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Contents

CHAPTER8

Antibacterial Antibiotics
CHAPT
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Antiba
JOHN M. BEALE, JR.
JOHN M. BEA
the presence of certain bacteria, alon…
the presence o
defineantibiosi
In 1942, Waksman3 proposed the wi…
destroys anoth
1. It is a product of metabolism (alth… public, as well
become obscu
2. It is a synthetic product produced … In 1942, Waks
produced by m
3. It antagonizes the growth or surviv… microorganism
substance prod
4. It is effective in low concentrations…
of microorgan
CHAPTEROVERVIEW antibiotics and
the definition.
Since Alexander Fleming accidentally… 1. It is a produ
2. It is a synthe
HISTORICAL BACKGROUND 3. It antagoniz
4. It is effectiv
Sir Alexander Fleming’s accidental …
Bacillus brevis
COMMERCIAL PRODUCTION impetus for the
isolate streptom
The commercial production of antibi… Mycobacterium
evident that so
(a) preparation of a pure culture of t… instituted to fin
chemotherapeu
(b) fermentation, during which the a…
broad-spectrum
CHAPTER
(c) isolation of the antibiotic from th…
Since Alexand
(d) purification; (e) assays for potenc… to our therapeu
turned the tide
SPECTRUM OF ACTIVITY

The ability of some antibiotics, such …

HISTORIC
Title has no content Sir Alexander
with initiating
Title has no content therapy, did pr
humans had le
Title has no content
assume to be e
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