+

Renal Pharmacology
Shan Nanji
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Question

n Which receptor can be stimulated

to increase the release of Renin?

n  __________________

Shan Nanji - NanjiMD@gmail.com

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Osmotic Diuretics
n Mannitol

MOA:
n  Increases Renal Tubular Fluid Osmolarity

n  Clinical Use:

n  Used to lower IOP and ICP

Shan Nanji - NanjiMD@gmail.com

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Osmotic Diuretics
n Mannitol

n  Contraindicated:
n  __________________
n  __________________

Shan Nanji - NanjiMD@gmail.com

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Loop Diuretics
n Furosemide/Ethycrynic Acid
n  Ethycrynic Acid – __________________

MOA:
n  __________________in the Thick Ascending limb
of the __________________
n  Stimulates the release of __________________

n  Action of __________________inhibited by

_________________
n  Clinical Use:
n  __________________

Shan Nanji - NanjiMD@gmail.com

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Loop Diuretics
n Furosemide/Ethycrynic Acid
n  Ethycrynic Acid – Does NOT have sulfur

n  S/E:
n  __________________
n  __________________
n  Dehydration
n  Sulfa-drug Allergy
n  Interstitial Nephritis
n  Gout

Shan Nanji - NanjiMD@gmail.com

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Carbonic Anhydrase Inhibitor

n Acetazolamide - “ACIDazolamide”

n  MOA:
n  Inhibits Carbonic Anhydrase in Proximal Convoluted Tubule
n  Causes Increased [Bicarb] in the Lumen

n  Clinical Use:

n  __________________
n  __________________

Shan Nanji - NanjiMD@gmail.com

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Carbonic Anhydrase Inhibitor

n Acetazolamide - “ACIDazolamide”

n  S/E:
n  __________________
n  Sulfa-drug Allergy

Shan Nanji - NanjiMD@gmail.com

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Thiazide Diuretics
n Hydrochlorothiazide
MOA:
n  Inhibits __________________Reabsorption in
Early Distal Convoluted Tubule

n  Clinical Use:

n  Hypertension
n  CHF
n  __________________
n  __________________
n  Decreases __________________of the Kidney
n  Urine becomes __________________

Shan Nanji - NanjiMD@gmail.com

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Thiazide Diuretics
n HydrOchlOrOthiazide

n S/E:
n  HyperGlycemia
n  __________________
n  HyperUricemia
n  HyperCalcemia
n  __________________
n  HypOnatremia

Shan Nanji - NanjiMD@gmail.com

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Potassium Sparing Diuretics

n Spironolactone
MOA:
n  _______________________________________ in the
Cortical Collecting Tubule

Clinical Use:
n  Hirsutism!
n  __________________
n  CHF

Shan Nanji - NanjiMD@gmail.com

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Potassium Sparing Diuretics

n Spironolactone

S/E:
n  __________________ -> possible Arrythmias
n  Gynecomastia
n  Anti-Androgen Effects

Shan Nanji - NanjiMD@gmail.com

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Potassium Sparing Diuretics

n Triamterene/Amiloride

MOA:
n  __________________in the Cortical Collecting Tubule

Clinical Use:
n  __________________
n  CHF
n  K+ depletion

Shan Nanji - NanjiMD@gmail.com

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Potassium Sparing Diuretics

n Triamterene/Amiloride

S/E:
n  __________________

Shan Nanji - NanjiMD@gmail.com

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ACE Inhibitors
n Captopril, Enalapril, and Lisinopril
MOA:
n  Inhibit Angiotensin Converting Enzyme
n  Therefore decreases [Angiotensin II]
n  Also __________________
n  Decreased __________________ (NO
Constriction __________________)
Clinical Use:
n  Hypertension
n  CHF

n  Renal Disease due to Diabetes

Shan Nanji - NanjiMD@gmail.com

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ACE Inhibitors
n Captopril, Enalapril, and Lisinopril
S/E:
n  __________________
n  Angioedema

n  Teratogen
n  Fetal
Renal Abnormalities
n  HypOtension
n  Hyperkalemia

n  __________________
n  Decreased GFR
Shan Nanji - NanjiMD@gmail.com
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Angiotensin Receptor Blocker

n CandeSARTAN, -sartans
n  “Sweet as CANDYsartan because Least Side Effects”
MOA:
n  Block Angiotensin II Receptor
n  Actions similar to ACE inhibitors
n  Do NOT __________________

n  Clinical Use:

n  Hypertension
n  CHF

n  Renal Disease due to Diabetes

Shan Nanji - NanjiMD@gmail.com

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Angiotensin Receptor Blocker

n CandeSARTAN, -sartans
n  “Sweet as CANDYsartan because Least Side Effects”

S/E:
n  Similar to ACE Inhibitors EXCEPT:
n  ___________
n  ______
n  _Due to Not Increasing __________________

Shan Nanji - NanjiMD@gmail.com