Professional Documents
Culture Documents
ON
BRONCHIAL ASTHMA
SUBMITTED BY:
SHABNA BEEGUM .A
VARKALA.
INTRODUCTION
In childhood asthma, the lungs and airways become easily inflamed when exposed to certain
triggers, such as inhaling pollen or catching a cold or other respiratory infection. Childhood
asthma can cause bothersome daily symptoms that interfere with play, sports, school and
sleep. In some children, unmanaged asthma can cause dangerous asthma attacks.
Childhood asthma isn't a different disease from asthma in adults, but children face unique
challenges. The condition is a leading cause of emergency department visits, hospitalizations
and missed school days.
Unfortunately, childhood asthma can't be cured, and symptoms can continue into adulthood.
But with the right treatment, you and your common chronic diseases of childhood, affecting
more than 6 million children. Asthma is a chronic inflammatory lung disease that can cause
repeated episodes of cough, wheezing and breathing difficulty. During an acute asthma
episode, the airway lining in the lungs becomes inflamed and swollen. In addition, mucus
production occurs in the airway and muscles surrounding the airway spasm. Combined, these
cause a reduction in air flow. t damage to growing lungs.
Asthma is the commonest chronic disease in childhood. Due to the various different
phenotypes of childhood asthma, it has been difficult to agree on a clear definition of the
condition and instead an operational description is used: ‘Asthma is a chronic inflammatory
disorder of the airways in which many cells and cellular elements play a role. The chronic
inflammation is associated with airway hyperresponsiveness that leads to recurrent episodes
of wheezing, breathlessness, chest tightness, and coughing, particularly at night or in the
early morning. These episodes are usually associated with widespread, but variable, airflow
obstruction within the lung that is often reversible either spontaneously or with treatment.’
(Global Initiative for Asthma, 2012). However, in children <5 years of age, clinical
symptoms of asthma are variable and nonspecific, and a symptoms-only approach that
defines various wheezing phenotypes has been recommended.
BRONCHIAL ASTHMA
DEFINITION
EPIDEMIOLOGY
ETIOPATHOGENESIS
Aerobiologicals
Children develop sensitivity to indoor allergens as they grow older in the atmosphere they are
reared. The predominant indoor allergen is the house dust mite. It takes 100 mites/g of dust
to get sensitization and 500 dust mites/g of dust to produce wheezing. 50% of perennial
asthma is due to dust mites. The pollen and mould sensitivity is observed less frequently
whereas cockroach sensitivity is fairly common.
Viral infections
The precipitating factor for an asthma attack in 40% of the children is viral URTI. Most
children develop rhinitis with or without fever followed by cough. Respiratory syncytial
virus and rhinovirus are the predominant viruses triggering asthma.
Season
Food
The role of food allergy in asthma is difficult to prove in children. The most suspected food
items that may cause asthma are grapes, banana, guavas, citrus fruits, ice creams, fried foods.
Pets
Cats are more allergic than dogs. The saliva , urine and dander are the causes for allergy
sensitization.
Air pollution is both outdoor and indoor. The important outdoor pollutants are black smoke,
respirable suspended particulates, SO2 , NO, CO, O 3 and lead produced by combustion of
fossils fuels, factories, mines, paper pulp mills and automobiles exhaust. Nitrogen oxide
triggers asthma in 65% of patients and also sensitizes to dust mites allergy.
IMMUNOPATHOGENESIS
Inducers
Which generates an immune response , common genes associated with asthma included the
Interleukin-4(IL-4) gene on chromosome 5 (proinflammatory) , ADAM-33(metalloproteinase
family), IL-12 on chromosome 5q31, genes for prostanoid DP receptors and polymorphisms
in the beta-adrenergic receptors.
Enhancers known to aggravate this response with T helper cells, mast cells and eosinophils,
resulting in AHR. The role of anti-inflammatory therapy and immunotherapy is targeted at
this stage f pathogenesis.
