CAIRAN ANTIBIOTIK

 KOLOID  PENICILLINS : Inhiibit cell wall synthesis

Hight Molecular, menjaga tekanan onkotik plasma Backtericidal: block cross linking via inhibit transpeptide enzyme.
Disebut juga cairan pengganti plasma.
Lebih efektif & efisien mengembalikan volume plasma. Class Drug Indication
Penicilin - Penicilin G - Strep. Pyogenes
Sebagian besar bertahan diplasma.
- Aqueous Penicilin (Grp.A)
G - Step. Agalactiae
- Procain Pen. G (Grp.B)
- Benzathine Pen. G - C. perfringens
- Pen. V (Bacilli)
Aminopenicillins - Ampicilin - Above (+)
- Amoxicilin - Gram (-) ↑
- E. Faecalis
- E. Coli
Penicillinase- - Methicillin - Above (+)
resistant- - Naf [cillin] - PCNase-producing
penicillins - Oxa [cillin] - Staph. Aureus
- Cloxa [cillin]
- Dicloxa [cillin]
Antipseudomonal - Carbane [cillin] - Above (+)
Penicillins - Ticar [cillin] - Pseudomonas
- Pipera [cillin] aeruginosa
 KRISTALOID  CEPHALOSPORINS : Inhiibit cell wall synthesis
Low molecular Backtericidal: inhibit bacterial cell wall synthesis via inhibit
Paling banyak digunakan: Normal Saline & Ringer Laktat transpeptide enzyme.
Hanya ¼ yang bertahan dalam plasma pada akhir infus.
Class Drug Indication
Solution Tonici Na+ Cl- K+ Ca2+ Glucose Lactate 1st Gen - Cefazolin - Staph. Aureus
ty (mEq/L) (mEq/L) (mEq/L) (mEq/L) (g/L) (mEq/L)
- Cephalexin - Staph. Epidermalis
D5% in
water
Hipo
50 - Some Gram (-)
(253) - E. Coli
(D5W)
Normal - Klebsiella
Iso
Saline (308)
154 154 2nd Gen - Cefoxitin - Above (+)
(NaCl 0,9%) - Cefactor - Gram (-) ↑
D5% Iso - Cefuroxime
38,5 38,5 50
¼ NS (330)
3rd Gen - Ceftriaxone - Above (+)
Hipe
D3% - Cefotaxime - Gram (-) ↑
r 77 77 50
½ NS (407) - Ceftazidime - Pseudomonas
D5%
Hipe - Cefepime (4th Gen)
r 154 154 50 *MRSA: methicilin-resistent staphylococcus aureus. [biasanya
NS (561)
Iso resisten penicilin]
RL 130 109 4 3 28
(273) *Semua coccus gram (+) kecuali Neiserriaceae.
Hipe
D5% *Semua bacil gram (-) kecuali cornybacterium, listeria, bacillus &
r 130 109 4 3 50 28
RL (525) clostridium.
Sering digunakan: *saluran nafas bawah kebanyakan gram (+): Strep. Pneumoniae.
 OTHER : Inhiibit cell wall synthesis
Nama Na+ K+ Mg+ Cl- Laktat Glucose Kalori
Cairan (mEq/L) (mEq/L) (mEq/L) (mEq/L) (mEq/L) (g/L) (Kcal/L) Backtericidal.
Ringer
130 4 109 28 Class Drug Indication
Laktat
NaCl Vancomycin - Vancomycin - MRSA
154 154 (Bactericidal) - PCN/Ceph allegies
0,9%
Dextros - S. Aureus
27 108
e 5% - S. Epidermalis
B-Lactamase - Clavulanic Acid - S. Aureus
Inhibitor - Sulbactam - S. Epidermis
(Bactericidal) - Tazobactam - E. Coli
- Klebsiella
Carbapenems - Imipenem - Broad except MRSA,
(+ Cistatin) Mycoplasma
ANTIBIOTIK DAN CAIRAN - [1]
 - Meropenem 4th Gen - Maxifloxacin - Above (+)
- Doripenem - Gemifloxacin - Gram (+)
- Ertapenem - Anaerob (+)
Aztreonam - Aztreonam - Gram (-)  OTHER DNA INHIBITORS : DNA synthesis Inhibition
- Hospital-acquired
infection Class Drug Indication
Polymyxins - Polymixin B - Topical gram (-) Metronidazole - Metronidazole - Anaerob
- Polymixin E Infection (Bactericidal)
Bacitracin - Bacitracin - Topical gram (+)  FOLID ACID SYNTHESIS INHIBITORS

Class Drug Indication

 ANTI - 30S RIBOSOMAL SUBUNIT : Protein synthesis Inhibition Trimethroprim/ - Trimethoprim - UTI Organism
Backtericidal: inhibit bacterial cell wall synthesis via inhibit Solfonamides - Sulfametoxazole - Proteus
 transpeptide enzyme. (Bacteriostatik) (SMX) - Enterobacter
- Sulfisoxazole
Class Drug Indication
- Sulfadiazine
Aminoglikosida - Gentamicin - aerob gram (-)
Pyrimethamine - Pyrimethamine - Malaria
(Bactericidal) - Neomycin - Enterobacteriaceae
- T. Gondii
- Amikacin - Pseudomonas
- Tobramycin

- Streptomycin
Tetracyclines - Tetracycline - Rickettsia
(Bacteriostatic) - Doxycycline - Mycoplasma
- Minocycline - Spirochetes
- Demeclocycline (Lyme disease)
 ANTI - 50S RIBOSOMAL SUBUNIT : Protein synthesis Inhibition
Backtericidal: inhibit bacterial cell wall synthesis via inhibit
transpeptide enzyme.

Class Drug Indication

Makrolid - Erythromycin - Streptococcus
(Bacteriostatik) - Azithromycin - H. Influenza
- Clarithromycin - Mycoplasma
Pneumonia
Kloramfenikol - Cholramphenicol - H. Influenza
(Bacteriostatic) - Meningits bakterial
- Brain Abses
Linkosamide - Clindamycin - Bacteroides fragilis
(Bacteriostatic) - S. Aureus
- coagulase (-)
- Staph & Strep
- Excellent bone
Penetration
Linezolid - Linezolid - Resisten gram (+)
Streptogramins - Quinupristin - VRE
- Dalfopristin - GAS & S. aureus skin
infection
 FLUOROQUINOLONES : DNA synthesis Inhibitor
Backtericidal: inhibit DNA gyrase enzyme, inhibit DNA Synthesis

Class Drug Indication

1st Gen - Nalidixic acid - Streptococcous
- Mycoplasma
- Aerob gram (+)
2nd Gen - Ciprofloxaxin - Above (+)
- Norfloxacin - Pseudomonnas
- Enoxacin
- Ofloxacin
- Levofloxacin
3rd Gen - Gatifloxacin - Above (+)
- Gram (+)

ANTIBIOTIK DAN CAIRAN - [2]