Professional Documents
Culture Documents
Women
Should
Never Take
Most of them are actually recreational
drugs, causing addiction & withdrawal
By:
John Tilton
Admin of the Facebook group
Nootropics are for Women too
Before You Read
Know what a nootropic is. A nootropic is a drug, supplement, or other substance that gives cognitive
benefits to the human brain. The problem is that only two of the substances I mention in this guide have
been proven to enhance cognition. Thus, they are the only nootropics included. But due to false
advertising and misinformation that is exchanged through subreddits, Facebook groups, YouTube
videos, etc., you may falsely believe that the other three substances are nootropics as well. This can
potentially get you into a world of trouble due to the inherent dangers of these three substances. You
may believe that just because something is labeled as a ‘nootropic,’ that it is inherently safe. But as you
will learn in this guide, that is far from the truth. Let’s start at number five with one of the substances
that is misidentified as a nootropic.
By The Way
I have included what I believe to be a harsh truth about the nootropic community at the very end of this
guide. It’s kind of sad!
Can Prevagen
Improve Your Memory?
According to the Madison Memory Study, Prevagen can, in fact, improve your memory. More
specifically, it can improve verbal memory, reduce the need for reminders, and improve memorization
of driving directions. Therefore, it does support better memory, right? Not so fast. There are two major
flaws in the Madison Memory Study. The first is that the company that sells it (Quincy Bioscience)
sponsored the study. This is known as a funding bias, which means the study results were most likely
bias toward Quincy Bioscience’s interests. The other flaw is the study was never published in a peer-
review journal. In a peer-review journal, experts in that particular field review the study for accuracy.
This was not the case for the Madison Memory Study, as a non-bias expert never critiqued it.
I am not the only one to pick up on those flaws of the Madison Memory Study. In fact, the FTC (Federal
Trade Commission) did as well, and even went as far as confronting Quincy Bioscience about it. In the
end, the FTC concluded that the Madison Memory Study failed to show an improvement in the
treatment group (those taking Prevagen) over the placebo group (those not taking it) [1] . The FTC also
went on to make the following statements regarding Prevagen:
• There is not “competent and reliable scientific evidence” to support Prevagen’s claims
• The claim that Prevagen is clinically proven is false
But it doesn’t stop there. Quincy Bioscience also faced a lawsuit alleging deceptive marketing practices
[1] . That is, based off the fact that Apoaequorin is unlikely to be absorbed to a significant enough degree
and degrades into amino acids instead of improving memory. New York attorney general Eric
Schneiderman went on to say, “The marketing for Prevagen is a clear-cut fraud, from the label on the
bottle to the ads airing across the country.” Federal Trade Commission
[2] Daniel Moran, Palma Ann Marone, Mark Bauter, Madhu Soni. “Safety assessment of Apoaequorin, a
protein preparation: Subchronic toxicity study in rats.” Food and Chemical Toxicity 57, (2013): 1-10. URL:
https://www.sciencedirect.com/science/article/pii/S0278691513001567?via%3Dihub.
[3] Daniel Moran, Afua Tetteh, Richard Goodman, Mark Underwood. "Safety assessment of the calcium-
binding protein, apoaequorin, expressed by Escherichia coli.” Regulatory Toxicology and Pharmacology
69, no. 2(2014): 243-249. URL:
https://www.sciencedirect.com/science/article/pii/S0273230014000671?via%3Dihub.
Modafinil is undoubtedly the most popular nootropic within the industry. Why? It works extremely well
and its effects are noticeable. As a wakefulness-promoting agent (or stimulant), it’s most commonly
used for treating narcolepsy. Modafinil also goes by the brand name Provigil and is marketed as an
alternative to amphetamines in some cases. But as you will learn (if you keep reading), it is not the safe
alternative to amphetamines that it some claim it to be.
• Brain fog
• Fatigue
• Depression
• Shortness of breath
• Sleepiness
In addition to potential addiction and withdrawal, Modafinil has other dangers, some of which occur as
side effects from simply using it. These side effects from general use can include:
• Insomnia
• Headaches
• Skin rashes
• Anxiety attacks
Finally, there are no studies on the long-term effects of Modafinil-use. There’s no way of knowing if
using it now may come back to bite you later. Your best bet is to stay away from this nootropic
altogether.
