1 st 

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1st
 
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MRCP

SM  SAROWAR   HOSSAIN
 Only Basic
Science Part

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 1. Cardiac actio piteotal: descriptio
Early repilarisatio - effl of potasx sx ifm, Rapid depilarisatio - rapid sx odifm inffl
Fioal repilarisatio - effl of potasx sx ifm, Plateau - sx low inffl of calcifm

2. Cardiac actio piteotal: phases

Phasx e 3 - effl of potasx sx ifm, Phasx e 2 - sx low inffl of calcifm
Phasx e 0 - rapid sx odifm inffl, Phasx e 4 - resx tnn potental isx resx tored by Na/K ATPasx e
Phasx e 1 - effl of potasx sx ifm

3.Proteasx ome - denradaton of protein molecflesx that have been tanned with fbiqfitn

4. Mitochondrion - aerobic resx piraton. Containsx mitochondrial nenome asx circflar DNA

5. Golni apparatfsx - modifesx , sx ortsx , and packanesx thesx e molecflesx that are desx tned for cell
sx ecreton

6. Lysx osx ome - breakdown of larne molecflesx sx fch asx proteinsx and polysx accharidesx

7. Clinical trial: phasx esx

Optmal disiog - clinical trial phasx e Iia, Efectieoess - clinical trial phasx e III
Efficacy - clinical trial phasx e Iib, Pharmacikioetcs aod pharmacidyoamics - clinical trial
phasx e I, Liog-term side-efects - clinical trial phasx e IV

8. CD8 - co-receptor for MHC clasx sx I

9. C5 defciency - Leiner disx easx e

10. C3 defciency - recfrrent bacterial infectonsx

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 11. C5-9 defciency - Neisx sx eria meninnitdisx infecton

12. C1 inhibitor (C1-INH) protein defciency - hereditary annioedema

13.C1q, C1rsx , C2, C4 defciency - immfne complel disx easx esx

14. Kawasx aki disx easx e complicaton - coronary artery anefrysx m

15.Measx lesx complicaton - sx fbacfte sx clerosx inn panencephalitsx

16. Type 2 renal tfbflar acidosx isx complicaton - osx teomalacia

17. Type 1 renal tfbflar acidosx isx complicaton - renal sx tonesx

18.Paralysx isx of masx tcaton mfsx clesx - CN V

19. A 'down and oft' eye - CN III

20. Losx sx of corneal refel - CN VII and V

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 21. Hypersx ensx itve carotd sx infsx refel - CN IX

22. Uvfla deviated away from the sx ide of lesx ion - CN X

23. Ptosx isx - CN III

24. Flaccid paralysx isx of fpper lower face - CN VII

25. Eferent limb of the pfpillary linht refel - CN III

26. Thfmb indel fnner - C5, C6

27. Bin toe - L5

28.Rinn litle fnner - C8

29.Umbilicfsx - T10

30. Low LH and low tesx tosx terone - Kallman'sx sx yndrome

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 31. Hinh LH and low tesx tosx terone - Klinefelter'sx sx yndrome

32. Hinh LH and normal/hinh tesx tosx terone - andronen insx ensx itvity sx yndrome

33. Low LH and hinh tesx tosx terone - tesx tosx terone-sx ecretnn tfmofr

34. Intravenofsx immfnonlobflin , fsx esx inclfde: Kawasx aki disx easx e
Asx pirin , fsx esx inclfde: Kawasx aki disx easx e

35. Patent dfctfsx arteriosx fsx - collapsx inn pflsx e - Patent dfctfsx arteriosx fsx - wide pflsx e
presx sx fre - lef sx fbclavicflar thrill- contnfofsx 'machinery' mfrmfr

36. Edward'sx sx yndrome (trisx omy 18) - low-sx et earsx

37. Leadsx to actvaton of protein kinasx e C - Gq receptor

38. Homocysx tnfria - learninn difcfltesx

Homocysx tnfria - downwardsx lensx disx locaton

39. Cysx tc fbrosx isx - chromosx ome 7

40. Ankylosx inn sx pondylitsx - HLA-B27

Narcolepsx y - HLA-DR2
Sjonren'sx sx yndrome - HLA-DR3
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 41. Type 1 diabetesx mellitfsx - HLA-DR4
Acfte anterior fveitsx - HLA-B27
Behcet'sx disx easx e - HLA-B5

