ENHANCEMENT COURSE FOR CLERKS C.

Occurs primarily by adenine

BIOCHEM EXAMINATION PART 2 salvage using A-PRT
D. Involves hypoxantine salvage
1. What is the major end-product of using HG-PRT
beta oxidation of fatty acid?
6. Involve(s) reduction and cleavage of
A. Acetoacetyl CoA the nitrogen-containing ring:
B. Acetyl CoA
C. Proprionyl CoA A. All items
D. Butyroyl CoA B. Catabolism of guanine
C. Catabolism of guanine and uracil
2. Per cycle of beta oxidation D. Catabolism of uracil
generates how many ATPs?
7. Thioredoxin is involved in the:
A. Five
B. Eleven A. Conversion of a ribonucleotide
C. Nine to a deoxyribonucleotide
D. Seven B. Conversion of dUMP to dTMP
C. Conversion of AMP to ATP
3. The HMG-CoA lyase reaction D. Inhibition of xanthine oxidase as
produces the first ketone body? treatment for gout

A. Acetoacetic acid 8. The following enzymes are involved

B. Pyruvate in the catabolism of AMP to uric
C. 3-hydroxybutyrate acid, EXCEPT:
D. Acetone
A. A deaminase
4. What is the complication of B. A nucleotidase
excessive ketogenesis? C. Xantine oxidase
D. Lipooxygenase
A. Respiratory acidosis
B. Metabolic acidosis 9. The major control of de novo
C. Respiratory alkalosis pyrimidine nucleotide synthesis in
D. Metabolic alkalosis man is:

5. In tissues that do not carry out A. Feedback inhibition of aspartate

active de novo synthesis,
maintenance of an adequate supply
of adenine nucleotides:
A. Depends upon the action of
nucleoside phosphorylase
B. Requires ATP uptake from the
blood
transcarbamylase
B. Competitive inhibition of
carbomyl phosphate synthetase
II
C. Availability of N-acetyl glutamate
D. Feedback inhibition of
glutamine-PRPP
amidotransferase

10. In the catabolism of CTP:
A. Nitrogen will be release in the
form of ammonia (ammonium
ion)
B. Hypoxanthine will be an
intermediate
C. The nitrogen-containing ring will
be oxidized
D. Uric acid is an end product
11. The formation of dATP for DNA
synthesis occurs primarily by:
A. Converting ADP to dADP using
thioredoxin
B. De novo synthesis beginning
with dPRPP
C. Salvaging adenine using a
nucleoside phosphorylase and
dR 1-P
D. Salvaging using A-PRT
12. Which of the following would NOT
be expected to contribute to
hyperuricemia (gout)?
A. Deficiency of HG-PRT
B. Unusually high levels of PRPP
C. Unusually high turnover of
nucleic acids
D. Inhibition of xanthine oxidase
13. Direct sources of purine ring atoms
in the de novo synthesis of IMP
include:
A. All items are included
B. Glutamine
C. Glycine
D. Aspartate
14. Which of the following is/are
effect/s of epinephrine?
A. All choices are correct
B. It stimulates adenylate cyclase
thereby converting ATP to cyclic
AMP
C. It stimulates gluconeogenesis by
activating glucose-6-
phosphatase
D. It stimulates liver glycogenolysis
but not muscle glycogenolysis
15. This is an intermediate that
stimulates PFK 1 and inhibits
gluconeogenesis:
A. Fructose-1,6-biphosphate
B. Glucose-6-phosphate
C. Fructose-2,6-biphosphate
D. Glucose-1-phosphate
16. Which statement/s is/are true
regarding glucokinase?
A. All choices are true
B. It has a low Km for glucose
C. It is not inhibited by high levels
of glucose-6-phosphate
D. It is inhibited by high levels of
AMP
17. Which statement/s is/are true
regarding the reaction(s) that occur
in glycolysis?
A. All choices are correct
B. Conversion of 3-
phosphoglycerate to 2-
phosphoglycerate is a
phosphoryl transfer
C. Conversion of 2-
phosphoglycerate to
 phosphoenolpyruvate is a
phosphoryl shift
D. Conversion of glucose-6-PO4 to
fructose-6-PO4 is an
isomerization reaction
18. If the energy level of the cell is high,
which pathyway/s is/are inhibited?
A. Gluconeogenesis and
glycogenolysis
B. Glycolysis and Krebs cycle
C. Lactic acid cycle and Krebs cycle
D. Glycogenesis and glycolysis
19. Which statement/s is/are true
regarding the tricarboxylic acid
cycle?
A. It is an amphoteric pathway
B. One complete round of the cycle
yields 2 moles of CO2, H20, 3
NADH, 1 FADH2, and 12 ATPs
C. It is the final common pathway
of metabolism
D. All choices
20. What reaction/s is/are stimulated by
insulin?
A. Conversion of glucose-6-
phosphate to fructose-6-
phosphate
B. All choices are included
C. Conversion of
phosphoenolpyruvate to
pyruvate
D. Succinate thiokinase reaction
21. Which of the following reactions
is/are common to glycolysis and
HMP shunt?
A. Glucose  Glucose 6-phosphate
B. All choices
C. Glucose  Glucose-6-phosphate
D. Glucose-6-PO4  Glucose-1-PO4
22. Which enzyme/s is/are common to
glycolysis and gluconeogenesis?
A. Phosphoglucose isomerase
B. Pyruvate carboxylase
C. Transaldolase
D. All choices
23. Which bypass enzyme/s is/are
needed when aspartic acid
undergoes gluconeogenesis?
A. Glucose-6-phosphatase and
phosphoglucoisomerase
B. Pyruvate carboxylase and PEPCK
C. Pyruvate carboxylase, PEPCK and
glucose-6-phosphatase
D. Glucose-6-phosphatase and
PEPCK
24. What are the major function/s of
the HMP shunt?
A. Production of ribose and NADPH
B. Interconversion of sugars and
production of ribose
C. Production of NAD and ribose
D. Interconversion of sugars and
production of NAD
25. Acetyl CoA is the precursor of the
following substances:
A. Triacylglycerol and HMG CoA
B. All choices
C. Cholesterol and prostaglandins
D. Bile acids & steroid hormones