Thyroid-stimulating hormone, also known as thyrotropin or human TSH.

TSH stimulates the thyroid

gland placed in neck, which then produces two hormones: thyroxine and triiodothyronine. TSH is
glycoprotein hormone produced in the anterior pituary gland in hypophysis, and is produced by
thyrotrope cells. It is placed near your throat on trachea. If TSH produces too much of thyrotropin
you can get hyperthyriodism, and if it does not produce enough thyrotropin you can get
hypothyriodism. These conditions can lead to irregular body performance.

On this picture you can see anatomy of the thyroid gland. In top of the nect you can see larynx which
is involved in breathing and producing sound. Thyroid gland is placed below larynx, and it consists of
two lobes, left and right. On the other side of thyroid glade there are four parathyroid glands. And at
the end below thyroid glade is trachea, tube connected with lungs.

The hypothalamus contains thyrotropin releasing hormone (TRH) which is carried down to the
pituitary gland through the hypothalamic vein where it releases thyroid stimulating hormone (TSH).
The released TSH reaches thyroid glands via blood stream to bind to TSH receptor to stimulate
production and release of thyroxin (T4), triiodothyronine (T3) calcitonine.

Thyroxine is the main hormone secreted into the bloodstream by the thyroid gland. It is the inactive
form and most of it is converted to an active form called triiodothyronine by organs such as liver and
kidneys. Thyroid hormones play vital roles in regulating the body’s metabolic rate, heart and
digestive functions, muscle control, brain development and maintenance of bones. The production
and release of thyroid hormones, thyroxine and triiodothyronine, is controlled by a feedback loop
system that involves the hypothalamus in the brain and the pituitary and thyroid glands. Lack of
thyroxine in blood can cause depression, weight gain, poor memory, when on the other side too
much of thyroxine can cause weight loss, irregular heartbeat, tiredness and many other symptoms

Triiodothyronine is the active form of the thyroid hormone, unlike thyroxine. The alternative name
for triiodothyronine is T3. While thyroid gland produces only 20% of triiodothyronine, 80% comes
from thyroxine. Both T3 and T4 hormones regulate body’s metabolic rate, and affect heart, muscles,
brain development and other organs. Because of its active form, it is controled in body tissues like
liver, brain or kidneys.Production of polymerase I and II is stimulated by triiodothyronine. It
increases heart rate and our blood pressure.

Hypothyroidism (underactive thyroid) is a condition in which your thyroid gland doesn't produce
enough of certain crucial hormones. Hypothyroidism may not cause noticeable symptoms in the
early stages, but as your metabolism continues to slow, you may develop more-obvious problems.
The first is a result of inflammation of the thyroid gland, which leaves a large percentage of the cells
of the thyroid damaged or dead. A rare cause of hypothyroidism is the failure of the pituitary gland
to produce enough thyroid-stimulating hormone. The most common cause is autoimmune
thyroiditis, which develop special antibodies that kill thyroids cells.

Some symptoms of hypothyroidism are feeling of weakness, dry hair, hair falling off, depression,
losing memory, getting muscle cramps and many other symptoms.

This picture shows us how inflammation of thyroid gland looks like, when we have hypothyroidism.
Hyperthyroidism is a condition where thyroid gland produces too much of the hormone. It can
fasten your body’s metabolism. One of the first symptoms you may notice are weight loss or
irregular heartbeat. If you have hyperthyroidism you can treat it with anti-thyroid medications or
radioactive iodine. If not treated on time, hyperthyroidism can cause some serious problems with
heart, bones, muscles or menstrual cycle

Some symptoms of hyperthyroidism are tachycardia or rapid heratbeat, aritmia or irregular

heartbeat, increased appetite, sweating, insomnia or lack of sleep, skin thinning and others.

If you think you have problems with thyroid-stimulating hormones you should get tested. The test
shows you is your thyroid gland working the way it should. It can detect a thyroid disorder which is a
seriuos health problem. You can get tested by getting your blood analized in lab. It can show you if
you have overactive, normal or underactive syndrome. If you are taking dopamine your test can
show fake negative, so results will look better than they are. There is multiple TSH tests, such as
third-generation assays or ultrasensitive assay. A normal test result should show that you have 0.4
miliunits per liter to 4.0 miliunits per liter.

This picture show