[2] R. Pigeau, P. Naitoh, A. Buguet, C. McCann, J. Baransk, M. Taylor, M. Thompson, I. Mack. “Modafinil, d-
amphetamine and placebo during 64 hours of sustained mental work.” Journal of Sleep Research 4, no.
4(1995). URL:
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2869.1995.tb00172.x?sid=nlm%3Apubmed&.
[3] Nora D. Volkow, Joanna S. Fowler, Jean Logan, David Alexoff, Wei Zhu, Frank Telang, Gene-Jack
Wang. “Effects of Modafinil on Dopamine and Dopamine Transporters in the Male Human Brain.” JAMA,
(2009). URL: https://jamanetwork.com/journals/jama/fullarticle/183580
For women, an addiction to Nicotine is especially dangerous because it tends to affect them more than
men. There are a few reasons behind this. For one, a woman’s body is faster at processing Nicotine than
a man’s body due to higher levels of the sex hormone estrogen [7] . Since this is the case, the perceived
positive effects of having a cigarette wear off faster for a woman, thus creating a shorter time window
for them in between smoking, vaping, etc. Secondly, women tend to use Nicotine when they are
stressed [8] as opposed to men who tend to use it when they are content. Since women tend to be
more stressed than content throughout the day, you can see how it would be tough for a woman
addicted to Nicotine to give it up.
Regardless of gender, there are more inherent dangers to Nicotine itself aside from addiction. To
demonstrate this, Indian researchers at the Institute of Indian Medicine searched the databases of
Medline and PubMed for “All the animal and human studies investigating only the role of nicotine.” Their
review found that Nicotine-use increases the risk of cardiovascular, respiratory, and gastrointestinal
disorders. It also decreases immune response, negatively effects reproductive health, and leads to
cancer through cell proliferation, oxidative stress, apoptosis, and DNA mutation [9] . Yikes!
In my experience, one of the biggest dangers of nicotine-use was how it induced anxiety. This was
especially troubling when I was driving since I would sometimes have to pullover on the shoulder of the
road because of Nicotine-induced anxiety. Another danger that was quite apparent to me was a rise in
blood pressure. I specifically remember (during my days of Nicotine-use) that sometimes if I stood up
too fast I would get a temporary sense of lightheadedness. Sometimes it would be a double whammy,
as the lightheadedness would then send me into an anxiety attack. Trust me, Nicotine is not worth it, not
even once and not even in a small dosage as a nootropic. The next substance is not worth it either.
[2] Warburton, DM. “Nicotine as a cognitive enhancer.” Prog Neuropsychopharmacol Biol Psychiatry,
(1992). url: https://www.ncbi.nlm.nih.gov/m/pubmed/1579636/.
[5] Rawson, Richard. “Meth and the Brain.” Frontline. February 14, 2006.
https://www.pbs.org/wgbh/pages/frontline/meth/body/methbrainnoflash.html.
[6] Rawson, Richard. “Effects of Drugs on Dopamine Levels.” February 14 2006. online image. Frontline.
https://www.pbs.org/wgbh/pages/frontline/meth/body/methbrainnoflash.html.
[7] Benowitz, Neal L., Christina N. Lessov-Schlaggar, Gary E. Swan, Peyton Jacob III. “Female sex and oral
contraceptive use accelerate nicotine metabolism.” Clinical Pharmacology & Therapeutics 79,
no.5(2006): 480-488. doi: 10.1016/j.clpt.2006.01.008
[8] Torres, Oscar V. and Laura E. O’Dell. “Stress is a principal factor that promotes tobacco use in
females.” Progress in Neuro-Psychopharmacology and Biological Psychiatry 65, (2016): 260-268. url:
https://www.sciencedirect.com/science/article/pii/S0278584615000718?via%3Dihub.
[9] Mishra A, Chaturvedi P, Datta S, Sinukumar S, Joshi P, Garg A. “Harmful effects of nicotine.” Indian
Journal of Medical and Paediatric Oncology 36, no. 1(2015): 24-31. url:
http://www.ijmpo.org/article.asp?issn=0971-
5851;year=2015;volume=36;issue=1;spage=24;epage=31;aulast=Mishra.
