Lumipulse G whole PTH assay on
from worldwide sources to update the readers with the current trends in the industry the company’s Lumipulse G1200 immunoassay platform.

Microbioz India, January 2020 06


ear friends and readers, I hope you would have enjoyed reading
our previous issue. Once again, I am delighted to bring to you
the January 2020 edition of the Microbioz India Health edition,
supported by the cover story entitled “Purification and
Maintenance of Cardiomyocytes” an editorial submitted by
AMSBIO.
AMSBIO has introduced human recombinant iMatrix Laminin
211 fragment for the purification and maintenance of
cardiomyocytes in culture.
The Laminin family of glycoproteins are an integral part of the
structural scaffolding in almost every tissue of an organism.
They are secreted and incorporated into cell-associated
extracellular matrices. Laminin is vital for the maintenance and
survival of tissues. Defective Laminins can cause muscles to
form improperly, leading to a form of muscular dystrophy,
lethal skin blistering disease and defects of the kidney filter.
Added to this, the current edition has a special featured guest
article entitled “Effectiveness of healing with Beej Mantra”
authored by Dr Arti & Dr Gaurav Shukla along with Dr. Tarini and
Dr. Neelam Vats.Beej Mantra is the shortest form of a Mantra
just like a Beej (seed) which when sown grows into a tree. When
recited together these Beej Mantras give humans lot of positive
energy. They are the vibrations, and represent the "call" of the
soul. It is a belief that when the universe was created then the
sounds produced during the cosmic evolution were basically
the Beej mantras. After attaining knowledge of the Beej
Mantras and understanding its connections with Mind, Body &
Soul, the individual can use subtle energy to heal physical and
psychological ailments.
We have the latest market research news and insightful
product launches inside, collected from worldwide sources to
keep you updated with what is going on in the industry.
Dear friends and readers, I hope you find some value in the
magazine. Also, I would like to thanks you for being together in
this beautiful journey so far. We would love to have your
valuable feedback and suggestions as they help us to come up
with better content each time. For any further valuable
addition, please write to us at editor@microbiozindia.com.
Cover Story

Purification and Maintenance


of Cardiomyocytes
AMSBIO has introduced human recombinant iMatrix Laminin 211
fragment for the purification and maintenance of cardiomyocytes in
culture.

T
he Laminin family
of glycoproteins are
an integral part of
the structural
scaffolding in
almost every tissue
of an organism.
They are secreted
and incorporated
into cell-associated extracellular
matrices. Laminin is vital for the
maintenance and survival of
tissues. Defective Laminins can
cause muscles to form
improperly, leading to a form of
muscular dystrophy, lethal skin
blistering disease and defects of
the kidney filter.

Laminin 211 is known to support


the growth, survival, and
differentiation of a wide range of
tissue-specific cell types,
including cardiac cells, skeletal muscle cells and
motor neurons. As one of the main isoforms 211 fulfils this purpose through its binding
present in adult muscle tissue, Laminin 211 is of membrane bound integrin, and
critical for cardiomyocyte function and heart
muscle development. activation of intracellular signal cascades.
The recombinant human iMatrix-211 is a
Proven to support functional cardiomyocytes and high-quality matrix for basic research and
skeletal muscle cells culture, AMSBIO iMatrix
Laminin-221 is a simple to use recombinant drug development and toxicity studies with
fragment that retains the full integrin-binding these critical cell types.
activity of Laminin-211.
For further information on iMatrix Laminin 211
The culture of iPSC derived heart and please visit http://www.amsbio.com/imatrix-
recombinant-laminin-e8-fragments.aspx or
muscle cells under feed-free conditions contact the company on +44-1235-828200 / +1-
requires the use of extracellular matrix 617-945-5033 / info@amsbio.com.
proteins as an anchor to promote
adherence and functionality. Laminin

Microbioz India, January 2020 10


Cover Story

Founded in 1987, AMS Biotechnology (AMSBIO) biorepository, AMSBIO is widely recognised as a


is recognized today as a leading transatlantic leading provider of high-quality tissue specimens
company contributing to the acceleration of (including custom procurement) from both human
discovery through the provision of cutting-edge life and animal tissues. The company provides unique
science technology, products and services for clinical grade products for stem cell and cell therapy
research and development in the medical, nutrition, applications these include high quality solutions for
cosmetics and energy industries. AMSBIO has in- viral delivery (lentivirus, adenovirus and adeno-
depth expertise in extracellular matrices to provide associated virus) in addition to GMP
elegant solutions for studying cell motility, cryopreservation technology.
migration, invasion and proliferation. This For further Information:
expertise in cell culture and the ECM allows MEDIA: Dr Bill Bradbury
AMSBIO to partner with clients in tailoring cell Primetek Solutions, tel. +44-208-546-0869 /
systems to enhance organoid and spheroid email info@primetek-solutions.com
screening outcomes using a variety of 3D culture TECHNICAL: Dr Phillip Pridham Field
systems, including organ-on-a-chip microfluidics.
AMSBIO, tel. +44-1235-828200 / email
For drug discovery research, AMSBIO offers info@amsbio.com
assays, recombinant proteins and cell lines.
Drawing upon a huge and comprehensive

Microbioz India, January 2020 11


Research News

One dose of HPV vaccine may prevent


infection from cancer-causing virus, study
reveals
A new study revealed that one dose of the HPV vaccine may prevent
infection from the potential cancer-causing virus, according to research
published in JAMA Network Open from The University of Texas Health Science
Center at Houston (UTHealth).