42. Primary biliary cirrhosx isx - HLA-DR3

Haemochromatosx isx - HLA-A3
Rhefmatoid arthritsx - HLA-DR4

43. Goodpasx tfre'sx - HLA-DR2

Dermattsx herpetformisx - HLA-DR3
Coeliac disx easx e - HLA-DQ2/DQ8
Reiter'sx sx yndrome - HLA-B27

44. Gasx trin - increasx esx pepsx inonen sx ecreton

45. CCK - increasx esx pancreatc sx ecretonsx rich in dinesx tve enzymesx
Somatosx tatn - decreasx esx nasx tric H sx ecreton
Secretn - decreasx esx nasx tric H sx ecreton

46. Gasx trin - increasx esx nasx tric motlity

VIP - increasx esx sx ecreton of water from pancreasx and intesx tnesx
Somatosx tatn - decreasx esx nasx tric emptyinn

47.Secretn - increasx esx pancreatc bicarbonate sx ecreton

Ghrelin - increasx esx appette
Somatosx tatn - decreasx esx pancreatc sx ecretonsx

48. Leptn - decreasx esx appette

CCK - decreasx esx nasx tric emptyinn
VIP - decreasx esx nasx tric H sx ecreton

49. CCK - increasx esx nallbladder contracton

Gasx trin - increasx esx nasx tric H sx ecreton
Somatosx tatn - decreasx esx nallbladder contracton

50. Somatosx tatn - decreasx esx pepsx inonen sx ecreton

Gasx trin - sx tmflatesx parietal cell matfraton

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 51. Dehydroepiandrosx terone - zona retcflarisx of adrenal cortel
Gasx trin - G cellsx in antrfm of the sx tomach
Aldosx terone - zona nlomerflosx a of adrenal cortel

52. Secretn - S cellsx in fpper sx mall intesx tne

Somatosx tatn - D cellsx in the pancreasx & sx tomach
Ghrelin - P/D1 cellsx lininn the ffndfsx of the sx tomach and epsx ilon cellsx of the pancreasx

53. Leptn - adiposx e tsx sx fe

CCK - I cellsx in fpper sx mall intesx tne
Cortsx ol - zona fasx cicflata of adrenal cortel

54. Bronchiolitsx - immfnofforesx cence of nasx opharynneal sx ecretonsx

56. Contnfofsx 'machinery' mfrmfr - patent dfctfsx arteriosx fsx

56. Child with fever, fne pfnctate erythematofsx rasx h with 'sx andpaper' teltfre, sx trawberry
tonnfe -sx carlet fever

57. Child with fever, conjfnctvitsx , desx qfamatnn rasx h, cracked lipsx , sx trawberry tonnfe –
kawasx aki disx easx e

58. Child with fever, conjfnctvitsx , white sx potsx on bfccal mfcosx a, rasx h sx tartnn behind earsx
-measx lesx

59. Child with fever, barkinn cofnh at ninht, sx tridor - crofp

60. Dilated cardiomyopathy, malnftriton/alcoholisx m - thiamine defciency

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 61. Child, perianal itch - Enterobifsx vermicflarisx infecton

62. Black necrotc esx har on face, diabetc - mfcormycosx isx

63. Tall, lonn fnnered, downward lensx disx locaton, learninn difcfltesx , DVT -
homocysx tnfria

64. Cafe-af-lait sx potsx , precociofsx pfberty, sx hort sx tatfre - McCfne-Albrinht sx yndrome

65. Hyperkalaemia, low aldosx terone, diabetc patent on ACE-inhiibitor - type 4 renal
tfbflar acidosx isx

66. Hypokalaemia, nephrocalcinosx isx - type 1 renal tfbflar acidosx isx

67. Hypokalaemia, osx teomalacia - type 2 renal tfbflar acidosx isx

68. NF1 - nefrofbromatosx isx

RET - mfltple endocrine neoplasx ia (typesx II and III)
WT1 - Wilm'sx tfmofr

69. Mfltple tfmor sx fppresx sx or 1 (MTS-1, p16) - melanoma

RAS - nefrofbromatosx isx
N-MYC - nefroblasx toma

70. Erb-B2 (HER2/nef) - breasx t and ovarian cancer

P53 - Li-Frafmeni sx yndrome
ABL - chronic myeloid lefkaemia
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 71.RAS - pancreatc cancer
BCL-2 - follicflar lymphoma
C-MYC - Bfrkit'sx lymphoma

