Nov AIIMS 2018 Pathology Questions

and explanations by Dr. SUSHANT SONI

Dear friends…
I am in the process of compiling questions with authentic options and answers.. Having the right set of
options is extremely important for AIIMS exam… Really thanks for the nice response wrt to the
questions…

Q1. In apoptosis, all are seen except:

a. Intact plasma membrane

b. Absence of Inflammation
c. Cellular Swelling
d. programmed

Answer: c. cell swelling

Q2. Immunohistochemistry marker to differentiate thymoma from ALL ?

a. CD1a
b. TdT
c. Cytokeratin
d. CD3

Answer: Cytokeratin
Thymoma is CK positive whereas all others markers are seen in both: thymoma and ALL. See below the
image of common markers to differentiate between the two.

Q3. Patient comes to ER with severe bleeding. Blood group is unknown. Which FFP will you give..?

a. O+ve
b. O-ve
c. AB
d. A+

Answer: AB

Group O people have both Anti-A and Anti-B so group O FFP can ONLY be given to group O patients.
Group A plasma contains anti-B. A FFP can only be given to patients who are group A or O ie only
patients who do not have group B red cells. Group B plasma contains anti-A. B FFP and can only be given
to patients who are group B or O. Group AB plasma does not contain any Anti-A or Anti-B. AB FFP can be
given to patients who are group AB, A, B or O. Group AB donors are called ‘universal plasma donors’.

Q4. 2018 nobel prize in medicine and physiology won on which topic ?

Answer: Inhibition to immune system.

This post was put in detail yesterday only. Plz see link on my fb wall.

https://www.facebook.com/sushantt.soni/posts/194153214847432

Q5. Nipah virus lifecycle image?

This was updated on my fb wall with the link

https://www.facebook.com/sushantt.soni

The virus is named after the Malaysian village where it was first discovered. This virus along with Hendra
virus comprises a new genus designated Henipavirus in the subfamily Paramyxovirinae

Natural reservoirs: Fruit bats of the genus Pteropus

Virus has been isolated from: Brain and spinal fluid of victims, environmental samples of bat urine and
partially-eaten fruit

Case fatality rate of NiV ranges from 40-70% although it has been as high as 100% in some outbreaks

Mode of transmission: Infected bats shed virus in their excretion and secretion such as saliva, urine,
semen and excreta but they are symptomless carriers. The NiV is highly contagious among pigs, spread
by coughing. Direct contact with infected pigs was identified as the predominant mode of transmission
in humans

Precipitating cause: Loss of natural habitats of bats. As the flying fox habitat is destroyed by human
activity the bats get stressed and hungry, their immune system gets weaker, their virus load goes up and
a lot of virus spills out in their urine and saliva

Q6. 35 year male with proteinurea with Immunofluroscence image pic (attached). Diagnosis?
 a. PSGN
b. Good-pasteurs syndrome
c. FSGS
d. Lupus Nephritis

Answer: D. Lupus nephritis: it is the full house effect Lupus. We have numerous times discussed IF pics
of other options and you v well know, FSGS is non-specific in nature.

Q7. Image showing macrophage. Process ?

a. Autophagy
b. Phagocytosis
c. Emperipolesis
d. ?

Emperipolesis: Megakaryocyte containing a segmented neutrophil

In phagocytosis, the engulfed cell is killed by lysosomal enzymes of the macrophage.

Emperipolesis is an uncommon biological process, in which the cell exists as viable cell
within another and can exit at any time without any structural or functional
abnormalities for either of them. This process can either be physiological or pathological
and may be a pathognomonic feature of certain diseases. Histiocytes and
Megakaryocytes are involved in Emperipolesis normally but tumour giant cells in
Hodgkin’s disease and Rosai-Dorfman disease are pathologic conditions in which this
process is seen.
Q8. Patient with severe bleeding comes to emergency dept. As per your demand you
get 4 platelet and 2 PRC units from blood bank? What should be the next step?

A. Transfuse PC and store PRC at room temp

B. Transfue PC and store PRC between 2-4 degrees
C. Transfuse PRC and store PC at room temp
D. Transfuse PRC and store PC in 2-4 degrees

Answer: C: Transfuse PRC and store PC at room temp

Common-sensical; in severe bleeding first u will transfuse RBCs followed by platelets

(which u know are stored at room temperature.)

Further, have a look at WHO guidelines for blood transfusion in severe bleeding.
Q9. ADCC is seen in:
a. Only NK cells
b. Macrophages
c. NK cells, neutrophils and eosinophils
d. ?

Answer: C. NK cells, neutrophils and eosinophils

Antibody-dependent cellular cytotoxicity (ADCC) you very well know is by NK cells.

However, it is also seen in neutrophils and eosinophil killing certain parasitic worms like
helminthes via IgE antibodies

Q10. Clearance of Necrotic cell during inflammation by

a.p selectin
b.toll like receptor
C.neutrophilic extra cellular traps
D.??

Answer: B. toll like receptor.

Mediated by HMGB1 which is bound by the receptor for advanced glycation end
products (RAGE)

Q11. Color of container of Sodium fluoride?

Answer: Grey
Q12. Diagnosis of which of the following can not be made without the presence of anti
nuclear antibodies ?
A. Scleroderma
B. Sjogrens
C. Drug induced Lupus
D. SLE
Answer: C: Drug Induced lupus
Q13. Naïve T cells get activated by:

a. NK cells
b. Dendritic cells
c. Macrophages
d. B-cells

Answer: B. Dendritic cells.

Naïve T cells get activated by Antigen presenting cells. And dendritic cell is the most potent APC.
Q14. Immune privilege site is:

a. Optic nerve
b. Seminiferous tubule
c. Area postrema
d. Spinal canal

Answer: B. Seminiferous tubule

The Immune privilege sites are testis, eye and brain… No explanation needed in this question I guess !

Q15. Specific marker for Alcoholic hepatitis is ?

a. GGT
b. Alkaline transaminase
c. Alkaline Phosphatase
d. LDH

Answer: A. GGT

GGT is increased in alcoholics even without liver disease is a specific marker for Alcoholic hepatitis.

This is the first list of questions. I am in the process of accumulating more path questions with authentic
options.

Plz help me in the same by sending them to me in my fb inbox or email: sushantssoni@gmail.com or

whats app @ 9958450600