Pathogenesis:

most cases the disease is transmitted via the bite of rabid animals which shed infectious virus with their
saliva.

 A virus can enters the body through wound or direct contact of infectious material (i.e. saliva,
cerebrospinal liquid, nerve tissue) to mucous membranes or skin lesions.
Note: a virus cannot penetrate an intact skin
 entry the virus binds to cell receptors. Viruses may replicate within striated muscle cells are
directly infect nerve cells.
 virus then travels via retrograde axoplasmatic transport mechanisms to the central nervous
system
 has reached the CNS, rapid virus replication takes place, causing pathologic effects on nerve cell
physiology.
 virus then moves from the CNS via anterograde axoplasmic flow within peripheral nerves,
leading to infection of some of the adjacent non-nervous tissues, for example, secretory tissues
of salivary glands.
 The virus is widely disseminated throughout the body at the time of clinical onset

https://www.who-rabies-bulletin.org/site-page/transmission-and-pathogenesis

Statistics Of Rabies Cases In Iloilo By 2019

 There are 17 human rabies deaths from January to May, two of cases were confirmed by
laboratories as positive.
 Highest death was in Negros Occidental with eight. Aklan and Iloilo province each has three
cases; Capiz has two; while Iloilo City has one death.
 Six of the death cases were children less than 13 years old.
 First quarter of the year, the region recorded 22,206 animal bites.

https://www.pna.gov.ph/articles/1073471