Echevarria Jonille S.

BS-Pharmacy 2

November 03, 2020

1. Comment in House M.D. “Hunting”

It is a good episode and Its helps to learn more about HIV and aids how to treat or diagnose
when a person have AIDS.

2. Pathogenesis of Echinococcosis

Echinococcus granulosus infections often remain asymptomatic for years before the cysts grow
large enough to cause symptoms in the affected organs. The rate at which symptoms appear
typically depends on the location of the cyst. Hepatic and pulmonary signs/symptoms are the
most common clinical manifestations, as these are the most common sites for cysts to develop In
addition to the liver and lungs, other organs (spleen, kidneys, heart, bone, and central nervous
system, including the brain and eyes) can also be involved, with resulting symptoms. Rupture of
the cysts can produce a host reaction manifesting as fever, urticaria, eosinophilia, and potentially
anaphylactic shock; rupture of the cyst may also lead to cyst dissemination.

Echinococcus multilocularis affects the liver as a slow growing, destructive tumor, often with
abdominal pain and biliary obstruction being the only manifestations evident in early infection.
This may be misdiagnosed as liver cancer. Rarely, metastatic lesions into the lungs, spleen, and
brain occur. Untreated infections have a high fatality rate.

Echinococcus vogeli affects mainly the liver, where it acts as a slow growing tumor; secondary
cystic development is common. 

3. Treatment for Echinococcosis

In the episode of House M.D. “Hunting” Father and son go into surgery and have the cysts and
parasites removed. 

Surgery remains the most effective treatment to remove the cyst and can lead to a complete cure.

4. Comment on the characters of the House M.D. “Hunting”

Cameron amazed me as she clearly determined to keep on working despite after a patient spewed
blood into her face for the possibility of having HIV.

5. What I have learned from this activity

I have learned new disease “Echinococcosis”

1. Comment in House M.D. “The Mistake”

The relationship between doctors-patients is very important as Kayla wanted to ask Dr. Chase
about something but changes her mind at last minute, and Chase didn’t ask her and just assumed
it was acid reflux or upset stomach from the prednisone causes a mistake at the end.

2. Pathogenesis of Behcet’s disease

In this episode, the patient had Behcet’s disease, perforated ulcer, sepsis, liver failure and
hematoma.

Behçet’s disease (BD) is an inflammatory disorder of unknown aetiology characterised by

recurrent attacks affecting the mucocutaneous tissues, eyes, joints, blood vessels, brain and
gastrointestinal tract. It is a multifactorial disease classified as a variable vessel vasculitis, and
several environmental triggers may induce inflammatory episodes in genetically susceptible
individuals. BD has several autoinflammatory features including recurrent self-limited clinical
manifestations overlapping with monogenic autoinflammatory disorders, significant host
predisposition and abnormally increased inflammatory response, with a robust innate component.
Human leukocyte antigen (HLA)-B*51 is the strongest susceptibility factor described so far
affecting the disease risk and typical phenotype. Non-HLA genetic associations such as
endoplasmic reticulum aminopeptidase 1 (ERAP1), interleukin 23 receptor (IL23R) and IL10
variations suggest that BD shares susceptibility genes and inflammatory pathways with
spondyloarthritis. Although genomewide association studies revealed an increased risk
associated with recessively inherited ERAP1 variations in HLA-B*51 positive patients, it is not
clear yet whether certain peptide-HLA allele combinations result in an adaptive response by a
self-antigen-directed cytotoxic response or an innate response by modulating an NK cell activity
or causing an unfolded protein response. Understanding of major histocompatibility complex
(MHC) Class I-driven inflammatory response is expected to provide insights for the development
of better treatment and remission-induction options in BD as well as in ankylosing spondylitis
(AS) and psoriasis.

3. Treatment for Behcet’s disease

In the Episode “The mistake” Dr. Chase gave Prednisone to Kayla.

It is Corticosteroids; prednisone, It is used to reduce the inflammation caused by Behcet's
disease.

4. Comment on the characters of the House M.D. “The mistake”

I felt sad for Dr. Chase were depressed and distracted on his father’s death, and made a mistake
so that he sued for malpractice over the sister's death.

The brother of the patient also made a mistake on lying about his undiagnosed hepatoma that was
transplanted with his liver as he eagerly want to help his sister which is the proximate cause of
her cancer.

5. What I have learned from this activity

I have learned how to see someone cope with their problems in life, Kyla being grateful even
though she knew that she’ll die, patient is satisfied she got three more months and saved her
brother’s life.