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Estimating and Simulating

a SIRD Model of COVID-19

Jesús Fernández-Villaverde and Chad Jones

April 13, 2020


(Very preliminary and incomplete)

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Outline

• Basic model

◦ Social distancing via a time-varying β

• Estimation and simulation

◦ Different countries and states


◦ Robustness to parameters
◦ “Forecasts” from each of the last 7 days
◦ Standard errors coming soon

• How much can we relax social distancing?

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Basic Model

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Notation

• Number of people who are (stocks):

S = Susceptible
I = Infective
R = Recovered
D = Dead

• Constant population size is N

St + It + Rt + Dt = N

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SIRD Model: Overview

• Susceptible get infected at rate βIt /N

New infections = βIt /N · St

• Infections resolve at Poisson rate γ, so the average number of


days until resolution is 1/γ so γ = .2 ⇒ 5 days.

• Resolution happens in one of two ways:

◦ Death: fraction δ
◦ Recovery: fraction 1 − δ

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SIRD Model: Laws of Motion

∆St+1 = −βSt It /N
| {z }
new infections

∆It+1 = βSt It /N − γIt


| {z } |{z}
new infections resolving infections

∆Rt+1 = (1 − δ)γIt
| {z }
recover

∆Dt+1 = δγIt
|{z}
die

R0 = D0 = 0

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New notation (terrible) R0 : Initial infection rate

• Let s0 ≡ S0 /N = fraction susceptible

• Terrible recycled notation: “Reproduction number” R0 ≡ β/γ

◦ β = rate at which you get the virus from one infective person
◦ 1/γ = average time infected
◦ So R0 = expected number of infections generated by one
sick person when no herd immunity (s0 ≈ 1)

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Basic Properties of Differential System (Hethcote 2000)

• If R0 s0 > 1, the disease spreads, otherwise declines immediately

• Initial exponential growth rate is β − γ

• As t → ∞, the total fraction of people ever infected, e∗ , solves


(assuming s0 ≈ 1)

1
e∗ = − log(1 − e∗ )
R0

Long run is pinned down by R0 (and death rate),


γ affects timing

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Social Distancing

• What about a time-varying infection rate βt ?

◦ Disease characteristics – fixed, homogeneous


◦ Regional characteristics (NYC vs Montana) – fixed,
heterogeneous
◦ Social distancing – varies over time and space

• Model: assume two key parameters β0 and β ∗

• Economy decays exponentially from β0 to β ∗ at rate λ:

βt = β0 e−λt + β ∗ (1 − e−λt )

⇒ can think about initial R0 = β0 /γ


and final R∗0 = β ∗ /γ
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Estimates and Simulations

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Estimation: Countries and States

• Parameters that are fixed and homogeneous

◦ γ = 0.2: average duration is 5 days (or γ = 0.1)


◦ δ = 0.003 (Heinsberg, Germany random sampling)
◦ λ = 7%: βt falls halfway to new value each 10 days

• Parameters that vary across countries/states

◦ β0 and β ∗
◦ I0 : initial number of infections (gets timing right)

• Objective function:

◦ Equally weighted SSR for Cumulative deaths (logs) and


Daily deaths (logs)

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Guide to Graphs

• 7 days of forecasts: ROY-G-BIV (old to new, low to high)

◦ Black=current
◦ Red = oldest, Orange = second oldest, Yellow =third oldest...
◦ Violet (purple) = one day earlier

• For robustness graphs, same idea

◦ Black = baseline (e.g. δ = .003)


◦ Red = lowest parameter value (e.g. δ = .001)
◦ Green = highest parameter value (e.g. δ = .005)

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New York: Cumulative Deaths per Million People (δ = .003/.001/.005)
New York
R0=4.2,0.9 = 0.003, =0.07, =0.2, %Infected(today)=21
450
THRU APR 10

