EBME 306: Introduction to Biomaterials – Fall 2020

CLASS SCHEDULE: Remote Asynchronous (pre-recorded lectures posted on

Canvas for access ANY TIME).

ADDITIONALLY: Remote LIVE Discussion Day (hosted by Faculty Instructor) once

weekly and LIVE Recitation Hour (Hosted by TAs) once weekly via ZOOM. These
LIVE sessions will also be recorded for ‘remote asynchronous’ access.

Course Description: Applications of biomaterials in different tissue and organ

systems. Relationship between physical and chemical structure of materials, resultant
engineering properties and biological system response. Choosing, fabricating and
modifying materials for specific biomedical applications.

Course Pre-Requisites: ENGR 145, EBME 201 and EBME 202 or instructor
permission

Biomaterials (NIH definition): Any material, natural or synthetic or a combination

thereof, which can be used for any period of time, as a whole or as a part of a biological
system which treats, augments, or replaces any tissue, organ, or function of the system.

Course Outcomes:
1. Recognize how the core concept of structure-function relationship is used in
designing and analyzing the behavior of biomaterials. (This helps fulfill ABET
outcome c “An ability to design a system, component, or process to meet desired
needs.”)

2. Recognize that the variety of available polymers is used when taking a modular
approach to the design, synthesis and behavior of biomaterials. (This also helps
fulfill ABET outcome c.)

3. Gain an ability to identify and apply fundamental concepts of physiology, chemistry,

mechanics, and materials science in biomaterials engineering. (This helps fulfill
ABET outcome a, “An ability to apply knowledge of mathematics, science, and
engineering.)

Textbooks:
 Biomaterials: The Intersection of Biology and Materials Science 2008, J.S.
Temenoff and A.G. Mikos, Pearson/Prentice Hall –REQUIRED READING.

Additional Reference Textbooks (if needed we will provide chapter PDFs):

 Biomaterials Science: An Introduction to Materials in Medicine, Edited by
Ratner, Hoffman, Schoen, and Lemons, Elsevier Academic Press, 2004 or newer
editions.

 Biomaterial Science and Biocompatibility, by Silver, FH and Christiansen DL,

Springer-Verlag, New York, 1999
 EBME 306: Introduction to Biomaterials – Fall 2020

 Introduction to Biomedical Engineering, Ed. John Enderle, Susan Blanchard,

Joseph Bronzino, Academic Press, New York, 2000

Important Changes for Fall 2020 Logistics in COVID-19 Framework:

 No Labor Day Holiday on September 7 (instead Nov 25 designated as holiday)
 No Fall Break days on October 19 and 20 (instead moved to Nov 23 and 24)
 BMES Conference is Virtual from Oct 14-17
 Last Day of ‘on-campus’ classes (does not apply to EBME 306) is Nov 20
 No classes (in person or remote) during Thanksgiving Week (Nov 23-27)
 Remote classes can continue Nov 30-Dec 4 (Final Week)
 All Final Exams (and/or Projects) will be conducted REMOTELY

Important Changes in EBME 306 under Fall 2020 Logistics described above:
 No weekly quizzes
 Additional home work (done as groups) and reading assignments
 Three (3) Midterm Exams (done as individual) conducted REMOTELY
 A Project Assignment (done in groups) progressively due every third week
 No FINAL EXAM: Instead the Project Assignment builds into FINAL PROJECT

Discussion Sessions (hosted by instructor): Highlighted in GREEN on next page

These will be every Friday at class hour 2:15-3:05 PM EDT on most weeks. These will
be conducted via ZOOM. Attendance in these is not mandatory but HIGHLY
RECOMMENDED.

Recitation and Review Sessions (hosted by TAs):

Held by TAs REMOTELY via ZOOM at a time once weekly. The time will be determined
through student polling after the start of the course. These are Q/A and discussion
sessions. TA’s will not be preparing Questions or Discussion topics; the discussions
should be initiated by students. TA’s do not know what will be on the exams and so do
not focus discussions in that direction. Before each exam one recitation/review hour will
be hosted the instructor(s) to summarize content (and answer any pending questions).

