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Inet wegen | un (TM isotype ath peti g g a tee py A a aly | TM HAD Gee Yael Kethed os oy Las WS QE a, Active immunity Yaw acu -1 Rael sph colts Wal Da ot ee a) Passive immunity ats seus Mt) Se oe SS Ss pl oy tetas Jaa hee Me J Sac ul We G Rett pei tay oy ust oy ys gaye Berdy ple ety Py A coe US Atl Jot oily off Gets PID pp tend oy sh omer sb ce ods cay pul deal IS Guay jy ay zouk ED Se Wy da Wo SUTRA IY Siig My We A Leu ey oh Me 1 WB OSH Sas ene yee att j Cells - mediated inumunity gan Ze9 Seu, | shelper T-cells Opes Eeeetiet st irtrutrets ay een PES NAL gh Om ae es sy Cytotoaie Te ells 2.44 eww by Ne Lees pt Loud a beg Ulis Cytokines ¢ L; ymokines) go PT UULS so Shy je BU Bebe Reeds oe thet yey bets 24 B - eellsy Liudy pl al Finkaye beled Jali ad yp eed pel As A Ea canta Cytotoxic T- Cells wie pyc» tout gtgl ll pow Zeudd gag pli tay bets ge LEN Legg te St ls a atl Siem oe tad Mall Ob Je Dette ae GBI ah ey i SU gee ag ate gh a Abad BS Skee Shans! pd anc! de T-cells, B - cells » 3 PS SEN ae le Bycl) Gaytead WIEN oy cat lI AS Qe OS pt biter gett BSABL SUNT US ge lag y og ght Nk ge Uj ye Baud SU Me OT ay egy La ts we» epitopes j! antigenic determinants Ln23! Sistt! Lite set de Ball BWM gs abl as Bi ge Zul bo gots gs cist Bb OEY oy 9 She p28 ae le le alts Ny Bele Sen SE ep a yh a ted de Tuts Bt be a alll coed sll gt Ot ball a sSetty ou Uke ges le ae gt Major histoeompatibility complex (MHC ) T 9 BUMS! 2 sity peucdal Ada all yi Generation of B- cell and T-cell specificity and diversity Syed stl Ht at Yee g BS yy Ut JS do ent ike oF gale Boll Gf Datel iy ad Lele Oe Le pe ced te nk ee Ws pile le Hy taty Goal tale JL ge A ee Se Le YY OS Wyte Jel Ub Soy ett Es belt Lary uth WB oy OR as po Wage sts Se bs cory Joly Dt Sy RE pL ecle os tly 2 LE I Ue Co Ale IS y, Le enall Lett pa My BN S giles gets oe Ne Sle abe le 2 US I al is agit ssi Sg Ses gy tL gE DB ME ats ett pe oo ott g pt a SG ge Wes og owt ads a gy oh Le “ tad Sry gM OMEN a taal te at Bhs JE Ve le cept Tate OF ob B Wp POS Stent ately Ei pt ee Insy pal! op ety § SS ay $5 hye boas Ay SS SUNS aya a SPU Ott Sey Leena “geeape gh Ud yet Ld yy > ceed sted As A Ryaed clalat Ratt BG Ce A sead col st ehiyal 392 Role of major histocomptibility complex Bt gas ta dm at ghia ge Ue yg bla ple sill yall opt NOE at pen Se LN go edt ght yy OF eget UP SH by Joe eB CEI Stead — peat Be) ark Ua CS le Ne git ay De Se SS HN al gad 3 Ee a gd 8 AUD a ge sj ts ay Yl Nyy et ge Wage pW ge Uple D pall op eth SE Ue ty HY oe MAL Spb! Sas an pensiy palit St. yaa Ula Si Ue aed ee oy Ag pl uy ew Bey pet ale le sly IT as oe De Bagh bth te eT eZ major histocomptability complex genes Arc Mga gles yoy BNW le ty We ey BI ale ay Oe ppb class DP genes poy pit ft SAN ot de SUE oe ei all We pt WE get gle class | met See yall cytotonie T - Cells goed ally de sda WAH oly gt chet SS pe el 1a) Sy ( at) eats 2a ee Wm le ld Ltt eytotonic T j3 yp 20d yal LU ol gh de Lisyy ae o Sy wll ob oy god AT ct yy ge pp ott Sty SR ot dnd tht aU = cells Gell tt rm Sy gd oe UU lls beso a psd HY a gle Bett class HH glycoprotein e+ cine Sr ost o> class HM genes pS Macrophages M42! WS) B= lymphocyle fo HW sem he cell prese 1 gait pile ly Py (1-9 JS2y ed cones gle Dad oy Helper T cells gos gly 2st! UAL SIL tage Adis helper T cell bef coy Mosy pie tas bs fy QUI al gle iy Sy op Uy Interleulin HM Jo ey tokinas 5 pity eye ie gat St Spey YB - coll Bay or eth wo PA ue SHG ap geht Ysday (THT WSS) UPL We Gas abe OLS Ne ayy Se My Gay pe clase Iv gene Ga ot Yd Gh A Es gle pT id eg antigen (HLA) Blood group locus (1F- ys J histocamptability 2 - oprotein ga oo gy Se ae Stebel OW ped 3b ee gem (Hs) Locus )JAD gb AEA jy awd yyy ond ctf es gh Raa? datas : Processing and presentation of Antigens Gs .03! j45)y suc! O55 gy Bp ees J! AS OA cam aly a gle T Oe Dd ge | Bid pull Us gle lly) Class HT 3! Class | MHC apt ou oS d 3141 sungy antigen processing aw! 3441! 