According to the Centers for


Disease Control (CDC), 34,800 new
cancer diagnoses are linked to
human papillomavirus (HPV)
annually. The virus is thought to
account for more than 90% of all
cervical and anal cancers, more than
60% of all penile cancers, and
approximately 70% of all oral
cancers.
While results of the paper showed
that a single dose may be as effective
as the currently recommended two-
or three-dose series, it's too early for
people to rely on a single dose of the
vaccine for protection, according to
senior author Ashish A. Deshmukh, PhD, MPH, an
assistant professor at UTHealth School of Public HPV infections. Yet, current vaccinations rates are
Health. less than ideal – half of people in the U.S. are not
HPV vaccine coverage is less than 10% globally because of vaccinated against this common sexually
poor vaccine uptake rates in many resource-limited countries. transmitted infection.
Ensuring boys and girls receive their first dose is a big The current HPV vaccine dosing regimen can be cumbersome
challenge in several countries and a majority of adolescents are for people to understand. If one dose is proven effective in
not able to complete the recommended series due to a lack of trials, the vaccine regimen will be simplified. This will help
intensive infrastructure needed to administer two or three improve the coverage rate among adolescents that are currently
doses. If ongoing clinical trials provide evidence regarding below the Healthy People 2020 goal and possibly will also
sustained benefits of a one-dose regimen, then implications of increase the momentum of uptake in the newly approved age
single-dose strategy could be substantial for reducing the group."
burden of these cancers globally." Kalyani Sonawane, PhD, lead author, assistant professor at
Ashish A. Deshmukh, PhD, MPH, senior UTHealth School of Public Health
author, assistant professor at UTHealth School Source:
of Public Health University of Texas Health Science Center at
Although the study participants included only Houston
women, the CDC recommends a two-dose regimen Journal reference:
for all children starting the series before age 15 or a Sonawane, K., et al. (2019) Prevalence of Human
three-dose regimen if the series is started between Papillomavirus Infection by Number of Vaccine
ages 16 to 26. The latest generation of HPV vaccine Doses Among US Women. JAMA Network
can protect against nearly 90% of cancer-causing Open. doi.org/10.1001/jamanetworkopen.2019.185
71.

Microbioz India, January 2020 12


Research News

Proton therapy has similar cure rates,


fewer serious side effects compared with
traditional radiation
Cancer patients who receive high-tech proton across several cancer types -- including lung, brain,
therapy experience similar cure rates and fewer head and neck, gastrointestinal and gynecologic
serious side effects compared with those who cancers -- to show a reduced side-effect profile for
undergo traditional X-ray radiation therapy, proton therapy compared with X-ray radiation
according to a study led by Washington University therapy for patients receiving combined
School of Medicine in St. Louis and the Perelman chemotherapy and radiation. None of the
School of Medicine at the University of patients had metastatic cancer, in
Pennsylvania. which a tumor has spread to
The reduction in side effects -- particularly other parts of the body.
lower hospitalization The researchers
rates and fewer found no differences
emergency room visits between the two
-- could offset the groups in survival
higher initial cost of and cancer control,
proton therapy, which suggesting that proton
often is not covered by therapy is just as effective
private insurance in treating the cancer even as
because of its higher it caused fewer side effects.
upfront expense and Overall survival at one year
limited data on its for the
effectiveness proton
compared to X-ray therapy
radiation, according to group was
the researchers. 83 percent
The study is published versus 81
Dec. 26 in JAMA percent
Oncology. Some of the findings for the X-
also were presented in June at the American ray
Society of Clinical Oncology's annual meeting, in radiation
Chicago. therapy
We observed significantly fewer unplanned hospitalizations group. This difference tipped
in the proton therapy group, which suggests the treatment may slightly in favor of proton therapy but was not
be better for patients and, perhaps, less taxing on the health- statistically significant.
care system. If proton therapy can reduce hospitalizations, The difference in side effects was more
that has a real impact on improving quality of life for both pronounced. Forty-five of 391 patients receiving
our patients and their caregivers." proton therapy experienced a severe side effect in
Brian C. Baumann, MD, first author, assistant professor the 90-day time frame (11.5 percent). In the X-ray
of radiation oncology at Washington University and an radiation therapy group, 301 of 1,092 patients
adjunct assistant professor of radiation oncology at Penn experienced a severe side effect in the same period
While radiation therapy can be curative for certain (27.6 percent). The patients receiving proton
cancers, it also causes severe side effects -- such as therapy experienced fewer side effects despite the
difficulty swallowing, nausea and diarrhea -- that fact that they were, on average, older and had more
reduce quality of life and can, in some cases, require medical problems than those receiving standard X-
hospitalization, said Baumann, who treats patients ray radiation therapy. After taking steps to control
at Siteman Cancer Center at Barnes-Jewish Hospital for these differences, the researchers found that
and Washington University School of Medicine. patients receiving proton therapy experienced a
The study, which included almost 1,500 patients two-thirds reduction in the relative risk of severe
from Penn Medicine, is the first large review of data side effects within the first 90 days of treatment,

Microbioz India, January 2020 14


Research News

compared with patients receiving X-ray radiation conditions -- who are typically excluded from
therapy. clinical trials because of their frailty -- to participate
Both types of radiation therapy are approved by the in trials investigating more intensive treatments that
Food and Drug Administration for cancer could be beneficial.
treatment. X-ray beams are made up of photons, "Clinical trials often are limited to patients who
which are electromagnetic particles that have have serious cancers but are otherwise quite
almost no mass, allowing them to travel all the way healthy, and that's not the real-world cancer
through the body, passing through healthy tissue on population," said Baumann. "Doctors, rightly, are
the way out. Protons are relatively heavy, positively concerned about toxicity. But with the reduced
charged particles that hit their target and stop, toxicity that we found with proton therapy, this
essentially eliminating the exit dose of radiation. might open the doors to the possibility of older
Since the study found proton therapy to have fewer patients with multiple medical problems getting
adverse events, Baumann said it could prompt cancer therapy they can tolerate that is more likely
radiation oncologists to design clinical trials to to be curative.
investigate whether increasing the dose of proton "With our aging population, this could have a big
radiation would help patients do better, while still impact on a lot of patients," he added. "To me,
maintaining acceptable levels of side effects. that's an exciting implication of this research."
Similarly, the reduced side effects of proton therapy Source:
could allow older patients with additional medical Washington University School of Medicine

Microbioz India, January 2020 15


Featured Article

Effectiveness of healing
with Beej Mantra
Beej Mantra is the shortest form followed diligently can make you free from