Recorded Lectures: Please access the EBME 306 Canvas Page to find pre-recorded
lectures for various topics relevant to the syllabus. These lectures are pre-recorded in
2019 and 2018 and you will have access to these at all times. Additional content will be
Reading Sections from the Required Textbook, as well as PDF documents posted.

Academic Integrity Policy: All students in this course are expected to adhere to
University standards of academic integrity. Cheating, plagiarism, misrepresentation, and
other forms of academic dishonesty will not be tolerated. This includes, but is not limited
to, consulting with another person during an exam, turning in written work that was
prepared by someone other than you, making minor modifications to the work of
someone else and turning it in as your own, or engaging in misrepresentation in seeking
a postponement or extension. Ignorance will not be accepted as an excuse. If you are
not sure whether something you plan to submit would be considered either cheating or
 EBME 306: Introduction to Biomaterials – Fall 2020

plagiarism, it is your responsibility to ask for clarification.  For complete information,

please go to http://bulletin.case.edu/undergraduatestudies/academicintegrity/
 
Disability Resources: ESS Disability Resources is committed to assisting all CWRU
students with disabilities by creating opportunities to take full advantage of the
University's educational, academic, and residential programs.  For further information,
please go to https://students.case.edu/academic/disability/
For students who have registered with the disability services, you will receive individual
emails from Sen Gupta, Shoffstall and TAs regarding your LIVE Midterm logistics.

How to watch Pre-recorded Lectures of Canvas

 Log into CANVAS and make sure you have access to EBME 306 (if you don’t email
Dr. Sen Gupta at axs262@case.edu and Dr. Shoffstall at ajs215@case.edu
immediately)
 On the list of Tabs to the left of your page click ‘Modules’ – this should open up
Weekly Modules of course content activated for your access. Here you will find
Powerpoint Files relevant to that module, pre-recorded lectures (from 2019 and in
some cases 2018) relevant to that module, as well as recommended Textbook chapter
sections that are relevant to that module. If you don’t have access, email Sen
Gupta/Shoffstall.

How to keep track of assignments and projects:

 Log into CANVAS and make sure you have access to EBME 306 (if you don’t email
Dr. Sen Gupta at axs262@case.edu and Dr. Shoffstall at ajs215@case.edu
immediately)
 On the list of Tabs to the left of your page click ‘Assignments’ – this should open up
list of Project dates, Home Work due dates and Midterm dates. Content for each of
these assignments will be updated accordingly as we move through the semester.

 
Aug ASG 24 Introductions, course overview, Biomaterials Device Failure, ZOOM
Core Concepts of Biomaterials LIVE
Additional assignment: Watch Aug 28, 2019 lecture on
Canvas Echo 360
NPZ 26 Watch “Aug 30” lecture on Canvas Echo 360 REMOTE
Reference Material: Ziats Lectures 1-3 PPT files on Canvas
NPZ 28 Pre-watch “Sep 4” & “Sep 6” Lecture on Canvas Echo 360 ZOOM
Biocompatibility and Bioanalysis Discussion of lecture content LIVE
NPZ 31 Biocompatibility and Bioanalysis (continue watching pre-
recorded lectures): “Sep 9” Lecture on Echo 360
 EBME 306: Introduction to Biomaterials – Fall 2020