400
Cumulative deaths per million people

350
Three estimates (δ = .003/.001/.005)
300 fit equally well in levels
250

200

150

100

50

0
Mar 14 Mar 17 Mar 20 Mar 23 Mar 26 Mar 29 Apr 01 Apr 04 Apr 07 Apr 10
2020

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New York: Daily Deaths per Million People (δ = .003/.001/.005)
New York
R0=4.2,0.9 = 0.003, =0.07, =0.2, %Infected(t+30)=42
50
THRU APR 10

45

40

Different futures for daily


Daily deaths per million people

35
deaths
30

25

20

15

10

0
Mar 15 Mar 29 Apr 12 Apr 26 May 10 May 24 Jun 07
2020

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New York: Cumulative Deaths per Million (Future, δ = .003/.001/.005)
New York
R0=4.2,0.9 = 0.003, =0.07, =0.2, %Infected(end)=44 = 0.005
1500
THRU APR 10

= 0.003
Cumulative deaths per million people

1000

= 0.001

500

But very different futures!

0
Mar 14 Mar 28 Apr 11 Apr 25 May 09 May 23 Jun 06
2020

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Italy: Cumulative Deaths per Million People (λ = .07/.05/.10)
Italy
R0=5.3,0.7 = 0.003, =0.07, =0.2, %Infected(today)=12
350
THRU APR 10

300
Cumulative deaths per million people

250
Three estimates (λ = .07/.05/.10) fit
pretty well in levels
200

150

100

50

0
Feb 21 Feb 28 Mar 06 Mar 13 Mar 20 Mar 27 Apr 03 Apr 10
2020

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Italy: Daily Deaths per Million People (λ = .07/.05/.10)
Italy
R0=5.3,0.7 = 0.003, =0.07, =0.2, %Infected(t+30)=15
16
THRU APR 10

14

12 λ = .07/.05 better fit for daily


Daily deaths per million people

deaths
10

0
Feb 22 Mar 07 Mar 21 Apr 04 Apr 18 May 02 May 16
2020

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Italy: Cumulative Deaths per Million (Future, λ = .07/.05/.10)
Italy
R0=5.3,0.7 = 0.003, =0.07, =0.2, %Infected(end)=15
600
THRU APR 10

= 0.1
500
Cumulative deaths per million people

= 0.07
= 0.05
400

300

200

Slightly different futures!


100

0
Feb 21 Mar 06 Mar 20 Apr 03 Apr 17 May 01 May 15
2020

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Spain: Cumulative Deaths per Million People (γ = .2/.1)
Spain
R0=5.9,0.3 = 0.003, =0.07, =0.2, %Infected(today)=14
400
THRU APR 10

350
Cumulative deaths per million people

300
γ = .2 fits slightly better in levels
250

200

150

100

50

0
Mar 03 Mar 10 Mar 17 Mar 24 Mar 31 Apr 07 Apr 14
2020

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Spain: Daily Deaths per Million People (γ = .2/.1)
Spain
R0=5.9,0.3 = 0.003, =0.07, =0.2, %Infected(t+30)=16
25
THRU APR 10

20
Daily deaths per million people

γ = .2 better fit for daily deaths


15

10

0
Mar 04 Mar 18 Apr 01 Apr 15 Apr 29 May 13 May 27
2020

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Spain: Cumulative Deaths per Million (Future, γ = .2/.1)
Spain
R0=5.9,0.3 = 0.003, =0.07, =0.2, %Infected(end)=16
800 = 0.1
THRU APR 10

700
Cumulative deaths per million people

600

500 = 0.2

400

300

200
Very different futures!
100

0
Mar 03 Mar 17 Mar 31 Apr 14 Apr 28 May 12 May 26
2020

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Repeated “Forecasts” from the
past 7 days of data

– After peak, forecasts settle down.


– Before that, very noisy!