Kratom is a tree (also known as Mitragyna Speciosa) that is prevalent in parts of Southeast Asia. In the
United States, its leaves are usually sold in powdered form (as a herbal product) at smoke shops and
gas stations. The reason being that the Kratom tree’s leaves contain about 40 alkaloids in which two of
them (Mitragynine & 7-hydroxymitragynine) are thought to have psychoactive effects [1] . While there
are few people who will overtly refer to Kratom as a nootropic, it is still a common topic on blogs,
subreddits, and Facebook groups within the nootropic community. That being said, it is easy to mistake
Kratom as a nootropic. However, it’s actually more of a recreational drug. This will become evident to
you after reading the next few paragraphs.
My Unexpected
Experience With Kratom
Most of Kratom’s effects are similar to those of recreational drugs. Many people use it as a way to get
“high.” Trust me, I know from experience. One of the first times I ever took Kratom was back in high
school (this was years ago by the way). I dosed it perfectly, according to several dosage charts I found
online (like this one), and then proceeded to walk into school for the start of class that day. As I started
my day, the nasty taste of Kratom was still stuck in my mouth (along with green powder in between my
teeth). As I got to homeroom and sat in my seat, I really began to feel the effects. It was overwhelming,
so much so that I felt intense waves of anxiety that disabled me from focusing on my work. By the time
the anxiety and stimulatory effects had passed, I began to feel tired, further diminishing my ability to
focus. In fact, I became so tired that I was falling in and out of sleep during class. By that time, it was
only the second period of the eight-period day. Eventually, I returned to a baseline level; however, one
thing was certain: Kratom was counterproductive for not only focus, but also productivity. Despite that
experience, I would go onto to take Kratom numerous times after that, sometimes in smaller dosages
and sometimes in larger dosages. Every time, the initial stimulatory effects would always lead to a crash
characterized by extreme tiredness. The only time I ever use it anymore is during my fantasy football
league’s draft ritual, and trust me, we don’t take it to be productive.
In larger doses, Kratom acts more like an opioid that’s typically used for chronic-pain management
(analgesia). Some of the other effects of large doses of Kratom include euphoria, drowsiness, a
dreamlike mental state, and cough suppression. However, reducing the symptoms of opioid withdrawal
is the best-known effect of taking a larger dose of Kratom. This is why many ex-Heroin addicts credit
Kratom for helping them get them clean. They swear by Kratom, claiming it was what got them through
the intense withdrawal symptoms. Just check out this video by Vice that shows how Kratom helped a 6-
year Heroin addict kick the addiction in under a month. With regard to Heroin users trying to get clean,
Kratom can indeed do wonders. However, in the scenario of someone who is just looking to enhance his
or her cognition, it should be avoided. That is, due to the dangers of Kratom discussed below.
Even if you are not withdrawing off Kratom, but simply using it on a regular basis, it still has the potential
to cause psychotic symptoms, such as mental confusion, delusion, and hallucinations [4] . According to
multiple published case reports, it can even cause seizures, regardless of the size of the dosage [5] .
Another factor that makes Kratom dangerous is its legal status. It’s banned in some states but not in
others. In fact, a single county in Florida (Sarasota) has banned Kratom (while it is legal in the rest of a
state). Individual towns in Illinois (Jerseyville) and California (San Diego) have also banned Kratom
(although you would be able to possess it everywhere else in those states) [6] . The following states are
where you could be fined, penalized, or even sentenced to jail time if caught in possession of Kratom
[6] :
• Alabama
• Arkansas
• Wisconsin
• Tennessee
• Vermont
• Indiana
• New Hampshire (if you are under 18)
• Illinois (if you are under 18)
• Banned for members of the US Armed Forces as well
[2] Suwanlert, Somsong. “A study of kratom eaters in Thailand.” Bulletin on Narcotics 27, no. 3(1975): 21-
27. url:
https://www.google.com/amp/s/www.researchgate.net/publication/22112751_A_study_of_kratom_e
aters_in_Thailand/amp
[3] PsychedSubstance. “Why I Stopped Taking Kratom.” January 11 2018. online video. YouTube.
https://youtu.be/HedEeSDzNSY.
[4] Eduardo Cinosi, Giovanni Martinotti, Ornella Corazza, et al. “Following ‘the Roots’ of Kratom (Mitragyna
speciosa).” Biomed Res Int., (2015). doi: 10.1155/2015/968786.