GROUPS FINALIZED BY THIS DAY

Sep NPZ 2 Biocompatibility and Bioanalysis (continue watching pre-
recorded lectures): “Sep 11” Lecture on Echo 360
PROJECTS INITIATED BY THIS DAY
NPZ 4 Biological Constraints in using Biomaterials: ZOOM
Pre-watch “Sep 14” lecture on Echo 360 LIVE
Understanding the ‘Bio’ of Biomaterials I – Inflammation
Reference Material: Ziats Lectures 4-6 PPT files on Canvas
NPZ 7 Biological Constraints in using Biomaterials:
Watch “Sep 17” lecture on Echo 360
Understanding ‘Bio’ of Biomaterials I – Inflammation (Contd)
HOME WORK 1 POSTED BY THIS DAY
NPZ 9 Biological Constraints in using Biomaterials:
Understanding the ‘Bio’ of Biomaterials II – Immunology and
Infection Immunology/Infection (contd)
Watch “Sep 17” lecture on Echo 360
PROJECT REPORT 1 DUE BY THIS DAY
NPZ 11 Biological Constraints in using Biomaterials: ZOOM
Pre-watch “Sep 21” lecture on Echo 360 LIVE
Understanding the ‘Bio’ of Biomaterials II – Immunology and
Infection Immunology/Infection (contd)
NPZ 14 Biological Constraints in using Biomaterials:
Watch “Sep 24” lecture on Echo 360 Understanding the ‘Bio’
of Biomaterials II – Immunology and Infection (contd)
NPZ 16 Biological Constraints in using Biomaterials:
Watch “Sep 26” lecture on Echo 360
Understanding the ‘Bio’ of Biomaterials II – Immunology and
Infection (contd)
NPZ 18 Pre-Watch “Sep 28” lecture on Echo ZOOM
Review Discussion of Biocompatibility, Inflammation, Immune LIVE
Response, Infection in the context of Biomaterials
Applications;
Emphasize Translational Value of these ‘BIO’characteristics
HOME WORK 1 DUE
HOME WORK 2 POSTED BY THIS DAY
 EBME 306: Introduction to Biomaterials – Fall 2020

VIDEO DATES POSTED BELOW THIS LINE ARE

SUBJECT TO CHANGE: PLEASE REFER TO
CANVAS:MODULES FOR THE MOST ACCURATE
REFLECTION OF VIDEO LINKS.

NPZ 21 Biological Constraints in using Biomaterials:

Watch Sep 23, 2019 lecture on Echo 360
Understanding the ‘Bio’ of Biomaterials III – Hemostasis,
Thrombosis, Blood Compatibility
Reference Material: Ziats Lectures 7-9 PPT files on Canvas
PROJECT REPORT 2 DUE BY THIS DAY
NPZ 23 Biological Constraints in using Biomaterials:
Watch Sep 23, 2019 and Sep 25, 2019 lecture on Echo 360
Understanding the ‘Bio’ of Biomaterials III – Hemostasis,
Thrombosis, Blood Compatibility
Intro to Cardiovascular Devices: Grafts, LVAD, ECMO, Others
NPZ 25 Biological Constraints in using Biomaterials: ZOOM
Pre-watch Sep 23, 25, and 27, 2019 lecture on Echo 360 LIVE
Understanding the ‘Bio’ of Biomaterials III – Hemostasis,
Thrombosis, Blood Compatibility
Wrap up blood compatibility and cardiovascular devices
Re-emphasize Regulatory components in Translation
HOME WORK 2 DUE
HOME WORK 3 POSTED BY THIS DAY
AJS 28 Nature Inspired Materials, Biomimicry, Examples in Devices
and Research (natural, synthetic and semi-synthetic)
Watch Sep 30, 2019 lecture on Echo 360
AJS 30 Understanding the “Materials” aspect of Biomaterials:
Natural vs. Synthetic Materials, Hierarchical Scale: Atoms to
Bulk (Nano-to-Macro), Connection to Structure-Property-
Function correlations
Watch Oct 2, 2019 lecture on Echo 360
 EBME 306: Introduction to Biomaterials – Fall 2020

