Professional Documents
Culture Documents
ICAAC Poster 2010 II
ICAAC Poster 2010 II
K-2188 Pneumonia (HAP) Due to Methicillin-Susceptible Staphylococcus aureus (MSSA) Duke University Medical Center
Box 3281 Medical Center
Durham, NC 27710
Phone: 919-684-6854
Batu K. Sharma-Kuinkel,1,2 Martin E .Stryjewski,1,3 Thomas H. Rude,1,2 Fredric C. Genter,4 Steven L. Barriere,4 G. Ralph Corey,1,2 Vance G .Fowler Jr,1,2 Fax: 919-684-8902
1Duke Clinical Research Institute, Durham, NC, USA; 2Duke University Medical Center, Durham, NC, USA; 3Centro de Educación Médica e Investigaciones Clínicas (CEMIC), Buenos Aires, Argentina; 4Theravance, Inc., South San Francisco, CA, USA E-mail: fowle003@mc.duke.edu
% Cure Rate
Introduction 40 variables.
4. None of the 33 other virulence genes tested in the study were associated with
20
Staphylococcus aureus is the most important cause of life-threatening bacterial clinical outcome.
infections in the present developed world including USA1. 0
pvl + pvl - pvl + pvl - 5. agr dysfunction has no impact on outcome of patients with S. aureus
The role of Panton-Valentine Leukocidin ( PVL) in the pathogenesis of Hospital- MRSA MSSA Hospital-Acquired Pneumonia.
Acquired Pneumonia ( HAP) is very conflicting and not well understood2,3,4,5,6. 6. The differential in amount of alpha haemolysin production has no impact on
PVL is a beta pore forming bi-component cytotoxin , encoded by two contiguous and outcome of patients with S. aureus Hospital-Acquired Pneumonia.
E. Estimated K-M survival at 28 days among patients
co-transcribed genes carried on a bacteriophage, causing pores in the membranes 7. Differential in mortality among patients with S. aureus Hospital-Acquired
with MRSA and MSSA pneumonia according to
of the infected cells leading to its necrosis or apoptosis7. Pneumonia is not due to a single pvl-constitutive S. aureus clone.
presence or absence of pvl :
Hospital acquired pneumonia ( HAP) or nosocomial pneumonia is the second most p=0.001
common nosocomial infection in United States and the leading cause of morbidity
and mortality from nosocomial infections 8. 1
p=0.834 References
DUKE MEDICINE
This study was supported by a grant from Theravance, Inc. South San Francisco; CA.