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Spain (7 days): Daily Deaths per Million People
Spain
R0=5.9,0.3 = 0.003, =0.07, =0.2, %Infected(t+30)=16
25
THRU APR 10

20
Daily deaths per million people

15

10

0
Mar 04 Mar 18 Apr 01 Apr 15 Apr 29 May 13 May 27
2020

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Italy (7 days): Daily Deaths per Million People
Italy
R0=5.3,0.7 = 0.003, =0.07, =0.2, %Infected(t+30)=15
16
THRU APR 10

14

12
Daily deaths per million people

10

0
Feb 22 Mar 07 Mar 21 Apr 04 Apr 18 May 02 May 16
2020

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New York (7 days): Daily Deaths per Million People
New York
R0=4.2,0.9 = 0.003, =0.07, =0.2, %Infected(t+30)=42
60
THRU APR 10

50
Daily deaths per million people

40

30

20

10

0
Mar 15 Mar 29 Apr 12 Apr 26 May 10 May 24 Jun 07
2020

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New York (7 days): Cumulative Deaths per Million (Future)
New York
R0=4.2,0.9 = 0.003, =0.07, =0.2, %Infected(end)=44
1600
THRU APR 10

1400
Cumulative deaths per million people

1200

1000

800

600

400

200

0
Mar 14 Mar 28 Apr 11 Apr 25 May 09 May 23 Jun 06
2020

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California (7 days): Cumulative Deaths per Million
California
R0=4.0,1.0 = 0.003, =0.07, =0.2, %Infected(today)= 1
18
THRU APR 10

16
Cumulative deaths per million people

14

12

10

0
Mar 04 Mar 11 Mar 18 Mar 25 Apr 01 Apr 08 Apr 15
2020

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California (7 days): Daily Deaths per Million People
California
R0=4.0,1.0 = 0.003, =0.07, =0.2, %Infected(t+30)= 3
20
THRU APR 10

18
(noisy and unreliable)
16
Daily deaths per million people

14

12

10

0
Mar 05 Mar 19 Apr 02 Apr 16 Apr 30 May 14 May 28
2020

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California (7 days): Cumulative Deaths per Million (Future)
California
R0=4.0,1.0 = 0.003, =0.07, =0.2, %Infected(end)= 5
450
THRU APR 10

400 (noisy and unreliable)


Cumulative deaths per million people

350

300

250

200

150

100

50

0
Mar 04 Mar 18 Apr 01 Apr 15 Apr 29 May 13 May 27
2020

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U.K. (7 days): Cumulative Deaths per Million
U.K.
R0=3.6,1.5 = 0.003, =0.07, =0.2, %Infected(today)= 8
200
THRU APR 10

180

160
Cumulative deaths per million people

140

120

100

80

60

40

20

0
Mar 05 Mar 12 Mar 19 Mar 26 Apr 02 Apr 09 Apr 16
2020

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U.K. (7 days): Daily Deaths per Million People
U.K.
R0=3.6,1.5 = 0.003, =0.07, =0.2, %Infected(t+30)=51
120
THRU APR 10

(noisy and unreliable)


100
Daily deaths per million people

80

60

40

20

0
Mar 06 Mar 20 Apr 03 Apr 17 May 01 May 15 May 29
2020

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U.K. (7 days): Cumulative Deaths per Million (Future)
U.K.
R0=3.6,1.5 = 0.003, =0.07, =0.2, %Infected(end)=60
2500
THRU APR 10

(noisy and unreliable)

2000
Cumulative deaths per million people

1500

1000

500

0
Mar 05 Mar 19 Apr 02 Apr 16 Apr 30 May 14 May 28
2020

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Sweden (7 days): Daily Deaths per Million People
Sweden
R0=3.2,1.3 = 0.003, =0.07, =0.2, %Infected(t+30)=32
40
THRU APR 10

35 (noisy and unreliable)

30
Daily deaths per million people

25

20

15

10

0
Mar 12 Mar 26 Apr 09 Apr 23 May 07 May 21 Jun 04
2020

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France (7 days): Daily Deaths per Million People
France
R0=4.4,1.7 = 0.003, =0.07, =0.2, %Infected(t+30)=66
100
THRU APR 10

90 (noisy and unreliable)


80
Daily deaths per million people

70

60

50

40

30

20

10

0
Feb 16 Mar 01 Mar 15 Mar 29 Apr 12 Apr 26 May 10
2020

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Cumulative Deaths per Million, Log Scale
CUMULATIVE DEATHS PER MILLION

Spain Italy
256 France DATA THROUGH 12-APR-2020

U.K.
128

3%
35%
64 U.S. Hubei, China

=2
Iran

s, g
s, g

ay
32 day

3d
%
14
ry 2

ery
16
ev , g=
ys
eve

da
les

8 5
bles

ub

ry
ve
Do
Dou

e S. Korea
4 es
ubl
Do , g=
7%
2 ays
d
y 10
ver
1 es e
ubl
Do
0.5

Italy seems a better guide to France/U.K.