A
of a Mantra just like a Beej (seed) diabetes, BP, Thyroid etc.
which when sown grows into a
tree. When recited together these
About us:
Dr Arti & Dr Gaurav Shukla
Beej Mantras give humans lot of
Dr Arti Shukla: A PhD in psycho-sociology and is
positive energy. They are the
a depression expert, a dermatoglyphics expert, she
vibrations, and represent the
is a healer and an expert counselor.
"call" of the soul. It is a belief that
Dr Gaurav Shukla: Previously a MBA marketing
when the universe was created then the sounds
with 16 yrs of corporate exposure - a DGM in
produced during the cosmic evolution were
Videocon Telecom, Cadbury, Reliance, Airtel till he
basically the Beej mantras. After attaining
decided to move into a completely different field
knowledge of the Beej Mantras and understanding
and went on to do extensive research in Education,
its connections with Mind, Body & Soul, the
Diagnostics and Healing and got Masters & PhD in
individual can use subtle energy to heal physical and
Sanskrit. Both live in Mumbai. Together we are
psychological ailments. Today we are having
amongst the pioneers in the field of researching our
diseases / disorders primarily due to a sedentary
traditional wisdom practices and creating
lifestyle. From our traditional eastern knowledge &
meditative techniques and applications that can
understanding of the source code we have designed
bring about fast healing. We
a unique meditation program using Beej Mantras
This program aims at
reducing ill effects of
diseases connected
with stress like
Diabetes, BP,
Thyroid, obesity and
keeps you tranquil- a
key to stay healthy.
Diabetes occurs due
to imbalance in us, so
we have to bring
back homeostasis.
Mainly stress,
anxiety, fear, desire
for approval from
self and others, lack
of self love or love in
life. Increased stress
levels or hidden
stress start affecting the whole internal physical integrated behavior, with Beej Mantras and
system, including metabolism, hormone secretion conceived the comprehensive techniques designed
etc. causing the pancreas to get overburdened. This to cleanse and energize the physical body, mind &
disrupts its proper functioning and results in a rise Soul. This process accelerated the rate at which the
of the sugar level. By training to bring back the body can heal itself. Our training process is
homeostasis/balance through meditation Total designed in a manner that even new students can
Wellness Program can be helpful in managing most rapidly learn the techniques to heal simple ailments.
of the diseases. It is free from side effects and if

Microbioz India, January 2020 16


Featured Article
This enables them to produce immediate positive 3) Soulfulness Meditation
results that contribute to a life of good health and 4) Diet
well-being. 5) Healing
Dr. Tarini Vats, MD.: Adaptive medical graduate 6) Consultation
with proven experience with data entry and medical 7) Ayurvedic Supplements with Tissue salts
terminology. Experience with multiple fields of 8) Stress buster techniques
medicine. Multi-tasker, detail-oriented and team 9) Sandhi Marma stress points Knowledge
player with excellent interpersonal skills. sessions
Effectively communicates with medical personnel, Duration:
colleagues, and patients. 1) 45 Minutes
Dr. Neelam Vats: Certified CBT Practitioner 2) 5 Min Opening
(CBT), September, 2018, The Academy of Modern 3) 10 Min. of Intro to Concept, Chakra
Applied Psychology, San Francisco CA. assessment & Report
4) 20 Min of Labdhikagra Meditation
Our vision 5) 5 Min of Mass Pronunciation of
Vision is to put India onto the world map in Phonemes.
traditional wisdom practices of healing by 6) 5 Min Closing
leveraging past wisdom residing in our shastras,
devoid of superstitious beliefs and ancient End results:
unsubstantiated rituals. After more than a decade Activates all cells in the body, improves circulation
of research, we formulated new concepts and and increases
vital energy
flow, reduces
stress,
anxiety and
depression
Deep relaxation
and pain relief
Lowers anger
and blood
pressure
Cleanses
negative energy
and emotions
Balances both
hemispheres of
brain and
improves sleep
Stimulates,
balances and
purifies our
senses and
techniques - Beej Mantra Healing that helped chakras, and enhances aura removes blockages and
explain energy healing as a practical science. Our toxins, and gives you a healthy glow
endeavor is to systematize the world of energy
healing in to a comprehensive structured body of Promotes stillness, happiness and well being
knowledge. We have, in fact, demonstrated this in Strengthens immune system, soothes
one hour sessions with more than 150 people and harmonizes emotions & feelings, changes old
concurrently whose BP and Sugar readings showed unhealthy thought patterns & habits that no longer
a significantly lower value post the meditation. serve us deepens meditation and connection with
Program details: higher self.
1) Special Beej Mantra techniques
2) Breathing techniques

Microbioz India, January 2020 17


Business News

Indian Non-Profit YRGCARE Selects


NetSuite to Support its Mission to Save
More Live
NetSuite helps non-profit expand operations across India
and focus time, resources and expertise to support those
in need

YRGCARE, an Indian non-profit that provides lives.” With NetSuite, YRGCARE has been able to
clinical care to individuals diagnosed with HIV and automate previously manual processes and enhance
other infectious diseases, has selected Oracle visibility across its growing operations. NetSuite
NetSuite to support its mission to save more lives. has enabled YRGCARE to reduce the time taken
to close its financial processes from 45 days to 10
Through NetSuite’s Social Impact program, days and redeploy resources that were previously
YRGCARE has been able to focus its resources on dedicated to procurement and IT management to
helping those in need and support a growing focus on directly helping those in need. The
number of patients across India by taking enhanced visibility into business operations has
advantage of unified platform to streamline enabled YRGCARE to track expenses on a per-
business processes and reduce operating project basis and comply with reporting
costs.Founded in 1993 by the late Dr Suniti requirements from donors, which includes several
U.S. government agencies, while also meeting
Solomon, a pioneer in India’s fight against HIV, Indian government tax requirements.
YRGCARE has supported more than 20,000
patients ranging from small children to pregnant “Nonprofits like YRGCARE do amazing and
women and other infected adults. To bring its incredibly difficult work and that requires complete
clinical care, education and research to more people focus,” said Graeme Burt, VP & Chief Commercial
and support expanded services for patients with Officer, Oracle NetSuite JAPAC. “With NetSuite,
the YRGCARE team has been able to drive
hepatitis C, tuberculosis, STDs and other infectious
efficiencies across their core business processes so
diseases, YRGCARE has expanded from three they can focus their time, resources and expertise
locations across India to 15. To support its growing on reducing the spread of infectious diseases in
operations, which currently help approximately India. We have huge admiration for the
4,000 people a year, and ensure all resources are YRGCARE team and applaud their commitment
used as efficiently as possible to support its to the communities in which we live and work.”
mission, YRGCARE selected NetSuite.
As a nonprofit, YRGCARE is benefitting from
“We are focused on the needs of those who are donated software through the Oracle NetSuite
not receiving care, support, education, and Social Impact program. Through the Suite Pro
information about HIV other infectious diseases,” Bono part of the program, the organization is
said Ganesh Aylur Kailasam, chief program officer receiving support, at no cost, from skilled NetSuite
and research administrator, YRGCARE. “I joined employees to help them use the platform more
YRGCARE when we launched 25 years ago and as effectively.
we have grown to help more and more people, our
operations have become more complex. With About YRGCARE
NetSuite we have been able to reduce that YRGCARE, founded in 1993 in Chennai, India is
complexity so we can ensure we can spend time and a premier HIV/AIDS service organization offering
resources on making a real difference in people’s services including: Adolescent and young adult
sexuality education, HIV intervention at
workplaces and communities, Voluntary

