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    1. The document discusses several mass spectrometry techniques including chemical ionization (CI), direct chemical ionization (DCI), electronspray ionization (ESI), fast atom bombardment (FAB), field desorption (FD), field ionization kinetic (FIK), and gas chromatography-mass spectrometry (GC-MS). 2. Each technique is described in terms of its spectrum and fragmentation patterns. Examples of molecular structures and their m/z ratios are provided. 3. The techniques are used to analyze different types of molecules and generate structural information through fragmentation patterns observed in their mass spectra.

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    1. The document discusses several mass spectrometry techniques including chemical ionization (CI), direct chemical ionization (DCI), electronspray ionization (ESI), fast atom bombardment (FAB), field desorption (FD), field ionization kinetic (FIK), and gas chromatography-mass spectrometry (GC-MS). 2. Each technique is described in terms of its spectrum and fragmentation patterns. Examples of molecular structures and their m/z ratios are provided. 3. The techniques are used to analyze different types of molecules and generate structural information through fragmentation patterns observed in their mass spectra.

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    8 views10 pages

    Bunga Asri Ibrahim

    Uploaded by

    Bunga asry
    1. The document discusses several mass spectrometry techniques including chemical ionization (CI), direct chemical ionization (DCI), electronspray ionization (ESI), fast atom bombardment (FAB), field desorption (FD), field ionization kinetic (FIK), and gas chromatography-mass spectrometry (GC-MS). 2. Each technique is described in terms of its spectrum and fragmentation patterns. Examples of molecular structures and their m/z ratios are provided. 3. The techniques are used to analyze different types of molecules and generate structural information through fragmentation patterns observed in their mass spectra.

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    of 10

    BUNGA ASRI IBRAHIM

    442416038

    KIMIA B

    1. Metode ionisasi kimia (chemical ionization, CI)

     spectrum

     Fragmentasi
    m/z: 150.13 (100.0%)
    CH3
    CH3
    -
    NH
    HN
    H
    H

    CH3 CH3

    m/z: 119.09 (100.0%)

    CH3 m/z: 91,05

    NH
    H

    CH3

    m/z: 59,07

    sumber (M. Pellegrini, 2001)

    2. Metode ionisasi kimia langsung (direct chemical ionization,DCI)


     Spektrum

     Fregmentasi
    H3CO H3CO
    CH2 CH2
    OCH3
    O O
    OCH3
    O O CH2CH C C CH(CH2)12CH3
    H H
    OCH3
    NCH3

    C O
    OCH3 OCH3
    C23H47
    H3C
    O

    OCH3
    O HC
    OCH3
    HC OCH3
    H3C C N O COOCH3

    H2C CH2CH C C CH(CH2)12CH3


    CH3 H H
    OCH3
    NCH3

    C O

    C23H47
    H3CO H3CO m/z : 660,67
    CH2 CH2

    O O
    OCH3
    O O

    OCH3

    OCH3 OCH3

    OCH3

    COCH3
    O H

    HCOCH3 COOCH3
    H3C C N O

    H2COCH3
    CH3

    m/z: 1066,69

    sumber (Toshio Argia, 1984)

    3. Metode ionisasi semprotan elektron (electronspray ionization, ESI)


     Spektrum
     Fregmentasi

    N N
    OH
    NH
    NH2

    S
    N
    m/z: 144.05 (100.0%)
    OH
    S

    m/z: 265.11 (100.0%)

    N N

    NH2

    CH2

    m/z: 122.07 (100.0%)

    sumber (Arnold Steckel, 2019)


    4. Metode pengeboman atom cepat (fast atom bombardment, FAB)
     Spektrum
     Fregmentasi
    CH3 H H
    H2 H2 H2
    N C C C C NH2 N
    H

    N CH3
    H2 H2
    N C C C C NH2 O
    H H2 H2 H2
    O NH C C C C NH2
    CH3
    H H2 H2 H2
    CH3 NH C C C C NH2 CH3

    CH3
    m/z: 262.19 (100.0%)

    m/z: 358.26 (100.0%) H

    H H N

    O CH3 H2N C CH2


    H
    H H2 m/z: 201.10 (100.0%)
    CH3 HN C C C CH2
    H

    CH3

    m/z: 243.15 (100.0%)

    H
    H H HOCH3
    N
    N

    O
    H2N
    CH3 H2N
    m/z: 144.07 (100.0%)
    m/z: 175.09 (100.0%)

    sumber (Sukesh N. Sinha,2003)


    5. Metode desorpsi medan (field desorption, FD)
     Spektrum
     Fregmentasi

    NH O

    H2N C NH(CH2)3 CH C

    NH2 OH

    m/z: 174.11 (100.0%)


    sumber (H. J. Heinen,1977)

    6. Metode ionisasi kinetic medan (field ionization kinetic, FIK)


     Spektrum
     Fregmentasi
    O O

    HN NH

    O N N O
    H H
    m/z: 252.09 (100.0%) O

    HN
    -
    O N
    NH H
    -

    O
    O

    NH

    O O
    N O
    H

    NH m/z: 126,04

    HN N O
    H
    m/z: 209,08

    sumber (C. FENSELAU, 1970)

    7. Metode ionisasi
     Spektrum
     Fregmentasi
    O

    F
    NH

    N O
    H
    m/z: 130.02 (100.0%)
    sumber (Damon B. Robb, 2000)

    8. GC-MS
     Spektrum

     Fragmentasi

    H2C COOH H2C COO H2C COO

    ESI -CO2
    HOOC C OH HOOC C OH H C OH
    -H
    H2C COOH H2C COOH H2C COOH

    m/z: 191.02 (100.0%)

    O
    O
    HC COO
    C -CHCH HC C
    H 2O
    H C
    HC O O
    HC
    C H2C COOH
    C C
    H
    m/z: 129.02 (100.0%)
    O O

    m/z: 84.99 (100.0%) m/z: 111.01 (100.0%)

    sumber (MU-CHANG,2001)

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