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  • Neonat Alhypocal Cemi A Et I Ol Ogy: ST ST

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    Dijattx
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    1. Neonatal hypocalcemia can occur in the first few days of life or later in the first week. Common causes include prematurity, perinatal asphyxia, and infant of a mother with hyperparathyroidism. 2. Clinical symptoms only occur with late onset hypocalcemia and include jitteriness, hypertonia, hyperreflexia, seizures, apnea, and carpopedal spasms. 3. Investigation shows decreased serum calcium and ionized calcium levels, elevated phosphorus suggesting hypoparathyroidism, decreased magnesium levels suggesting hypomagnesemia.

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    1. Neonatal hypocalcemia can occur in the first few days of life or later in the first week. Common causes include prematurity, perinatal asphyxia, and infant of a mother with hyperparathyroidism. 2. Clinical symptoms only occur with late onset hypocalcemia and include jitteriness, hypertonia, hyperreflexia, seizures, apnea, and carpopedal spasms. 3. Investigation shows decreased serum calcium and ionized calcium levels, elevated phosphorus suggesting hypoparathyroidism, decreased magnesium levels suggesting hypomagnesemia.

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    9 views3 pages

    Neonat Alhypocal Cemi A Et I Ol Ogy: ST ST

    Uploaded by

    Dijattx
    1. Neonatal hypocalcemia can occur in the first few days of life or later in the first week. Common causes include prematurity, perinatal asphyxia, and infant of a mother with hyperparathyroidism. 2. Clinical symptoms only occur with late onset hypocalcemia and include jitteriness, hypertonia, hyperreflexia, seizures, apnea, and carpopedal spasms. 3. Investigation shows decreased serum calcium and ionized calcium levels, elevated phosphorus suggesting hypoparathyroidism, decreased magnesium levels suggesting hypomagnesemia.

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    © All Rights Reserved
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    of 3

    Neonat

    alhy
    pocal
    cemi
    a(serum cal
    cium <7andi
    noni
    zedca<4mg/
    dl)

    Et
    iol
    ogy

    Earl 1st3day
    yonset( sofl
    i
    fe) l
    at (endof1stweekor
    eonset
    l
    ater)

    (
    Decr
    easePTH,
    i
    ncr
    easecal
    cit
    oni
    n)

    1.Pr
    emat
    uri
    tyandLBW(
    50%)

    2.Peri
    nat
    alasphy
    xia hy
    poPTH(
    mostcommon)
    miscel
    l
    aneous

    3.I
    DM (25%) i
    diopat
    hic
    hyper
    phosphat
    e

    4. I
    nfantofhy
    per
    par
    athy
    roi
    dmot
    her v
    itDdef
    ici
    ency
    TPN,
    fur
    osemi
    de

    Pseudohy
    popar
    athy
    roi
    dism 2r
    ytomat
    ernal
    vitDdef
    ici
    ency

    Congeni
    tal
    (di
    Geor
    ge) mal
    absor
    pti
    on

    Mgdef
    ici
    ency(
    decr
    easePTHr
    elase) l
    i
    verorr
    enal
    disease

    Ant
    ir
    iconv
    ulsantdur
    ing
    pr
    egnancy

    Cl
    i
    nical
    pict
    ure:
    Sy
    pmt
    omsoccuronl
    ywi
    thl
    ateonsethy
    pocal
    cemi
    aandi
    ncl
    ude:

    (
    Jit
    erness,
    hyper
    toni
    a,
    hyper
    ref
    lexi
    a,
    si
    zur
    es,
    apnea,
    car
    popedal
    spasm)

    I
    nvest
    igat
    ion:

    Ser
    um :cal
    cium t
    otal
    andi
    oni
    zeddecr
    eased conf
    ir
    m di
    agnosi
    s

    Phosphor
    usl
    evel
    elev
    ated suggesthy
    popar
    a,r
    enal
    i
    nsuf
    fi
    ciency
    Mgl
    evel
    decr
    ease hy
    pomagnesi
    mia

    Ur
    ine: hyper
    cal
    cur
    ia(>4mg/
    kg/
    dayof24hur
    inet
    oget
    herwi
    th
    cr
    eat
    ini
    ner
    ati
    on>0.
    2

    ECG:
    pronl
    ongedQ-
    Tint
    erv
    al

    Xr
    ay:
    absenceoft
    hymi
    cshadowmaysuggestdeGeor
    gesequence

    Tr
    eat
    ment
    :

    Hy
    pocal
    cemi
    awi
    thoutsi
    zur
    es hypocal
    cemiawit
    hsi
    zur
    es hy
    pocal
    cemi
    awi
    th
    hy
    perphosphat
    e

    Add5ml/
    kg/
    day i
    vbol
    us(
    1-2ml
    /kg)ov
    er10mi
    nut
    es decr
    ease
    i
    ntake

    ofcal
    cium gl
    uconat
    e10% ofcal
    cium gl
    uconat
    e10%,
    i
    tcanbe l
    owphosphor
    us
    for
    mula

    (
    45mgelement
    alca)t
    o r
    epeat
    edwi
    thmoni
    torHR,
    i
    fnor
    esponse av
    oidl
    act
    ose
    f
    reemi
    l
    k

    i
    vflui
    dinf
    usi
    onov
    er24h suggesthy
    poMg andPTf
    ormul
    a
    (
    highP)

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