OUR LADY OF FATIMA UNIVERSITY – ANTIPOLO
PHYSICAL PHARMACY ADDITIONAL PRACTICE
COLLOGATIVE PROPERTY, BUFFER AND ISOTONIC
SOLUTION
BOILING POINT ELEVATION
1. A solution was made by adding 150.5 g of drug
dissolve in 500 g of water. What is the mw of the
drug if the solution boils at 118C?
Answer: 8.70 g/mole
2. What is the is the boiling point elevation when
147 g of lactic acid (C6H10O5) is dissolved in
647 g of (C6H12) kb= 2.79 C/m
Answer: 3.91C
FREEZING POINT DEPRESSION
1. Camphor (C6H16)) melts at 179.8C, and it jas
particularly large freezing point depression
constant 40C/m. when 0.186g of an organic
substance of unknown molar mass is dissolved
in 22.01 g of liquid camphor, the freezing point of
the mixture is found to be 176.7C. what is the
molar mass if the solute?
Answer: 109g/mol
2. What is the freezing point of water solution made
by dissolving 10.9 g of magnesium chloride in
88.41 g water?
Answer: -7.23C
OSMOTIC PRESSURE LOWERING VAPOR PRESSURE LOWERING
1. A 45.3 g of drug was dissolved in water and 1. The vapor pressure of pure CFC 11
yield in 100ml of solution at 30C was found to (MW=137.4g/mole) is 24.5 psi and CFC 12
produce an osmotic pressure of 0.89atm. what is (MW=120.9g/mole) is 94.5 psi. A mixture of
the molecular weight of the solute? 500g of 5:7. What is the partial pressure of CFC
Answer: 4.19g/mole 11 and CFC 12 and What is the total partial
pressure of the mixture?.
Answer: 58.04 atm, 9.45 atm = 67.49 atm = 52.79 psig

2. A solution was made by dissolving 1.25 g of

chemical x with a MW of 123 g/mole, is
dissolved in 150 ml of solution at 27C. what is
the osmotic pressure of the solution
Answer: 1.66 atm

OSMOLARITY AND OSMOLARITY

1. 1% of zinc chloride Answer: 220.59 mosmol/L
 2. 0.9% of sodium acetate Buffer and isotonic
Answer = 219.51 mosmol/L What is the pH of a buffer solution prepared with 0.05 M
sodium borate and 0.005M boric acid? Pka= 9.24
Answer: 10.24

What is the pH of buffer solution prepared with 0.05M

ammonia and 0.05M ammonium chloride? Kb=1.80x10-5
3. 3% magnesium chloride Answer: 9.26
Answer: 947.37 mosmol/L

What molar ratio S/A and the mole percent is required to

pH and Poh a sodium acetate – acetic acid buffer solution with a pH
1. Convert 1.25x10-11 hydroxyl ion to PH 5.76? Pka = 4.76
Answer: 10:1 90.91% 9.09%

2. Convert 2.25x10-7 hydronium ion to POH

Compute for Freezing point and E value of the following :

1. 1% Neostigmine Br MW = 303.2
3. Convert pH = 8.5 to hydroxyl ion E= 0.22 FP = 0.11

4. Covert pOH = 12.5 to hydronium ion

2. 1% Ascorbic acid MW = 176.12
E= 0.18 FP = 0.11
Isotonic solution
How much gram of sodium chloride should be used in
compounding the prescription?
RX Zinc sulfate 0.06g
NaCl qs
PW qs 30ml

How many grams of sodium chloride should be used in

compounding the prescription? (used both FP and NaCl
E value) Check the MW in PPAR book Also write the
compounding procedure.
Rx Pheneleprine HCl 1%
Chlorobutanol 0.5%
NaCl qs
PW qs 15ml