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doi: 10.1093/pm/pnw011
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Fritz et al.
Results. We present an algorithm and supportive many years [13]. Except in rare instances of progressive
materials to help guide the care of older adults with neurologic deficits or cauda equina involvement, a period
LSS, a condition that occurs not uncommonly in of non-operative management is generally advocated as
those with CLBP. The case illustrates the impor- an initial strategy [14,15]. Various non-surgical approaches
tance of function-focused management and a ratio- have been recommended including watchful waiting, med-
nal approach to conservative care. ications, physical therapy using a variety of interventions,
and epidural steroid injections [16,17]; however there is lit-
Conclusions. Lumbar spinal stenosis exists not un- tle evidence to inform the selection or sequencing of these
commonly in older adults with CLBP and manage- options [18]. An increasing number of individuals with LSS
ment often can be accomplished without surgery. receive surgery, particularly complex fusion procedures
Treatment should address all conditions in addition [4,5,19,20]. More than 37,000 surgical procedures for LSS
to LSS contributing to pain and disability. were performed in 2007 among Medicare recipients at a
total cost of $1.65 billion [5]. Despite this level of utilization,
Key Words. Aged; Assessment; Lumbar Spinal a lack of consensus regarding appropriate indications for
Stenosis; Spinal Stenosis; Chronic Pain; Elderly; surgery is evidenced by high rates of geographic variation
Low Back Pain; Primary Care; Chronic Low Back Pain in LSS surgical procedures [21].
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Deconstructing Chronic Low Back Pain in the Older Adult
Figure 1 Algorithm for the evaluation and treatment of lumbar spinal stenosis.
and a resulting right knee flexion contracture. She has least 4 days per week without pain or having to forward
no history of any surgeries. Her current medications and flex her trunk to limit symptoms.
supplements included: Lovastatin, Vitamin D-3; calcium
citrate, fish oil, Coenzyme Q10, and Magnesium. She
did not have any prescribed pharmaceutical pain man- Relevant Physical Examination
agement, but she uses non-prescription acetaminophen
as needed several times a week to reduce pain with The patient is alert and oriented with no apparent dis-
walking. She had three previous epidural steroid injec- tress. Her standing posture reveals increased flexion of
tions to manage past episodes. Her primary goal is to lumbar spine and hips as well as the right knee due a
return to her usual routine of walking 45-60 minutes at flexion contracture of her knee. Her weight bearing is
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Fritz et al.
1. Watchful waiting Natural history of LSS can be favorable in 1=3 to 1=2 of patients. [12,13]
Catastrophic neurologic decline is rare.
2. Physical therapy Improvements in pain and function with physical therapy including [36,42]
exercise and manual therapy. Can provide favorable results even in
patients considered surgical candidates.
3. Manipulation Improvement in function for patients with chronic low back pain. No [35]
studies specific to LSS.
4. Massage Improvements in pain and disability for patients with chronic low back
pain. Improvements enhanced when combined with exercise. No
studies specific to LSS. No evidence of superiority for any specific
6. Epidural steroid injection Short-term improvement in pain and walking ability for patients with [44]
LSS.
7. Cognitive behavioral therapy Short-term improvement in pain and function reported in comparison to [45]
controls for patients with chronic LBP. No studies specific to LSS.
8. Lumbosacral corset Suggested to increase walking distance and decrease pain in patients [46]
with LSS. There is no evidence that results are sustained once the
corset is removed.
9. Aquatic therapy Exercises performed in the water may provide an opportunity for –
physical activity in patients with LSS whose symptoms substantially
limit land-based exercise.
shifted to be greater on the left lower extremity. Her gait characterized as severe central canal stenosis at the L3/
reveals increased forward flexion in the lumbar spine 4 and L4/5 spinal levels in the radiology report.
and hip flexion. Her spinal range of motion is full without
pain in flexion; lumbar extension is limited to a few de-
grees with complaints of stiffness in her low back. There
were no hip range-of-motion deficits. Her right knee Clinical Course
range of motion reveals a 10 degree extension lag.
Neurological assessment of her lower extremities reveals The patient initially received an epidural steroid injection
symmetrical strength and intact sensation with symmet- which abated her left lower extremity symptoms and back
rical Patellar and Achilles reflexes graded as 1þ bilater- pain. However, she continued to have difficulty walking
ally. Select muscle strength testing shows hip extension without leaning on a shopping cart, her exercise program
weakness graded as 4/5 bilaterally, and abdominal was limited to walking 1.5 miles using a walking stick and
weakness graded as a 3/5 using Kendall’s leg lowering approximately two rest breaks, and she was unable to
test. Examination of muscle length indicates tightness of stand fully upright after walking two blocks. Due to these
her hip flexors (iliopsoas and rectus femoris) and her ilio- continued activity limitations she began physical therapy
tibial band bilaterally. care three weeks after her injection. Over six visits of
physical therapy focused on manual therapy and exer-
cises to improve hip extension and hip flexor flexibility,
Imaging she was able to stand more erect statically, but she still
needed to flex forward after approximately 5 minutes of
Spinal radiographs were performed indicating multi-level walking. Her walking distance was still limited to 1.5 mi-
degenerative disc disease and facet joint hypertrophy. les, but she indicated she needed breaks due to “breath-
There was no indication of degenerative spondylolisthe- ing hard” rather than pain. Throughout her treatment, she
sis. MRI was also performed and the results were continued going to a group exercise class for older adults
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Deconstructing Chronic Low Back Pain in the Older Adult
First-line medication
Acetaminophen 325-1000 mg q4-6h while awake, Ask about all OTCs with acetaminophen;
max 3000 mg/d increased toxicity from chronic use if heavy
Adjust dosing interval for renal func- EtOH use, malnourishment, pre-existing liver
tion: CRcl 10-50: q6 hrs; CRcl disease–decrease maximum daily dose to
< 10: q8h 2 gm.