The enhancers are;
Enhancers
Viral infections
Ozone
Sulfur dioxide
Particulate matter
Diesel particles
Endotoxins
The agents that stimulate symptoms in a child predisposed to wheezing due to prior
sensitization with these inducers are triggers. This includes:
Triggers
Exercise
Pollution
Histamine/methacholine
PATHOPHYSIOLOGY
The severity of asthma is classified based on how often the symptoms occur and how bad
they are , including symptoms that happen at night, the characteristics of episodes and lung
function . these classification do not always work well in children because lung function is
difficult to measure for younger children. A child’s symptoms can be categorized into one
of four main categories of asthma each with different characterestics and requiring different
treatment approaches.
Brief episodes of wheezing, coughing or shortness of breath that occur no more than
twice a week . children rarely have symptoms between episodes . mild asthma should
never be ignored because even between flares ,always airways are inflamed.
Symptoms occurring every day and requiring medication every day. Night
symptoms occur more than once a week. Episodes of wheezing, coughing or
shortness of breath occur more than twice a week and may last for several days.
These symptoms affect normal physical activity.
Other classification:
Atopic: IgE mediated, triggered by allergen.
Nonatopic: Non IgE-mediated triggered by infection.
Exercise or drug induced.
CLINICAL MANIFESTATIONS
The clinical features of asthma are variable. Symptoms vary from simple recurrent cough to
severe wheezing .Children may present with recurrent cough with or without wheezing. The
symptoms occur with change in season , aggravated by exercise and more in nights.
symptoms
Cough
Intermittent, chronic and a dry nature characterize the cough in asthma. Early morning
worsening of cough or following physical exertion is classical. Acute asthma usually begin
with a cold, or bouts of spasmodic coughing mores so at night. In early phase of the attack
cough is non-productive. The patient become dyspneic, with prolonged expiration and
wheezing.
wheeze
Wheezing is when the air flowing into the lungs makes a high pitched whistling sound.
Expiratory wheeze noted at night or following exercise characterizes asthma. Improvement
following bronchodilator use increases the possibility of asthma. Mild wheezing occurs at
the end of a breath when the child breathing out. More severe wheezing is heard during the
whole exhaled breath.
signs
Shortness of breath
Prolonged expiratory phase
Audible wheeze
Chest tightness
May have a malar flush and red ears
Lips deep, dark red color
May progress to cyanosis of nail beds or circumoral cyanosis
Restlessness
Apprehension
Prominent sweating as the attack progresses
Older children sitting upright with shoulders in a hunched- over position, hands on the
bed or chair, and arms braced (tripod)
Speaking with short, panting , broken phrases
Chest
Barrel chest
Elevated shoulders
Use of accessory muscles of respiration
Facial appearance- flattened malar bones, circles beneath the eyes, narrow nose, and
prominent upper teeth.
DIAGNOSTIC EVALUATION
Asthma is often difficult to diagnose in infants. However , in older children the disease can
often be diagnosed based on child’s medical history , symptoms and physical examination.
History collection
Physical examination
Pulse oximetry
It shows eosinophilia
Chest x- ray
Usually reveals hyperinflation and also it shows bilateral and symmetric air trapping in
lungs. Also areas of atelectasis due to mucus plugs may be seen.
Blood gases
Allergy test
Skin test or RAST can determine allergic triggers for the asthmatic child.
An exercise test such as running on a treadmill can be useful in diagnosing asthma in children
with a history suggestive of exercise induced bronchospasm.
Fractional Exhaled Nitric Oxide
MANAGEMENT
There are a large number of guidelines on the management of asthma; however, the key
messages of them remain similar. The principal goal is disease control using least possible
medication.
Asthma education is a continuous and dynamic process. Education should highlight chronic
nature of the disease , the recognition of asthma symtoms, different types of medication, need
for long term medication, importance of compliance and adherence and a demonstration of
use of inhalers and spacers.
The bedroom of the child should be kept clean and as free from dust as possible. Wet
mopping of the floor should be done because dry dusting increases exposure of the
child to house dust.
Heavy tapestry attracts dust and therefore light plain cloth sheets should be used as
curtains in the child’s room.
Carpets, stuffed furniture, loose clothing, wall hangings, calendars and books attract
lot of dust and should be regularly cleaned at periodic intervals.
The bed of the child should be made of light material and should be aired regularly.