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MHC HW spice ay tb 1 pn Gr te J ae als Gad Ue fos Se aa Sy ts SI ce tye Se ny PE coe ogy OS i oes i a te oe a ae Pe SS MIC eit JUSTO HO oe Je we SMNIC Pesos MIC | city ry es ty OSS BI ge Byte Cytotoxic Te oe cgellall Fgeld WMS els oot) cliny Act Atay he Cellular Interactions required for generation of an immune t response ee Eg UML 2 IE Le ue te Los It as humoral 40 218) Sued B-cell + sty helper T cell 9c Hav Wt, ae ySh WS cell ~ mediated agbs 221 creed cytotoxic Th cell ve ji AIT AY ee god BRD UAE ge tet Come alae Jt Cue MeL! interleukin |(IL-E) aay tee Sty macrophages { WA sis Activation and proliferation of helper T cells (1, ) helper — es ety Ty AME Ss Sh tS Hygtb ly YL) TELM oy oe ght WE hg MHC ote ew petty Age Ty sue ye ae Le Oo eke aye way ht bets Lely Interleukin 2 (ML - 2) 238 xd OY als bao It Py dds ue dtl ALL Siar! Sigal Ptety ge Odi dag IT {seed gb Pad Mad Lied yD Ce ee Aw fd ee ca sa DL 2 ct pit Sad WA pi ples de pS ML Ape Api gb Se Ty Ce oy Byard edn pylth tligty pees GSI YAY wh gS te ae uy UE alt MEF AS eu Yin) UY bay 8B Te i ey pee ye gb Akai det Generation of the humoral response A a rel Spon tt deh 1 IN gg Ua gy Ll tt Ca ge nae ay tet pL gale SE oe Bs Opie gles ol ayy Loe pest DE MIN Ste ge tt ey gs Ub pty ate Gand Bue oe Nd Manan) Ty We Citi pin! yo A! aya cmd Bgite Whe YB ae IL Us use gay Ty oe ast HMC + eet) 0 ot sis py tb (IFN - V )Interferan gamma ti) IL-6 91-452 WI co 5 gty IL = 1 tag Gat ode gS atey Bye pty tig hey oust AAD BE yo ae Sy gp ul o Sie od Bape guy aig be yy) sly plasma cells Wj9Ut ide UY sis goog got Ub Lett Lett pt it memary #1 ye 4g) Get Gey as Generation of the cell - mediated immune response de ate DL = 2 phi cl cone Raed Ty ee Jay oie ty Bye Ve We OU RV IS) Ss py yl! te a Te aie TL 2 spy edo ale ge ae tT MAIC By os Bott pnt ye Lp ud uve St py ST od SUS ya) cytonic T lymphocyte (C) QML = 2 AS pp ng cath Sy Leste abs elie py aly AS interferon gamma (IFN - ¥) se ited! y id a IYI SEY A ot ase ly ed Os eee ete ag tl J da RN LS at ND datas a) a Ue al AS icy at LS lad UM VME oe Aig gd ee RSIS 9, BS or a yeh ey wal oA natural Killer (NK jay Paihia all sey aa t Tae co Sith a AY Le pds a I ae Large granular lymphocyte ee FE PB OSs EN Wipe SME EU oo US et gL Ot sh ies toutesed Bed Heats dy Se dg J te a Ld OSS ae V Bop FS ph at gel BN OP le ed yg Ly oe ISS pad pelle Sta OS July cemesl ge pratt Mus gay AF oI Jb And eet ge ge) eet Lilet Baer ty 5 eS gt UT Db Sat tt DSR INK Ray QI ye IS alts eC Uh OSs Haig any LL y St INK yi eth bt oo sty LA bg! ty htc bad ae Ld EE ge pe Uy Le al te ght OU Ret i ods lh Jord . Antibody - dependent cell - mediated cytotonicity % 94! 6.4 de ftTard B Ceils are genercied by tite prumary iymphatic organs: che kymuat ond bursa. From there, T ond 8 ceils migrate 40 severa! erate gic tacations throughout the body, ex indireared in rhe figure,ay —alall (68 gall Cal 2G glut JSaulLymphoid sien) cell Pre-B cell Pre-T cell Memory B Teel cell TY cell ‘The development of T and B lymphocytes. Both arise from bone marrow Precursors. B cells develop in the bursa. Pey er’s patches or hone marrow. T cells develop in the thymus, NK cells are a third population of lymphocytes that are somewhat related to T cells,Assigen (nicroorganism, Insoluable partigles, cottular del iis) \ ee Heiman vagy ly srssnmne ches iG dhypathesizedd / | Lei tts 1G cumptex loge material Seabeaty) W251 Unul gs Ces styt AUA! be etyhaorcas sel) Sito yeantigen binding sites ‘ Variable region are onheavy % chain . Light DO s chain 1 Disulfide bridges a Variable region ‘on light chain Constant region 1 on light chain 1 Heavy chaiiy al Constant region on heavy chain IgG ject hess q ‘ dy Liat eda yAuitenty tev on Una Theantiy Primary immunoglobulin response 3 t i t ' ' : t ‘ 1 1 ’ -a manoglobulin resgonse Antigen injected Js! al#w Antigen reinjected ng / ele |e / Isc W4,6 Time scalefame % area ed See CO at (a wore 2 wes PrueAmigens ge Tt OT > Fovehyn Vieuses, Uacierit —— Uarlles Faint protcins Aleumoral response JZ v ead OY aKori a Rf mi ee nase Ve emery ES re ary,