Salsalate choline 500-750 mg twice daily; maximum Does not interfere with platelet function; GI
magnesium trisalicylate dose 3000 mg/day bleeding and nephrotoxicity rare; salicylate
750 mg three times daily concentrations can be monitored if toxicity
suspected. Providers should educate
patients about symptoms associated with
salicylism (e.g, nausea, vomiting, tinnitus,
Hydrocodone/ 2.5/325 or 5/325-10/325 mg q4-6h; For all opioids, increased fall risk in patients
acetaminophen max acetaminophen dose 3gm/d with dysmobility. May worsen or precipitate
urinary retention when BPH present.
Increased risk of delirium in those with
dementia.
Because of increased opioid sensitivity, older
adults are at greater risk for sedation,
nausea, vomiting, constipation, respiratory
depression, urinary retention and cognitive
impairment.
Start stimulant laxative to prevent/treat consti-
pation. Many would start at opioid initiation if
patient has existing complaints of constipation
or other risk factors. Some providers
advocate ensuring all patients initiating opi-
oids have a stimulant laxative available to
start at the first sign of constipation.
Exercise caution and follow closely if opioids
are started in patients who drive. Avoid
concomitant prescription of opioids and other
CNS depressants.
Risk of addiction/diversion present with all
opioids. Before starting assess risk with the
Opioid Risk Tool. During maintenance,
monitor using tool such as Current Opioid
Misuse Measure. (www.painedu.org)
(continued)
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Fritz et al.
Table 2 Continued
Drug Dose/titration Important adverse events/precautions
Oxycodone or Start with 2.5-5 mg oxycodone or Side effects and risks of addiction/diversion as
morphine morphine q4h and titrate no more per hydrocodone.
frequently than q7d; assess total NEVER start long acting opioid before
needs after 7d on stable dose, determining needs with short acting.
then convert to long acting.
Morphine
Renal impairment: Clcr 10-50 mL/
minute: Administer at 75% of
normal dose; Clcr <10 mL/minute:
Administer at 50% of normal dose.
Hepatic impairment: No dosage
adjustment provided in manufac-
turer’s labeling. Pharmaco-kinetics
Duloxetine Start 20-30 mg/d; increase to May precipitate serotonin syndrome when
60 mg/d in 7d. Not recommended combined with triptans, tramadol, and other
in ESRD or CLcr<30. antidepressants. Key drug-disease interac-
tions: HTN, uncontrolled narrow-angle glau-
coma, seizure disorder. Precipitation of
mania in patients with bipolar disorder.
Important adverse effects include nausea,
dry mouth, sedation/falls, urinary retention,
constipation. Contra-indicated with hepatic
disease and heavy alcohol use. Abrupt dis-
continuation may result in withdrawal syn-
drome. Contraindicated within 14 days of
MAOI use.
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Deconstructing Chronic Low Back Pain in the Older Adult
that involved sitting and standing exercises, which was the preferred options for an individual patient is recom-
very important to her. mended (Figure 1). Re-assessing the benefits of which-
ever non-surgical treatment approach is selected is an
Approach to Management important consideration for effective management since
there is little information to a priori identify which treat-
Diagnostic Considerations
ment may be helpful for any particular patient. The im-
pact of treatment on patients’ pain and function should
The patient presented in this case was diagnosed with
be the focus of the re-assessment process. On average,
degenerative LSS based on clinical criteria that were con-
an improvement of 30% in pain (2 points on a 0-10 nu-
sistent with imaging findings. The high false-positive rate
meric pain-rating scale) or function assessed with a vali-
for imaging in older adults [23] makes clinical correlation
dated questionnaire such as the Oswestry or Roland
of any imaging findings a key consideration in the diagno-
Morris can be considered as clinically meaningful im-
sis of LSS as described in the expert panel algorithm
provement [28,29]. If meaningful improvement is not
(Figure 1). This patient was most debilitated by her leg
achieved, an alternative treatment strategy may be
symptoms, providing a rationale for the imaging that had
recommended. Surgery for degenerative LSS can be
been performed. As noted in the expert panel algorithm,
effective for many patients who fail to respond to non-
imaging for patients in the absence of debilitating leg
surgical treatments [30]. In the absence of spondylolis-
symptoms or other indications should be approached
thesis or instability, decompression surgery without
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Fritz et al.
