Sample Test 2-Answers

Chem 661, 2016

1. Which of the following statements does not apply to collagen?

A) It contains hydroxylated amino acids.
B) The polypeptide forms a left-handed helix.
C) Hydrogen bonds between the -OH groups of Hyp residues stabilize the helix.
D) There is an absolute requirement for glycine every third position.
E) The triple helical structure twists in the right-handed direction.

2. Of the following, which amino acid is least likely to be found on the surface of a single-subunit
protein?
A) Gly
B) Asp
C) Lys
D) Trp
E) Ser

3. _________ is a triple-helical fibrous protein.

A) -Keratin
B) -Keratin
C) Collagen
D) RNase A
E) None of the above

4. Which gas does not bind to the porphyrin ring Fe2+ ion in myoglobin?
A) NO
B) CO
C) CO2
D) O2
E) H2S

5. Myoglobin’s primary physiological role is to facilitate oxygen ________.

A) storage
B) metabolism
C) binding
D) reduction
E) diffusion

6. BPG stands for:

A) biphenylglycine
B) boronylphenylglutamate
C) bisphosphoglycerate
D) bisphenylglycerol
E) betapropylglutamine

7. At equilibrium in solution, D-glucose consists of a mixture of its anomers. Which statement most
accurately describes the solution?
A) The solution consists of approximately equal amounts of the - and -anomers.
B) The straight-chain form is present in high concentration.
 C) The -anomer is more stable and is slightly preferred over the -anomer.
D) The -anomer predominates over the -anomer by a ratio of approximately 2:1.
E) None of the above.

This figure is used in questions 8-10

8. Which of the sugars shown in the figure above are L sugars?

A) A and B
B) B and C
C) C and D
D) A and D
E) None of the above

9. Which two sugars shown in the figure above are epimers?

A) A and B
B) B and C
C) C and D
D) A and D
E) None of the above

10. Which sugar shown in the figure above is the enantiomer of sugar A?
A) B
B) C
C) D
D) B and D
E) none of the above
11. The structure below shows -D-gulopyranose.

Which of the structures below represents a Fischer projection of D-gulose?

Ans: C

12. Which of the following lipid types is the least polar?

A) triacylglycerols
B) glycerophospholipids
C) sphingolipids
D) gangliosides
E) glycolipids

13. Triglycerides contain more metabolic energy per unit weight than glycogen because:

I. Glycogen has greater polarity than fatty acids.

II. Fatty acids predominate in an anhydrous form
III. Fatty acids are less oxidized than carbohydrates.
IV. Triglycerides have a higher average molecular mass.

A) I, II, III, IV
B) I, II, III
C) I, II
D) II, III
E) III
14. Cholesterol

A) incorporation into the membrane results in increased rigidity.

B) functions as a precursor to cerebrosides.
C) is synthesized in two-carbon units.
D) is synthesized from steroid hormones.
E) all of the above

15. Which of the following lipid types is the least polar?

A) triacylglycerols
B) glycerophospholipids
C) sphingolipids
D) gangliosides
E) glycolipids

16. Sphingolipids

I. contain a glycerol core with a phosphocholine headgroup.

II. contain a modified sphingosine.
III. often function as receptor components of membranes.
IV. function as a precursor to sterols.

A) I, II, IV
B) II, IV
C) I, II, III
D) II, III
E) II, III, IV

17. Which one of the following is correct?

I. All enzymes are highly specific for the reactions they catalyze.
II. Prosthetic groups are loosely associated with the polypeptide chain of an enzyme.
III. If an enzyme-catalyzed reaction requires a group with a low pK to be deprotonated
and a group with a higher pK to be protonated, the pH vs. rate curve will have a peak
in the middle of the two pK values.
IV. When comparing types of catalysis, the proximity effect provides the largest rate
enhancement.

A) I, II, III, IV
B) I, III
C) I
D) III
E) IV

18. If you add enzyme to a solution containing only the product(s) of a reaction, would you
expect any substrate to form?

A) It depends on the time interval and temperature of reaction.

B) It depends on the concentration of products added.
C) It depends on the energy difference between E + P and the transition state.
D) All of the above may determine if product forms.
E) None of the above determines if product forms.

19. Which of the following amino acid residues would not provide a side chain for acid-base
catalysis at physiological pH? (Assume pK values of each amino acid are equal to the pK value
for the free amino acid in solution.)

I. leucine
II. lysine
III. aspartic acid
IV. histidine

A) I, II, III
B) I, II
C) I
D) II
E) I, III

20. Which of the following processes would yield and increase in rate?

A) the proximity of the reacting groups

B) the rotational motions of the substrates and catalytic groups
C) the orientations of the substrates and catalytic groups
D) all of the above
E) none of the above

21. Which of the following is TRUE regarding transition state?

A) The free energy between the transition state and the reactants must be negative.
B) The transition state can be stabilized by covalent catalysis.
C) The transition state represents the ES complex.
D) Transition state analogs bind the substrate not the enzyme
E) All of the above are true.

22. Acid-base catalysis may be accomplished by:

A) active site specificity

B) charge delocalization
C) buffer effects
D) induced strain
E) conformational change