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  • Ricin T?xicity T?xic Minds Maps For T?xic Detective ?????of IST

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    Giovanni Valer
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    Ricin is a toxic compound found in castor beans that can cause illness or death through ingestion, injection, or inhalation. It works by inhibiting protein synthesis and causing cell necrosis, preventing healing in vital organs. Symptoms range from mild gastroenteritis to multi-organ failure and death, depending on dosage and route of exposure. Early treatment focuses on supportive care, gastric decontamination if ingested, and monitoring for complications like dehydration, hypoglycemia, and hemolysis.

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    Ricin is a toxic compound found in castor beans that can cause illness or death through ingestion, injection, or inhalation. It works by inhibiting protein synthesis and causing cell necrosis, preventing healing in vital organs. Symptoms range from mild gastroenteritis to multi-organ failure and death, depending on dosage and route of exposure. Early treatment focuses on supportive care, gastric decontamination if ingested, and monitoring for complications like dehydration, hypoglycemia, and hemolysis.

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    © All Rights Reserved
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    18 views1 page

    Ricin T?xicity T?xic Minds Maps For T?xic Detective ?????of IST

    Uploaded by

    Giovanni Valer
    Ricin is a toxic compound found in castor beans that can cause illness or death through ingestion, injection, or inhalation. It works by inhibiting protein synthesis and causing cell necrosis, preventing healing in vital organs. Symptoms range from mild gastroenteritis to multi-organ failure and death, depending on dosage and route of exposure. Early treatment focuses on supportive care, gastric decontamination if ingested, and monitoring for complications like dehydration, hypoglycemia, and hemolysis.

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    © All Rights Reserved
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    of 1

    Ricin Toxicity by ingestion, injection or

    inhalation. However, its oral absorption is


    poor, and most oral poisonings cause
    gastroenteritis

    Inhibits protein synthesis,


    and cause cell necrosis, Not contagious, no need to
    preventing healing of isolate victims, use DR
    damaged mucosa of vital ABCDE approach by ISTOLS
    organs

    Anaphylaxis in sensitised
    Mild toxicity Moderate toxicity Severe toxicity
    individuals

    Even a single seed Nausea, Vomiting, Abdominal pain, Persistant Hemorrhagic Pulmonary Intramuscular
    Hemorrhagic gastritis CNS depression Hypovolemic shock Delayed Hepatotoxicity Renal Failure administration
    ingestion can be lethal Diarrhoea vomiting, Dehydration, edema
    Elevated liver enzymes,
    Malena

    ARDS Suicide transport: Hypotension & multiorgan Due to (hemolysis)


    Ricin can cause Glycogen stores deplete produces severe local
    destruction of neurons by failure due to necrosis of presents as microscopic
    anaphylactic shock & Antiemetics & IV fluids Vitamin K 5-10mg IV resulting in recurrent necrosis with extension
    IV fluids, monitoring for retrograde transport of the liver, spleen, and hematuria, cylinduria with
    death hypoglycemia into the lymphatics
    hypoglycemia, hemolysis & ricin from PNS to CNS kidney elevated creatinine
    complications of
    hypovolemia Rx- Ventilation with low
    PEEP
    Gastric decontamination If ECG is not showing signs Alkalinastion of urine by
    High flow oxygen, If GCS is <8, Intubate & Replace IV fluids & Blood Rx- Dextrose Normal Saline NaHCO3 infusion 1mEq/kg Systemically causes severe
    by stomach wash within of cardiac ischemia,
    intravenous fluids Ricin has a special binding ventilate transfusion IV infusion probably has a role in Comatose status & death
    one hour of ingestion Terlipressin IV 1mg slowly
    protein that enables it to preventing crystallisation
    gain access to the of hemoglobin
    Inhalation of aerosolized
    endoplasmic reticulum in ricin results in increased
    GI mucosal cells, where it alveolar-capillary
    inhibits cellular protein N Acetyl Cysteine
    Epinephrine 0.1mg Activated Charcoal 50g UGI Endoscopy to stop the permeability and airway Despite the obvious
    synthesis and causes Delayed CNS toxicity 150mg/kg IV to prevent
    (1:1000) Subcutaneously orally bleeders necrosis following a latent toxicity of ricin, death
    severe diarrhea Hepatic failure
    phase of 4 to 8 hours probably can be prevented Dialysis may help
    by early and aggressive
    fluid and electrolyte
    replacement after oral
    ingestion (but not injection
    Prophylactic immunization Can Potentially cause toxic involve cranial nerves-
    No specific antidote to PRBC, Platelets, Clotting or inhalation)
    with ricin toxoid and disaster of mass casualty optic nerve damage
    neutralise or counteract factor concentrates (Fresh in multiple victims by its
    passive postexposure causing blindness,
    toxicity, at present frozen Plasma) aerosol spray
    treatment with antiricin Hypoglossal & vagus nerve
    antibody have been
    reported in animals

    Citation: Pillay, VV. Comprehensive Medical Toxicology. 3rd. Ed. Paras Medical Publishers. 2018. Poisonous Plants. p940-43.

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