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Mucoceles, exclusive of the irritation fibroma, are the from deep blue to normal pink in color. The deep
most common of the benign soft tissue masses blue color results from tissue cyanosis and vascular
present in the oral cavity. Mucoceles (muco meaning congestion associated with the stretched overlying
mucus and coele meaning cavity), by definition, are tissue and the translucent character of the accumu-
cavities filled with mucus. When in the oral floor, they lated fluid beneath. The variation in color depends on
are called ranula (rana meaning frog and ula meaning the size of the lesion, its proximity to the surface, and
little) because the swelling resembles the vocal or air the elasticity of the overlying tissue. The bluish color
sacs of the frog (Fig 1). may be subtle when there is reduced elasticity of the
Mucus is the exclusive secretory product of the overlying tissue or if it is somewhat distant from the
accessory (minor) salivary glands and the more prom- surface mucosa, but it will become evident after the
inent product of the sublingual (major) salivary gland. initial mucosal incision (Fig 3).
The mechanisms for mucus cavity development are Mucoceles of all of the accessory glands and the
extravasation or retention. Extravasation (extra, out-
retention cysts of the major glands are rarely larger
side; vasa, vessel) is the leakage of fluid from the ducts
than 1.5 cm and they are always superficially posi-
or acini into the surrounding tissue, while the much
tioned. Conversely, those arising from the deeper
less common retention phenomenon occurs as a re-
areas of the body of the sublingual gland are generally
sult of a narrowed ductal opening that cannot ade-
quately accommodate the exit of saliva produced, significantly larger and can be massive.
leading to ductal dilation and surface swelling. Mucous cysts rarely present significant problems.
In the case of the accessory salivary glands, the Discomfort, interference with speech, mastication,
extravasation of mucus is the primary cause of muco- and swallowing, and external swelling depend on size
cele formation with physical trauma as the initiating and location (Fig 4A). In cases of very large sublingual
factor. The one exception is the mucous glands of the gland mucoceles, the tongue may compress the ran-
midportion of the posterior hard palate and the adja- ula to such a degree during eating and swallowing
cent soft palate, where a low-grade chronic superfi- that there is interference with submandibular salivary
cial irritation can lead to mucoceles of the retention flow. This results in obstructive symptoms and clini-
variety. This is sometimes seen in cases of nicotinic cal enlargement of the gland (Fig 4B). This has led to
stomatitis, in which irritation from heat and noxious diagnostic confusion in the past, when it was believed
tobacco products can result in narrowing of the duc- by some that the source of a ranula may be the
tal openings (Fig 2). The majority of retention cysts submandibular duct. Retention cysts of Wharton’s
develop at the orifices of the major salivary glands. duct occur but with a distinct clinical appearance.
The exception is the sublingual gland: only the open- The lower lip is by far the most frequent site of the
ings of the ducts of Rivini (5 to 15), which service the mucocele because it is the area most often susceptible
superficial portion of the gland, may develop such to trauma, especially in the cuspid location (Fig 5). It
cysts. is not surprising that mucoceles are rarely if ever
The pseudocystic mucoceles, regardless of their found on the upper lip even though it has the same
location, present as soft, painless swellings ranging concentration of mucous glands. The lip is followed
in frequency by the cheek and palate. On occasion,
mucoceles may be seen on the ventral surface of the
*Retired Clinical Professor of Oral and Maxillofacial Surgery,
Columbia University, School of Dental and Oral Surgery, New York,
tongue involving the glands of Blandin-Nuhn. In most
NY.
cases, this results from self-inflicted bite wounds. On
Address correspondence and reprint requests to Dr Baurmash: even rarer occasions, the incisal gland in the anterior
4666 Hazleton Lane, Lake Worth, FL 33467; e-mail: hali2533@aol. oral floor and the retromolar pad area may be in-
com volved.
© 2003 American Association of Oral and Maxillofacial Surgeons The most common origin of the ranula is the
0278-2391/03/6103-0015$30.00/0 deeper areas of the body of the sublingual gland,
doi:10.1053/joms.2003.50074 followed to a lesser degree by the retention cysts from
369
370 MUCOCELES AND RANULAS
FIGURE 1. A, Large ranula closely resembling the air or vocal sacs of the frog. B, Air or vocals sacs of the frog, which are used for mating calls
with a range of 1 mile.
the ducts of Rivini. Less frequently, retention cysts of tive tissue with varying amounts of inflammation and
the opening of Wharton’s duct are encountered. vascular engorgement. The condensed connective tis-
sue may be mistaken for epithelium (Fig 6). It is not
Histopathology of Mucoceles unusual to find salivary gland tissue in the neighbor-
ing areas. The retention cyst will have a similar ap-
The extravasation variety consists of a granulation pearance minus adjacent salivary glands. In addition,
tissue lining surrounded by a condensation of connec- remnants of ductal epithelium (columnar or cuboidal)
may be present (Fig 7).
FIGURE 3. A, Extremely large ranula with only a subtle blue appearance. B, After the mucosal incision, the cystic mass shows a deep blue color.
