Product Guideline Membrapure

Product Guideline 2020
membraPure GmbH
More than 25 years ….
Made in Germany
membraPure systems – experts in water purification systems and related analyzers

Who we are
Systems from membraPure – Water purification systems and analyzers for TOC, amino acids and ions
at the highest level.
Since 1993 we have been dealing with water purification systems. In the course of time, we have
continuously expanded our activities to include the associated analyzers like miniTOC, uniTOC, ARACUS
and IONUS. For more than a quarter of a century, membraPure has been an established player in the
market for pure and ultra pure water systems, TOC, amino acid analyzer and ion chromatograph.
We are developing continuously our systems and applications and to applying for patents. In our work,
we exclusively use high-end technology such as EDI, post-column derivatization with ninhydrin and NDIR-
TOC detection.
Our instruments are low-maintenance and enable online service support. We sell our instruments
worldwide via a dealer network and our own sales offices in Beijing/PR China, Kuala Lumpur/Malaysia
and Sao Paulo/Brazil, Mumbai/India.
In 2015, we opened a new manufacturing hall at our headquarters in Hennigsdorf near Berlin to meet
rising demand and to maintain and improve our quality in an even more efficient environment.
Our dedicated team of experts locally and at headquarters in Hennigsdorf/Berlin helps to keep your
systems running smoothly at all times.
Working with membraPure offers you the following advantages:
 Fast response times for deliveries and service

 Latest technology and applications, backed by patents
 All our products are made in Germany
Dr. Erdmann Flindt
Managing Director
Timeline
Water Purification Systems
2
1 Water Purification Systems ............................................................................................................... 4

1.1 Astacus² ........................................................................................................................................ 4
1.2 Aquinity² P10................................................................................................................................ 7
1.3 Aquinity² P35/70 ...................................................................................................................... 10
1.4 Aquinity² E35/70....................................................................................................................... 13
1.5 AquaRO² and EDI² .................................................................................................................... 17
2 Total organic carbon analyzer ....................................................................................................... 21
2.1 miniTOC ..................................................................................................................................... 21
2.2 uniTOC ....................................................................................................................................... 27
3 Amino Acid Analyzer ........................................................................................................................ 32
3.1 ARACUS ..................................................................................................................................... 32
3.1.1 Separation performance of columns and supplement kits ..................................... 35
3.1.1.1 Physiological high speed Lithium system .......................................................... 35
3.1.1.2 Physiological high resolution Lithium system ................................................... 36
3.1.1.3 Physiological advanced plus Lithium system .................................................... 37
3.1.1.4 Short program, analysis within 15 min ................................................................ 38
3.1.1.5 Hydrolysate Lithium system.................................................................................. 39
3.1.1.6 Hydrolysate Sodium system ................................................................................. 39
3.1.1.7 Feedstuff high resolution Sodium system ......................................................... 39
3.1.1.8 Feedstuff advanced Sodium system ................................................................... 40
3.1.1.9 Feedstuff advanced + Amino Sugars Sodium system ..................................... 40
3.1.1.10 Biogenic Amine Potassium system ..................................................................... 40
3.1.2 Constituent parts of supplement kits .......................................................................... 45
4 Ion Chromatograph .......................................................................................................................... 49
4.1 IONUS ......................................................................................................................................... 49
4.1.1 Separation performance of columns for anions, cations and other ...................... 52
4.1.1.1 Separation performance of anions ...................................................................... 52
4.1.1.2 Separation performance of cations ..................................................................... 54
4.1.1.3 Separation of organic acids .................................................................................. 55
4.1.1.4 Detection of bromate .............................................................................................. 56
3
1 Water Purification Systems
1.1 Astacus²
The system Astacus² is designed for the production of ultra pure water
(0.055 μS/cm) out of permeate from a reverse osmosis or deionized
water.
The ultra pure water is produced with a combination of optimized mixed
bed cartridges and can be tapped with a flexible dispenser. If water is not
used, automatic recirculation within the Astacus² system ensures a
permanent high quality of ultra pure water. All components of the
Astacus² are assembled in an especially designed housing. The system
can be easily opened by removing the side panel to access the ultra pure
module, UV lamp (185 nm/ 254 nm) and ultrafiltration module. The μS -
control checks the conductivity of feed water to protect the cartridges
against inappropriate feed water (black line). If conductivity is too high
the water will be rejected.
Figure 1: Scheme shows flowchart of Astacus² Life Science TI.
4
Technical Specifications
ultra pure water quality 0.055 μS/cm; Type I
resistivity 18.2 MΩ·cm
total organic carbon (TOC) < 10 ppb Reagent | < 5 ppb Life Science | < 3 ppb Analytical
productivity rate 2 L/min, 1.5 L/min*
bacteria < 1 cfu/mL*
particulate > 0.2 μm less than 1 particulate/mL
pyrogen (endotoxins) < 0.001 EU/mL*
RNAse < 1 pg/mL*
DNAse < 5 pg/mL*
dimensions, weight, power 297 x 340 x 535 mm, 16 - 20 kg, 110 - 230 V
*with Life Science model
Feed Water Requirements

type of feed water reverse osmosis (RO) water or deionized (DI) water
feed water conductivity < 10 μS/cm
inlet pressure 0 to 1.5 bar
total organic content (TOC) < 50 ppb
temperature 5 to 25 °C
Configurations
Model UV reactor UF module TOC monitoring Cat. No.
Reagent - - - 110-0089
Analytical + - - 110-0090
Life Science + + - 110-0091
Analytical TI + - + 110-0092
Life Science TI + + + 110-0093
Reagent BI - - - 110-0099
Analytical BI + - - 110-0095
Analytical TI/ BI + - + 110-0096
Life Science BI + + - 110-0097
Life Science TI/ BI + + + 110-0098
5
Options
µS-control The μS-control checks the conductivity of feed water to protect 180-0009
the cartridges against inappropriate feed water. If conductivity is
too high the water will be rejected.
TOC monitoring The TOC monitoring during production and intermittent See
(TI version) measurements during non-use periods allows to check the configurations
organic content in water continously between 1 and 999 ppb.
volumetric upgrading of water system to volumetric dispense function 180-0093
dispensing allows the volumetric controlled dispensing of water with an
increment of 0.1 L and a tap volume from 0.1 to 99 L. The system
prevents overflow of containers and allows to dispense water
without supervising.
bench integrated To save valuable benchtop space the Astacus² can be ordered See
as BI configuration. The system will be installed underneath the configurations
work bench and only the display and dispenser are mounted on
the wall or table.
IQ/OQ Validation of IQ/OQ documents for Astacus² & Aquinity² 915-0042
documents
Consumables & Spare Parts

Ultrapure Module MemPak LS (Life Science) 190-0087
Ultrapure Module MemPak AL (Analytical) 190-0088
UV lamp (185 nm/ 254 nm) 921-0138
Ultrafiltration Module, Replacement of 190-0052 190-0096
Final Filter, capsule 0.2 μm 190-0013
Disinfection Tablets 290-0227
memCap LS final filter for life science applications, filter removes endotoxins for about 190-0082
3-4 months. (using instead of 190-0013, if no UF module is installed)
6
1.2 Aquinity² P10
The system Aquinity² P10 is designed for the production of ultra pure water
(0.055 μS/cm) out of tap water. The Aquinity² P10 system is equipped with
a reverse osmosis (RO) to produce deionised water into the integrated
10 liter storage tank with a production rate of 8 L/h. In the next step the ultra
pure water is produced with a combination of optimized mixed bed cartridge
and can be tapped with a flexible dispenser. If water is not used, automatic
recirculation within the Aquinity² system ensures a permanent high quality
of ultra pure water. All components of the Aquinity² are assembled in an
especially designed housing. The system can be easily opened by removing
the side panel to access the ultra pure module and UV lamp
(185 nm/ 254 nm).
Figure 2: Scheme shows flowchart of Aquinity² P10 Analytical.
7
ultra pure water quality 0.055 μS/cm; Type I
resistivity 18.2 MΩ·cm
total organic carbon (TOC) < 10 ppb Reagent | < 3 ppb Analytical
dispensing flow rate 1.5 L/min
productivity rate 8 L/h*
bacteria < 1 cfu/mL**
RNAse < 1 pg/mL*
DNAse < 5 pg/mL*
*not possible to tap pure water ** with microbiological final filter

type of feed water Tap water
inlet pressure 1.5 to 6 bar
Free chlorine < 0.1 mg/L
Silt Density Index (SDI) <3
pH 3 to 9
Configurations
Model UV reactor Cat. No.
Reagent - 114-0070
Analytical + 114-0071
8
Options
TOC monitoring The TOC monitoring during production and intermittent 830-0584
(TI version) measurements during non-use periods allows to check the
bench To save valuable benchtop space the Aquinity² can be ordered Upon request
integrated as BI configuration. The system will be installed underneath the
the wall or table.
documents