Microbioz India, January 2020 18


Business News

counselling and testing services, treatment for Follow NetSuite’s Cloud blog, Facebook page and
sexually transmitted diseases, Care and support @NetSuiteJAPAC Twitter handle for real-time
services to over 20,000 People Living with updates.
HIV/AIDS (PLHA), education and advocacy to
reduce violence against women and much more. About Oracle
The Oracle Cloud offers complete SaaS application
In partnership with leading centres from around suites for ERP, HCM and CX, plus best-in-class
the world, YRGCARE is currently implementing database Platform as a Service (PaaS) and
research in the fields of epidemiology, laboratory Infrastructure as a Service (IaaS) from data centers
sciences, prevention, implementation science and throughout the Americas, Europe and Asia. For
treatment outcomes. It is among the few more information about Oracle (NYSE:ORCL),
institutions in Asia monitoring the emerging HIV please visit us at www.oracle.com
drug resistance.
Trademarks
For more information on how nonprofits and Oracle and Java are registered trademarks of Oracle
social enterprises are leveraging Oracle NetSuite, and/or its affiliates. Other names may be
visit www.netsuite.com/socialimpact trademarks of their respective owners.

About Oracle NetSuite For further information, kindly contact:


For more than 20 years, Oracle NetSuite has helped Oracle NetSuite India
organisations grow, scale and adapt to change. Monica Srivastava
NetSuite provides a suite of cloud-based Public Relations
applications, which includes financials / Enterprise +91 95990 45075
Resource Planning (ERP), HR, professional
services automation and omnichannel commerce, K2 Communications Pvt. Ltd.
used by more than 18,000 customers in 203 Lavanya Venkatesh / Vellaichamy
countries and dependent territories. For more +91 9902242957 / +91 9884552209
information, please visit
https://www.netsuite.com/portal/in/
Interview

Dr Ryan M Nunley Shares His Experiences


with City Doctors on Technological Advancements
in Wound Closure Management in Joint
Replacement Procedures
A three-day training and knowledge sharing
program was flagged off in New Delhi on October
2, 2019 by Dr Ryan M Nunley, Associate Professor
from Washington University Orthopaedics in St.
Louis to educate and equip surgeons with the latest
technological advancements in the field of wound
closure management. As the incidence of surgical
site infections is relatively higher in India compared
to rest of the world, the 3-day program gave the
potential to highlight the benefits of latest
advancements in the space of wound closure,
especially in joint replacement procedures. The
training and knowledge sharing program was
Dr Ryan M Nunley
planned to increase awareness about soft tissue
management with leading surgeons in India across
three cities – New Delhi, Hyderabad and Pune. patient’s hospitalization time by up to two weeks
and care costs by more than 300%. SSIs in
More than 50 Orthopedic surgeons across 3 cities orthopedic procedures also present a stark and
participated and were educated on the catastrophic complication for patients, surgeons
technological advancements to improve the and hospital institutions. The SSI range from low
treatment process to enable patients with faster to high for Total Knee Replacement (TKR) is
mobility, minimum scar, reduced infection, easier 1.74% to 12.5%.
self-care and ensure better quality of life. These Speaking on this, Dr Ryan M Nunley further added,
advanced systems will also provide minimally “One of the biggest challenges with joint
invasive skin closure techniques that lead to greater replacement surgery across the world is infection.
patient satisfaction and better cosmesis. It is one thing that we've not been able to eliminate.
Hence, adopting technologies which reduces risk of
The primary aim of the educational initiative was to infection is a key goal in all aspects of orthopedic
highlight the effective use of safe and secure wound surgical procedures, especially Total Knee and
closure, as it is critical to avoid the risk of Surgical Total Hip Arthroplasty. With latest advancements
Site Infections (SSI), which can lead to re- in wound closure management in joint replacement
admission and ultimately resulting in higher costs surgeries, we can meet the changing customer
for the healthcare system. In Asia Pacific alone, demands and provide better treatment to patients.
patients are up to 20 times more likely to acquire a The last 3 days in India gave us this opportunity to
healthcare-associated infection with SSIs. equip surgeons with information and share my
According to the World Health organization more experiences with wound closure systems in
than 1 in 10 patients in low- and middle-income orthopedic surgeries which are less invasive, have
countries will get a surgical site infection. A lack of reduced incidence of drainage/hematoma/SSI,
surveillance and implementation of global provide watertight closure techniques, are easier to
guidelines continue to inhibit progress around SSI remove by patients at the convenience of their own
prevention in Asia Pacific, taking the mortality rate home (less visits back to the clinic which can be
up to 46% in Asia Pacific countries. expensive and time consuming for the patient and
family members), dressings with significantly less
Moreover, an SSI infection pertaining to pain than staples (skin clips) and provide better
orthopedic surgical procedure can increase the cosmesis.”