0.1
0 10 20 30 40 50 60 70 80 90
DAYS SINCE 1 DEATH PER 10 MILLION PEOPLE

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Hubei, China (7 days): Daily Deaths per Million People
Hubei, China
R0=2.5,0.5 = 0.003, =0.07, =0.2, %Infected(t+30)= 2
4.5
THRU APR 10

3.5
Daily deaths per million people

2.5

1.5

0.5

0
Jan 23 Feb 06 Feb 20 Mar 05 Mar 19 Apr 02 Apr 16
2020

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S. Korea (7 days): Daily Deaths per Million People
S. Korea
R0=1.8,0.9 = 0.003, =0.07, =0.2, %Infected(t+30)= 0
0.25
THRU APR 10

0.2
Daily deaths per million people

0.15

0.1

0.05

0
Feb 21 Mar 06 Mar 20 Apr 03 Apr 17 May 01 May 15
2020

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Washington (7 days): Daily Deaths per Million People
Washington
R0=1.4,1.4 = 0.003, =0.07, =0.2, %Infected(t+30)=19
40
THRU APR 10

35 (noisy and unreliable)

30
Daily deaths per million people

25

20

15

10

0
Mar 01 Mar 15 Mar 29 Apr 12 Apr 26 May 10 May 24
2020

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Louisiana (7 days): Daily Deaths per Million People
Louisiana
R0=3.5,0.6 = 0.003, =0.07, =0.2, %Infected(t+30)=13
16
THRU APR 10

14

12
Daily deaths per million people

10

0
Mar 15 Mar 29 Apr 12 Apr 26 May 10 May 24 Jun 07
2020

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Florida (7 days): Daily Deaths per Million People
Florida
R0=4.0,1.3 = 0.003, =0.07, =0.2, %Infected(t+30)=11
80
THRU APR 10

70 (noisy and unreliable)

60
Daily deaths per million people

50

40

30

20

10

0
Mar 07 Mar 21 Apr 04 Apr 18 May 02 May 16 May 30
2020

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Michigan (7 days): Daily Deaths per Million People
Michigan
R0=3.7,0.5 = 0.003, =0.07, =0.2, %Infected(t+30)=13
25
THRU APR 10

(noisy and unreliable)


20
Daily deaths per million people

15

10

0
Mar 19 Apr 02 Apr 16 Apr 30 May 14 May 28 Jun 11
2020

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Massachusetts (7 days): Daily Deaths per Million People
Massachusetts
R0=2.4,1.6 = 0.003, =0.07, =0.2, %Infected(t+30)=55
70
THRU APR 10

60 (noisy and unreliable)


Daily deaths per million people

50

40

30

20

10

0
Mar 21 Apr 04 Apr 18 May 02 May 16 May 30 Jun 13
2020

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Assessing Uncertainty

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How Do We Evaluate Uncertainty?

• Basic SIRD model is deterministic

◦ There is an implicit appeal to a law of large numbers holding


in populations.
◦ How do we map it into data?
◦ Measurement error (huge undercount of deaths in Italy and
Spain, massive under-reporting of infections). However,
unlikely to be classical measurement error.
◦ Un-modeled shocks (we have not specified them explicitely).

• Thus, assessing uncertainty is not straightforward.

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Our Approach

• A simple empirical Bayesian method


◦ Specify a prior on β, γ, and δ centered around our point
estimates and having a variance based on plausibility/our
reading of the medical literature.
◦ You sample from the prior and forecast the future behavior of
the model based on the sampled parameter values.
◦ Informative about the properties of the model and range of
likely outcomes

• We tried to compute standard errors.