UV lamp (185 nm/ 254 nm) 921-0508
RO module for all Aquinity² versions 290-0261
Pretreatment Module ProPak R10 290-0065
Vent filter for Aquinity² P10 450-0025
9
1.3 Aquinity² P35/70
The system Aquinity² P35/70 is designed for the

production of pure water (< 2 μS/cm) and ultra pure water
(0.055 µS/cm) out of tap water.
The Aquinity² P35/70 system is equipped with a reverse
osmosis (RO) and conditioning module to produce
deionised water (DI water) into the external storage
reservoir (35 L or 70 L) with a production rate of 10 L/h
and an access to tap DI water directly. Out of the storage
tank the ultra pure water is produced with mixed bed
cartridges and then can be tapped with a flexible
dispenser. During non-use automatic recirculation within
the Aquinity² system ensures a permanent high quality of
ultra pure water. All components of the Aquinity² are
assembled in an especially designed housing. The system
can be easily opened by removing the side panel to
access the ultra pure module and UV lamp (185 nm/
254 nm).
Figure 3: Scheme shows flowchart of Aquinity² P35/70 Life Science TI.
10
Pure water + ultra pure water < 2 µS/cm; Type II + 0.055 μS/cm; Type I
resistivity > 0.5 MΩ·cm; Type II + 18.2 MΩ·cm
dispensing flow rate 2 L/min (1.5 L/min Life Science)
productivity rate 10 L/h, optionally 20 L/h
RNAse < 1 pg/mL*
DNAse < 5 pg/mL*
*with Life Science model

inlet pressure 0 to 1.5 bar
free chlorine < 0.1 mg/L
total organic content (TOC) < 50 ppb
Configurations
Model UV UF module TOC Cat. No. Cat. No. Aquinity² 20
reactor monitoring
(10 L/h) (35 L) (70 L) (20 L/h)
Reagent - - - 114-0050 114-0060 -
Analytical + - - 114-0051 114-0061 -
Life Science + + - 114-0052 114-0062 -
Analytical TI + - + 114-0056 114-0066 114-0074
Life Science TI + + + 114-0057 114-0067 114-0075
11
Options
the wall or bench.
documents

UV lamp (185 nm/ 254 nm) 921-0508
UV lamp for tank of all Aquinity² P & E versions 921-0483
Vent filter for tank for all Aquinity² P & E35/70 190-0085
Ultrafiltration Module 190-0096
12
1.4 Aquinity² E35/70
The system Aquinity² E35/70 is designed for the

production of pure water (< 0.2 µS/cm) and ultra pure
water (0.055 μS/cm) out of tap water.
The Aquinity² E35/70 system is equipped with reverse
osmosis and EDI cell to produce deionised water (DI
water) into the external storage reservoir (35 L or 70 L)
with a production rate of 10 L/h and an access to tap DI
water directly. Out of the storage tank the ultra pure water
is produced by passing further mixed bed cartridges and
then can be tapped with a flexible dispenser. During non-
use automatic recirculation within the Aquinity² system
ensures a permanent high quality of ultra pure water. All
components of the Aquinity² are assembled in an
especially designed housing. The system can be easily
opened by removing the side panel to access the
ultrapure module and UV lamp (185 nm/ 254 nm).
Figure 4: Scheme shows flowchart of Aquinity² E35/70 Life Science TI.
13
Pure water + ultra pure water < 0.2 µS/cm; Type II + 0.055 μS/cm; Type I
resistivity > 5 MΩ·cm; Type II + 18.2 MΩ·cm
dispensing flow rate 1.5 L/min
productivity rate 10 L/h, optionally 20 L/h*
RNAse < 1 pg/mL**
DNAse < 5 pg/mL**
*with Life Science model ** with microbiological final filter

inlet pressure 1.5 to 6 bar
free chlorine < 0.1 mg/L
carbon dioxide < 30 mg/L
silica < 10 mg/L
Silt Densitiy Index (SDI) <3
Iron | manganese | sulfate < 0.01 mg/mL | < 0.01 mg/mL | < 2 mg/mL
pH 3 to 9
14
Configurations
Model UV UF module TOC Cat. No. Cat. No. Aquinity² 20
reactor monitoring
(10 L/h) (35 L) (70 L) (20 L/h)
Reagent - - - 110-0053 114-0063 -
Analytical + - - 110-0054 114-0064 -
Life Science + + - 110-0055 114-0065 -
Analytical TI + - + 110-0058 114-0068 114-0076
Life Science TI + + + 110-0059 114-0069 114-0078
Options
the wall.
documents
15

Conditioning Module E 290-0218
UV lamp (185 nm/ 254 nm) 921-0508
UV lamp for tank of all Aquinity² P & E versions 921-0483
Vent filter for tank for all Aquinity² P & E35/70 190-0085
Ultrafiltration Module 190-0096
3-4 months. (using instead of 190-0013)
16
1.5 AquaRO² and EDI²
The series of AquaRO² and EDI² are designed for the production of pure water (10 μS/cm to 0.2 μS/cm)
out of tap water.
The series of AquaRO², AquaRO²DI and EDI² are based on a reverse osmosis (RO) unit to produce
deionised water. The EDI² series further processes the osmosis water by using an EDI cell to get type II
water. The advantages of both series is the flexibility in terms of configuration. A production rate of 8 to
40 L/h in three different degrees of pure water (10 μS/cm to 0.2 μS/cm) is available. Optionally the
systems can be equipped with a dispenser. The customer can optionally choose a 35 L or 70 L tank or
individual. All components of the AquaRO² and EDI² series are assembled in an especially designed
housing. The systems can be easily opened by removing the side panel to access the spare parts.
Figure 5: Scheme shows flowchart of AquaRO².
Figure 6: Scheme shows flowchart of AquaRO² DI.
Figure 7: Scheme shows flowchart of AquaRO² 8 P10.
17
Figure 8: Scheme shows flowchart of AquaRO² 8 P10 DI.
Figure 9: Scheme shows flowchart of EDI² 10 & EDI²20.
Figure 10: Scheme shows flowchart of EDI² 40.
18
Model AquaRO² AquaRO² DI AquaRO² 8 P10 EDI²
AquaRO² 8 P10 DI
Pure water quality < 10 µS/cm < 2 µS/cm; Type II < 10 µS/cm < 0.2 µS/cm; Type II
< 2 µS/cm
Resistivity > 0.1 MΩ·cm 0.5 MΩ·cm > 0.1 MΩ·cm 5 MΩ·cm
> 0.5 MΩ·cm
total organic carbon < 50 ppb < 40 ppb < 40 ppb < 20 ppb
(TOC)
productivity rate 8 L/h to 40 l/h 8 L/h to 20 l/h 8 L/h 10 L/h to 40 l/h
bacteria < 50 cfu/mL < 50 cfu/mL < 50 cfu/mL < 10 cfu/mL
dimensions, weight, power (except AquaRO² 40 and EDI² 40):