72. APC - colorectal cancer

BRCA2 - breasx t and ovarian cancer
BRCA1 - breasx t and ovarian cancer

73. Rb - retnoblasx toma

74. Prolactn - receptor-asx sx ociated tyrosx ine kinasx e

GABA-C - linand-nated ion channel receptor

75. Noonan sx yndrome isx aftosx omal dominant,

Antthrombin III defciency isx aftosx omal dominant, Haemophilia A,B isx l-linked recesx sx ive
Fanconi anaemia isx aftosx omal recesx sx ive, Connenital adrenal hyperplasx ia isx aftosx omal
recesx sx ive, Wilsx on'sx disx easx e isx aftosx omal recesx sx ive

76. Marfan'sx sx yndromesx isx aftosx omal dominant

Fabry'sx disx easx e isx l-linked recesx sx ive, Von Willebrand'sx disx easx e isx aftosx omal dominant
Hfnter'sx disx easx e isx l-linked recesx sx ive, Ehlersx -Danlosx sx yndrome isx aftosx omal dominant
Familial adenomatofsx polyposx isx isx aftosx omal dominant

77.Achondroplasx ia isx aftosx omal dominant, Mfcopolysx accharidosx esx : Hfrler'sx isx aftosx omal
recesx sx ive, Friedreich'sx atalia isx aftosx omal recesx sx ive,Atalia telanniectasx ia isx aftosx omal
recesx sx ive, Romano-Ward sx yndrome isx aftosx omal dominant
Von Hippel-Lindaf sx yndrome isx aftosx omal dominant

78. Wisx kot-Aldrich sx yndrome isx l-linked recesx sx ive

Albinisx m isx aftosx omal recesx sx ive
Hereditary haemorrhanic telanniectasx ia isx aftosx omal dominant

79. Alport'sx sx yndrome isx l-linked dominant, PKU isx aftosx omal recesx sx ive
Retnitsx pinmentosx a isx l-linked recesx sx ive,Cysx tnfria isx aftosx omal recesx sx ive
Myotonic dysx trophy isx aftosx omal dominant

80. Glyconen sx torane disx easx e isx aftosx omal recesx sx ive
Osx teonenesx isx imperfecta isx aftosx omal dominant, Hfntnnton'sx disx easx e isx aftosx omal
dominant, Hereditary non-polyposx isx colorectal carcinoma isx aftosx omal dominant
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 81. Familial Mediterranean Fever isx aftosx omal recesx sx ive,Vitamin D resx isx tant ricketsx isx l-
linked dominant, Tfberofsx sx clerosx isx isx aftosx omal dominant
Sickle cell anaemia isx aftosx omal recesx sx ive,Colofr blindnesx sx isx l-linked recesx sx ive

82.Hereditary sx pherocytosx isx isx aftosx omal dominant, Retnoblasx toma isx aftosx omal
dominant , Homocysx tnfria isx aftosx omal recesx sx ive, G6PD defciency isx l-linked recesx sx ive
Nefrofbromatosx isx isx aftosx omal dominant

83. Ocflar albinisx m isx l-linked recesx sx ive, Gilbert'sx sx yndrome isx aftosx omal recesx sx ive
Cysx tc fbrosx isx isx aftosx omal recesx sx ive, Haemochromatosx isx isx aftosx omal recesx sx ive
Dfchenne mfsx cflar dysx trophy isx l-linked recesx sx ive,Peftz-Jenhersx sx yndrome isx aftosx omal
dominant