Microbioz India, January 2020 20


Interview

During orthopaedic surgeries, it is important to pay Minimizing risk of surgical site infections is
attention to the management of soft tissue as possible with attention to the wound both during
improper management can lead to pain, drainage, and post-surgery by surgeons as well as patients.
hematomas, infection, readmission or other For any medical procedure, improved patient
complications, which can be devastating to patient outcome and patient satisfaction is the key goal.
and the families. Attention to wound closure It is important to understand that in the case of
systems at the time of surgeries orthopedic surgeries, the challenges affecting
increases patient leading to dis-satisfaction include the
surgeon’s need for more clinic visits to remove staples
precision and or sutures, superficial infections, abscess
can positively formation, wound dehiscence, prolonged
impact wound discharge, readmission to the
patient’s hospital, and re-operation. Using wound
functional closure systems that reduce wound healing
recovery, complications that do not require manual
quality of removal by a physician or healthcare
life and provider as a solution will significantly
patient improve patient satisfaction and outcome,
satisfaction. as well as reduce the over cost the healthcare
It will reduce system.
the economic burden on healthcare system and re-
hospitalization rates.

Microbioz India, January 2020 22


Pre Event Coverage

India Health Exhibition launches to


facilitate growth in India’s US$372 bn
healthcare market
 India Health Exhibition will take place from 14-16 April 2020, in New Delhi,
brought to you by Arab Health organisers, Informa Markets
 India’s healthcare sector is set to increase three-fold to US$ 372 billion by 2022
 Introducing conferences that will focus on the country’s healthcare strategy
and developments

New Delhi, India, 25


November 2019: Informa
Markets, the largest
international exhibitions
organiser, are gearing up to
launch India Health
Exhibition from April 14-
16, 2020. This comes in
response to the global
industry’s desire to develop
business within one of the
world’s fastest growing
markets. The show will
host a unique combination
of a full-scale exhibition
along with a diverse range
of educational conferences
that are run in partnership
with leading local
associations.

With over 44 years of experience in hosting Arab India Health into our family of global healthcare
Health Exhibition and Congress, the largest exhibitions brands, which includes the trusted Arab
healthcare exhibition in the Middle East, along with Health Exhibition and Congress. Recent reports
market leading shows such as Africa Health and have highlighted that the growing demand for
Florida International Medical Expo (FIME), quality healthcare and the absence of a matching
Informa’s events work on the tried and tested delivery mechanism pose a great challenge in India.
methodology of providing topical, affordable and This launch event will allow us to facilitate business
high-quality education alongside a comprehensive interaction within the growing Indian healthcare
exhibition made up of the world’s latest innovators market and provide a springboard to growth
in the medical space. Informa Group’s acquisition drivers.
of UBM further allows it to leverage on the
strength of the annual CPhI India event that brings “One of the other common challenges that
key players from India's pharma sector together. companies often face in the Indian healthcare
market is the lack of connection and relationships
Commenting on the launch of the show, Wouter with the right healthcare entities, authorities and
Molman, Executive Vice President Healthcare, associations in India. India Health will help bridge
Informa Markets, said: “The show firmly brings this gap.”

Microbioz India, January 2020 24


Pre Event Coverage

The three-day event will take place in New Delhi’s Yogesh Mudras, Managing Director, Informa
Pragati Maidan and host 300 plus international and Markets India, highlighted: “India’s healthcare
local exhibitors from a variety of sectors ranging
from disposables and consumables through to sector at present is growing at 15.8 per cent
high-tech imaging and diagnostic equipment. The Compound Annual Growth Rate (CAGR) for a
show will welcome 4,000 plus key decision makers plethora of reasons. India Health will bring
and stakeholders right from hospital directors, together the key players in the global market to
doctors, medical practitioners, government meet and do business with the Indian healthcare
policymakers, medical laboratory technicians, sector and to capitalise on this growth.
distributors and traders.
“A significant percentage of purchasers of medical
The event’s three CME-accredited conferences devices are private medical institutions and
have been curated around the country’s healthcare hospitals. Due to increased competition in Tier I
strategy to explore the challenges it faces, and the cities, private enterprises have started to focus on
innovation required to overcome them. These will Tier II and Tier III cities, a market which is until
be held in collaboration with notable associations, now untapped in India. As private enterprises
including Association of Healthcare Providers expand in lesser explored markets, the demand for
(India), Healthcare Federation of India and more. medical devices will expand proportionally, and
India Health will help the industry tap that
Explore opportunities created by a billion- potential.”
dollar market
As the second most populous country in the world, With exciting opportunities in store for R&D,
India has become one of the fastest growing medical tourism and investment in healthcare
healthcare markets globally, both in terms of infrastructure developments, attending India
revenue and employment. Health is essential in order to understand and
operate in one of the world’s largest healthcare
The country’s healthcare market is all set to markets.
increase three-fold to US$ 372 billion by 2022.
India is expected to rank amongst the top three For more information visit www.indiahealth-
healthcare markets in terms of incremental growth. exhibtion.com
The country will generate 40 million jobs by 2020.
Projections are that US$ 200 billion will be spent More about Informa Markets:
on medical infrastructure by 2024.
The medical device market is expected to reach Informa Markets – Healthcare Group, organises 15
US$ 11 billion by 2022. exhibitions and 110 conferences yearly covering the
India has emerged as a hub for R&D activities for Middle East, Africa, Asia, Europe and US market,
international players due to the relatively low cost connecting more than 720,000 healthcare professionals
worldwide and offering a range of marketing solutions
of clinical research.
for companies involved with the healthcare sector. Over
India imports nearly 80 per cent of its medical 100 congresses take place in parallel with the exhibitions.
devices.
The cost of surgery in India is about one-tenth of Informa Markets have a number of digital and print
that in the U.S. This has helped in attracting offerings, publishing a variety of healthcare magazines
medical tourists and the value of India’s medical and medical directories, with a readership of top
tourism industry is forecasted to reach US$ 9 billion decision-makers in the MENA region’s healthcare
by 2020. industry. Additionally, Omnia Health, their global
medical directory, is a unique digital platform providing
India Health will put the spotlight on all these company and product information 365 days of the year,
allowing users to connect with exhibitors and products
developments and facilitate conversations that will
in one simple click of a button.
allow these strategies to be brought to life. The
show will attract international participation and https://informa.com/divisions/informa-markets/
offer access to those who haven’t been able to enter
this vast market yet.