AquaRO²: 504 x 340 x 535 mm, 16 to 20 kg, 110 V - 230 V
EDI²: 504 x 340 x 535 mm, > 40 kg, 110 V - 230 V

Model AquaRO² EDI²
type of feed water Potable water /Tap Potable water /Tap water
water
feed water conductivity < 1400 μS/cm < 1400 μS/cm
inlet pressure 1.5 to 6 bar < 5 bar
free chlorine < 0.1 mg/L < 0.02 mg/L
Silt Densitiy Index (SDI) <3 <3
pH 3 to 9 3 to 9
temperature 5 to 25 °C 5 to 25 °C
iron / manganese n. a. | n. a. < 0.01 mg/L | < 0.01 mg/L
sulfate n. a. < 2 mg/mL
19
Configurations
Model Cat. No. Model Cat. No. Model Cat. No.
AquaRO² 10 200-0014 AquaRO² 10 DI 200-0023 EDI² 10 250-0064
AquaRO² 20 200-0018 AquaRO² 20 DI 200-0024 EDI² 20 250-0065
AquaRO² 40 200-0019 AquaRO² 8 P 10 200-0016 EDI² 40 250-0066
AquaRO² 8 P 10 DI 200-0017 EDI² 80 250-0069
Options
Softener Unit Compact system in cabinet including control box for the 280-0014
pretreatment.
Upgrade with Upgrade of system with fixed and flexible dispenser 180-0088
Dispenser

increment of 0.1 L and a tap volume from 0.1 to 99 L. The
system prevents overflow of containers and allows to dispense
water without supervising (180-0088 is needed).
TOC monitoring The TOC monitoring during production and intermittent 830-0610
(Only for EDI²) measurements during non-use periods allows to check the
Additional tank The series of AquaRO² and EDI² Tank 35 L 830-0602
can be equipped with a tank of
35 L or 70 L or individual size Tank 70 L 830-0603
and if requested also with an Tank 35 L with UV 830-0581
integrated UV lamp.
Tank 70 L with UV 830-0582

Conditioning Module for AquaRO² DI 190-0086
Conditioning Module for EDI² 10 & EDI² 20 290-0218
Reverse Osmosis (RO) Module 290-0261
20
Total organic carbon analyzer
2 Total organic carbon analyzer
2.1 miniTOC
The miniTOC system is designed for total organic carbon (TOC)

online/offline monitoring of pure and ultra pure water. The miniTOC
instrument uses the high speed flow through concept and the efficient
„direct surface“ UV oxidation. In combination with conductivity detection
the miniTOC guarantees the fast monitoring of values. By measuring the
conductivity before and after the UV oxidation the TOC value can be
calculated.
Figure 11: The scheme shows the principle of measuring the TOC value via conductivity with miniTOC.
21
Total organic Carbon
operating range 0.5 to 1000 ppb
display resolution 0.1 ppb
accuracy < 50 ppb ± 0.5 ppb

> 50 ppb ± 1 %
limit of detection 0.1 ppb
precision 0.1 ppb
Sample
type of sample medium pure or ultra pure water
sample volume flow approx.14 mL/min
min. input conductivity 0.055 µS/cm
max. input conductivity < 2 μS/cm (upgradable to < 10 μS/cm and 30 µS/cm)
inlet pressure < 1 bar (otherwise pressure reducer is needed)
sample temperature 10 °C to 50 °C / 50 °C to 95 °C (heat exchanger is needed)
particle size < 100 µm
Input Connector All ports are UNF ¼ - 28
Outlet Connection 1 Port for waste UNF ¼ - 28
Measurement
method & detection UV oxidation & conductivity
ports, basic 1 online + 1 for calibration/SST and offline

ports, pro 1 online + 3 for calibration/SST, offline and autosampler
period of measurement 2 sec (online mode) | 1 min (offline mode)
Conductivity & temperature
display resolution 0.001 µS/cm
accuracy 0.5 % or 0.001 µS/cm (whatever is greater)
precision 0.001 µS/cm
cell constant accuracy 1.5 %
conductivity reporting mode temperature compensated to 25 °C or uncompensated
Temperature sensor PT 1000
Temperature accuracy ± 0.25 K
22
Operating Conditions
ambient parameters relative humidity: 10 to 95 %, temperature: 10 to 45 °C
relative Humidity 10 - 95%
maximum Altitute up to 3500 m
power requirements 100-240 ±10 % VAC, 60 watt
Physical Specifications
UV lamps 1 with UV sensor
interface/display 8" TFT Touch Screen Color Display
operating system Windows 7 Embedded
software MiniTOC Control
dimensions, weight 300 x 200 x 500 mm, 14 kg
Communication
analog output Basic system: 2 x 0-20 mA Output according to Namur NE43

(TOC & Cond.)
Pro system: up to 4 x 0-20 mA Output according to Namur NE43
(3 TOC & Cond.)
digital output 1 x Relay Signal (Alarms & TOC Limit) + USB for Data export
digital input 1 x Digital Input (For remote control)
Compliance
CE Compliance DIN EN 1484
related norms USP <643>, EP 2.2.44
enclosure rating IP 42 (optional IP 54)
Software 21 CFR part 11 (optional)
Required items for first installation & instrument commissioning

miniTOC basic or professional configuration 275-0011 or
instrument
275-0016
installation kit Installationskit miniTOC-Analyzer 275-0024

- 2x Norprene tube 3.2 mm ID, 6.4 mm OD (825-0196)
- 5 m PTFE tube 1.6 mm ID, 3.2 mm OD (825-0105)
- 1 x ferrule (825-0091)
- 4 x fitting UNF ¼“ 28, PEEK, short incl. ferrule (825-0328)
installation & Installation and customer/distributor training at customer site 915-0022
training or on site of membraPure of a miniTOC. Travel and
accomodation to be paid separately by customer.
23
Options
configuration The miniTOC can be ordered as configuration with 4 inputs. 275-0016
miniTOC pro This and an additional software called interval mode upgrade
option allows the user to measure up to 3 loops sequentially
and configure the duration of the interval.
analog output 0-20 mA signal of TOC and conductivity, according to Namur 275-0020
NE43 it is adjustable 0 - 4 mA to differentiate between idle
status and signal error
analog output, just needed if interval mode is requested 275-0030
interval mode
conductivity II extended conductivity of sample up to 10 µS/cm 275-0054
conductivity III extended conductivity of sample up to 30 µS/cm 275-0052
interval mode Allows in combination with the configuration miniTOC pro the 275-0029
user to measure up to 3 loops sequentially and configure the
duration of the interval.
check of inlet control of inlet pressure, miniTOC, initiates alarm in case of inlet 275-0023
pressure flow is zero
collective alarm miniTOC collective alarm, potentialfree 275-0039

- sample input error
- UV
- liquid sensor, leakage
is only functional when 275-0020 or 275-0030 have been
installed
Trigger Input starts system if potentialfree contact is present 275-0034
pressure If the medium pressure is higher than 1 bar a pressure 921-0362

regulator transducer is required.
heat exchanger If the medium temperature is higher than 50 °C a heat 275-0063

exchanger is required.
21 CFR part 11 Software with 21 CFR part 11 conformity for pharma 275-0062
software applications
IP 54 The housing protects the miniTOC from dust deposits a water 275-0058 +
jets.
275-0059
offline version An offline configuration is available for the miniTOC. 275-0051
autosampler By using the offline mode of the miniTOC the system is also 275-0055
upgradable with an autosampler with 15 positions for 100 mL
vials (miniTOC pro 275-0016 and offline mode 275-0051 are
required)
24