84. Hyperlipidaemia type II isx aftosx omal dominant, Malinnant hyperthermia isx aftosx omal
dominant, Thalasx sx aemiasx isx aftosx omal recesx sx ive, Nephronenic diabetesx insx ipidfsx isx l-linked
recesx sx ive, Andronen insx ensx itvity sx yndrome isx l-linked recesx sx ive

85. Acfte intermitent porphyria isx aftosx omal dominant, Lesx ch-Nyhan sx yndrome isx l-linked
recesx sx ive, Lipid sx torane disx easx e: Tay-Sach'sx , Gafcher, Niemann-Pick isx aftosx omal recesx sx ive,
Ret sx yndrome isx l-linked dominant, Becker mfsx cflar dysx trophy isx l-linked recesx sx ive
Hypokalaemic periodic paralysx isx isx aftosx omal dominant,Adflt polycysx tc disx easx e isx
aftosx omal dominant

86. ELISA - detect antnensx and antbodiesx fsx inn a colofr channinn enzyme

87. Wesx tern blotnn - detectsx proteinsx

88.ELISA - an elample inclfdesx the inital HIV tesx t

89. Wesx tern blotnn - an elample inclfdesx the confrmatory HIV tesx t

90. Wesx tern blotnn - fsx esx nel electrophoresx isx to sx eparate natve proteinsx by 3-D sx trfctfre

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 91. Northern blotnn - detectsx RNA

92. Facial nerve pasx sx esx throfnh the internal acofsx tc meatfsx

93. Vanfsx nerve pasx sx esx throfnh the jfnflar foramen

94. Abdfcensx nerve pasx sx esx throfnh the sx fperior orbital fsx sx fre

95. Hyponlosx sx al nerve pasx sx esx throfnh the hyponlosx sx al canal

96. Vesx tbflocochlear nerve pasx sx esx throfnh the internal acofsx tc meatfsx

97. A 15-year-old presx entsx with pain in the rinht iliac fosx sx a asx sx ociated with anorelia and
low-nrade pyrelia - appendicitsx

98. An infant isx noted to have sx hort limbsx asx sx ociated with a larne head and frontal bosx sx inn -
achondroplasx ia

A 6-year-old nirl isx invesx tnated for precociofsx pfberty. On elaminaton sx he isx noted to have
cafe-af-lait sx potsx predominately on one sx ide of her body and a sx kfll deformity -
McCfneAlbrinht sx yndrome

100. A 6-week-old baby isx invesx tnated for cyanosx isx and feedinn difcfltesx . An
echocardionramsx howsx a rinht-to-lef sx hfnt throfnh a VSD, rinht ventricflar oftlow tract
obsx trfcton withasx sx ociated rinht ventricflar hypertrophy and an overridinn aorta - tetralony
of Fallot
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 101.A baby isx reviewed sx hortly afer birth asx a fetal fltrasx ofnd sx howed a cysx tc hynroma.
On elaminaton the baby hasx sx wollen handsx and feet and echocardionraphy sx howsx a
bicfsx pid aortc valve - Tfrner'sx sx yndrome

102.A yofnn boy isx noted to have learninn difcfltesx , macrocephaly, larne earsx and macro-
orchidisx m- franile X

103.A yofnn boy isx noted to have a webbed neck, pflmonary sx tenosx isx , ptosx isx and sx hort
sx tatfre. The karyotype isx normal - Noonan sx yndrome

104.A baby isx born with micronnathia, low-sx et earsx , rocker botom feet and overlappinn of
fnnersx - Edward'sx sx yndrome

105.A 6-month-old boy isx invesx tnated for developmental delay and infantle sx pasx msx . On
elaminaton he hasx fair hair and blfe eyesx . There isx sx ome eczema on the torsx o and he isx
notedto have a sx linhtly 'mfsx ty' odofr - phenylketonfria
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106.A baby isx noted to have micronnathia and a clef palate. He isx placed prone dfe to
fpper airway obsx trfcton. There isx no family hisx tory of sx imilar problemsx - Pierre-Robin
sx yndrome

107.A baby isx born with microcephaly, sx mall eyesx , low-sx et earsx , clef lip and polydactyly –
Pataf sx yndrome

