Cellular Reprogramming via Co-culture Bioreactor

Contact:
Lisa Lyu
Licensing Manager
848-932-4539
lisa.lyu@rutgers.edu

Inventors:
Biju Parekkadan

Rutgers ID:
2018-056

Invention Summary:  Market Applications:
Reprogrammed cell manufacturing
Co-culture systems are a popular method for engineering Immune cell therapy
complex multicellular systems. Specifically, for cell Genetically engineered cell therapy
therapy, where one cell population can help differentiate Research tool
another therapeutic cell population. Current co-culture
Advantages:
methods have shown benefits, though there still remains
a need for a scalable, integrated system that can maintain Ex vivo cell differentiation
cell viability and phenotype with downstream ease of Industrial scale-up
purification of differentiated therapeutic cells.  Suitable for use at bedside
Simple cell recovery and purification
Dynamic co-culture with adjustable exposure times
Researchers at Rutgers University developed a scalable
hollow-fiber bioreactor system for co-culturing two cell Intellectual Property & Development Status: 
types in a continuous flow system separated by
membranes permeable to secreted factors, vectors, and Patent pending. Available for licensing and/or research
exosomes. As opposed to static culture, the current collaboration.
bioreactor system allows therapeutic cells to be exposed
to the microenvironment defined by soluble factors
secreted from stimulator cells by flowing through the
bioreactor system. Therapeutic cells can be
subsequently recovered and purified after co-culture. 
This system has been applied for the manufacturing of
immune cell therapeutics and is suitable for use point-of-
care at clinical locations.

Direct Link:
http://techfinder.rutgers.edu/tech/Cellular_Reprogramming_via_Co-culture_Bioreactor