UV reactor 921-0040*
tube for peristaltic pump 825-0196*
calibration solution for miniTOC, USP traceable 275-0041
SST Kit miniTOC, USP traceable 275-0042
Kit TOC stock solutions 100 ppm of sucrose and 100 ppm of benzoquinone in 2 bottles 275-0047
(10 mL)
documents for IQ/OQ validation (non conform with 21CFR part11 software) 915-0066
documents for IQ/OQ validation (conform with 21CFR part11 software) 915-0067
documents for PQ validation (non conform with 21CFR part11 software) 915-0071
documents for PQ validation (conform with 21CFR part11 software) 915-0072
Validation support IQ/OQ TOC Analyzer miniTOC, cooperation in qualifying the setup 915-0052
during the installation
100 mL vial for autosampler (Lot size 88) 275-0046*
septa for 100 mL vials (Lot size 100) 275-0060*
nut for port, short 825-0247
nut for port, long 825-0219
ferrule for port nut 825-0091
fitting UNF ¼“ 28, PEEK, short incl. ferrule 825-0328
fitting UNF ¼“ 28, PEEK, long incl. ferrule (needed for connection to heat exchanger) 825-0333
tube for port 825-0105
luer connection 825-0199
3/2 valve 825-0226
electronic ballast for UV lamp 827-0003
pump head 825-0012
LF sensor 827-0009
Electronic controller 825-0011
*We recommended to have one item in stock
25
In addition to the spare parts listed above, the customer can also purchase the contents of our service kits for
miniTOC.
Content of service kit for service / miniTOC

ferrule 3 mm 825-0091 10 pcs
fitting UNF ¼ “ 28, PEEK, long 825-0219 5 pcs
fitting UNF ¼ “ 28, PEEK, short 825-0247 5 pcs
dummy plug 825-0260 5 pcs
tube clip 825-0170 5 pcs
connector luer with tube 825-0199 5 pcs
PP connector luer for tube ID 3.2 mm 825-0200 5 pcs
PP T connector tube ID 3.2 mm 825-0198 2 pcs
PP screw connection 3.2 mm 825-0097 1 pc
T connector 825-0269 1 pc
PP control panel connector luer for tube ID 3.2 mm 825-0201 1 pc
PP connector 3.2 x 3.2 mm 825-0125 1 pc
connector 2.3 x 2.3 mm Kynar for tube 825-0249 1 pc
bulkhead unions PEEK ¼-28 B 825-0291 1 pc
bulkhead unions PEEK ¼-28 N 825-0292 1 pc
bulkhead unions PEEK ¼-28 825-0294 1 pc
PVDF screw connection 1/8” NPTM to OD 3.2 mm tube 825-0234 1 pc
PP angled screw connector 1/8” x 3.2 mm 825-0098 1 pc
3/2 valve miniTOC 825-0226 1 pc
PTFE tube 1/8” 825-0105 2m
tube PE 4 mm/ 2 mm 860-1081 1m
compressed air tube 4 mm 825-0229 1m
pump tube norprene 825-0196 2 pcs
silicone tube OD 6 mm/ ID 3 mm, transparent 860-1445 1.5 m
electronic balast for UV reactor 825-0055 1 pc
26
2.2 uniTOC
The uniTOC system is designed for total organic carbon (TOC)

online/offline monitoring from water to ultra pure water. The uniTOC
instrument uses the full oxidation by UV. The oxidation process can
be enhanced with additional dosage of reagent and is required by a
TOC level higher than 2 ppm. The NDIR detector (non dispersive
infrared) is absolutely selective to carbon dioxide and therefore
independent from conductivity and sample temperature. In a first
step the TIC (total inorganic carbon) is removed with carbon dioxide
free stripped gas and after that value is measured.
Figure 12: The scheme shows the principle of uniTOC with the two different pathways for TIC and TOC and the
principle of measuring the TOC value.
27
method & detection UV oxidation & NDIR (enhanced oxidation; configurable with reagent)
sample volume 20 mL loop (low range), 5 mL loop (high range)
period of measurement 5 to 15 min
measurement range 2 to 5000 ppb (low range), 15 ppb to 20000 ppb (high range)
detection accuracy ± 3 ppb or 2 % (whatever is greater)
ports 2 for samples | 1 for reagent
related norms USP <643>, EP 2.2.44, DIN EN 1484, DIN 32645, 21 CFR part11, IP 45
interface ports analog (4 – 20 mA)
dimensions, weight, power 400 x 300 x 600 mm, 24 kg, 110 - 230 V, 50 Hz, 70 to 105 Watt
Medium Requirements
type of sample medium from water to ultra pure water
inlet pressure < 1.5 bar
sample temperature 10 to 50 °C
compressed gas air, oxygen, nitrogen | free of carbon dioxide
inlet pressure of gas Nitrogen/oxygen: 1 to 1.5 bar | air: 3.5 to 5 bar

uniTOC low range or 275-0021 or
instrument high range configuration 275-0048
installation kit A Installationkit uniTOC-Analyzer (low range) 275-0025
Installation kit B Installationkit uniTOC-Analyzer (high range) 275-0125
installation & Installation and customer/distributor training at customer site 915-0022

training or on site of membraPure of an uniTOC. Travel and
28
Options
air filtration unit to use compressed air instead of oxygen or nitrogen 275-0012
Software unidata software for additional PC enables the user to evaluate 275-0018
the results at an external computer
pressure If the medium pressure is higher than 1 bar a pressure reducer 921-0362
regulator is required.
heat exchanger If the medium temperature is higher than 50 °C a heat 275-0063

exchanger is required.

UV reactor for low range 921-0002*
UV reactor for high range 921-0567
calibration solution for uniTOC, USP traceable 275-0041
SST Kit uniTOC, USP traceable 275-0042
documents for IQ/OQ validation 915-0068
documents for PQ validation 915-0075
Validation support for IQ/OQ 915-0028
silicone tube for uniTOC 921-0331*
power cable 17 for UV photoelement 825-0150
fluid sensor setup 825-0069
pressure sensor setup uniTOC 825-0132
logic element air filter 825-0056
3/2 valve big (in valve block) 825-0002

3/2 valve small 825-0017
cuvette IR detector 921-0001
peltier element 825-0004
power supply 825-0016
air filter (2 pcs are needed) 921-0003
NDIR detector 825-0003
4/2 way pneumatic valve, 6/4, 24V DC 825-0001
*We recommended to have one item in stock
29
In addition to the spare parts listed above, the customer can also purchase the contents of our service kits for uniTOC.
Content of service kit for service / uniTOC