108.A boy isx noted to have redfced tone, hypononadisx m and obesx ity - Prader-Willi
sx yndrome

109.A boy with learninn difcfltesx isx noted to be eltremely friendly and eltroverted. He
hasx sx hort for hisx ane and hasx sx fpravalvflar aortc sx tenosx isx - William'sx sx yndrome

110.A 1-year-old boy with a recent hisx tory of rectal bleedinn presx entsx with intesx tnal
obsx trfcton. Dfrinn sx frnery he isx fofnd to have a omphalomesx enteric band - Meckel'sx
divertcflfm
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111.A 6-week-old baby boy presx entsx with 'projectle' vomitnn 30 minftesx afer feedinn. On
elaminaton he isx mildy dehydrated and hasx a sx mall palpable masx sx in the fpper abdomen -
pyloric sx tenosx isx

112.A 10-day-old baby boy presx entsx with abdominal disx tensx ion and vomitnn. He frsx t
pasx sx ed meconifm at 72 hofrsx and hasx not opened isx bowelsx sx ince. An abdominal l-ray
sx howsx a dilated colon - Hirsx chsx prfnn'sx disx easx e

113.A teenane nirl presx entsx with medial knee pain followinn actvity. The knee hasx niven
way onoccasx ion - patellar sx fblflaton

114.A teenane nirl presx entsx with anterior knee pain which isx worsx e when noinn down sx tairsx
and risx inn from prolonned sx itnn - chondromalacia patellae

115.A sx porty teenane boy presx entsx with pain, tendernesx sx and sx wellinn over the tbial
tfbercle -Osx nood-Schlater disx easx e

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116.A sx porty teenaner presx entsx with knee pain afer elercisx e asx sx ociated with intermitent
sx wellinn and lockinn - osx teochondritsx disx sx ecansx

117.A patent cannot addfct hisx thinh followinn an anterior hip disx locaton - obtfrator
nerve

118.A patent losx esx the ability to plantarfel and invert hisx foot - tbial nerve

119.A patent developsx tnnlinn and nfmbnesx sx on the ofter asx pect of the thinh - lateral
cftaneofsx nerve of the thinh

120.A patent isx noted to have impaired hip eltensx ion and lateral rotaton. He hasx difcflty
risx inn from a sx eat and can't climb sx tairsx - inferior nlfteal nerve

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 121.A patent developsx losx sx of knee eltensx ion and sx ensx ory losx sx to the anterior and medial
asx pect of the thinh followinn a sx tab injfry - femoral nerve

122.A patent isx fofnd to have a posx itve Trendelenbfrn sx inn - sx fperior nlfteal nerve

123.A patent developsx foot drop followinn a fbflar neck fractfre - common peroneal
nerve

124.A 3-year-old child isx noted to have haematfria. On elaminaton there isx a masx sx in the
lef loin - Wilmsx ' tfmofr

125.A patent developsx a 'claw' hand followinn a medial epicondyle fractfre - flnar nerve

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126.A newborn'sx arm isx noted to be hanninn loosx ely followinn a difcflt forcepsx delivery.
The arm isx addfcted and internally rotated, elbow eltended - fpper trfnk of the brachial
plelfsx (C5,C6)

127.A boy presx entsx with arm problemsx afer fallinn from a tree, dfrinn which he cafnht a
branch to sx ave himsx elf. On elaminaton he hasx a claw hand with a hypereltended wrisx t -
lower trfnk of the brachial plelfsx (C8, T1)

128.A patent hasx difcflt abdfctnn their arm followinn a hfmeral neck fractfre - alillary
nerve

129.A patent isx noted to have wrisx t drop followinn a hfmeral midsx haf fractfre - radial
nerve

130.A patent complainsx of pinsx /needlesx and pain arofnd the thfmb and indel fnner which
isx worsx e at ninht - median nerve

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131.A woman developsx a winned sx capfla followinn a masx tectomy - lonn thoracic nerve

132.Myotonic dysx trophy - CTG

Franile X - CGG

133.Hfntnnton'sx - CAG

134.Friedreich'sx atalia - GAA

135.Vitamin B1 defciency may be cafsx ed by alcohol elcesx sx

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