Oct AJS 2 Pre-watch Oct 4, 2019 lecture on Echo 360 ZOOM

Reactivity, bonds, functional groups, analysis and tools, LIVE
examples of structure-property correlations across scales
Discussions on content covered in Sep 28-Oct 2 period
PROJECT REPORT 3 DUE BY THIS DAY
ASG 5 Polymer Basics: Synthesis Methods, Nomenclature, MW
Watch Oct 11, 2019 lecture on Echo 360
HOME WORK 3 DUE
HOME WORK 4 POSTED BY THIS DAY
ASG 7 Polymer Configuration, Conformation, Tacticity, Crystallinity
Watch Oct 11 and Oct 14, 2019 lecture on Echo 360
NPZ 9 Ziats and TAs hold Review Session for Midterm 1 ZOOM
(Content Aug 24 – Sep 25) LIVE
TAs 12 Midterm 1 (Content Aug 24 – Sep 25)
ASG 14 Polymer Properties, Characterization and Structure-Property
Correlation, Thermal Properties, Mechanical Properties
Watch Oct 23 and Oct 25, 2019 lecture on Echo 360
ASG 16 Polymer mechanical properties (contd.) ZOOM
Polymer degradation and Biodegradation LIVE
Pre-watch Oct 28, 2019 lecture on Echo 360
Discussions on content covered in Oct 5,7,14,16
ASG 19 Polymer degradation and Biodegradation
Watch Oct 28, Oct 30 2019 lecture on Echo 360
HOME WORK 4 DUE
ASG 21 Polymer Hydrogels primer
Biomaterials in Drug Delivery primer
Watch Oct 30, Nov 1, 2019 lecture on Echo 360
ASG 23 Biomaterials in Drug Delivery and Nanomedicine ZOOM
Pre-watch Nov 1, Nov 4, Nov 25, 2019 lecture on Echo 360 LIVE
Discussions on content covered Oct 19,21,23
HOME WORK 5 POSTED BY THIS DAY
PROJECT REPORT 4 DUE BY THIS DAY
AJS 26 Protein-Biomaterial interactions (pros and cons)
Watch Nov 8, 2019 lecture on Canvas Echo 360
Inflammation in the Central Nervous System
AJS 28 Cell-Biomaterial Interactions (pros and cons)
 EBME 306: Introduction to Biomaterials – Fall 2020

Watch Nov 8 and Nov 18, 2019 lecture on Echo 360

ASG 30 Sen Gupta and TAs hold Review Session for Midterm 2 ZOOM
(Content Sep 28 - Oct 28) LIVE
Nov TAs 2 MIDTERM 2 (Content Sep 28 - Oct 28)
AJS 4 Inflammation in the Central Nervous System
Watch Nov 18, Nov 20, 2019 lectures on Echo 360
HOME WORK 5 DUE
HOME WORK 6 POSTED BY THIS DAY
AJS 6 Biomedical Devices and Biomaterials in Neural Interfacing: I ZOOM
Applications, Physiology, Materials Response LIVE
Continue Pre-watching Nov 20, 2019 lecture on Echo 360
Discussions connecting protein and cell interactions on
surfaces to electrode-induced neuroinflammation pathology
AJS 9 Biomedical Devices and Biomaterials in Neural Interfacing: II
CNS Specific Biomaterial Design Strategies
Watch Nov 20, Nov 22, 2019 lectures on Echo 360
AJS 11 Biomedical Devices and Biomaterials in Neural Interfacing: II
CNS Specific Biomaterial Design Strategies
Continue watching Nov 22, 2019 lectures on Echo 360
AJS 13 Discussions on content covered in Nov 9, 11 ZOOM
HOME WORK 6 DUE LIVE
ASG 16 Bone physiology
Biomaterials in Orthopedic Applications
Pre-recorded lecture will be posted on Canvas
ASG 18 Bone physiology
Biomaterials in Orthopedic Applications
Pre-recorded lecture will be posted on Canvas
ASG 20 Biomaterials in Tissue Engg and Regenerative Med primer ZOOM
Pre-watch Nov 11, 2019 on Canvas Echo 360 LIVE
Discussions on content covered in Nov 16, 18, 20 period
PROJECT REPORT 5 DUE BY THIS DAY
23 No Class: Thanksgiving Week starts
24 No Class: Thanksgiving Week
27 No Class: Thanksgiving Week
 EBME 306: Introduction to Biomaterials – Fall 2020