ferrule 3 mm 825-0091 10 pcs
fitting UNF ¼ “ 28, PEEK, long 825-0219 5 pcs
fitting UNF ¼ “ 28, PEEK, short 825-0247 5 pcs
dummy plug 825-0260 5 pcs
tube clip 825-0170 5 pcs
connector luer with tube 825-0199 5 pcs
PP connector luer for tube ID 3.2 mm 825-0200 5 pcs
PP T connector tube ID 3.2 mm 825-0198 2 pcs
PP screw connection 3.2 mm 825-0097 1 pc
PP control panel connector luer for tube ID 3.2 mm 825-0201 1 pc
connector luer for tube 1.6 mm 825-0280 2 pcs
PP connector 3.2 x 3.2 mm 825-0125 1 pc
connector 2.3 x 2.3 mm Kynar for tube 825-0249 1 pc
bulkhead unions PEEK ¼-28 B 825-0291 1 pc
bulkhead unions PEEK ¼-28 N 825-0292 1 pc
bulkhead unions PEEK ¼-28 825-0294 1 pc
PVDF screw connection 1/8” NPTM to OD 3.2 mm tube 825-0234 1 pc
PP angled screw connector 1/8” x 3.2 mm 825-0098 1 pc
PTFE tube 1/8” 825-0105 2m
tube PE 4 mm/ 2 mm 860-1081 1m
silicone tube OD 6 mm/ ID 3 mm, transparent 860-1445 1.5 m
electronic balast for UV reactor 825-0055 1 pc
Membrex 25 PTFE 0.45 µm 825-0057 2 pcs
screw-in connection 1/8” 6 mm 825-0180 2 pcs
rotatable angled screw connector 825-0050 2 pcs
fluid sensor setup 825-0069 1 pc
pressure sensor setup uniTOC 825-0132 1 pc
logic element air filter 825-0056 1 pc
3/2 valve 16 mm analysis 12 V DC 825-0002 1 pc
30
3/2 valve Sco 825-0017 1 pc
power cable 17 for UV photoelement 825-0150 1 pc
pump tube uniTOC 921-0331 2 pcs
4/2 way pneumatic valve, 6/4, 24V DC 825-0001 1 pc
31
Amino Acid Analyzer
3 Amino Acid Analyzer
3.1 ARACUS
ARACUS works according to gold standard of post column derivatization with ninhydrin, with detection at
440 nm and 570 nm using maintenance free LED photometers. A separation of up to 44 amino acids in
about one hour is possible, but also of a few amino acids within a few minutes. ARACUS is used in clinical
laboratory (e.g. newborn screening), in quality control for Food (own patent 10 2016 010 887), beverages
and feedstuff and in research.
Figure 13: The scheme shows the principle of ARACUS with the pathways for eluents, sample and reagent solution.
Following the separation of the amino acids inside the column, the mixture of sample and reagent solution flows
through a reactor for the chemical reaction. Finally the flow passes the LED photometers (570 nm + 440 nm), where
the amino acids will be detected indirectly by formed dye.
32
Amino Acid Analyzer
method post column derivatization with ninhydrin
Separation performance Up to 55 amino acids
autosampler 2 racks, each of them with space for 48 vials (1.5 mL), sample
cooling dosage in 3 different injection modes:
full loop (100 μL), partial loop (5-50 µL), microliter pickup (1-35 μL)
column stainless steel, cation exchange resin
reproducibility of retention time < 0.3 % RSD
reproducibility of peak area ~ 1.0 % RSD
column oven 20 – 80 °C, accuracy 0.1 %
reactor temperature 20 – 140 °C
spectroscopic detection LED photometers (440 nm + 570 nm), 8 years warranty

measuring range: high, low
flow cell: 10 µL volume, 3 years warranty
optional: Fluorescence detector (200 – 650 nm) for OPA method
detection limit < 2 nmol/mL

quantification limit > 5 nmol/mL (with OPA method < 0.5 nmol/mL, limited to primary
amino acids)
pump system single pump (ARACUS), dual pump (ARACUS advanced)
max. pressure: 400 bar | flow rate: 0.01 - 10.00 mL/min
reproducibility of low rate: 0.1 % RSD at 100 μL/min
2 channel degasser
maximum operating pressure 120 bar/ 1740 PSI (pressure shut off feature)
ready to use kits kits including eluents, reagent and additional dilution buffer,
ammonia adsorber and separation columns for 500 runs
(customized kits upon request)
control software & data Clarity (21 CFR Part 11 compliant) or AminoPeak
acquisition
dimensions, weight, power 1080 x 370 x 690 mm*, 60 kg, 110 - 230 V, 50/60 Hz
*800 mm with opened main unit
33
Amino Acid Analyzer

ARACUS basic (1 pump) or 600-0049 or
analyzer advanced (dual pump) configuration 600-0066
accessory kit Tubes, fittings, syringe for pump, sample vials 1.5 mL and 600-0051
caps (100 pcs). The included components are listed under the
section spare parts.
computer Tested to control analyzer 600-0032
Software Clarity or AminoPeak 600-0061 or

600-0002
column kit depends on customer´s applications see 3.1.1
supplement depends on customer´s applications see 3.1.1

application kit
installation Installation and customer/distributor training at customer site 915-0022

training or on site of membraPure of an ARACUS. Travel and
accommodation to be paid separately by customer.
Options
ARACUS 2 pump system allows to operate in a single fluidic line for 600-0066
advanced buffer and reagent (required for OPA post column derivatization
method)
Upgrade Elubox Active control of fluid volume by weight cell of each bottle. (only 600-0038
available with software AminoPeak)
inert gas it supplies the main unit and eluent box with a protective gas 600-0056
atmosphere by reducing the presence of atmospheric oxygen
to enhance the signal to noise ratio
Software 21 Manual and automatic peak integration with integrated IQ/OQ 600-0061
CFR part 11 procedure for software (only available with software Clarity)
Microwave Hydrolysis system based on microwave-enhanced reaction 650-0099

sample digestor
Fluorescence is needed in case of using OPA method 600-0068

detector
34
Amino Acid Analyzer
Columns suitable Supplement Kits*

Lithium High Speed 650-0157 650-0162
75 mm x 4 mm ID, 4 µm
Lithium High Resolution 650-0126 650-0153
Lithium High Resolution, 100 min 650-0126 650-0211
Lithium Advanced Plus 650-0178 650-0131
150 mm x 4.6 mm ID, 5 µm
Sodium High Speed 650-0187 650-0185
Sodium High Resolution 650-0190 650-0196
Sodium Advanced (Feedstuff) 650-0165 650-0167
150 mm x 4.6 mm ID, 7 µm
Sodium Advanced (Feedstuff + Amino 650-0165 650-0197
Sugars) 150 mm x 4.6 mm ID, 7 µm
Potassium Biogenic amines 650-0140 650-0147
*each buffer, eluent, columns and reagent can be ordered separately. See 3.1.2.
3.1.1 Separation performance of columns and supplement kits
3.1.1.1 Physiological high speed Lithium system
Figure 14: performed with the column kit Cat. No. 650-0157 and supplement kit Cat. No. 650-0162.
35
Amino Acid Analyzer
3.1.1.2 Physiological high resolution Lithium system
3.1.1.3 Physiological high resolution Lithium system in 100 min
36
Amino Acid Analyzer
3.1.1.4 Physiological advanced plus Lithium system
Figure 18: The illustration is an excerpt of Figure 17.
37
Amino Acid Analyzer
3.1.1.5 Short program, analysis within 15 min
Example I:
Example II:
Figure 19: Both chromatograms were performed with the column kit Cat. No. 650-0157 and supplement kit
Cat. No. 650-0162.
38
Amino Acid Analyzer
3.1.1.6 Hydrolysate Lithium system
3.1.1.7 Hydrolysate Sodium system
3.1.1.8 Feedstuff high resolution Sodium system
Figure 22: performed with the column kit 650-0190 and supplement kit Cat. No. 650-0196.
39
Amino Acid Analyzer
3.1.1.9 Feedstuff advanced Sodium system
3.1.1.10 Feedstuff advanced + Amino Sugars Sodium system
3.1.1.11 Biogenic Amine Potassium system
Figure 25: performed with the column kit Cat. No. 650-0140 and supplement kit Cat. No. 650-0147
40
Amino Acid Analyzer
3.1.1.12 Collagen Lithium system
3.1.1.13 Collagen Sodium system
Figure 27: performed with the column kit 650-0190 and supplement kit Cat. No. 650-0196.
41
Amino Acid Analyzer
Consumables & Spare Parts (for recurring request)

