525426-12-1CO AID: 66627 | 29/03/2020

ADME: It means Absorption, Distribution, Metabolism, and Excretion (ADME).

Absorption  describes the mechanisms of drug input into the body and tissue within the
organism. Distribution depends on many parts, involving blood perfusion, cell membrane
permeability and tissue binding. Metabolism is a method in which the body transforms a
drug that absorbed by the body from its primary form into a new way, called a
metabolite. Excretion is the method by which a drug or metabolite is eliminated from the
body without additional chemical modification.

Disposition can break down into distribution and elimination. After a drug penetrates the
systemic circulation, it passed to the body’s tissues.

Elimination defines the chemical conversion and physical elimination of the drug from
the body. Hence, removal is the sum of the methods compared to drug loss from the
body, namely metabolism and excretion.

Bioavailability describes the rate and extent in which the active drug ingredient
assimilated from a drug product and available at the site of drug action. Pharmacologic
usually associated with the concentration of drug at the place of drug action, the
availability of a prescription from a dosage form is a vital element of a drug product’s
clinical efficacy.