Therapeutic Effects: The Adult: PO 10-15 mg q.d.

May
mechanism of action is unknown. increase at 2-wk intervals to
Efficacy of Aripripazole may be max of 30mg/d if needed.
mediated through a combination of Administration
partial agonist activity at D2 and 5-  Oral
HT1a receptors and antagonist o Note that dose should
activity at 5-HT2a receptors. be reduced by 50%
Actions at other receptors may with concurrent
explain some other clinical effects treatment with
of aripripazole (e.g., orthostatic ketoconazole,
ARIPRIPAZOLE (Abilify) hypotension) quinidine, fluoxetine, or
Classifications: Central Nervous paroxetine.
System (CNS) Agent; Uses: Treatment of schizophrenia o Store at 15-30 degree
Psychotherapeutic; Antipsychotic; Celsius (59-86 degree
Atypical Contraindications: Fahrenheit)
Prototype: Clozapine Hypersensitivity to aripripazole; Adverse Effects (≥1%)
Pregnancy Category: C lacatayion; pregnancy (category C).  Body as a whole: Headache,
Cautious Use: History of seizures asthenia, fever, flu-like
Availability: 10 mg, 15mg, 20mg, or conditions that lower seizure symptoms, peripheral
30mg tablets threshold (e.g., Alzheimer’s edema, chest pain, neck
Actions: Exhibits high affinity for Dementia); patients with known pain, neck rigidity
dopamine D2 and D3, serotonin 5- cardiovascular disease(History of  CNS: Anxiety, insomnia,
HT1a and 5-HT2a receptors, MI or ischemic heart disease, heart lightheadedness,
moderate affinity for dopamine D4, failure, or conduction somnolence, akathisia,
serotonin 5-HT2c and 5-HT7, alpha- abnormalities), cerebrovascular tremor,extrapyramidal
1adrenergic and histamine H1 disease, or conditions that symptoms, depression,
receptors, and moderate affinity for predispose to nervousness, increased
the serotonin reuptake site. hypotension(dehydration, salivation, hostility, suicidal
Functions as partial agonist at the hypovolemia, and treatment with thoughts, manic reaction,
dopamine D2 and the serotonin 5- antihypertensive medications). abnormal gait, confusion,
H1a receptors, and as an cogwheel rigidity.
antagonist at serotonin 5-HT2a Route and Dosage
receptors.  Schizophrenia
  CV: Hypertension,  Metabolism: Metabolized in  Monitor for and report signs
tachycardia, hypotension, liver by CYP3A4 and 2D6. of tardive dyskinesia.
bradycardia Major  Monitor for and immediately
 GI: nausea,, vomiting, metabolite,dehydoaripripazol report signs and symptoms of
constipation, anorexia e has some activity. neuroleptic malignant
 Hematologic: Echymosi,  Elimination: 55% excreted in syndrome (NMS) that include:
anemia feces, 25% in urine. hyperpyrexia, muscle rigidity,
 Metabolic: Weight gain,  Half-Life: 75 h (94h for altered mental status,
weight loss, increased metabolite) irregular pulse or blood
creatine kinase pressure, tachycardia,
 Musculoskeletal: Muscle Nursing Implications diaphoresis, and cardiac
cramp Assessment and Drug Effects dysrhythmia. Withhold drug if
 Respiratory: Rhinitis, cough  Monitor cardiovascular NMS is suspected.
status. Asses for and report  Lab tests: Monitor
 Skin: Rash
orthostatic hypotension. Take periodically Hct and Hgb.
 Special Senses: Blurred
BP supine then in sitting Monitor for elevated CPK nad
vision
position. Report systolic drop myoglobinuria if NMS is
of >15-20 mm Hg. Patients suspected.
Interactions:
at increased risk are those Patient and Family Education
 Drug: Carbamazepine will
who are dehydrated,  Do not drive or engage in
decrease aripripazole levels
hypovolemic, or receiving other potentially hazardous
(may need to double
concurrent antihypertensive activities until reaction to
aripripazole dose);
therapy. drug is known.
ketoconazole, quinidine,
 Monitor body temperature in  Avoid situations where you
fluoxetine, paroxetine may
situations likely to elevate are likely to become
increase aripripazole levels
core temperature (e.g., overheated or dehydrated.
(reduce dose by ½; may
exercising strenuously,  Notify physician if you
enhance effects of
exposure to extreme heat, become pregnant or intend
Antihypertensive agents)
receiving drugs with to become pregnant while
Pharmacokinetics:
anticholinergic activity, or taking this drug.
 Absorption: Well absorbed,
being subject to  Do not breast feed while
87% bioavailable
dehydration.) taking this drug.
 Peak: 3-5 h