ASG 30 Sen Gupta, Shoffstall and TAs hold Review Session for ZOOM
AJS Midterm 3 LIVE
Dec 2 Midterm 3 (Content Nov 4 - Nov 20)
ASG 4 Concluding Overview ZOOM
Last Day of Class LIVE

FINAL PROJECT DUE: Dec 14, 2020

 EBME 306: Introduction to Biomaterials – Fall 2020

Groups: Home works and Projects are to be worked on in groups of students. Usual
group contains 3-4 students. Students will be asked to form their own groups within the
first week of class and send the group member information to the lead TA. Students
who will not send this information by the first week of class will be assigned groups by
the Prof. Sen Gupta. Each group will be assigned a group leader who will be
responsible for communication with the instructor(s) and TAs, and for turning in
assignments.

Homeworks:
Homeworks are to be submitted by MIDNIGHT on Due Date via onine submission link
on Canvas (TAs will send detailed instructions for this). Late submissions will not be
accepted. Groups are encouraged to work together on these homeworks. One
compiled PDF Format answer document should be submitted from each group, with a
Face Page containing Member names and corresponding signatures. Members of each
group should also evaluate each other in terms of percent contribution, using a face
page attached onto the answer. The face page will contain names of all students,
percent contribution and signature of each student beside his/her percent contribution.
Unless there are disputes regarding percent contribution among the members of a
group, credit is distributed evenly across all students who have signed the assignment.
Lack of your signature on the cover page of the assignment will result in a zero grade
for that student. Students cannot be included on the homeworks of groups other than
their own. It is each group’s responsibility to make sure the homework gets turned in by
the deadline.

Exams:
There will be total 3 Midterm exams during the semester, conducted LIVE online (unless
you are a student not in the American continent). Students take these Midterms
individually and not as a group. Each midterm will cover primarily the material from 10-
12 lectures, with a moderate integration of knowledge from previous areas. The
integration is focused at elucidating the synergistic components of each area.

Projects:
Projects are to be submitted by MIDNIGHT on Due Date via onine submission link on
Canvas (TAs will send detailed instructions for this). Late submissions will not be
accepted. Groups are encouraged to work together on these Projects. The projects will
be of ‘adaptive/progressive’ nature where the ‘project idea’ builds up over Project 1,
Project 2, Project 3 and so on over time. One compiled PDF Format ‘Project Report’
document should be submitted from each group, with a Face Page containing Member
names and corresponding signatures. Members of each group should also evaluate
each other in terms of percent contribution, using a face page attached onto the answer.
The face page will contain names of all students, percent contribution and signature of
each student beside his/her percent contribution. Unless there are disputes regarding
percent contribution among the members of a group, credit is distributed evenly across
all students who have signed the assignment. Lack of your signature on the cover page
of the assignment will result in a zero grade for that student. Students cannot be
 EBME 306: Introduction to Biomaterials – Fall 2020

included on the projects of groups other than their own. It is each group’s responsibility
to make sure the Project Report gets turned in by the deadline.

Final Project:
The ‘Final Exam’ of the course is a ‘Final Project Report’ which will be the conclusive
and cumulative report of all the information that you will collect from Project 1 onwards.
Specifics and Format of the report will be provided in due time.

Canvas:
Grades, course documents, and supplemental material will be available on the course's
Canvas site. Please notify Prof. Sen Gupta and Prof. Shoffstall if you are unable to gain
access.

