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17 Gutierrez-Quiz 1
17 Gutierrez-Quiz 1
2. Like a chemical catalyst, an enzyme is efficient (or even better) in speeding up rate of reaction without
affecting equilibrium concentration of reactant/product. Both are also recycled after the reaction. Give at
least one advantage of using enzyme over a chemical catalyst.
Enzymes are involved in life process. Since enzymes are larger than chemical catalysts, there are more contact points
between the enzyme and substrates wherein enzymes can function in milder conditions meaning the new formed
molecules does not need protection during the reaction. Because of this, modification can also be made to the enzyme
through protein engineering, so it can bind with different substrate.
4. The active site confers to specificity of an enzyme. What is the difference between geometric and electronic
complementarities of active site (on an enzyme) to substrate?
In geometrical specificity, the substrate binding site has indentation or cleft on the surface of an enzyme. The cleft is
complementary in shape to the substrate. In electronic complementarity, the amino acid residues forms the binding site
specifically to attract the substrate.
5. Identify the two models of active site and describe each briefly
There are two models used to describe the active site: (1) Lock and key model, it proposed that the lock symbolizes
the enzyme, the key is the substrate, while the keyhole is the active site. The appropriate size of the key will only fit the
keyhole of the lock. (2) induced fit model, it proposed that the enzyme's active site is flexible that it changes its shape so
that the substrate will fit.