Standard Physiological (42 amino acids)** 650-0035
Standard Hydrolysate (18 amino acids)** 650-0036
Standard Feedstuff (20 amino acids)** 650-0037
Standard Canonical (20 amino acids)** 650-0120
Standard Biogenic Amines (8 amines)** 650-0150
Standard Norleucin (internal standard) 650-0069
sample preparation kit (150 analysis) contains: 650-0022
- 100 mL solution for precipitation
- MembraSpin Mini 0.22 µm (150 pcs)
solution for precipitation (100 mL) 650-0005
MembraSpin Mini 0.22 µm (50 pcs) 520-0013
Reagent for derivatization (500 mL) 650-0009
Activator for reagent for derivatization (1 mL) 650-0151
reactor wash solution for Lithium and Sodium systems (500 mL) 650-0010
sample dilution buffer – Lithium system 650-0018
autosampler dilution for amino acid analysis (500 mL) 650-0094
Screw Vials 1.5 mL (100 pcs) for autosampler with rack up to 96 vials 860-1794
short thread cap, blue (100 pcs), suitable for 860-1794 860-1795
Snap ring Bottle 1.5 mL (100 pcs) for autosampler with rack up to 96 vials 860-0295*
Snap ring caps (100 pcs), suitable for 860-0295 860-0296*
bottle clear (500 mL) 860-1249
bottle brown (500 mL) 860-1296
pre column (ammonia adsorber, Lithium system) 650-0020
pre column (ammonia adsorber, Sodium system) 650-0031
documents for IQ validation 915-0045
documents for OQ validation 915-0046
invitro Diagnostic (IVD) Kit 650-0146
suitable column for invitro Diagnostic (IVD) Kit 650-0126
invitro Diagnostic (IVD) Kit 650-0199
suitable column for invitro Diagnostic (IVD) Kit advanced 650-0127
*The marked items are included in the Accessory Kit (600-0051).
** The contained amino acids in standard can be found in the appendix.
42
Amino Acid Analyzer
In addition the customer can also purchase our spare parts for ARACUS. Usually it is not needed because our system
is low maintanance and all components have a long service life.
spare parts ARACUS

Vaccum pump 926-0028
Bottle set with caps (7+1) 600-0036
Bottle set without caps (7+1) 600-0037
Waste tank, 5 liter 860-1358
Pump 10 mL ceramic 860-1650
Pump head ceramic 860-1885
Damping unit 926-0040
Reactor unit 926-0052
Column unit 926-0051
3/2 valve 926-0018
Pressure sensor set 926-0027
Photometer LED 570 nm 926-0024
Photometer LED 440 nm 926-0025
Degasser Chamber 860-1918
Inertgas Gauge glass 926-0041
Intergas valve 860-1074
Inertgas valve adapter 860-1088
Inertgas Adapter ¼” to 3/8” 860-1247
Inertgas Adapter 1/8” to ½” 860-1246
Tube cutter & 5 pcs reserve blades 860-0207*
Tube cutter reserve blades 860-0208
Air vent syringe with luer adapter 10 mL 860-0209*
Allen key – SW 3 mm K 75, L175 926-0022
Ethylene glycol for pump backflush 861-0016*
syringe with luer adapter 10 mL for pump backflush 860-1869*
Bottle, HDPE, natural, 30 mL for ethylene glycol 860-0301*
Fitting 1/16” 10/32 PEEK natural 860-0188*
Fitting 1/16” 10/32 PEEK green 860-0187*
Fitting 1/16” 10/32 PEEK red 860-0186*
Fitting litetouch short male nut PEEK 1/16” ¼-28 – grey 860-1046*
43
Amino Acid Analyzer
Fitting litetouch short male nut PEEK 1/16” ¼-28 – red 860-1048*
Fitting litetouch short male nut PEEK 1/16” ¼-28 - blue 860-1043*
Tube cutter for intergas 860-1079
Opener for inertgas valve 860-1078
Tubing inertgas PE, natur 4/2.7 mm 860-1081
Tubing 0.17 mm PEEK 1/16” yellow 860-0196*
Tubing 0.25 mm PEEK 1/16” blue 860-0195*
Tubing 0.75 mm FEP 1/16” 860-0193
Tubing 1 mm FEP 1/16” 860-0192*
Eluent valve, 6 ports 860-1984
Inertgas connection set 926-0038
Electronic drawer 860-1169
Injection needle, 1.2 mm x 40 mm, sterile 860-1872*

44
Amino Acid Analyzer
3.1.2 Constituent parts of supplement kits
Supplement Kit Lithium High Speed (cat. No. 650-0162)

8 x 500 mL Eluent A High Speed 650-0158
4 x 500 mL Eluent B High Speed 650-0159
5 x 500 mL Eluent C High Speed 650-0160
4 x 500 mL Eluent D Advanced 650-0130
5 x 500 mL Eluent E 650-0015
3 x 500 mL Eluent F 650-0016
1 x 500 mL Sample dilution buffer 650-0018
2 x 500 mL autosampler dilution for amino acid analysis 650-0094
3 x 500 mL reactor wash solution 650-0010
12 x 500 mL Reagent for derivatization 650-0009
12 x 1 mL Activator for reagent for derivatization 650-0151
Supplement Kit Lithium High Resolution (cat. No. 650-0153)

11 x 500 mL Eluent A 650-0011
7 x 500 mL Eluent B 650-0012
7 x 500 mL Eluent C 650-0013
5 x 500 mL Eluent D 650-0014
7 x 500 mL Eluent E 650-0015
4 x 500 mL Eluent F 650-0016
45
Amino Acid Analyzer
Supplement Kit Lithium Advanced Plus (cat. No. 650-0131)

13 x 500 mL Eluent A Advanced 650-0128
8 x 500 mL Eluent B 650-0012
8 x 500 mL Eluent C 650-0013
7 x 500 mL Eluent D 650-0014
7 x 500 mL Eluent E 650-0015
3 x 500 mL Eluent F 650-0016
Supplement Kit Sodium High Speed (cat. No. 650-0185)

8 x 500 mL Eluent A Feedstuff High Speed 650-0181
4 x 500 mL Eluent B Feedstuff High Speed 650-0182
5 x 500 mL Eluent C Feedstuff High Speed 650-0183
4 x 500 mL Eluent D Feedstuff High Speed 650-0184
3 x 500 mL Eluent F Feedstuff High Speed 650-0047
46
Amino Acid Analyzer
Supplement Kit Sodium High Resolution (cat. No. 650-0196)

6 x 500 mL Eluent A Feedstuff Advanced 650-0168
3 x 500 mL Eluent B Feedstuff Advanced 650-0173
3 x 500 mL Eluent C Feedstuff Advanced 650-0174
7 x 500 mL Eluent D Feedstuff 650-0026
3 x 500 mL Eluent F Feedstuff 650-0047
3 x 500 mL Reactor wash solution 650-0010
Supplement Kit Sodium Advanced (cat. No. 650-0167)

8 x 500 mL Eluent A Feedstuff Advanced 650-0168
3 x 500 mL Eluent F Feedstuff 650-0047
Additional Kit Sodium Amino Sugar (cat. No. 650-0198)

3 x 500 mL Eluent E Feedstuff Advanced (Aminosugar) 650-0175
47
Amino Acid Analyzer
Supplement Kit Potassium Biogenic amines (cat. No. 650-0147)

4 x 500 mL Eluent A Biogenic Amines 650-0141
3 x 500 mL Eluent B Biogenic Amines 650-0142
5 x 500 mL Eluent C Biogenic Amines 650-0143
3 x 500 mL Eluent D Biogenic Amines 650-0144
2 x 500 mL Eluent F Biogenic Amines 650-0145
Our Service
Sample preparation and hydrolysis 690-0002
Includes hydrolysis of peptide/protein, deproteination and desalting of
sample according to standardized procedure
Sample preparation of Physiological samples 690-0006
includes hydrolysis, deproteination and desalting of samples following our
standard procedure.
Analytical Run - Single Run 690-0003
measurement of identity and quantity of amino acid content of sample, one
analytical run with internal and/or external standard
Analytical Runs - Double Run 690-0004
Includes measurement of identity and quantity of amino acid content of
sample, two analytical runs with internal and/or external standard
Analytical Runs - Triple Run 690-0005
Includes measurement of identity and quantity of amino acid content of
sample, three analytical runs with internal and/or external standard
Final Report with discussion of results, Single run* 690-0007
Includes qualitative and quantitative evaluation of samples, complete
report with discussion and conclusions of results
Final Report with discussion of results, Double run* 690-0008
Final Report with discussion of results, Triple run* 690-0009
*Pricing depends on the evaluation of 10, 20 or 42 amino acid.
Each sample must be provided with a precise description of the sample by the customer.
48
Ion Chromatograph
4 Ion Chromatograph
4.1 IONUS
IONUS can be used for the analysis of anions and cations in research, development and everyday
routine for aqueous solutions as well as for waters within the scope of environmentally relevant
investigations. This chromatograph separates anions (for anions optionally with suppressor
technology) according to EPA 300.0 and cations. The advantage of IONUS is the compatibility with the
common eluents of anion and cation exchange chromatography. By suitable post column
derivatization, transition metals (VIS detection) as well as bromate (EPA 317.0 or EPA 326) can be
detected. If requested, the IONUS can be equipped with an UV/VIS detector for indirect UV detection.
Technical Specifications (in progress)