Keeping of animal pets should be discouraged, as the child may be sensitive to their
fur.
Generally , it is not necessary to restrict the diet of the child because bronchial asthma
due to food allergy is unusual.
Adolescent patients must be refrain from smoking.
Exposure to strong or pungent odors such as wet paint, dissinfectants and smoke
should be minimized.
The child should not got o attics or basements, especially if these were unoccupied
and kept closed for some days . These should be minimized.
The child should be properly cleaned and aired for some time before the asthmatic
patent goes there.
The most common causes of chronic coughing in children include rhinitis , sinusitis and GER
in addition to asthma. Effective management of these comorbid conditions is shown to
reduce medication requirement, disease severity and asthma symptoms.
Pharmacotherapy
The pharmacological therapy of bronchial asthma involves use of drugs that relax the smooth
muscles and dilate the airways and drugs that decrease inflammation and there by prevent
exacerbations. The medications used for long term treatment of asthma include
bronchodilators , steroids, mast cell stabilizers, leukotriene modifiers and theophylline.
Bronchodilators
This group of drugs provides symptomatic relief. They may be short acting and long
acting. The commonly used short acting bronchodilators are adrenaline, terbutaline
and salbutamol. All of these have quick onset of action .adrenaline stimulates alpha
and both beta receptors; thus causes cardiac side effects. Terbutaline and salbutamol
are specific beta 2 agonist and hence have least cardiac side effects. Inhalation route is
preferred because of quick onset of action and least side effects.
Long acting beta agonists include salmetrol and formoterol. Both these drugs are
specific beta 2 agonist and have a longer duration of action of 12-24 hours.
Corticosteroids
Asthma is a chronic inflammatory disease of airways. Corticosteroids being potent
anti-inflammatory agents, are the corner stone of long –term treatment of asthma.
Systemic glucocorticoids used early in the treatment of acute exacerbation can lessen
the need for visits to emergency department and hospitalization. The advantage of
inhaled corticosteroids is application of potent medication to the sites of where it is
specifically needed. This potentially reduces the risk for systemic adverse effect of
these medications.
The commonly used inhaled steroids include beclomethasone, budesonide and
fluticasone. Beclomethasone or budesonide has almost the same effect .
The newer inhalation steroid , fluticasone is considered to be superior to
Beclomethasone or budesonide.
Mast cell stabilizers
In this group of drugs includes cromolyn sodium, nedocromil sodium and ketotifen.
Cromolyn sodium belongs to chromone group of chemicals. It reduces bronchial
reactivity and symptoms induced by irritants , antigens and exercise. Indications for
use of chromolyn includes mild to moderate persistent asthma and exercise induced
asthma.
Nedocromil is another nonsteroidal drug used for control of mild to moderate asthma.
Ketotifen is administered orally . significant clinical improvement may be evident
after 14 weeks of therapy.
Leukotriene modifiers
Leukotriene inhibitors are new pharmacological agents for the treatment of mild to
moderate persistent asthma and exercise –induced asthma. Leukotriene inhibitors act
either by decreasing the synthesis of leukotriene or by antagonizing the receptors.
Monteleukast and zafirlukast have received approval for use in pediatric asthma
patients . Monteleukast can be used in children above one year of age while
zafrilukast above 6 year of age.
Theophylline
Theophylline has concentration dependent bronchodilator effects . The bronchodilator
effect is exerted by inhibition of phosphodiesterace. In addition theophylline has anti-
inflammatory and immunomodulatory effects at therapeutic serum concentration that
appears to be distinct from its bronchodilator properties. It can also be used as
adjunctive therapy in moderate or severe persistent asthma.
Immunotherapy
This consists of giving gradually increasing quantities of an allergen extract to a
clinically sensitive subject, so as to ameliorate the symptoms associated with
subsequent exposure to causative allergen. This is considered only occasionally in
highly selected children who are sensitive to a specific allergen such as grass pollen,
mites etc.
