TERAPI PLASMA KONVALESEN PADA

PASIEN COVID-19

Dr. Th. Monica, R., dr., Sp.An., KIC., M.Si.

Fakultas Kedokteran Universitas Kristen Maranatha
Bandung
 KEKERABATAN
COVID-19

Adnan Shereen, M., Khan, S., Kazmi, A., Bashir, N., Siddique, R., COVID-19 infection: origin, transmission, and characteristics of
human coronaviruses, Journal of Advanced Research (2020), doi: https://doi.org/10.1016/j.jare.2020.03.005
 STRUKTUR COVID-19

Adnan Shereen, M., Khan, S., Kazmi, A., Bashir, N., Siddique, R., COVID-19 infection: origin, transmission, and characteristics of
human coronaviruses, Journal of Advanced Research (2020), doi: https://doi.org/10.1016/j.jare.2020.03.005
 SIKLUS HIDUP COVID-19

Adnan Shereen, M., Khan, S., Kazmi, A., Bashir, N., Siddique, R., COVID-19 infection: origin, transmission, and characteristics of
human coronaviruses, Journal of Advanced Research (2020), doi: https://doi.org/10.1016/j.jare.2020.03.005
 STRUKTUR GENOM COVID-19
KETERANGAN :
S = SPIKE (PENGAIT)
E = ENVELOPE (AMPLOP)
M = MEMBRANE (LAPISAN LUAR)
N = NUCLEOCAPSID (KAPSUL NUKLEAT)

X. Li et al., Molecular immune pathogenesis and diagnosis of COVID-19, Journal of Pharmaceutical Analysis,
https://doi.org/10.1016/j.jpha.2020.03.001
 VAKSINASI

TERAPI PLASMA
KONVALESEN

https://www.mlive.com/news/2014/12/how_do_vaccinations_work_the_s.html
 KEKEBALAN TERHADAP COVID-19

https://homehealth-uk.com/all-products/coronavirus-test-kit-rapid-covid-19-igg-igm-on-site-professional-testing/
 TERAPI PLASMA KONVALESEN

SALAH SATU BENTUK VAKSINASI PASIF

Arturo Casadevall, Liise-anne Pirofski. J Clin Invest. 2020. https://doi.org/10.1172/JCI138003.
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 TERAPI PLASMA KONVALESEN

Manfaat :
1. Kekebalan instan
2. Relatif lebih mudah & cepat
(seperti transfusi darah)
3. Biaya lebih terjangkau

Efek samping : Reaksi alergi

Bahan dasar : Plasma, Darah Utuh

Arturo Casadevall, Liise-anne Pirofski. J Clin Invest. 2020. https://doi.org/10.1172/JCI138003.

 KRITERIA CALON DONOR

1. PCR positif
2. 14 hari bebas gejala
3. 2 kali PCR negatif
4. Donor wanita antibodi HLA
negatif atau donor pria
5. Bila mungkin kadar antibodi
> 1:320 dan antibodi
netralisasi (NAT) > 1:80

Th. Monic R., Teguh Triyono, Patra R Harly. Penatalaksanaan Arturo Casadevall, Liise-anne Pirofski. J Clin Invest.
Terapi Plasma Konvalesen Bagi Pasien COVID-19 2020. https://doi.org/10.1172/JCI138003.
 KRITERIA CALON RESIPIEN
Diperhatikan
1. PCR positif 1. Dapat diberikan segera
2. COVID-19 Berat pada pasien rawat
• Sesak napas yang mengeluh sesak
• Frekuensi napas > 30x/menit napas
• PF Ratio < 300 2. Tidak diindikasikan
• Infiltrat paru > 50% dalam 24-48 jam pada pasien COVID-19
3. COVID-19 Kritis Ringan
• Gagal napas (PF Ratio < 200) 3. Informed Consent
• Syok septik dan/atau
• Disfungsi atau gagal organ multipel

Th. Monic R., Teguh Triyono, Patra R Harly. Penatalaksanaan Terapi Plasma Konvalesen Bagi Pasien COVID-19
HAL YANG HARUS DIPERHATIKAN SUPAYA
TPK MEMBERIKAN EFEKTIFITAS
MAKSIMAL
 BEBAN VIRUS
(JUMLAH VIRUS)

Yang Liu, et al. www.thelancet.com/infection Published

online March 19, 2020 https://doi.org/10.1016/S1473-
3099(20)30232-2
KADAR IMUNITAS
PELEPASAN VIRUS (VIRAL SHEDDING)

Fei Zhou, et al. www.thelancet.com Vol 395 March 28, 2020

 EFEKTIFITAS TPK
1. Donor sesuai kriteria
2. Titer IgG 1:320, NAT 1:80
3. Waktu pemberian

WAKTU TPK DIBERIKAN

1. Lebih dini lebih baik
2. 14 hari pertama pasien dirawat
3. Saat belum ada MOD/MOF
 TAKE HOME
MESSAGE

EARLIER IS BETTER

TIME IS IMPORTANT
TERIMA KASIH