[5] Bellamy, Josh, “Kratom: another dangerous ‘natural’ remedy.” Science-Based Medicine,
[6] “Is Kratom Legal in USA 2019? The Legality of Kratom.” Endonurse. January 5, 2019. url:
http://www.endonurse.com/is-kratom-legal/
• “Yes and no. In certain areas I noticed positive effects though in certain areas it exacerbated some
already negative symptoms I have like ADD. It highly spikes you're creative output potential and
increased drive and motivation. It’s effects on focus are iffy. In a light, it helps though due to
everything being twice as enjoyable and appealing. It’s easy to bounce from subject to subject or
project to project due to the mental stimulation.”
• “Yes it was pretty good for focus and attention at a medium to high dose for me. Smaller doses made
me a little too sleepy.”
• “No, only relaxation.”
With those responses in mind, the nootropic effects of Phenibut seem to vary from person to person.
But assuming it enhances cognition, it still would not be worth taking. After all, there is a reason it is
number one in this guide. Discover the scary dangers of Phenibut below.
During Phenibut withdrawals (caused by excessive glutamate floating), users can expect uncomfortable
feelings of physical stimulation/energy, anxiety/fear/panic, depression, social withdrawal, insomnia,
muscle twitches, sweating, hot flashes, irritability, and even nightmares/hallucinations [6] . Simply listing
all the effects of Phenibut withdrawal does not nearly do justice demonstrating how bad it is. Instead,
here is what a former user who had gone through withdrawals had to say about the experience in a
nutshell: “If you had problems in your life anyway, and were using Phenibut to mask them, then they will
come back twenty times as bad.” [7] The former user goes onto add: “You find it easy to believe in Hell,
but impossible to believe in Heaven.” Besides the potential withdrawals after just a few days of use,
even one-time use of Phenibut can subject the user to certain dangers that you will discover below.
One of these dangers is simply the fact that, in most cases, Phenibut is listed as a “dietary supplement.”
For example, all the Phenibut that Liftmode, a popular vendor in the nootropic industry, is selling has
“dietary supplement” listed on the label. Obviously, we now know that Phenibut is nowhere near a
dietary supplement and more akin to a depressant or benzo drug. However, most do not know this
because they read silly articles on the blogs of Phenibut vendors that lie to them about it having few
side effects. As a result, they are put at risk of taking way too much Phenibut (thinking it’s safe) to the
point of an overdose, which is characterized by dose-dependent cognitive impairment, drowsiness,
confusion, bradycardia, hypotension, hypothermia, respiratory depression, and variable levels of coma.
It is also easy to overdose on Phenibut because it has a slow onset, causing many first-time users to re-
dose before the initial effects set in. Even if you do not overdose, taking a little too much Phenibut can
cause you to fall asleep at random. That being said, you definitely do not want to drive under the
influence of this substance.
Another Phenibut danger that was mentioned earlier is that there are only around 300 published papers
on it, most of which are in Russian. For a substance that has been around since the 1960s, that is an
incredibly low amount of information. Therefore, we do not know the long-term risks of Phenibut use.
All in all, Phenibut is the most risky and dangerous so-called nootropic out there. As the Nootropic Dr.
Seuss would say, “I wouldn’t touch Phenibut with a thirty-nine-and-a-half foot pole!”
Anyways, thanks for reading and best wishes to you and your brain.
John Tilton
[2] N.N. Zavadenko and N. Yu. Suvorinova. “Results of Pharmacotherapy of Attention Deficit
Hyperactivity Disorder: Assessment Using Neuropsychological Methods.” Neuroscience and Behavioral
Physiology 46, no.3(2016): 354-359. url: https://link.springer.com/article/10.1007/s11055-016-0241-x.
[4] Menayang, Adi. “Supplement tarde associations warn retailers to not sell products with phenibut.”
Nutra. November 6, 2018. https://www.nutraingredients-usa.com/Article/2018/11/06/Trade-groups-
warn-of-potentially-harmful-brain-booster-
phenibut?utm_source=copyright&utm_medium=OnSite&utm_campaign=copyright.
[6] https://thedrugclassroom.com/video/phenibut/
[7] James, Christopher. “How Bad Are Phenibut Withdrawals?”. Quora . September 3, 2018.
https://www.quora.com/How-bad-are-phenibut-withdrawals.