Bronchodilators
Salbutamol
100 µg/puff MDI 1-2 puff 4-6 hourly
Respirator solution 5
mg/ml Respules 2.5
mg/3 ml 0.15-0.2 mg/kg dose
Dry powder capsules nebulization
200µg/cap (rotacap)
1-2 puff 4-6 hourly
Terbutaline
250 µg puff MDI 1-2 puffs 12-24 hourly
Salmetrol 1 dry powder cap
25 µg/puff MDI inhalation 12-24 hourly.
Drypowder capsules 50 1-2 puffs 12-24 hourly Step wise treatment of asthma
µg /cap (rotacap) 1 dry powder cap
inhalation 12-24 hourly. After the assessment of severity
Formoterol appropriate anti-asthma drugs are
12 µg / puff MDI 5-15 mg/kg/day
Dry powder capsules
selected .
2 divided dose
12 µg /cap (rotacap)
Theophylline 5 mg/puff
100, 150, 200, 300 mg
tablets 1-2 puffs3-4 times a
Oral day
Mast cell stabilizers
Sodium, cromoglycate 1 mg twice a day
5mg /puff MDI
Nedocromil sodium 50-800 µg/day in 2-3
Inhalation divided dose
Ketotifen
1 mg tab and 1 mg /5ml 25-400 µg/day Long
in2 term prevention
Corticosteroids divided doses
Inhaled corticosteroids
Beclomethasone
50,100,200,250 µg/puff
Budesonide
50,100,200 µg/puff
MDI respules-0.5 and 1
mg /mi
Rotacaps 100/200/400
µg /cap
Fluticasone 2-5 years:4mg/day
25, 50, 125 µg /cap 5-12years:5mg/day
Respules:0.5 and 1 mg >12years:10mg/day
per ml
Monteleukast
4,5, 10 mg tabs
Step 4 Inhaled short acting beta agonist are
Severe persistent required + inhaled
corticosteroids
budesonide/beclomethasone,400 µg twice
daily may increase up to 1000 µg /day+ long
acting bronchodilator : long acting inhaled
beta 2 agonist and / or sustained release
theophylline + corticosteroids low dose
alternate day ) if no relief with above
treatment)
Step 3
Moderate persistent Inhaled short acting beta agonist as
required + inhaled corticosteroids
Budesonide / Beclomethasone , 200-400 µg
divided twice daily. If needed long acting
bronchodilator : long acting inhaled beta 2
agonist salmeterol 50 µg once/twice daily
and/ or sustained release theophylline.
Step 2
Mild persistent Inhaled short acting bête agonist as
required + inhaled corticosteroids
Budesonide/beclomethasone, 100-200 µg or
cromolyn or sustained release theophylline or
leukotriene modifiers.
Step 1
Intermittent Inhaled short acting beta agonist as required
for symptoms relief. If they are needed more
than 3 times a week move to step 2.
The following are the common related factors for the nursing diagnosis
Ineffective Breathing Pattern.
Cough
Cyanosis
Dyspnea
Loss of consciousness
Nasal flaring
Prolonged expiration
Respiratory depth changes
Tachypnea
Use of accessory muscles
Desired Outcomes
Common goals and expected outcomes:
Here are the nursing assessment and interventions for this asthma
nursing care plan.
Nursing Assessment
Therapeutic Interventions
Administer medication as ordered:
Bronchospasms
Increased pulmonary secretions
Ineffective cough
Mucosal edema
Defining Characteristics
Here are the nursing assessment and interventions for this asthma
nursing care plan.
Nursing Assessment
Therapeutic Interventions
Break up activities into smaller parts and take
Pace the client’s activities. rest breaks in between to avoid fatigue.
increased effort in breathing properly.
Encourage increased fluid intake of up to 3000 Fluids help minimize mucosal drying and
ml/day within cardiac or renal reserve. increases ciliary action to remove secretions.
Activity Intolerance
Nursing Diagnosis
• Airway problem
Defining Characteristics
• Tired appearance
• Lethargy
Desired Outcomes
Here are the nursing assessment and interventions for this asthma
nursing care plan.
Nursing Assessment
Therapeutic Interventions
Encourage activities such as quiet play, reading, Avoids change in respiratory status and
energy depletion due to excessive
watching movies, games during rest.
activity.
Schedule and provide rest periods in a calm Promotes adequate rest and decreases
peaceful environment. stimuli.