◦ We got numerically unstable values.
◦ However, our provisional values are within the range of our
priors (if anything, our computed standard errors feel “too
small”).
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R0 is key for dynamics...

U.S., uncertainty regarding R 0


R0=2.4,1.3 = 0.003, =0.07, =0.2, %Infected(today)= 3
1600
R0 today = 1.1
R0 today = 1.3
1400 R0 today = 1.4
R0 today (point estimate) = 1.6
R0 today = 1.7
Cumulate deaths per million people

1200 R0 today = 1.9


R0 today = 2.0 10-Apr-2020

1000

800

600

400

200

0
Feb 29 Mar 14 Mar 28 Apr 11 Apr 25 May 09 May 23
2020

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R0 is key for dynamics...

New York, uncertainty regarding R 0


R0=2.4,0.9 = 0.003, =0.07, =0.2, %Infected(today)=21
1800

1600

1400
Cumulate deaths per million people

10-Apr-2020

1200

1000

800

600
R0 today = 0.9
R0 today = 1.1
400
R0 today = 1.2
R0 today (point estimate) = 1.4
R0 today = 1.5
200
R0 today = 1.7
R0 today = 1.8
0
Mar 14 Mar 28 Apr 11 Apr 25 May 09 May 23 Jun 06
2020

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R0 is key for dynamics...

California, uncertainty regarding R 0


R0=2.4,1.0 = 0.003, =0.07, =0.2, %Infected(today)= 1
300
R0 today = 0.8
R0 today = 1.0
R0 today = 1.1
250 R0 today (point estimate) = 1.3
R0 today = 1.4
Cumulate deaths per million people

R0 today = 1.6
R0 today = 1.7
200

150

10-Apr-2020

100

50

0
Mar 04 Mar 18 Apr 01 Apr 15 Apr 29 May 13 May 27
2020

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R0 is key for dynamics...

Spain, uncertainty regarding R 0


R0=2.4,0.3 = 0.003, =0.07, =0.2, %Infected(today)=14
600

500
10-Apr-2020
Cumulate deaths per million people

400

300

200
R0 today = 0.3
R0 today = 0.4
R0 today = 0.6
100 R0 today (point estimate) = 0.7
R0 today = 0.9
R0 today = 1.0
R0 today = 1.2
0
Mar 03 Mar 17 Mar 31 Apr 14 Apr 28 May 12 May 26
2020

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γ not so much

U.S., uncertainty regarding keeping R 0 constant


R0=2.4,1.3 = 0.003, =0.07, =0.2, %Infected(today)= 3
1400
= 0.170
= 0.180
= 0.190
1200
= 0.200 10-Apr-2020
= 0.210
Cumulate deaths per million people

= 0.220
1000 = 0.230

800

600

400

200

0
Feb 29 Mar 14 Mar 28 Apr 11 Apr 25 May 09 May 23
2020

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γ not so much

New York, uncertainty regarding keeping R 0 constant


R0=2.4,0.9 = 0.003, =0.07, =0.2, %Infected(today)=21
1400
10-Apr-2020

1200
Cumulate deaths per million people

1000

800

600

400 = 0.170
= 0.180
= 0.190
= 0.200
200 = 0.210
= 0.220
= 0.230
0
Mar 14 Mar 28 Apr 11 Apr 25 May 09 May 23 Jun 06
2020

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γ not so much

California, uncertainty regarding keeping R 0 constant


R0=2.4,1.0 = 0.003, =0.07, =0.2, %Infected(today)= 1
150
= 0.170
= 0.180
= 0.190
= 0.200 10-Apr-2020
= 0.210
Cumulate deaths per million people