method Ion exchange chromatography of anions and cations in
subsequent mode
manual injection 20 µL
Further injection loops upon request
autosampler Standard loop 100 µL, 2 racks, each of them with space for 48 vials,
(1.5 mL) or 12 vials (6 mL), sample cooling, full loop (100 µL),
partial loop (5-50 µL), microliter pickup (5-25 µL)
column Stainlees steel / PEEK
temperature stability/ range ± 0.5 °C / ambient up to 50°C
detection conductivity detector:

noise: 0.02 µS/ 1s | range: 0-10 mS/cm
effective cell volume: 1 µL
isocratic pump system max. pressure: 400 bar | flow rate: 0.01 – 10 mL/min
reproducibility of flow rate: 0.1 % RSD at 100 µL/min
maximum operating pressure 120 bar
control software & data Clarity (21 CFR Part 11 compliant) or IonPeak
acquisition
dimensions, weight, power 1000 x 370 x 690 mm*, 60 kg, 110 - 230 V
*800 mm with opened main unit
49
Ion Chromatograph

IONUS analyzer Manual injection configuration 600-0030
Autosampler In case of using an autosampler instead of manual injection 600-0047
accessory kit Tubes, fittings, syringe for pump, sample vials 1.5 mL and 860-1540
caps (100 pcs). The included components are listed under the
section consumables & spare parts.
computer Tested to control analyzer 600-0032
Software Clarity or IonPeak 600-0061 or

600-0002
Column oven Programmable column temperature 600-0042
Column(s) depends on customer´s applications. The IONUS can analyse see. 5.1.1
anions or cations in subsequent mode.
installation Installation and customer/distributor training at customer site 915-0022
training or on site of membraPure of an IONUS. Travel and
Options
Bromate Bromate Analyzer is a dedicated system with post column 600-0059
Analyzer derivatization for determination of Bromate according to EPA
317 or 326.
Software 21 Manual and automatic peak integration with integrated IQ/OQ 600-0061
CFR part 11 procedure for software (only available with software Clarity)
Suppressor Suppressor for anion analysis 600-0005
UV/VIS detector Detector with Deuterium and Tungsten lamp (190 – 800 nm), 600-0070
analytical measuring cell: volumina 12 µL, max pressure 100 bar
Deuterium Lamp Setup is preadjusted 860-2043

for detector
50
Ion Chromatograph
Columns
Dimensions Determination of Suppressor Remarks Cat. No.
PRP-X100 (Standard), SS Anions yes / no EPA 300 part A 650-0105
50 mm x 4.1 mm ID, 5 µm
PRP-X110S, SS Anions + yes EPA 300 part B 650-0195
250 mm x 4.1 mm ID, 7 µm Oxohalides
PRP-X100, PEEK Bromate no EPA 317 650-0105
100 mm x 4.6 mm ID, 5 µm
PRP-X100, PEEK Bromate no EPA 326 650-0132
150 mm x 2.1 mm ID, 5 µm
PRP-X800 (Standard), PEEK Standard Cations no - 650-0109
250 mm x 4.6 mm ID, 7 µm
Nucleosil 100, SS Transition metals no PCD with VIS 650-0099
150 mm x 4.6 mm ID, 5 µm
Eurokat, SS Organic Acids no Indirect UV 650-0180
300 mm x 8 mm ID
Further columns upon request!
suitable Guard Columns & corresponding spare parts

Guard Column Starter Kit* suitable for Replacement cartridge
column
Analytical Guard Column Kit for 650-0111 650-0105 650-0114 (stainless steel)
anion analysis (stainless steel)
Analytical Guard Column Kit for 650-0112 650-0106 650-0115 (PEEK)
anion analysis (PEEK) or
650-0132
Analytical Guard Column Kit for 650-0191 650-0195 650-0115 (PEEK) or
anion analysis (PEEK)
650-0193 (stainless steel)
Analytical Guard Column Kit for 650-0113 650-0109 650-0116 (PEEK)
cation analysis (PEEK)
Universal guard cartridge holder (stainless steel) 650-0117

Universal guard cartridge holder (PEEK) 650-0118
*each Starter Kit consist of 1 cartridge holder and 2 cartridges.
51
Ion Chromatograph
4.1.1 Separation performance of columns for anions, cations and others
4.1.1.1 Separation performance of anions
Figure 28: both chromatograms were performed with the column Cat. No. 650-0105 with 3.2 mM sodium
carbonate, 1.0 mM sodium hydrogen carbonate and 0.1 mM sodium thiocyanate as eluent with suppressor
technique.
52
Ion Chromatograph
Figure 29: chromatogram was performed with the column Cat. No. 650-0195 with 3.2 mM sodium carbonate,
1.0 mM sodium hydrogen carbonate and 0.1 mM sodium thiocyanate as eluent with suppressor technique.
53
Ion Chromatograph
4.1.1.2 Separation performance of cations
Figure 30: both chromatograms were performed with the column Cat. No. 650-0109 with 5.0 mM nitric acid as
eluent.
54
Ion Chromatograph
4.1.1.3 Separation of organic acids
Figure 31: both chromatograms were performed with the column Cat. No. 650-0180 with 10.0 mM sulfuric acid as
eluent with indirect UV method.
55
Ion Chromatograph
4.1.1.4 Detection of bromate
Figure 32: performed with the column Cat. No. 650-0106 with 200 mM methane sulfonic acid as eluent and
0.27 M potassium iodide and 50 µM ammonia heptamolybdate as reagent according to method EPA 326.0
(UV detection 355 nm) with a concentration range of 100 – 1 ppb for bromate.
Consumables & Spare parts (for recurring request)

Stock Solutions Anions (10 mL)** 650-0122
Stock Solutions Cations (10 mL)** 650-0123
Suppressor column for anion analysis 650-0074
Screw Vials 1.5 mL (100 pcs) for autosampler with rack up to 96 vials 860-1794
short thread cap, blue (100 pcs), suitable for 860-1794 860-1795
Snap ring Bottle 1.5 mL (100 pcs) for autosampler with rack up to 96 vials 860-0295*
Snap ring caps (100 pcs), suitable for 860-0295 860-0296*
Vials 6 mL for autosampler with rack of 12 vial 860-2005
Caps with septa for 860-2005 860-2006
** The contained ions in standard can be found in the appendix.
In addition the customer can also purchase our spare parts for IONUS. Usually it is not needed because our system
is low maintanance and all components have a long service life.
56
Ion Chromatograph
Content of spare parts Ionus

Vacuum Pump 926-0028
Pump 10 ml Ceramic 860-1650
Damping Unit 926-0040
3/2 valve 860-1772
solvent filter 20 x 7 mm, PTFE, pore size 4 μm 860-1755
Pressure sensor set 926-0027
Degasser Chamber 400 µl 860-1594
Tube cutter & 5 pcs reserve blades 860-0207*
Tube cutter reserve blades 860-0208*
Air vent syringe with luer adapter 10 mL 860-0209*
Allen key – SW 3 mm K 75, L175 926-0022*
Ethylene glycol for pump backflush 861-0016*
syringe with luer adapter 5 mL and needle for pump backflush 860-1869* + 1872*
Fitting 1/16” 10/32 PEEK natural 860-0188*
Fitting 1/16” 10/32 PEEK green 860-0187*
Fitting 1/16” 10/32 PEEK red 860-0186*
Fitting litetouch short male nut PEEK 1/16” ¼-28 – grey 860-1046*
Fitting litetouch short male nut PEEK 1/16” ¼-28 – red 860-1048*
Fitting litetouch short male nut PEEK 1/16” ¼-28 - blue 860-1043*
Tubing 0.17 mm PEEK 1/16” yellow 860-0196*
Tubing 0.25 mm PEEK 1/16” blue 860-0195*
Tubing 1 mm FEP 1/16” 860-0192*
Injection needle, 1.2 mm x 40 mm, sterile 860-1872*
PEEK injection loop 100 μL (autosampler) 860-1024
Injection needle for AS 96 with ferrule, tube and nut 926-0049
PEEK injection loop 20 μL (manually injection) 860-1599
Syringe 250 µl (manually injection) 860-1710
Syringe needle port 860-1711
Loop 2 ml (Bromate) Upon request
Rack preparative, 12 positions Upon request