Anxiety
Nursing Diagnosis
Apprehensiveness
Dyspnea
Frequent request for someone to be in the room
Restlessness
Tachycardia
Tachypnea
Desired Outcomes
Nursing Assessment
Sick child
Emergent hospitalization
Defining Characteristics
Here are the nursing assessment and interventions for this asthma
nursing care plan.
Nursing Assessment
Assess available resources and coping skills of Promotes the reinforcement of positive coping
the family. skills.
Therapeutic Interventions
Provide clear and accurate information to the Promotes a sense of control and relieves stress;
family about the condition, treatments, and reinforcement and individualizing the
implications; reinforce all information given. approach fosters better understanding.
Teach parents about the signs of Facilitates timely collaboration between parent
depression, particularly in the adolescent; and healthcare care team if a problem
suggest appropriate referrals as needed. develops.
Fatigue
Nursing Diagnosis
• Apprehensiveness
• Dyspnea
• Restlessness
• Tachycardia
• Tachypnea
Desired Outcomes
Nursing Assessment
Therapeutic Interventions
Allow the presence of a parent (if with with The presence of significant others minimizes
younger children) or significant others anxiety and fear hence it can lessen oxygen
during care. expenditure and fatigue.
Here are the nursing assessment and interventions for this asthma
nursing care plan.
Nursing Assessment
Assess family’s history of allergies, what Reveals familial tendency to airway reactive
does or does not trigger an attack, and disease or history of eczema, allergic rhinitis,
what behaviors result from the attack. urticaria.
Therapeutic Interventions
Instruct the child to refrain from stressful Provides information on how to prevent
situations and strenuous physical exercise. situations that may provoke an attack.
Provide contact with community agencies for Offers support to families with the child
information and support. suffering from asthma
Deficient Knowledge
Nursing Diagnosis
Chronicity of disease
Lack of information sources
Long-term medical management
Defining Characteristics
Absence of questions
Ineffective self-care
Inability to answer properly
Desired Outcomes
Here are the nursing assessment and interventions for this asthma
nursing care plan.
Nursing Assessment
Assess the client’s knowledge of care for status Knowledge of how to handle care can save
asthmaticus, as appropriate. time.
Smoke.
Environmental trigger control can lessen the
Exercise frequency of asthma attacks and improve the
client’s quality of life.
Air pollution.
Allergens.
Educate the client about the warning signs and A written treatment plan is needed by the
symptoms of an asthma attack and the client to reinforce information that was
importance of early treatment of an impending already taught. Early treatment within 6 hours
attack. Provide a written copy of daily of an attack may lessen the chance of
exacerbation management. hospitalization.
Short-acting beta-agonists are the first line
medication of choice since they relieve acute
asthma attacks very quickly compared to the
long-acting. Beta-2-adrenergic agonist should
be used before inhaled steroids since they
open the airways and allow the anti-
Review all medications with the client
inflammatory medication to reach deeper into
including a discussion of short versus long-
the lung fields. Rinsing the mouth after using
acting medications, a review of zones, and the
an inhaled steroids prevents yeast infection.
dosage of each medication in each zone.
Anti-inflammatory medications, such as
inhaled steroids, work by reducing swelling
and mucus production in the airways. As a
result, the airways are less sensitive and less
likely to respond to asthma triggers and cause
asthma symptoms.
Asthma is a chronic condition that is present
even when attacks are not occurring.
Reinforce the need for taking controller
Medications such as bronchodilators and anti-
medications as indicated.
inflammatory agents reduce the incidence of
attacks.
Teach how to administer nebulizer treatments, Providing return demonstrations on techniques
Diskus, MDIs spacers, or dry powder capsules are needed to ensure appropriate delivery of
with the correct technique. the medication.
Instruct in the use of peak flow meters and Use the zone system individualized to the
develop an individualized plan on how to adjust client. Personal best is established by having
medications and when to seek medical advice. the client take and document peak flow each
Establish the client’s personal best peak morning before medication use and in the late
expiratory flow rate (PEFR). afternoon for 2 weeks. Personal best is the
highest peak flow reading regularly blown,
which is then used to calculate the client’s
zone.