= 0.220
= 0.230
100

50

0
Mar 04 Mar 18 Apr 01 Apr 15 Apr 29 May 13 May 27
2020

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γ not so much

Spain, uncertainty regarding keeping R 0 constant


R0=2.4,0.3 = 0.003, =0.07, =0.2, %Infected(today)=14
500
10-Apr-2020

450

400
Cumulate deaths per million people

350

300

250

200

150
= 0.170
= 0.180
100 = 0.190
= 0.200
= 0.210
50 = 0.220
= 0.230
0
Mar 03 Mar 17 Mar 31 Apr 14 Apr 28 May 12 May 26
2020

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δ matters for deaths, not for dynamics

U.S., uncertainty regarding


R0=2.4,1.3 = 0.003, =0.07, =0.2, %Infected(today)= 3
2500
= 0.000
= 0.001
= 0.002
= 0.003
2000 = 0.004
Cumulate deaths per million people

= 0.005
= 0.006

1500

10-Apr-2020

1000

500

0
Feb 29 Mar 14 Mar 28 Apr 11 Apr 25 May 09 May 23
2020

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δ matters for deaths, not for dynamics

New York, uncertainty regarding


R0=2.4,0.9 = 0.003, =0.07, =0.2, %Infected(today)=21
2500
= 0.000
= 0.001
= 0.002
= 0.003
2000 = 0.004
Cumulate deaths per million people

= 0.005
= 0.006

1500

10-Apr-2020

1000

500

0
Mar 14 Mar 28 Apr 11 Apr 25 May 09 May 23 Jun 06
2020

53 / 68
δ matters for deaths, not for dynamics

California, uncertainty regarding


R0=2.4,1.0 = 0.003, =0.07, =0.2, %Infected(today)= 1
250
= 0.000
= 0.001
= 0.002
= 0.003
200 = 0.004
Cumulate deaths per million people

= 0.005
= 0.006

150

10-Apr-2020

100

50

0
Mar 04 Mar 18 Apr 01 Apr 15 Apr 29 May 13 May 27
2020

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δ matters for deaths, not for dynamics

Spain, uncertainty regarding


R0=2.4,0.3 = 0.003, =0.07, =0.2, %Infected(today)=14
700

600
Cumulate deaths per million people

500
10-Apr-2020

400

300

200 = 0.000
= 0.001
= 0.002
= 0.003
100 = 0.004
= 0.005
= 0.006
0
Mar 03 Mar 17 Mar 31 Apr 14 Apr 28 May 12 May 26
2020

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We can plot joint draws

U.S., uncertainty regarding and


R0=2.4,1.3 = 0.003, =0.07, =0.2, %Infected(today)= 3
2000

1800

1600
Cumulate deaths per million people

1400

1200
10-Apr-2020

1000

800

600

400

200

0
Feb 29 Mar 14 Mar 28 Apr 11 Apr 25 May 09 May 23
2020

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Policy Counterfactuals

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Reducing R0 has a huge impact...

U.S., infected reducing R 0 at the end of observations


R0=2.4,1.3 = 0.003, =0.07, =0.2, %Infected(today)= 3
6
R0 estimated on 10-Apr-2020 is 1.6
R0 lowered to 1.3
R0 lowered to 0.9
5 R0 lowered to 0.6
R0 lowered to 0.3

4
Infected, percentage

10-Apr-2020

0
Feb 29 Mar 14 Mar 28 Apr 11 Apr 25 May 09 May 23
2020

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Reducing R0 has a huge impact...

New York, infected reducing R 0 at the end of observations


R0=2.4,0.9 = 0.003, =0.07, =0.2, %Infected(today)=21
8
R0 estimated on 10-Apr-2020 is 1.4
R0 lowered to 1.1
7 R0 lowered to 0.8
R0 lowered to 0.5
R0 lowered to 0.3
6
Infected, percentage

10-Apr-2020
0
Mar 14 Mar 28 Apr 11 Apr 25 May 09 May 23 Jun 06
2020

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Reducing R0 has a huge impact...