HAROLD D. BAURMASH 371
FIGURE 8. A, A retention cyst of Stensen’s duct, which enlarges after salivary stimulation. B, The cyst is unroofed and a lacrimal probe is inserted
into the duct lumen before the duct margins are sutured to the adjacent mucosa.
during eating (Fig 8A). After the entire cyst-like cov- coceles are completely excised and primarily closed.
ering is excised, a lacrimal probe is inserted into the Healing is rapid and uneventful.
dilated duct, and the margins of the duct wall are
sutured to the mucosa with fine interrupted gut su-
Management of Ranula and Ranula-
tures (sialodochoplasty) (Fig 8B). The recommended
Like Lesions in the Oral Floor
follow-up care consists of salivary stimulating foods
(lemon drops, grapefruit, and pickles) and duct dila- Simple marsupialization, the oldest and most
tion using lacrimal probes. Healing is always rapid and widely reported method of surgical management of
uneventful. Because access may be a problem in the oral ranula, has fallen into disfavor primarily because
palate, all surface-prominent mucoceles are best of the excessive number of recurrences (61% to 89%)
treated with simple marsupialization with or without after it. For this reason, Crysdale et al,2 Catone et al,3
sutures. and Bridger et al4 proposed that sublingual gland
removal should be the primary treatment of all ranula.
TONGUE If simple marsupialization was the only other ap-
The anterior lingual gland, the gland of Blandin- proach available, then this conclusion would be irre-
Nuhn, is located on the inferior surface of the tongue futable.
close to the apex and midline, covered only by thin With our present knowledge concerning the devel-
mucous membrane. In reality, it is not a single gland opment of the ranula, simple marsupialization of rel-
but a compact package of smaller glands that open atively large lesions (⬎1.5 cm), which usually origi-
with several ducts on its inferior surface.1 nate from the deeper portions of the sublingual gland,
The proposed technique for managing moderate to is a procedure without sound foundation from an
large cysts of Blandin-Nuhn (Fig 9A) begins with the anatomic, mechanical, or histological standpoint.5
placement of a tongue-retracting suture at the tip of The procedure cannot succeed when the origin of the
the tongue. The goal of surgery is to completely mucocele is distant from the surface and when the
unroof the lesion along its entire periphery to visual- mucocele is of the extravasational variety with a gran-
ize and remove all of the glands present. Because the ulation tissue lining.
traction applied to stabilize the tongue tends to mask Unroofing this lesion will result in drainage of its
or obliterate the outline of the lesion periphery and contents, and the inferior compression by the tongue
the drainage of the mucus will be even more damag- during function will force the opposing granulation
ing regarding visualization, experts recommend that tissue walls together, leading to rapid healing with
immediately after a 1-cm longitudinal incision minimum fibrosis. Because this treatment does not
through the mucosa, 0.25-inch plain gauze should be eliminate the source of leakage of the mucus into the
packed into the cavity to restore the original periph- surrounding tissue, one would expect recurrence at
eral configuration (Fig 9B). The lesion is then un- even a higher rate than reported.
roofed and all glandular tissue is removed, leaving a There are, however, 2 reasons for reconsidering
muscular base (Fig 9C). The mucosa is undermined sublingual gland removal as primary treatment for the
and a primary closure performed. Healing without ranula. First, a number situations present as ranula
complication or recurrence should follow. Small mu- that do not arise from the sublingual gland.6 Second,
HAROLD D. BAURMASH 373
a slight variation to the standard marsupialization pro- of 13.4 centipoises) than that of the submandibular
cedure can reduce the incidence of recurrence to gland (more serous than mucus, with a viscosity of 3.4
10% to 12%.5 centipoises).7 In addition, Wharton’s duct retention
cysts are always associated with some degree of ob-
structive submandibular gland symptoms (gland
Treating Ranula-Like Lesions Not
swelling during eating). They are never larger than 1.5
Arising From the Body of the
cm in contradistinction to the massive ranula that can
Sublingual Gland
result in similar obstructive symptoms.
MUCOCELE OF THE INCISAL GLAND The procedure consists of unroofing the cyst, in-
The incisal glands are a small group of mucous serting a wide lacrimal probe into the dilated duct
(accessory) glands found on the floor of the oral lumen, and sialodochoplasty (Fig 10B). Postoperative
cavity behind the lower incisors.1 They are unrelated care consists of food sialogogues (lemon drops and
and superficial to the sublingual gland. Mucoceles citrus fruits) and ductal dilation with appropriately
that develop are treated with unroofing and removal sized probes. Rapid healing and the formation of a
of all glandular tissue with or without peripheral mar- new patent opening is the result.
gin suturing.