TA Responsibilities

 Student polling to form groups (with group leader named)

 Student polling to form weekly recitation hour time and then host this hour
 Setting up and conducting LIVE Midterm exams
 Collecting MIDTERM exam answer documents and provide to the Graders
 Setting up HOMEWORK submission links that get inactivated by 12 midnight on
specific deadlines
 Setting up PROJECT submission links that get inactivated by 12 midnight on
specific deadlines
 Collecting HOMEWORK and PROJECT documents to provide to the Graders
 Collect FINAL PROJECT document by Dec 14 deadline and assist in final
grading
 Collate all grades in Master Sheet and coordinate with instructors on Final
Grading (including statistical analysis of cut-off zones)

Grader Responsibilities
 Grade Midterms exams, Homeworks and Project reports (including Final Report)
 Assist TAs in collating and compiling Master Sheet of points and grade
breakdown

Breakdown of Grade Percentage:

 3 Midterm Exams: 12% each = 36%
 Home Work Assignments: 4% each = 24%
 Project Assignments: 5% each = 25%
 Final Project = 15%
 EBME 306: Introduction to Biomaterials – Fall 2020

EBME 306: Introduction to Biomaterials

I. What is a Biomaterial?

A material that interfaces or integrates with living tissue to maintain, augment, restore or treat
cell/tissue/organ function.

Crutch: Not a biomaterial device (no interface interaction or integration)

Artificial limb with direct bone attachment: Is a biomaterial

II. Why do we have a core biomaterials class?

A. Understanding ‘structure-property-function’ correlation in biomedical materials is the

primary learning objective for this class

B. Understanding the correlation leads to better understanding the application of specific

materials in specific biomaterials devices and also the rationale behind developing newer
materials tailored to unique biomedical applications.

Metals and Ceramics: hard tissue applications

Polymers: soft tissue applications
Composites: fine tune and tailor properties to have combined benefits

C. Please keep in mind

1. Engineering is not philosophy, entertainment or education

2. End goal is always to manipulate material to solve a problem

3. BME core designed to give breadth within BME

D. Special considerations for biomaterials

a. Variable service life (few minutes - 100 years)

b. Exposure to complex body fluid and physiological environment
(variable pH, variable salt concentrations, proteins, immune cells, vascular
cells,
specific tissue cells)
c. Exposure to complex cyclic mechanical loading in certain cases
d. Native materials in environment all built bottom-up (how do we mimic nature?)
e. Physiologic systems not very tolerant to perturbation (injury, immune response,
inflammation, infection)

Ideal Biomaterial should have specific structure (atomic/molecular/macro) that leads to certain
properties (nano/micro/macro) useful for performing a biological/biomedical function while
 EBME 306: Introduction to Biomaterials – Fall 2020

maintaining non-toxicity, non-carcinogenicity, no infection and minimal immunogenicity =

Biocompatibility
Biomaterials faculty at Case BME:
 Horst von Recum: stem cells, vascular TE, drug delivery
 Steve Eppell: orthopedic TE, nanomaterials
 Hari Baskaran: vascular TE, skin TE, biotransport
 Anirban Sen Gupta: nanomaterials, drug delivery, blood-material interfaces
 Z-R Lu: molecular imaging
 Jeff Capadona: Neural Interfaces
 Agata Exner: Image-guided Drug Delivery
 Stathis Karathanasis: Nanomedicine in Imaging
 Sam Senyo: Tissue models, Molecular Spectroscopy
 Andrew Shoffstall: Neural interface, drug delivery, inflammation

Multiple faculty at Macro, Chemistry, Chemical Engg, Mechanical Engg, Case SOM, CCF,
Metro and VA are involved in collaborative biomaterials research with primary faculty

If you want to know about biomaterials work done by faculty at Case as well as other
institutions, share your own research with your peers, find career opportunities in the
biomaterials areas and network with researchers and industry nationally and globally,
become a member of Society for Biomaterials. For details, contact Dr. Anirban Sen
Gupta: axs262@case.edu.