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  • Acute and Chronic Pancreatitis

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    Maryam Fadah
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    1. Acute pancreatitis has several main causes including gallstones, alcohol use, and genetic mutations. Grossly, the pancreas appears hemorrhagic with yellow-white areas of fat necrosis. Microscopically there is interstitial edema, fat necrosis, and acute inflammation. 2. Chronic pancreatitis is mainly caused by long term alcohol abuse which activates stellate cells. The pancreas appears hard with dilated ducts and visible calcifications. Microscopic findings include parenchymal fibrosis, fewer and smaller acini, and dilated ducts filled with protein plugs. 3. Diagnosis is based on characteristic clinical symptoms, elevated pancreatic enzyme levels, and imaging showing pancreatic inflammation.

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    Acute and chronic Pancreatitis

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    1. Acute pancreatitis has several main causes including gallstones, alcohol use, and genetic mutations. Grossly, the pancreas appears hemorrhagic with yellow-white areas of fat necrosis. Microscopically there is interstitial edema, fat necrosis, and acute inflammation. 2. Chronic pancreatitis is mainly caused by long term alcohol abuse which activates stellate cells. The pancreas appears hard with dilated ducts and visible calcifications. Microscopic findings include parenchymal fibrosis, fewer and smaller acini, and dilated ducts filled with protein plugs. 3. Diagnosis is based on characteristic clinical symptoms, elevated pancreatic enzyme levels, and imaging showing pancreatic inflammation.

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    15 views1 page

    Acute and Chronic Pancreatitis

    Uploaded by

    Maryam Fadah
    1. Acute pancreatitis has several main causes including gallstones, alcohol use, and genetic mutations. Grossly, the pancreas appears hemorrhagic with yellow-white areas of fat necrosis. Microscopically there is interstitial edema, fat necrosis, and acute inflammation. 2. Chronic pancreatitis is mainly caused by long term alcohol abuse which activates stellate cells. The pancreas appears hard with dilated ducts and visible calcifications. Microscopic findings include parenchymal fibrosis, fewer and smaller acini, and dilated ducts filled with protein plugs. 3. Diagnosis is based on characteristic clinical symptoms, elevated pancreatic enzyme levels, and imaging showing pancreatic inflammation.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    Pancreatitis Etiology Gross morphology Microscopic morphology Dx


    pathogenesis
    1) Typical
    clinical
    symptom

    - Hemorrhagic 2) High se
    parenchyma & amylase a
    scattered yellow- 1.Interstitial edema. lipase leve
    st white chalky areas of 2.Fat necrosis. greater th
    1 : Gallstones. Trypsinogen
    Acute fat necrosis. 3.Acute inflammation. three tim
    2nd: Alcohol. activation.
    - Peritoneal serous 4.Pancreatic parenchymal destruction. upper lim
    slightly turbid or 5.Blood vessels destruction normal
    brownish fluid
    contains fat globules. 3) Imagin
    showing
    pancreati
    inflamma
    CT is the b
    Clinical
    symptom
    1. Pancrea
    1. Parenchymal fibrosis. calcificatio
    2. ↓number/size of acini with relative
    sparing of islets of Langerhans. 2. Ductal
    Stellate cells Hard, dilated ducts,
    Chronic* Alcohol Abuse. 3. Pancreatic ducts dilatation with dilatation
    activation. Visible calcifications.
    luminal protein plugs.
    4. Chronic inflammation around lobules 3. Parench
    & ducts atrophy a
    focal
    inflamma
    masses.
    *PRSS1 or SPINK1 gene mutation

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