SUBMANDIBULAR DUCT INJURY WITH SALIVARY
RETENTION CYST OF WHARTON’S DUCT FLUID LEAKAGE
Retention cysts may present as small (0.5 cm) to On occasion, an iatrogenic injury to the anterior
moderately sized (1.5 cm) superficial cyst-like lesions section of Wharton’s duct may result in leakage of
in the area of the caruncular sublingualis extending saliva into the surrounding soft tissues in the anterior
posteriorly along the course of the plica sublingualis oral floor. When the patient eats, this may simulate
(Fig 10A). In this area, they may simulate retention ranula.6
cysts of the ducts of Rivini. Examination of the evac- Treatment consists of locating the damaged duct
uated cystic secretions may help to differentiate be- area after excising the overlying mucosa, isolating the
tween them. The secretion from the sublingual gland duct and milking the gland. A flow of saliva will locate
will be more viscous (mostly mucus, with a viscosity and demonstrate the extent of injury. In this case,
374 MUCOCELES AND RANULAS
Technique
The sublingual gland is always removed via an in-
traoral approach. Primary attention should be di-
rected toward avoiding injury to the lingual nerve or
Wharton’s duct that might result in perforation or
stenosis. A lacrimal probe should be inserted into the
submandibular duct before the incision and kept in
place for the entire procedure to make the duct
readily identifiable at all times (Fig 16A). A longitudi-
nal incision is made through the mucosa in a pos-
teroanterior direction midway between the plica sub-
lingualis and the lingual of the mandible from the
second molar to the cuspid area. This is anterior to
where the lingual nerve descends to enter the oral
floor.
Dissection begins on the lateral side of the anterior
two thirds of the gland and is carried down to the
surface of the mylohyoid muscle because there are no
vital structures in this plane. After the lateral and
anterior portion of the gland is freed, several retract-
ing sutures may be placed through its superior area to
facilitate the dissection of the medial surface of the
anterior two thirds of the gland and its careful sepa-
ration from the probe containing Wharton’s duct. A
moistened gauze pad or “peanut” in front of an ele-
vator provides safe blunt dissection. Bleeding will not
be a problem as long as the dissection remains lateral
FIGURE 15. A, A moderate swelling in the submandibular and to the duct because the sublingual artery is situated
submental area suggests a plunging ranula. B, Computed tomography medial and slightly inferior to it.
shows a cystic lesion in the area, confirming a plunging ranula.
After the anterior two thirds of the gland have been
dissected and freed, the retraction sutures are used to
lift the gland superiorly and somewhat anteriorly.
Additional indications for surgical removal of the sub- Careful blunt dissection is continued on the medial
lingual gland include a recurrent ranula after a single posterior portion of the gland until the lingual nerve
marsupialization with packing and hypertrophied is identified and isolated as it crosses underneath the
sublingual glands that interfere with prosthetic recon- submandibular duct. The lingual nerve is gently sep-
struction. arated from the gland followed by the complete sep-
FIGURE 16. A, The gland was excised for a recurrent ranula. Note the placement of a lacrimal probe in Wharton’s duct preoperatively. B, Two
weeks postoperatively, healing has progressed and the lacrimal probe confirms the absence of ductal stenosis. Remnants of the incision line (arrow)
clearly depict its location, direction, and length.
378 MUCOCELES AND RANULAS
aration and removal of the gland from the oral floor. 5. Baurmash HD: Marsupialization for treatment of oral ranula: A
second look at the procedure. J Oral Maxillofac Surg 50:1274,
After 1 week of healing, lacrimal probes may be used 1992
to prevent ductal stenosis (Fig 16B). 6. Baurmash HD: Treating oral ranula: Another case against blan-
ket removal of the sublingual gland. Br J Oral Maxillofac Surg
39:217, 2001
References 7. Mason DK, Chisholm DM: Salivary Glands in Health and Dis-
ease, (ed 1). Philadelphia, PA, Saunders, 1975, p 37
1. Sicher H: Oral Anatomy (ed 2). Philadelphia, PA, Mosby, 8. Harrison JD, Garrett JR: Mucocele formation in cats by glandu-
1952, p 201 lar duct ligation. Arch Oral Biol 17:1403, 1972
2. Crysdale WS, Mendelsohn JD, Conley S: Ranulas - mucocoeles 9. Glen JB: Salivary cysts in the dog: Identification of sublingual
of the oral cavity: Experience in 26 children. Laryngoscope duct defects by sialography. Vet Rec 78:488,1966
98:296, 1988 10. Harrison JD, Garrett JR: Histologic effects of ductal ligation of
3. Catone GA, Merrill RG, Henny FA: Sublingual gland mucus salivary glands of the cat. J Pathol 118:245, 1975
escape phenomenon: Treatment by excision of sublingual 11. Gossett JD, Smith KS, Sullivan SM, et al: Sudden sublingual and
gland. J Oral Surg 27:774, 1969 submandibular swelling. J Oral Maxillofac Surg 57:1353, 1999
4. Bridger AG, Carter P, Bridger GP: Plunging ranula: Literature 12. Nathan H, Luchanski E: Sublingual gland herniation through
review and report of 3 cases. Aust N Z J Surg 59:945, 1989 the mylohyoid muscle. J Oral Surg 59:21, 1985