Date: 30-03-2020

Spring Vacation Assignment no. 11

Topic: Protein metabolism
By: Dr. Taha A. Khan

MCQS
1. The main site of urea synthesis in mammals is
(A) Liver (B) Skin
(C) Intestine (D) Kidney
2. The enzymes of urea synthesis are found in
(A) Mitochondria only
(B) Cytosol only
(C) Both mitochondria and cytosol
(D) Nucleus
3. The number of ATP required for urea synthesis is
(A) 0 (B) 1
(C) 2 (D) 3
4. Control of urea cycle involves the enzyme:
(A) Carbamoyl phosphate synthetase
(B) Ornithine transcarbamoylase
(C) Argininosuccinase
(D) Arginase
5. Transfer of the carbamoyl moiety of carbamoyl phosphate to ornithine is
catalysed by a liver mitochondrial enzyme:
(A) Carbamoyl phosphate synthetase
(B) Ornithine transcarbamoylase
(C) N-acetyl glutamate synthetase
(D) N-acetyl glutamate hydrolase

VIVA QUESTION
1. A compound serving a link between citricacid cycle and urea cycle is?
2. The 2 nitrogen atoms in urea are contributed by?
3. In carcinoid syndrome the argentaffin tissue of the abdominal cavity
overproduce?
4. Tryptophan could be considered as precursor of?
5. Conversion of tyrosine to dihydroxyphenylalanine is catalysed by tyrosine
hydroxylase
which requires?

KEY
MCQS:
1. A Lippincott. 6E. p 253
2. C Lippincott. 6E. p 254
3. D Lippincott. 6E. p 225
4. A Lippincott. 6E. p 253
5. B Lippincott. 6E. p 245
VIVA QUESTIONS:
1. Fumarate Lippincott. 6E. p 255
2. Ammonia and aspartate Lippincott. 6E. p 255
3. Serotonin Lippincott. 6E. p 245
4. Melanotonin Lippincott. 6E. p 266
5. Tetrahydrobiopterin Lippincott. 6E. p 285