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Deconstructing Chronic Low Back Pain in the Older Adult
5 Deyo RA, Mirza SK, Martin BI, et al. Trends, major 18 de Tran QH, Duong S, Finlayson RJ. Lumbar spinal
medical complications, and charges associated with stenosis: A brief review of the nonsurgical manage-
surgery for lumbar spinal stenosis in older adults. ment. Can J Anaesth 2010;57:694–703.
JAMA 2010;303:1259–65.
19 Kovacs FM, Urrutia G, Alarcon JD. Surgery versus
6 Katz JN, Harris MB. Clinical practice. Lumbar spinal conservative treatment for symptomatic lumbar spi-
stenosis. N Engl J Med 2008;358: 818–25. nal stenosis: A systematic review of randomized
controlled trials. Spine 2011;36:E1335–51.
7 Hansson T, Suzuki N, Hebelka H, Gaulitz A. The
narrowing of the lumbar spinal canal during loaded 20 Kreiner DS, Shaffer WO, Baisden JL, et al. An evi-
MRI: The effects of the disc and ligamentum flavum. dence-based clinical guideline for the diagnosis and
Eur Spine J 2009;18:679–86. treatment of degenerative lumbar spinal stenosis
(update). Spine J 2013;13:734–43.
8 Singh V, Montgomery SR, Aghdasi B, et al. Factors
affecting dynamic foraminal stenosis in the lumbar 21 Weinstein JN, Bronner KK, Morgan TS, Wennberg
spine. Spine J 2013;13:1080–7. JE. Trends and geographic variations in major sur-
gery for degenerative diseases of the hip, knee, and
9 Suri P, Rainville J, Kalichman L, Katz JN. Does this spine. Health Aff 2004;Var81–9.
older adult with lower extremity pain have the clinical
syndrome of lumbar spinal stenosis? JAMA 2010; 22 Weiner DK. Introduction to Special Series:
304:2628–36. Deconstructing chronic low back pain in the older
adult: Shifting the paradigm from the spine to the
10 Saito J, Ohtori S, Kishida S, et al. Difficulty of person. Pain Med 2015;16:881–5.
diagnosing the origin of lower leg pain in patients with
both lumbar spinal stenosis and hip joint osteoarthritis. 23 Brinjikji W, Luetmer PH, Comstock B, et al.
Spine 2012;37:2089–93. Systematic literature review of imaging features of
spinal degeneration in asymptomatic populations.
11 Inouye S, Studenski S, Tinetti M, Kuchel G. Geriatric AJNR 2015;36:811–6.
syndromes: Clinical, research and policy implications
of a core geriatric concept. J Am Geriatr Soc 2007; 24 Takahashi K, Takino T, Matsui T, Miyazaki T, Shima
55:780–91. I. Changes in epidural pressure during walking in
509
Fritz et al.
patients with lumbar spinal stenosis. Spine 1995;20: 35 Chou R, Huffman LH. Nonpharmacologic therapies
2746–9. for acute and chronic low back pain: A review of the
evidence for an American Pain Society/American
25 Fritz JM, Erhard RE, Delitto A, Welch WC, College of Physicians clinical practice guideline. Ann
Nowakowski P. Preliminary results of the use of a Intern Med 2007;147:492–504.
two-stage treadmill test as a clinical diagnostic tool
in the differential diagnosis of lumbar spinal stenosis. 36 Delitto A, Piva SR, Moore CG, et al. Surgery ver-
J Spinal Dis 1997;10:410–6. sus nonsurgical treatment of lumbar spinal stenosis: A
randomized trial. Ann Intern Med 2015;162:465–73.
26 Jeon CH, Han SH, Chung NS, Hyun HS. The valid-
ity of ankle-brachial index for the differential diagno- 37 American Geriatrics Society 2012 Beers Criteria
sis of peripheral arterial disease and lumbar spinal Update Expert Panel. Updated Beers Criteria for
stenosis in patients with atypical claudication. Eur potentially inappropriate medication use in older
Spine J 2012;21:1165–70. adults. J Am Geriatr Soc 2012;60:616–31.
27 Weiner DK, Fang M, Gentili A, et al. Deconstructing 38 Weiner DK, Sakamoto S, Perera S, Breuer P.
chronic low back pain in the older adult–Step by Chronic low back pain in older adults: Prevalence,
34 Whitman JM, Flynn TW, Childs JD, et al. A 46 Macedo LG, Hum A, Kuleba L, et al. Physical ther-
comparison between two physical therapy treat- apy interventions for degenerative lumbar spinal
ment programs for patients with lumbar spinal ste- stenosis: A systematic review. Phys Ther 2013;93:
nosis: A randomized clinical trial. Spine 2006;31: 1646–60.
2541–9.
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