ENHANCEMENT COURSE FOR CLERKS C.

Phosphoglycerate and pyruvate

BIOCHEM EXAMINATION PART 1 kinase
D. Pyruvate kinase
1. Control enzyme(s) of the citric acid
cycle: 6. Vitamin(s) that act as coenzyme(s) in
the citric acid cycle:
A. Succinate thiokinase
B. Isocitrate dehydrogenase and A. Vit B5 and B2
citrate synthase B. Pyridoxine
C. Isocitrate dehydrogenase C. Panthothenic acid
D. Citrate synthase D. Riboflavin

2. If the energy requirement of the cell 7. Entry points of amino acids

is high: undergoing gluconeogenesis:

A. AMP level is high A. Acetyl-coA

B. PEPCK is stimulated B. Dihydroxyacetone phosphate
C. ATP/ADP ratio is high C. Alpha-ketoglutarate
D. PEPCK is activated D. Phosphoenolpyruvate

3. True of the rate limiting enzyme of 8. True regarding glycogenesis and

glycolysis: glycogenolysis:

A. It is activated by fructose-2,6 A. Glucose is added to the glycogen

biphosphate primer in the form of D-glucose
B. It is reversed by glucose-6- B. Insulin promotes glycogenesis by
phosphatase stimulating glycogen synthase
C. It is stimulated by glucagon C. Insulin prevents glycogenesis by
D. All items are correct stimulating glycogen synthase
D. Glucagon inhibits liver
4. Glucose-6-phosphate is an glycogenolysis by stimulating
intermediate in the following phosphorylase
pathways:
9. What are the major end-products of
A. Uronic acid pathway lipolysis of a triacylglycerol in the
B. Glycogenolysis adipose tissue?
C. All items are included
D. Gluconeogenesis A. 2-monoacylglycerol + 2 fatty
acids
5. Enzyme/s catalysing substrate level B. 1-monoacylglycerol +
of phosphorylation in the cytosol: diacylglycerol
C. 1-monoacylglycerol + 2-
A. Phosphoglycerate kinase monoacylglycerol
B. Succinate thiokinase D. 3 fatty acids + glycerol
10. Which of the following hormones 15. The committed step in cholesterol
inhibits lipolysis? synthesis results in the formation of:

A. Thyroxine A. Mevalonate
B. Insulin B. Isopentenyl pyrophosphate
C. Growth hormone C. Squalene
D. Cortisol D. Lanosterol

11. The committed step in 16. The steroid ring is produced when
extramitochondrial lipogenesis this intermediate metabolite is
involves the formation of: formed during cholesterol synthesis:

A. Malonyl CoA A. Squalene

B. Proprionyl CoA B. Zymosterol
C. Acetyl CoA C. 7-dehydrocholesterol
D. Succinyl CoA D. Lanosterol

12. What fatty acid is produced in 17. HMG-CoA reductase is inhibited by

extramitochondrial lipogenesis? this hypocholesterolemic agent:

A. Oleic acid A. Simvastatin

B. Palmitoleic acid B. Cholestyramine
C. Stearic acid C. Orlistat
D. Palmitic acid D. Nicotinamide

13. Which of the following is the 18. Which of these lipoproteins is

product of the action of involved in the reverse transport of
lipoxygenase? cholesterol?

A. Leukotriene A. LDL
B. Thromboxane B. VLDL
C. Prostaglandin C. Chylomicron
D. Prostacyclin D. HDL

14. Which of these is the substance of 19. This lipoprotein mobilizes the
cyclooxygenase that results in the triacylglycerols produced in hepatic
formation of series 2 cells thereby preventing the
prostaglandins? development of fatty liver:

A. Cervonic acid A. LDL

B. Palmitoleic acid B. Chylomicron
C. Arachidonic acid C. HDL
D. Timnodonic acid D. VLDL
 A. Phospholipase D
20. What is the cause of familial B. Phospholipase A2
hypercholesterolemia? C. Phospholipase C
D. Phospholipase B
A. Deficiency of LDL receptor
B. Increased activity of 25. This is the most important lipolytic
oxidoxyclase enzyme in the digestive tract
C. Excess lipoprotein(a) deficiency of which will cause
D. Overactivity of HMG-CoA steatorrhea:
reductase
A. Pancreatic lipase
21. Beta-oxidation of fatty acid is B. Lingual lipase
primarilu regulated at the level of C. Hepatic lipase
this enzyme: D. Gastric lipase

A. Hepatic lipase
B. Thiokinase
C. Phospholipase B
D. Fatty acyl-carnitine translocase

22. Which of the following enzymes

catalyzes the conversion of
cholesterol to cholic acid?

A. 19-beta hydroxylase
B. 17-alpha hydroxylase
C. 7-alpha hydroxylase
D. 9-beta hydroxylase

23. Which of these steps in beta

oxidation is rate-limiting?

A. Activation of free fatty acid to

fatty acyl CoA
B. Carnitine transport of the fatty
acid
C. Thiolytic cleavage of ketoacyl
CoA
D. Oxidation of fatty acyl CoA

24. Which of the following

phospholipases is inhibited by
steroid drugs?