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COPD
COPD
Trace the pathophysiological changes and highlight problems that are experienced by the client.
INTRINSIC EXTRINSIC
Male PATIENT
74y/o (+) hypertension -30pack/year smoker history (quit
(+) MI smoking after MI
(+) Hypertension -diagnosed w/ COPD
-denied drinking alcohol
(+) Diabetes Mellitus -no allergy to medication
(+) Heart failure and food
1. Father died of -had Appendectomy 20 yrs ago
myocardial infarction at
age of 59 years (diabetes,
hypertension, smoker)
2. Mother alive (atrial
fibrillation, heart failure)
3. Healthy siblings
Inflammation
Neutrophil elastase and Oxidative stress, inflammatory
matrix metalloproteianases mediators, cytokines
Destruction
of alveolar Fibrosis and thickening Edema and smooth muscle
walls and of the bronchiolar walls contraction
capillaries
Impaired Air
Enlarged gas trapping
Narrowing of small airways
air spaces diffusion on
expiration
Chronic bronchitis
If needed, assist
the patient for a This program
referral to a allows the
pulmonary patient to learn
rehabilitation about nutrition,
program. breathing and
relaxation
techniques,
medication
education,
avoiding
exacerbations,
and ways on how
to live better
while having
COPD.
DRUG STUDY:
Generic inhibits ACE Indicated for contraindicated in headache. Monitor patients closely in any
name: angiotensin- inhibitor the treatment patients with a dizziness. situation that may lead to a
Lisinopril converting of history of ACE- persistent cough. decrease in BP secondary to
enzyme (ACE) hypertension inhibitor induced low blood pressure. reduction in fluid volume (excessive
in human in adult angioedema, chest pain. perspiration and dehydration,
Brand Name: subjects and patients and hereditary vomiting, diarrhea) because
Zestril, animals. ACE pediatric angioedema, or excessive hypotension may occur.
Prinivil is a peptidyl patients 6 idiopathic Arrange for reduced dosage in
dipeptidase years of age angioedema. Risk patients with impaired renal
that catalyzes and older to of angioedema function.
the lower blood may also be
Dosage/Rout conversion of pressure. higher in patients
e/Frequency: angiotensin I Lowering with a history of
20 mg BID PO to the blood angioedema
vasoconstricto pressure unrelated to ACE
r substance, lowers the risk inhibitors.
angiotensin II. of fatal and
Angiotensin II non-fatal
also cardiovascular
stimulates events,
aldosterone primarily
secretion by strokes and
the adrenal myocardial
cortex. infarctions.
Generic relaxing the beta- used for the thyrotoxicosis. Hoarseness, throat -Notify physician immediately of
name: muscles agonists prophylaxis of diabetes. irritation, headache, worsening asthma or failure to
Salmeterol around the (LABAs) mild to low amount of rapid heartbeat, respond to the usual dose of
airways so moderate potassium in the nervousness, cough, salmeterol.
that they asthma and blood. dry mouth/throat, -Do not use an additional dose prior
Brand Name: open up and COPD and high blood or upset stomach to exercise if taking twice-daily
Advair you can should never pressure. may occur. doses of salmeterol.
Diskus breathe more be used to -Diminished -Take the pre-exercise dose 30–60
easily. treat acute blood flow min before exercise and wait 12 h
bronchospas through arteries before an additional dose.
- induces m. of the heart.
Dosage/Rout prolonged -prolonged QT
e/Frequency: bronchodilata interval on EKG.
50/500 dry tion, reduced -abnormal EKG
powdered vascular with QT changes
inhaler (PDI) permeability, from birth.
one puff inhibition of -seizures.
inhaled twice inflammatory
daily mediators,
stimulation of
ciliary
function and
modulation of
ion ...
Generic acts on beta-2 Sympathomi Relief and -overactive CNS: Restlessness, Nursing assessment should include
name: adrenergic metic, prevention of thyroid gland. apprehension, listening to lung sounds, obtaining
Albuterol receptors to Beta2- bronchospas -diabetes. anxiety, fear, CNS blood pressure, and heart rate prior
relax the selective m in patients -a metabolic stimulation, to use and during use of albuterol. If
bronchial adrenergic with condition where hyperkinesia, a patient has a productive cough, it's
Brand Name: smooth agonist, reversible the body cannot insomnia, tremor, important to assess amount, color,
AccuNeb, muscle. It also Bronchodila obstructive adequately use drowsiness, and consistency of sputum.
Novo-Salmol inhibits the tor, Anti airway disease sugars called irritability,
(CAN), release of asthmatic Inhalation: ketoacidosis. weakness, vertigo,
Proventil, immediate Treatment of -excess body acid. headache
Proventil hypersensitivit acute attacks -low amount of CV: Cardiac
HFA, y mediators of potassium in the arrhythmias,
Salbutamol from cells, bronchospas blood. tachycardia,
(CAN), especially m -high blood palpitations, PVCs
Ventodisk mast cells. Prevention of pressure. (rare), anginal pain
(CAN), exercise- -diminished blood Dermatologic:
Ventolin HFA induced flow through Sweating, pallor,
bronchospas arteries of the flushing
m heart. GI: Nausea,
Unlabeled vomiting, heartburn,
Dosage/Rout use: Adjunct unusual or bad taste
e/Frequency: in treating in mouth
metered- serious GU: Increased
dose inhaler hyperkalemia incidence of
(MDI) or in dialysis leiomyomas of
solution for patients; uterus when given
nebulization seems to in higher than
every 6 hours lower human doses in
as needed potassium preclinical studies
concentration Respiratory:
s when Respiratory
inhaled by difficulties,
patients on pulmonary edema,
hemodialysis coughing,
bronchospasm,
paradoxical airway
resistance with
repeated, excessive
use of inhalation
preparations
Generic -inhibits tetracycline indicated for Liver disease due weight loss -Take capsule or tablet forms with a
name: bacterial antibiotics the treatment to rare fatal nausea full glass (240 mL) of water to
Doxycycline protein of the hepatotoxicity. vomiting ensure passage into stomach and
synthesis by following History of yeast diarrhea prevent esophageal ulceration.
Brand Name: binding to the infections and infections. rash -Avoid exposure to direct sunlight
Vibramycin, 30S ribosomal diseases: Recent colitis skin sensitivity to and ultraviolet light during and for 4
Oracea, subunit. Rocky caused by sunlight or 5 d after therapy is terminated to
Adoxa, - has Mountain antibiotic use. hives reduce risk of phototoxic reaction.
Atridox bacteriostatic spotted fever, Kidney disease anemia, and
activity typhus fever diarrhea from C. vaginal yeast
against a and the Dificile. infection
broad range typhus group, History of lupus
Dosage/Rout of Gram- Q fever, (autoimmune)
e/Frequency: positive and rickettsialpox, Porphyria (a blood
100mg OD Gram negative and tick disease)
for one week bacteria. fevers, Myasthenia
respiratory gravis.
tract
infections,
urinary tract
infections.