Microbioz India, January 2020 26


Product Launches

Zeiss Introduces
Four Axiocam
Models for Light
Microscopy
Applications
All four of the newest Axiocom microscope
cameras utilize high-quality CMOS sensors to
Zeiss, Oberkochen, Germany, has introduced four
deliver a combination of excellent contrast,
new high-quality complementary metal oxide
resolution, dynamic range, sensitivity, and readout
semiconductor (CMOS) cameras to support digital
speed. Small 3.45 µm pixels and low noise levels, in
imaging in light microscopy. The cameras complete
combination with the fast USB 3.0 platform, enable
the portfolio of Zeiss Axiocam models:
researchers to carry out extremely fast imaging
The Axiocam 705 color and 712 color deliver the
experiments while maintaining excellent signal
best possible image quality for histology, pathology,
quality. Also, the new cameras’ global shutter
or materials research and analysis, thanks to
architecture allows the capture of dynamic samples
excellent color rendition and greatly improved
without motion artifacts.
Story source/Credit: Zeiss.

FDA Clears
Lumipulse G Whole
PTH Assay
dynamic range.
The Axiocam 705 mono and 712 mono are ideal
for demanding fluorescence live-cell imaging, with
fast frame rates and high dynamic range. Also, their
extended near-infrared sensitivity allows for deeper
insights into sample structures.
The Axiocam 705 mono and Axiocam
705 color are five-megapixel cameras
optimized for fast speed and high
dynamic range. The Axiocam 712 mono
and Axiocam 712 color are 12-megapixel
cameras that are especially suited for the
acquisition of large samples, with greatly Fujirebio Diagnostics, Malvern, Pa, has received
FDA clearance for use of its new Lumipulse G
reduced need for image stitching. whole PTH assay on the company’s Lumipulse
G1200 immunoassay platform.
Parathyroid hormone (PTH) is secreted by the four
small parathyroid glands, which are located behind
the thyroid. PTH regulates the metabolism of
calcium and phosphoric acid in the body. The
measurement of whole PTH (or PTH 1-84) using
the Lumipulse G whole PTH assay can be used in

Microbioz India, January 2020 28


Product Launches

the differential diagnosis of hypercalcemia and


hypocalcemia resulting from calcium metabolism
disorders.
VRNxT Technology
The Lumipulse G whole PTH assay has a
significant benefit over prior generation intact PTH
(iPTH) assays because the ability to measure
Automates Sample
biologically active PTH helps to understand
parathyroid function without potential
Volume Reduction
misclassification of the patients. There is no
detectable cross-reactivity to PTH 7-84 or other
PTH fragments that may be seen with iPTH assays;
the whole PTH assay measures only biologically
active PTH and is 100% specific. Intact PTH can
overestimate PTH-indicated bone or mineral
abnormalities because iPTH assays also detect
various PTH fragments.1
Clinical practice guidelines for chronic kidney
disease and mineral and bone disorder recommend
the measurement and monitoring of several tests,
including PTH, for chronic kidney disease patients
not yet on dialysis. A falsely high PTH
measurement due to a second-generation iPTH test
could result in falsely identifying a patient for
dialysis. The Lumipule G whole PTH assay is also Menarini Silicon Biosystems, Bologna, Italy, and
traceable to in-house calibrators that have been Huntingdon Valley, Pa., has launched its new
assigned to the World Health Organization VRNxT sample volume reduction instrument.
standard (UK National Institute for Biological By standardizing sample volume reduction, the
Standards and Control 95/646), while iPTH assays VRNxT instrument adds precision and accuracy to
are not standardized and their values can vary by rare-cell and single-cell analysis, minimizing the loss
manufacturer. of precious samples and increasing workflow
The Lumipulse G whole PTH assay on the throughput. While the VRNxT instrument has
Lumipulse G1200 analyzer offers a fully automated been developed to standardize workflows for the
assay with a reaction time of just 30 minutes, using company’s DEPArray single-cell analysis system,
a single test cartridge design for reagent stability, broader applications in volume reduction are
efficiency, and testing flexibility. The assay has possible.
demonstrated excellent precision with a coefficient
of variance ≤4.0%.
“The Lumipulse G whole PTH assay is an
innovative next-generation assay to help diagnose
calcium metabolism disorders, and to help monitor
and adjust treatment of CKD patients,” says
Matthew Bell, vice president of sales and marketing
at Fujirebio US.
Story source/Credit: Fujirebio Diagnostics.
Reference Fabio Piazzalunga, Menarini Silicon Biosystems.
Kazama JJ, Omori K, Higuchi N, et al. Intact PTH “The VRNxT was created in direct response to
assay overestimates true 1-84 PTH levels after customer feedback to help streamline, automate,
maxacalcitol therapy in dialysis patients with and standardize rare-cell analysis workflows,” says
secondary hyperparathyroidism. Nephrol Dial Fabio Piazzalunga, CEO of Menarini Silicon
Transplant. 2004;19(4):892–897. Biosystems.
The VRNxT automated volume reduction
instrument removes manual pipetting steps,
reducing hands-on time up to 90% and eliminating
operator variability. No specific skill sets or training

Microbioz India, January 2020 30


Product Launches

are required to operate the instrument, thereby


delivering user-independent results with high
reproducibility and success, with 99% of single cells
retained after volume reduction.

Quantitative Assay applications from BioTek


Instruments, Winsooki, Vt, offer convenience and
simplicity to researchers performing fluorescence-
Matija Snuderl, MD, NYU Langone Health. based DNA assays or commonly used detection-
“The instrument helped us to reduce our error rate based assays for quantifying protein concentrations
and processing time,” says Matija Snuderl, MD, in a sample, including absorbance-based
associate professor of pathology and director of bicinchoninic acid assays, Bradford protein assays,
molecular pathology at NYU Langone Health, who and Lowry protein assays. The apps are powered
tested the new instrument in his laboratory. “We through BioTek’s Gen5 data analysis software and
handle rare cell types isolated from FFPE are compatible with the company’s microplate
specimens. With the VRNxT, we were able to readers equipped with the relevant detection mode,
lower the chance of error in the volume reduction including the Cytation and Synergy multimode
step, which is especially important when single-cell readers.
samples are collected, and decrease the time User-friendly features include predefined protocols
required to process these samples.” with simple step-by-step setup, along with quick
The VRNxT uses rotational motion for sample plate map definition and easy data export. After
volume reduction and can process up to four detection, the Quantitative Assay applications
samples at once, decreasing the time required for perform automatic curve fitting as well as
sample preparation and consistently reducing concentration normalization and target volume
sample volume to approximately 12.5 μL in 25 calculations.
seconds. Downstream of analysis via the Story source/Credit: BioTek Instruments.
DEPArray system, VRNxT reduces volume to
approximately 2 μL in about 8 seconds, making the
samples ready for whole-genome amplification. Elysium Health
Story source/Credit: Menarini Silicon Biosystems.
Launches Tool to
Determine Biological
Quantitative Assay Age of Individuals
Applications
Simplify Detection-
Based Assays

