‫ باسط خالد حواس‬: ‫االسم‬

)‫الثالثه (استضافه صباحي‬: ‫المرحله‬

Serology Lab :‫الماده‬

C-Reactive Protein

CRP Test
A c-reactive protein test measures the level of c-reactive protein
(CRP) in your blood. CRP is a protein made by your liver. It's sent
into your bloodstream in response to inflammation. Inflammation is
your body's way of protecting your tissues if you've been injured or
have an infection. It can cause pain, redness, and swelling in the
injured or affected area. Some autoimmune disorders and chronic
diseases can also cause inflammation.

Production of CRP ?
CRP is produced in many sites within the human body (Figure 1). It
is produced in the liver in response to IL-6. Products of activated
monocytes in Hep 3B cells induce the production of human serum
amyloid A (SAA) protein and CRP, but not by IL-1β, TNF-α, or
some hepatocytestimulating factor preparations. It is also produced
in very limited concentration by non-hepatic cells like neurons,
atherosclerotic plaques, monocytes, Kupffer cells and
lymphocytes.1, 10, 11 Studies have shown that epithelial cells of
both respiratory tract and renal epithelium can also produce CRP
under certain circumstances.12, 13 Recent studies have
demonstrated that human coronary artery smooth muscle cells
could also synthesize CRP upon stimulation by inflammatory
cytokines.14, 15 Cogent data have indicated that the protein is also
produced by the atherosclerotic lesions (especially by smooth
muscle cells and macrophages), kidneys, neurons, and alveolar
macrophages.16 Additionally, there is evidence to suggest that lipid
peroxidation and infection, such as

Why
Are
CRP

Tests Done?
A CRP test may be done if a child has signs of inflammation or
infection. CRP tests are used to follow conditions such as
inflammatory bowel disease (IBD), arthritis, and lupus. CRP tests
also can help doctors see how well treatment for inflammation or
infection is working.
How Should We Prepare for a CRP Test?
Your child may be asked to stop eating and drinking for 8 to 12
hours before the CRP test. Tell your doctor about any medicines
your child takes because some drugs might affect the test results.
Wearing a T-shirt or short-sleeved shirt for the test can make things
easier for your child, and you also can bring along a toy or book as
a distraction.
How Is a CRP Test Done?
Most blood tests take a small amount of blood from a vein. To do
that, a health professional will:
• clean the skin
• put an elastic band (tourniquet) above the area to get the veins
to swell with blood
• insert a needle into a vein (usually in the arm inside of the
elbow or on the back of the hand)
• pull the blood sample into a vial or syringe
 • take off the elastic band and remove the needle from the vein
In babies, blood draws are sometimes done as a "heel stick
collection." After cleaning the area, the health professional will
prick your baby's heel with a tiny needle (or lancet) to collect a
small sample of blood.
Collecting a sample of blood is only temporarily uncomfortable and
can feel like a quick pinprick.
Can I Stay With My Child During a CRP Test?
Parents usually can stay with their child during a blood test.
Encourage your child to relax and stay still because tensing
muscles can make it harder to draw blood. Your child might want to
look away when the needle is inserted and the blood is collected.
Help your child to relax by taking slow deep breaths or singing a
favorite song.
How Long Does a CRP Test Take?
Most blood tests take just a few minutes. Occasionally, it can be
hard to find a vein, so the health professional may need to try more
than once.
What Happens After a CRP Test?
The health professional will remove the elastic band and the needle
and cover the area with cotton or a bandage to stop the bleeding.
Afterward, there may be some mild bruising, which should go away
in a few days.
When Are CRP Test Results Ready?
Blood samples are processed by a machine, and it may take a few
hours to a day for the results to be available. If the test results show
signs of a problem, the doctor might order other tests to figure out
what the problem is and how to treat it.
Are There Any Risks From CRP Tests?
A CRP test is a safe procedure with minimal risks. Some kids
might feel faint or lightheaded from the test. A few kids and teens
have a strong fear of needles. If your child is anxious, talk with the
doctor before the test about ways to make the procedure easier. A
small bruise or mild soreness around the blood test site is common
and can last for a few days. Get medical care for your child if the
discomfort gets worse or lasts longer.
If you have questions about the CRP test, speak with your doctor or
the health professional doing the blood draw.