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  • Punctured Wound Leads to Localized Clostridium tetani Infection and Potential Tetanus

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    Tetanus pathophy.docx

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    35 views1 page

    Punctured Wound Leads to Localized Clostridium tetani Infection and Potential Tetanus

    Uploaded by

    dickson

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 1

    Punctured Wound Local Abscess

    Clostridium tetani spore innoculation

    Development of Spores into vegetative


    organisms (localized)

    Tetanospasmin released into the systemic


    circulation (Toxemia)

    Toxin enters the presynaptic terminal of


    Peripheral Lower Motor Neurons & Spinal
    cord & Brainstem

    Toxin blocks release of inhibitory


    neurotransmitters GABA & Glycine

    Unrestrained Excitation of Motor Neurons

    Spasmodic Contractions of Muscles of Jaw,


    Upper & Lower Extremities, Abdomen,
    Chest, Pharynx

    Trismus, Dysphagia, Gait problems

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