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    This document appears to be a study guide for a pharmacology exam covering antipsychotic drugs. It lists several common antipsychotic drugs, their brand names, mechanisms of action, therapeutic uses, and potential adverse drug reactions. The drugs are grouped based on their primary mechanism of action, which is typically blockade of D2 receptors and 5-HT2A receptors to varying degrees. Their therapeutic uses include treating schizophrenia, bipolar disorder, and agitation associated with other conditions. Common adverse effects include extrapyramidal symptoms, sedation, weight gain, and cardiac issues like QT prolongation.

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    This document appears to be a study guide for a pharmacology exam covering antipsychotic drugs. It lists several common antipsychotic drugs, their brand names, mechanisms of action, therapeutic uses, and potential adverse drug reactions. The drugs are grouped based on their primary mechanism of action, which is typically blockade of D2 receptors and 5-HT2A receptors to varying degrees. Their therapeutic uses include treating schizophrenia, bipolar disorder, and agitation associated with other conditions. Common adverse effects include extrapyramidal symptoms, sedation, weight gain, and cardiac issues like QT prolongation.

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    18 views3 pages

    Philippine College of Health Sciences Pharmacology 1

    Uploaded by

    Ric Barros
    This document appears to be a study guide for a pharmacology exam covering antipsychotic drugs. It lists several common antipsychotic drugs, their brand names, mechanisms of action, therapeutic uses, and potential adverse drug reactions. The drugs are grouped based on their primary mechanism of action, which is typically blockade of D2 receptors and 5-HT2A receptors to varying degrees. Their therapeutic uses include treating schizophrenia, bipolar disorder, and agitation associated with other conditions. Common adverse effects include extrapyramidal symptoms, sedation, weight gain, and cardiac issues like QT prolongation.

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    of 3

    PHILIPPINE COLLEGE OF HEALTH SCIENCES

    College of Pharmacy
    PHARMACOLOGY 1

    NAME: SCORE:
    CHAPTER TITLE: DATE:
    INSTRUCTION: Please answer the following items based on Basic and Clinical Pharmacology by Bertam Katzung
    DRUG NAME BRAND NAME MECHANISM OF THERAPEUTIC USE ADVERSE DRUG
    ACTION REACTION
    Chlorpromazine Thorazine Blockade of D2 receptors >> 5- Psychiatric: schizophrenia akathisia, dystonia,
    HT2A receptors (positive symptoms), bipolar parkinsonian symptoms,
    α-Receptor blockade disorder (manic phase) tardive dyskinesia, and
    (fluphenazine least) • nonpsychiatric: antiemesis hyperprolactinemia
    muscarinic (M)-receptor , • pruritus
    blockade (especially
    chlorpromazine and
    thioridazine) • H1-receptor
    blockade (chlorpromazine,
    thiothixene) • central nervous
    system (CNS) depression
    (sedation) • decreased seizure
    threshold • QT prolongation
    Fluphenazine Prolixin Blockade of D2 receptors >> 5- Psychiatric: schizophrenia akathisia, dystonia,
    HT2A receptors. (alleviate positive symptoms), parkinsonian symptoms,
    *α-Receptor blockade bipolar disorder (manic phase) tardive dyskinesia, and
    (fluphenazine • nonpsychiatric: antiemesis, hyperprolactinemia
    • central nervous system • pruritus
    (CNS) depression (sedation) •
    decreased seizure threshold •
    QT prolongation
    Thioridazine Mellaril Blockade of D2 receptors >> 5- Psychiatric: schizophrenia akathisia, dystonia,
    HT2A receptors (alleviate positive symptoms), parkinsonian symptoms,
    • muscarinic (M)-receptor bipolar disorder (manic phase) tardive dyskinesia, and
    blockade • nonpsychiatric: antiemesis, hyperprolactinemia
    • central nervous system • pruritus
    (CNS) depression (sedation)
    • decreased seizure threshold
    PHILIPPINE COLLEGE OF HEALTH SCIENCES
    College of Pharmacy
    PHARMACOLOGY 1
    • QT prolongation
    Thiothixene Navane Blockade of D2 receptors >> 5- Psychiatric: schizophrenia akathisia, dystonia,
    HT2A receptors (alleviate positive symptoms), parkinsonian symptoms,
    • H1-receptor blockade bipolar disorder (manic phase) tardive dyskinesia, and
    • central nervous system • nonpsychiatric: antiemesis, hyperprolactinemia
    (CNS) depression (sedation) • pruritus
    • decreased seizure threshold
    • QT prolongation
    Haloperidol Haldol Blockade of D2 receptors >> 5- Schizophrenia (alleviates Extrapyramidal dysfunction is
    HT2A receptors positive symptoms), bipolar major adverse effect
    Some α blockade, but minimal disorder (manic phase),
    M-receptor blockade and Huntington’s chorea,
    much less sedation than the Tourette’s syndrome
    phenothiazines
    Aripiprazole Abilify Blockade of 5-HT2A receptors Schizophrenia—*improve
    > blockade of D2 receptors both positive and negative
    • variable H1-receptor symptoms *agitation in
    blockade (all) Alzheimer’s and Parkinson’s
    patients (low doses) • major
    depression (aripiprazole
    Clozapine Clozaril Blockade of 5-HT2A receptors Schizophrenia—improve both Agranulocytosis
    > blockade of D2 receptors positive and negative diabetes
    *Some α blockade and M- symptoms • agitation in hypercholesterolemia
    receptor blockad Alzheimer’s and Parkinson’s weight gain
    • variable H1-receptor patients (low doses)
    blockade (all)
    Olanzapine Zyprexa Blockade of 5-HT2A receptors Schizophrenia—improve both diabetes
    > blockade of D2 receptors positive and negative hypercholesterolemia ,
    *M-receptor blockade symptoms • bipolar disorder weight gain)
    (clozapine, olanzapine) (olanzapine or risperidone
    • variable H1-receptor adjunctive with lithium) •
    blockade (all) agitation in Alzheimer’s and
    Parkinson’s patients (low
    doses)
    Quetiapine Seroquel Blockade of 5-HT2A receptors Schizophrenia—*improve
    > blockade of D2 receptors both positive and negative
    PHILIPPINE COLLEGE OF HEALTH SCIENCES
    College of Pharmacy
    PHARMACOLOGY 1
    • variable H1-receptor symptoms • agitation in
    blockade (all) Alzheimer’s and Parkinson’s
    patients (low doses
    Risperidone Risperdal Blockade of 5-HT2A receptors Schizophrenia—*improve hyperprolactinemia
    > blockade of D2 receptors both positive and negative
    *Some α blockade symptoms • bipolar disorder
    *variable H1-receptor (olanzapine or risperidone
    blockade (all) adjunctive with lithium) •
    agitation in Alzheimer’s and
    Parkinson’s patients (low
    doses)
    Ziprasidone Blockade of 5-HT2A receptors Schizophrenia—*improve QT prolongation (ziprasidone
    > blockade of D2 receptors both positive and negative
    *Some α blockade symptoms
    • variable H1-receptor • agitation in Alzheimer’s and
    blockade (all) Parkinson’s patients (low
    doses)

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