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JOURNAL
JOURNAL REVIEW
REVIEW
Observational Study of
Hydroxychloroquine in Hospitalized
Patients with Covid-19
Joshua Geleris, M.D., Yifei Sun, Ph.D., Jonathan Platt, Ph.D., Jason Zucker, M.D., Matthew Baldwin, M.D., George Hripcsak, M.D.,
Angelena Labella, M.D., Daniel K. Manson, M.D., Christine Kubin, Pharm.D., R. Graham Barr, M.D., Dr.P.H., Magdalena E.
Sobieszczyk, M.D., M.P.H., and Neil W. Schluger, M.D.
Presented by:
Introduction
B a c k g r o u n d /
r a t i o n a l e
2.
s c i e n t i f i c
a n d
i n v e s t i g a t i o n
r e p o r t e d
STROBE CHECKLIST
Introduction
O b j e c t i v e s
3.
o b j e c t i v e s ,
a n py r e s p e c i f i e d
h y p o t h e s e s
STROBE CHECKLIST
Methods
S t u d y
4.
s t u d y
STROBE CHECKLIST
Methods
S e t t i n g
5
l o c a t i o n s ,
i n c l u d i n g
r e c r u i t m e n t , -
u p ,
STROBE CHECKLIST
Methods
P a r t i c i p a n t s
6
t h e
s e l e c t i o n
m e t h o d s -u p
P a r t i c i p a n t s
6b .
m a t c h i n g
e x p o s e d
STROBE CHECKLIST
Methods
V a r i a b l e s
7.
c o n f o u n d e r s ,
a p p l i c a b l e
STROBE CHECKLIST
Methods
D a t a
8.
s o u r c e s
m e t h o d s
(
c o m p a r a b i l i t y
m e t h o d s
g r o u p
STROBE CHECKLIST
Methods
B I A S S T U D Y
9. 1 .
p o t e n t i a l a r r i v e d
STROBE CHECKLIST
Methods
Q u a n t i t a t i v e
1.
v a r i a b l e s
a n a l y s e s .
w h i c h
w h y
STROBE CHECKLIST
Methods
S t a t i s t i c a l S t a t i s t i c a l S t a t i s t i c a l
1 1 B . 1 C .
m e t h o d s , e x a m in e a d d r e s s e d
c o n t r o l
STROBE CHECKLIST
Results
P a r t i c i p a n t s
1 A .
a t —e gn u m b e r s
p o t e n t i a l l y
e l i g i b i l i t y ,
i n c l u d e d
f o l l-uo pw, a n a l y s e d
1 B . -
p a r t i c i p a t i o n
STROBE CHECKLIST
Results
D e s c r i p t i v e
1
p a r t i c i p a n t s
1
w i t h
o f
STROBE CHECKLIST
Results
O U T C O M E
1 .
STROBE CHECKLIST
Results
M A I N M A I N M A I N
1 A . 1 B . 1
a p p l i c a b l e , -a d j u s t e d b o u n d a r i e s t r a n s l a t i n g
e s t im a t e s e ,g9 % v a r i a b l e s r e l a t i v e
c o n f id e n c e
w h ic h r i s k
a n d p e r i o d
STROBE CHECKLIST
Results
O t h e r
1 .
a n a l y s e—es g
a n a l y s e s
a n d
s e n s i t i v i t y
STROBE CHECKLIST
Discussion
K e y
1 . S u m m ak re iy s e
r e f e r e n c e
STROBE CHECKLIST
Discussion
L i m i t a t i o n s
1 .
t a k i n g
p o t e n t i a l
D i s c u s s
m a g n i t u d e
STROBE CHECKLIST
Discussion
I n t e r p r e t a t i o n
2
i n t e r p r e t a t i o n
c o n s i d e r i n g
m u l t i p l i c i t y
f r o m
r e l e v a n t
STROBE CHECKLIST
Discussion
G e n e r a l i s a b i l i t y
2.
g e n e r a l i s a b i l i t y
(
t h e
STROBE CHECKLIST
Other information
F u n d i n g
2 .
r o l e
s t u d y
o r i g i n a l
a r t i c l e
عَلَ كْ ُُ كم
سالَ ُم َ ل
ا ََّ