Microbioz India, January 2020 32


Product Launches

Elysium Health, New York City, has launched genetics, demographics, and lifestyle factors—and
Index, an at-home test intended to enable therefore, people of the same chronological age
individuals to measure their cumulative rate of don’t necessarily share the same current health
aging and determine their biological age. status or future outlook,” says Levine. “Index
Aging researcher Morgan Levine, PhD, associate provides a better picture of where an individual is
professor of pathology at the Yale School of in his or her aging process, which is why I’m excited
Medicine, has joined Elysium Health as head of to make this aging measure and the technology that
bioinformatics to lead the development of Index supports it directly available to consumers. It shows
using the latest generation of an epigenetic incredible promise when it comes to monitoring
biomarker called DNAm PhenoAge. overall health and wellness, and there is potential
Unlike earlier epigenetic clocks, which were for even more diverse applications in the future.
developed to support population-level research, “In clinical research, tools like this also enable
Index was developed by Levine and the Elysium faster evaluation of intervention efficacy, avoiding
Health team to further improve the testing the need for decades of follow-up,” Levine adds.
methodology and make its application accurate and “It may also inform basic and population research,
informative at the individual level. by shedding light on factors that alter the pace of
“Scientists in the field of aging research have long aging and facilitating the identification of
explored two fundamental questions: can aging therapeutic targets to slow the process. For people
itself be measured; and can we slow, stop, or in their everyday lives, while there are no
reverse the processes associated with aging?” says guarantees, understanding one’s cumulative rate of
Eric Marcotulli, CEO of Elysium Health. “With aging and the factors that are reflected on the
aging as the single greatest risk factor for all major epigenome may help them prioritize behaviors and
chronic conditions—and a force that affects lifestyle choices to proactively optimize their health
everyone even before birth—these questions are and wellness today and in the future.”
focused on supporting our collective ability to not While the technology required for epigenome and
only improve lifespan but, more importantly, genome mapping has historically made
‘healthspan.’ comprehensive testing cost-prohibitive, Elysium
“With the launch of Index, we hope to continue the Health enlisted the help of Illumina, San Diego, to
scientific exploration of these two questions by develop the custom Elysium chip to make the
extending the conversation to the consumer market initial release of Index as accessible as possible.
and allowing everyone to benefit from the ability to Elysium Health is committed to continuing to
determine their cumulative rate of aging and, with innovate the testing technology to make its measure
it, to see if lifestyle and other changes can impact of biological age available to everyone.
how they age in the future,” adds Marcotulli. Story source and Credit: Elysium Health
Levine helped to identify specific DNA
methylation sites along the epigenome that are Advanced Technology
highly correlated with nine known clinical
chemistry biomarkers of biological age and
chronological age. Since the development of the
Simplifies Purification
first epigenetic clock in 2011, the methodology has
been further refined and validated in multiple large-
of Nucleic Acids
scale datasets across diverse populations and
tissues.
A challenge to developing Index—and a key
differentiator—was ensuring its accuracy and
repeatability at the individual level. While the
published applications of the biological age
measure typically look at hundreds of sites on the
genome, Index examines global patterns across
more than 100,000 sites, which solves for issues
related to technical replicates—an important
consideration for making the technology available
to consumers and researchers.
“Historically, chronological age has served as the
best estimation of health and aging. However, not
all individuals age at the same rate—based on

Microbioz India, January 2020 34


Product Launches
Purigen Biosystems, Pleasanton, Calif, has
launched its ionic purification system, a small
benchtop unit that utilizes the company’s core
isotachophoresis technology to extract, purify, and
concentrate nucleic acids from biological samples
in 1 hour, with less than 3 minutes of hands-on
time per sample.

Barney Saunders, PhD, Purigen.


“The new ionic purification system will
fundamentally change how nucleic acids are
purified from precious samples prior to
downstream analysis using NGS and PCR,” says
Barney Saunders, PhD, CEO of Purigen. “When
The ionic purification system from Purigen Biosystems.
working with challenging sample types such as
The ionic purification system enables the
FFPE, or with small tissue samples, the ability to
automated extraction of nucleic acids with
dramatically increased yields and improved purity purify nucleic acids with maximal yield and quality
is crucial. More abundant and higher-quality nucleic
from a wide range of sample types, including
acids allow for superior quality data, which
cultured or sorted cells and formalin-fixed,
provides researchers with improved biological
paraffin-embedded (FFPE) tissues. Biological
samples are gently lysed and then loaded into the insights and empowers clinicians with more
actionable information.”
ionic fluidics chip. The ionic system then applies an
Story source/Credit: Purigen
electric field to the chip and the nucleic acids are
isolated in their natural, native form using the
company’s proprietary technology. The nucleic
Nona Scientific
acids are not denatured or dehydrated, and there is
no binding or stripping from fixed surfaces. The Introduces
process minimizes fragmentation and eliminates
any bead or buffer contamination. The extracted
nucleic acids are pure, abundant, and ready for
Technology That
analysis by any downstream technique, including
next-generation sequencing (NGS) or polymerase
Detects Synthetic
chain reaction (PCR).
Components of the ionic purification system Urine
include the ionic purification instrument, a small
benchtop system driven by a simple touchscreen
interface that can process one fluidics chip with
eight samples in approximately 1 hour; the ionic
FFPE to pure DNA kit, including six chips and a
reagent set with all the enzymes and buffers needed
to perform DNA extraction directly from as many
as 48 FFPE scrolls or slides; and the ionic cells to
pure DNA kit, including six chips and a reagent set
with all the enzymes and buffers needed to perform
cell lysis and DNA extraction from cultured or
sorted cells in up to 48 samples.