57
5 Appendix
5.1 Content of standard amino acids, physiological standard (cat. No. 650-0035)
No. Amino Acid code No. Amino Acid code
1 Phosphoserine PPS 23 Isoleucine ILE
2 Taurine TAU 24 Leucine LEU
3 Phosphoethanolamine PEA 25 Norleucine NLE
4 Urea Urea 26 Tyrosine TYR
5 Aspartic Acid ASP 27 Phenylalanine PHE
6 Hydroxyproline HYP 28 Homocystine HCYS2
7 Threonine THR 29 b-Alanin BALA
8 Serine SER 30 b-Aminoisobutyric Acid BAIB
9 Asparagine ASN 31 G Aminobutyric Acid GABA
10 Glutamic Acid GLU 32 Histidine HIS
11 Glutamine GLN 33 1-Methyl-Histidine 1MHIS
12 Sarcosine SAR 34 3-Methyl-Histidine 3MHIS
13 a-Aminoadipic Acid AAA 35 Tryptophan TRP
14 Proline PRO 36 Carnosine CAR
15 Glycine GLY 37 Anserine ANS
16 Alanine ALA 38 Hydroxylysine HLYS
17 Citrulline CIT 39 Ornithine ORN
18 a-Aminobutyric Acid ABU 40 Lysine LYS
19 Valine VAL 41 Ammonium Chloride Ammonia
20 Cystine CYS2 42 Ethanolamine ETH
21 Cystathionine CYSTA 43 Arginine ARG
22 Methionine MET
5.2 Content of standard amino acids, hydrolysate standard (cat. No. 650-0036)
1 Aspartic Acid ASP 10 Methionine MET
2 Threonine THR 11 Isoleucine ILE
3 Serine SER 12 Leucine LEU
4 Glutamic Acid GLU 13 Tyrosine TYR
5 Proline PRO 14 Phenylalanine PHE
6 Glycine GLY 15 Histidine HIS
7 Alanine ALA 16 Lysine LYS
8 Cystine CYS2 17 Ammonium Chloride Ammonia
9 Valine VAL 18 Arginine ARG

5.3 Content of standard amino acids, feedstuff standard (cat. No. 650-0037)
1 Cysteic acid CYS(OX) 11 Valine VAL
3 L-Methioninsulfon MET(SO2) 13 Isoleucine ILE
4 Threonine THR 14 Leucine LEU
5 Serine SER 15 Tyrosine TYR
6 Glutamic Acid GLU 16 Phenylalanine PHE
7 Proline PRO 17 Histidine HIS
8 Glycine GLY 18 Lysine LYS
9 Alanine ALA 19 Ammonium Chloride Ammonia
10 Cystine CYS2 20 Arginine ARG
5.4 Content of biogenic amines standard (cat. No. 650-0150)
No. Biogenic Amine

1 Agmatine
2 Cadaverine
3 Dopamine
4 Histamine
5 Putrescine
6 Spermidine
7 Spermin
8 Tyramine
5.5 Content of canonical amino acids standard (cat. No. 650-0120)
1 Ornithine ORN 11 Valine VAL
3 Tryptophan TRP 13 Isoleucine ILE
4 Threonine THR 14 Leucine LEU
5 Serine SER 15 Tyrosine TYR
6 Glutamic Acid GLU 16 Phenylalanine PHE
7 Proline PRO 17 Histidine HIS
8 Glycine GLY 18 Lysine LYS
9 Alanine ALA 19 Asparagine ASN
10 Cystin CYS 20 Arginine ARG

5.6 Content of standard, anions (cat. No. 650-0122) & cations (cat. No. 650-0123)
No. Anion No. Cation

1 Fluoride 1 Lithium
2 Chloride 2 Sodium
3 Nitrite 3 Ammonium
4 Bromide 4 Potassium
5 Nitrate 5 Calcium
6 Phosphate 6 Magnesium
7 Sulfate
Notes:
membraPure GmbH
Wolfgang-Küntscher-Str. 14
D - 16761 Hennigsdorf
Germany
Tel: +49-3302/201-20 0
Technical Service: +49-3302/201-20 20
Fax: +49-3302/201-20 21
info@membrapure.de
www.membrapure.de

Product Guideline Membrapure

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Product Guideline Membrapure

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Product Guideline 2020

More than 25 years ….

membraPure systems – experts in water purification systems and related analyzers

Working with membraPure offers you the following advantages:

 Fast response times for deliveries and service

Dr. Erdmann Flindt

1 Water Purification Systems ............................................................................................................... 4

1 Water Purification Systems

Figure 1: Scheme shows flowchart of Astacus² Life Science TI.

resistivity 18.2 MΩ·cm

productivity rate 2 L/min, 1.5 L/min*

bacteria < 1 cfu/mL*

particulate > 0.2 μm less than 1 particulate/mL

pyrogen (endotoxins) < 0.001 EU/mL*

RNAse < 1 pg/mL*

DNAse < 5 pg/mL*

Feed Water Requirements

feed water conductivity < 10 μS/cm

inlet pressure 0 to 1.5 bar

total organic content (TOC) < 50 ppb

Life Science + + - 110-0091

Life Science TI + + + 110-0093

Analytical TI/ BI + - + 110-0096

Life Science BI + + - 110-0097

Life Science TI/ BI + + + 110-0098

Consumables & Spare Parts

1.2 Aquinity² P10

Figure 2: Scheme shows flowchart of Aquinity² P10 Analytical.

resistivity 18.2 MΩ·cm

dispensing flow rate 1.5 L/min

productivity rate 8 L/h*

bacteria < 1 cfu/mL**

particulate > 0.2 μm less than 1 particulate/mL

pyrogen (endotoxins) < 0.001 EU/mL*

RNAse < 1 pg/mL*

DNAse < 5 pg/mL*

Feed Water Requirements

feed water conductivity < 1400 μS/cm

inlet pressure 1.5 to 6 bar

Free chlorine < 0.1 mg/L

Silt Density Index (SDI) <3

Consumables & Spare Parts

1.3 Aquinity² P35/70

The system Aquinity² P35/70 is designed for the

Figure 3: Scheme shows flowchart of Aquinity² P35/70 Life Science TI.

resistivity > 0.5 MΩ·cm; Type II + 18.2 MΩ·cm

dispensing flow rate 2 L/min (1.5 L/min Life Science)

productivity rate 10 L/h, optionally 20 L/h

bacteria < 1 cfu/mL*

particulate > 0.2 μm less than 1 particulate/mL

pyrogen (endotoxins) < 0.001 EU/mL*

RNAse < 1 pg/mL*

DNAse < 5 pg/mL*

Feed Water Requirements

feed water conductivity < 1400 μS/cm

inlet pressure 0 to 1.5 bar

free chlorine < 0.1 mg/L

total organic content (TOC) < 50 ppb

Reagent - - - 114-0050 114-0060 -

Analytical + - - 114-0051 114-0061 -

Life Science + + - 114-0052 114-0062 -

Analytical TI + - + 114-0056 114-0066 114-0074

Life Science TI + + + 114-0057 114-0067 114-0075