California, infected reducing R 0 at the end of observations


R0=2.4,1.0 = 0.003, =0.07, =0.2, %Infected(today)= 1
0.45 10-Apr-2020

R0 estimated on 10-Apr-2020 is 1.3


R0 lowered to 1.0
0.4 R0 lowered to 0.8
R0 lowered to 0.5
R0 lowered to 0.3
0.35

0.3
Infected, percentage

0.25

0.2

0.15

0.1

0.05

0
Mar 04 Mar 18 Apr 01 Apr 15 Apr 29 May 13 May 27
2020

60 / 68
...but it has a decreasing marginal effects on cumulate deaths

U.S., ever infected reducing R 0 at the end of observations


R0=2.4,1.3 = 0.003, =0.07, =0.2, %Infected(today)= 3
1200
R0 estimated on 10-Apr-2020 is 1.6 10-Apr-2020

R0 lowered to 1.3
R0 lowered to 0.9
1000 R0 lowered to 0.6
R0 lowered to 0.3
Cumulate deaths per million people

800

600

400

200

0
Feb 29 Mar 14 Mar 28 Apr 11 Apr 25 May 09 May 23
2020

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...but it has a decreasing marginal effects on cumulate deaths

New York, ever infected reducing R 0 at the end of observations


R0=2.4,0.9 = 0.003, =0.07, =0.2, %Infected(today)=21
1400
10-Apr-2020

1200
Cumulate deaths per million people

1000

800

600

400

R0 estimated on 10-Apr-2020 is 1.4


R0 lowered to 1.1
200 R0 lowered to 0.8
R0 lowered to 0.5
R0 lowered to 0.3
0
Mar 14 Mar 28 Apr 11 Apr 25 May 09 May 23 Jun 06
2020

62 / 68
...but it has a decreasing marginal effects on cumulate deaths

California, ever infected reducing R 0 at the end of observations


R0=2.4,1.0 = 0.003, =0.07, =0.2, %Infected(today)= 1
140
R0 estimated on 10-Apr-2020 is 1.3
R0 lowered to 1.0
R0 lowered to 0.8 10-Apr-2020
120
R0 lowered to 0.5
R0 lowered to 0.3
Cumulate deaths per million people

100

80

60

40

20

0
Mar 04 Mar 18 Apr 01 Apr 15 Apr 29 May 13 May 27
2020

63 / 68
Reopening and Herd Immunity

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Percent Ever Infected would be very informative

— Percent Ever Infected (today) —


δ = .001 δ = .003 δ = .005

New York 58 21 13
California 2 1 0
Italy 35 12 7
Spain 40 14 8
U.K. 22 8 5
France 34 13 8
Hubei, China 5 2 1
S. Korea 0 0 0
Sweden 14 5 3
Louisiana 22 7 4
Florida 3 1 1
Washington 8 3 2
Michigan 19 6 4
Massachusetts 15 5 3

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Herd Immunity

• How far can we relax social distancing?

• Let s(t) = S(t)/N = the fraction still susceptible

◦ The disease will die out as long as

R0 (t)s(t) < 1

◦ That is, if the “new” R0 is smaller than 1/s(t)


◦ Today’s infected people infect fewer than 1 person on
average

• We can relax social distancing to raise R0 (t) to 1/s(t)

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Herd Immunity and Opening the Economy?
Percent R0 (t+30) Percent
Susceptible with no way back
R0 R∗0 t+30 outbreak to normal

New York 4.2 0.9 57.7 1.7 26.0


California 4.0 1.0 96.9 1.0 -0.3
Hubei, China 2.5 0.5 98.2 1.0 25.0
Italy 5.3 0.7 85.3 1.2 10.0
Spain 5.9 0.3 84.1 1.2 15.3
U.K. 3.6 1.5 49.1 2.0 25.8
France 4.4 1.7 34.3 2.9 45.0
S. Korea 1.8 0.9 99.8 1.0 11.0
Sweden 3.2 1.3 68.5 1.5 8.8
Louisiana 3.5 0.6 87.0 1.1 18.7
Florida 4.0 1.3 89.1 1.1 -5.3
Washington 1.4 1.4 81.3 1.2 -456.2
Michigan 3.7 0.5 86.7 1.2 19.8
Massachusetts 2.4 1.6 44.7 2.2 76.7

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Conclusion

Thanks!

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