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Causes
Have a weak immune system from HIV/AIDS, an organ transplant, or because you were born with an
immune disease
Have an immune system disease such as rheumatoid arthritis, Sjögren's syndrome, lupus, or celiac
disease
Have been infected with a virus such as Epstein-Barr, hepatitis C, or human T-cell leukemia/lymphoma
(HTLV-1)
Symptoms
Swollen glands (lymph nodes), often in the neck, armpit, or groin that are painless
Cough
Shortness of breath
Fever
Night sweats
Fatigue
Weight loss
Itching
Many of these symptoms can also be warning signs of other illnesses. See your doctor to find out for
sure if you have lymphoma.
Getting a Diagnosis
Before you have any tests, your doctor will want to know:
Your doctor will do a physical exam, including a check for swollen lymph nodes. This symptom doesn't
mean you have cancer. Most of the time, an infection -- unrelated to cancer -- causes swollen lymph
nodes.
You might get a lymph node biopsy to check for cancer cells. For this test, your doctor will remove all or
part of a lymph node, or use a needle to take a small amount of tissue from the affected node.
You might also have one of these tests to help diagnose, stage, or manage lymphoma:
Bone marrow aspiration or biopsy. Your doctor uses a needle to remove fluid or tissue from your bone
marrow -- the spongy part inside bone where blood cells are made -- to look for lymphoma cells.
Chest X-ray. It uses radiation in low doses to make images of the inside of your chest.
MRI. It uses powerful magnets and radio waves to make pictures of organs and structures inside your
body.
PET scan. It uses a radioactive substance to look for cancer cells in your body.
Molecular test. It looks for changes to genes, proteins, and other substances in cancer cells to help your
doctor figure out which type of lymphoma you have.
Blood tests. These check the number of certain cells, levels of other substances, or evidence of infection
in your blood.
Are there any complementary treatments I could consider, along with the usual medical care? Are there
any I should avoid?
Treatment
The treatment you get depends on what type of lymphoma you have and its stage.
The main treatments for non-Hodgkin lymphoma are:
Immunotherapy, which uses your body's immune system to attack cancer cells
Targeted therapy that targets aspects of lymphoma cells to curb their growth
Chemotherapy
Radiation therapy
Immunotherapy
If these treatments don't work, you might have a stem cell transplant. First you'll get very high doses of
chemotherapy. This treatment kills cancer cells, but it also destroys stem cells in your bone marrow that
make new blood cells. After chemotherapy, you will get a transplant of stem cells to replace the ones
that were destroyed.
Lymphoma treatment can cause side effects. Talk to your medical team about ways to relieve any
symptoms you have.
Also ask your doctor about changes to your diet and exercise that can help you feel better during your
treatment. Ask a dietitian for help if you're not sure what types of food to eat. Exercises like walking or
swimming can relieve fatigue and help you feel better during treatments like chemotherapy and
radiation. You might also try alternative therapies like relaxation, biofeedback, or guided imagery to help
relieve pain.
What to Expect
Treatments have improved a lot, and many people do very well after treatment. Your doctor will talk to
you about a survivorship care plan. Your outlook depends on:
Your age
You can get support from people who have gone through this kind of illness.
Contact the Leukemia & Lymphoma Society or Lymphoma Research Foundation to learn more.
Sources
Hodgkin's Lymphoma
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