The new chiral imidazolium salt ‘1,3-bis[(R)-1-((S)-2-diphenyl phosphine

ferrocenyl)ethyl]imidazolium iodide (4, (PCPH)I)’ were prepared in three steps from

commercially available ‘N,N-dimethyl-1-ferrocenylethylamine (1)’ in 55% overall yield. Salt
four is the precursor for the in situ generation of a novel tridentates carbene ligand that could not
be isolated upon deprotonation of 4 with NaO tBu. Reaction of 4 with [Pd(OAc)2]3 afforded ‘(SP-
4)-1,3-bis[(R)-1-((S)-2-diphenylphosphino-κP-ferrocenyl)ethyl]imidazol-2-
ylideneiodopalladium(II) acetate’, [PdI(PCP)]OAc (6). Treatment of 4 with NaO tBu and
[RuCl2(PPh3)3] gave the mixed halide complex ‘(SP-5)-1,3-bis[(R)-1-((S)-2-diphenylphosphino-
κP-ferrocenyl) ethyl] imidazol-2-ylidene chloro iodoruthenium(II) [RuClI(PCP)]’ as a mixture of
two isomers in 60% yield. Additional complexes that could be obtained from 4 are
[PdCl(PCP)]PF6 (5), [RuCl2(PCP)] (7b), and [RuI(PCP)(NCCH3)2]PF6 (8). The crystal and
molecular structures of 5 and 7a were determined by X-ray diffraction. The Ru(II) center
undergoes a weak agostic interaction with one of the two stereogenic methine units[215].

Cl
PPh3
PPh2
I
H
Fe

Ferrocene-appended ternary copper(II) complexes of phenanthroline bases having

CuN3OS coordination with an axial Cu−S bond derived from L-methionine reduced Schiff base
shows red light induced oxidative DNA cleavage activity following a hydroxyl radical pathway.
The dipyridophenazine complex, in addition, displays photoinduced oxidative cleavage of bovine
serum albumin protein in UV-A light [216].

Detailed crystallographic and NMR measurements are reported for several Pd(II) allyl
complexes containing chiral ferrocene-based phosphinopyrazole ligands, CpFe{η5-C5H3(1-
CH(CH3)(NN C(R1CH CR2)-2-PPh2)}, 1. Relative to similar BINAP, CHIRAPHOS, and
diphosphine JOSIPHOS analogs, the major isomer of the β-pinene
allyl complex [Pd(η3-
C10H15)(1a)]CF3SO3, 2, R1 = R2 = H, shows a surprisingly large trans influence for the PPh 2 donor
moiety, based on 13C data. The solid-state structure for 2 shows normal bond lengths, although
there are indications that the allyl adjusts its position due to the relatively large P,N ligand. The
solid- and solution-state structures of [Pd(η 3-PhCHCHCHPh)(1g)]PF6, 3g, R1 = adamantyl and R2
= H (99% ee in the enantioselective allylic amination), show the allyl ligand to
be strongly rotated, thus placing the terminal allyl carbon proximate t o the pyrazole moiety,
significantly below the coordination plane. These structural results suggest that, for the
enantioselective catalysis using ligands 1, there is an “early” transition state [217].
Biochemistry and Organometallic chemistry have two side of one coin in the last
twenty years into a new field: bioorganometallic chemistry. This new research area was
explaining the synthesis of new organometallic compounds. The biological and medical effects
against some types of diseases, like cancer and malaria. From last twenty five years the use of
ferrocene in bioorganometallic chemistry have been growing very fastly with several promising
applications were developed , when ferrocene compound are stable at room temperature,
nontoxic compound and has good redox properties. This paper will focus on ferrocenyl
compounds which have been biologically active against some diseases. This area has attracted
many of the researchers due to its very good results of some ferrocene compounds in the
pharmaceutical and medicinal applications [219].