Classification Therapeutic class: Antiprotozoals Pharmacologic class: Nitroimidazoles Indications Tx. Amebiasis Tx Of anti biotic associated pseudomembranous colitis Tx. Gardnerella vaginalis infection Tx. Trichomoniasis Tx. Bacterial Vaginitis Tx. Of anerobic bacterial infection Preop, intraop, postop px of pts undergoing colorectal surgery Tx. Of inflammatory papules, pustules, erythema of rosacea Dosage Injection: 500 mg/100 mL in ready-to-use (RTU) minibags Tablets: 250 mg; 500 mg Action Direct-acting trichomonacide and amebicide that works inside and outside the intestines. It’s thought to enter the cells of microorganisms that contain nitroreductase, forming unstable compounds that bind to DNA and inhibit synthesis, causing cell death. Adverse Reactions Anorexia, ataxia, darkened, urine, dizziness, dry mouth, H/A, injection site reaction, n/v/d, superinfections, unpleasant metallic taste
Patient education Not for use in breastfeeding.
while taking this Urine may be dark and newline patient should take a full course : medication take orally with food , avoid alcohol or alcohol containing preparations during and for 24-72 hrs After treatment use sugar list lozengesfor dry mouth /metallic taste Report severe GI problems and fever