Mechanism of Indications and Contraindications Side effects Nursing Responsibilities

Action rationale

Generic name: Cross-links Acute lymphocytic There are no There are no side 1. Monitor CBC, renal function, and
Cyclophosphamide strands of leukemia contraindications effects seen on the LFT results.
cellular DNA found in the patient. patient. 2. Monitor for renal, pulmonary, and
Brand name: and interferes cardiac toxicity.
Cytoxan with RNA 3. Warn patient that hair loss may
transcription, occur.
Classification: causing an 4. Advise patient to report all adverse
Antineoplastics imbalance of reactions.
growth that 5. Monitor temperature.
Dose: leads to cell 6. Adequately hydrate the patient
300mg/㎡ in 250mL death. Not before and after dose.
of NS specific to cell 7. Monitor the patient’s response to
cycle. the therapy
Frequency:
OD, Day 1-3, Cycle
A

Route:
IV

Mechanism of Indications and Contraindications Side effects Nursing Responsibilities

Action rationale

Generic name: Arrests mitosis Acute lymphocytic There are no There are no side 1. Monitor for extravasation.
Vincristine in metaphase, leukemia contraindications effects seen on the 2. Monitor for neurotoxicity,
blocking cell found in the patient. patient. hyperuricemia, fluid intake and
Brand name: division. output, and bowel function.
Oncovin 3. Monitor for Achilles tendon reflex
depression, numbness, tingling,
Classification: footdop, wrist drop, difficulty
Antineoplastics walking, ataxia, and slapping gait.
4. Maintain hydration and provide
Dose: allopurinol.
2mg 5. Provide safety.
6. LASA: don’t confuse Vincristine with
Frequency: Vinblastine or Vinorelbine.
OD, Day 4 and Day 7. Monitor the patient’s response to
11, Cycle A the therapy

Route:
IV

Mechanism of Indications and Contraindications Side effects Nursing Responsibilities

Action rationale

Generic name: Interferes with Acute lymphocytic There are no Orange to red 1. Monitor cardiotoxicity.
Doxorubicin DNA-dependent leukemia contraindications colored urine 2. Advise patient to report pain or
RNA synthesis found in the patient. burning at injection site during or
Brand name: by intercalation. after administration.
Adriamycin 3. Perform cardiac function studies,
including ECG and LVEF, before
Classification: treatment and then periodically
Antineoplastic throughout therapy.
4. Ensure hydration before starting
Dose: therapy.
50mg/㎡ 5. Immediately wash with soap and
water if contact with skin or mucosa
Frequency: occurs.
Day 4, Cycle A 6. Inform patient that hair loss may
occur.
Route: 7. LASA: don’t confuse doxorubicin
IV with doxorubicin liposomal,
daunorubicin, or idarubicin.
 8. Monitor the patient’s response to
the therapy

Mechanism of Indications and Contraindications Side effects Nursing Responsibilities

Action rationale

Generic name: Decreases immunosuppressa There are no There are no side 1. Monitor BP, weight, glucose levels,
Dexamethasone inflammation; nt contraindications effects seen on the and electrolyte levels.
mainly by found in the patient. patient. 2. Inspect skin for petechiae.
Brand name: stabilizing 3. Instruct to take the medication with
Decadron leukocyte food or milk.
lysosomal 4. LASA: don’t confuse
Classification: membranes; dexamethasone with
Corticosteroids suppresses desoximetasone.
immune
Dose: response.
40mg

Frequency:
OD, Days 1-4 and
11-14, Cycle A

Route:
IV; PO