Microbioz India, January 2020 36


Product Launches

Reference laboratory Nona Scientific, Ocala, Fla, ‘TechnoConnect’ has also been organized in
has released its Synthetic Urine Detection test, a markets including Mumbai, Cochin and Dhaka
new technology that can detect both synthetic and with overwhelming response.
adulterated urine, including 18 classes of Targeted across key metros in India, Philips’
subversion and adulteration. ‘TechnoConnect’ comprises an in-house
The laboratory’s goal for its cutting-edge biomedical workshop for all Philips imaging and
technology is to help stop Florida’s spiraling opioid patient care equipment and activities. It is focused
epidemic and save lives. According to the Centers on highlighting expertise of biomedical engineers
for Disease Control and Prevention, opioid and healthcare technology professionals. This is
overdoses kill close to 200 people daily in the first of its kind initiative to bring the biomedical
United States. Moreover, the President’s Council of fraternity together, recognize their innovations and
Economic Advisers estimates that the cost of the give them a platform to share their thoughts to
opioid crisis was $696 billion in 2018— bring collective improvement to their daily
3.4% of the US practices.
gross domestic
The program will benefit health care staff across
the country to enhance performance in operational
theatres.
product—
and more than $2.5 trillion for the 4-year period Commenting on the initiative, Rohit Sathe,
from 2015 to 2018. Vice President, Philips Health Systems, Indian
“We are tired of everyone talking about the opioid Subcontinent said “Aligned with Philips’ customer-
epidemic but not using our technology to stop the centric approach, we are glad to introduce TechnoConnect
epidemic in its tracks,” says Mike Palmer, CEO of programme in India. This comprehensive training and
Nona Scientific. “Awareness is crucial, but it is time learning suite of services will empower our customers across
to deploy breakthrough technology to save lives the country to support both operational excellence and deliver
and help heal our communities and state. If connected, predictive and personalized care.”
someone has an addiction problem and they can
pass a drug test 10 out of 10 times while abusing The initiative also introduced Technology
opioids, how can we get them help?” Maximizer, a cross-modality solution designed to
Nona Scientific is also releasing an oral mouthwash boost the clinical capabilities and performance of
saliva drug test that detects more than 100 different imaging equipment through proactive and
drugs. This technology will be important not only structured upgrades. The service provides relief and
for ‘shy bladder’ patients, but also in in rehab confidence to radiology and cardiology department
settings, law enforcement, and workplaces. leaders as well as clinicians that their systems are up
Story source and credit: Nona Scientific. to date and compliant at a fraction of the cost of
Featured image: Urine samples ready for study. individual upgrades.
Photo © Tatiana Belova, courtesy Dreamstime
(ID 134698681). With Philips’ Technology Maximizer, healthcare
organizations no longer need to upgrade systems or
Philips India organizes knowledge sharing and software on an individual basis. Through regular
learning workshop ‘TechnoConnect’ in Delhi upgrades and by refreshing existing hardware, this
five-year subscription program provides radiology
Delhi, India – Royal Philips (NYSE: PHG, AEX: and cardiology departments with the latest software
PHIA), a global leader in health technology today and hardware updates while maintaining cost
conducted its knowledge sharing and learning efficiency through a predictable fee. Technology
workshop ‘TechnoConnect’ in New Delhi. The Maximizer is available for selected Philips MR, CT,
initiative is aimed at familiarizing hospitals, nursing IGT and Ultrasound systems, and runs in tandem
homes and clinics in the country with the latest with existing RightFit Customer Service
advancements in healthcare as well as sharing Agreements[1].
knowledge on best industry practices. This year

[1]
Philips introduces Technology Maximizer to boost
imaging equipment performance and clinical
capabilities, and help manage security risk

Microbioz India, January 2020 38


Product Launches
TechnoConnect in Delhi saw a presence of 270+ For further information, please contact:
healthcare fraternity representatives from 100+
healthcare institutions spread across the northern Philips India Corporate Communications
region of India and Nepal. Dr. Vidur Mahajan– Geetika Bangia
Associate Director, Mahajan Imaging Pvt. Ltd. and M: +91 9818102133
Head of R&D, CARING, shared his thoughts on E-mail: geetika.bangia@philips.com
the role of artificial intelligence in healthcare.
AvianWE
The session also hosted several eminent speakers Arshiya Ahmad
from the healthcare industry who talked about M: +91 83779 84933
various issues including current trends in E-mail: arshiya@avianwe.com
healthcare, future of healthcare technology, and
addressed questions from the curious participants. About Royal Philips
The professionals discussed on the optimum usage, Royal Philips (NYSE: PHG, AEX: PHIA) is a
equipment safety and maintenance of Philips’ leading health technology company focused on
Radiology, Cardiology and various critical care improving people's health and enabling better
solutions. The program also showcased Philips’ outcomes across the health continuum from
latest range healthy living and prevention, to diagnosis,
of treatment and home care. Philips leverages
advanced technology and deep clinical and
consumer insights to deliver integrated solutions.
Headquartered in the Netherlands, the company is
a leader in diagnostic imaging, image-guided
therapy, patient monitoring and health informatics,
innovative healthcare solutions such as as well as in consumer health and home care.
Compressed SENSE, Ambition 1.5T MR, Zenition Philips' health technology portfolio generated 2018
series, DigitalDiagnost C90, EPIQ Ultrasound sales of EUR 18.1 billion and employs
series and therapeutic care solutions. approximately 80,000 employees with sales and
services in more than 100 countries. News about
By providing advanced, well-maintained medical Philips can be found at
technology solutions and services, Philips aims to http://www.philips.com/newscenter.
improve health outcomes for people in India,
enhancing the patient experience, improving staff
satisfaction, reducing stress among care providers,
and lowering the cost of care.

Microbioz India, January 2020 40


PUBLISHED ON: 1st January 2020 RNI NUMBER: UPENG/2017/73675

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