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Cytotoxic Safety Cabinet Esco
Cytotoxic Safety Cabinet Esco
Model CYT-4A_
Introduction
The Esco Cytoculture Cytotoxic Safety Cabinet is
the premium solution for cytotoxic/antineoplastic
drug processing, providing the highest level of patient,
pharmacist and environmental protection. This
revolutionary product builds on Esco’s experience of
more than 20 years as a global leader in biological
Esco Cytoculture Cytotoxic Safety Cabinet, Model CYT-4A_. safety containment technology.
When used as a Class II biological safety cabinet, the Cytoculture meets
the requirements of the European EN 12469 std. for microbiological The unique demands of handling and preparing
safety cabinets and offers an added level of safety and personnel
protection by permitting a filter change without decontamination. cytotoxic drugs for use in chemotherapy require
a specialized cabinet. As cytotoxic drugs cannot be
inactivated by chemical decontamination, Class II
biosafety cabinets should not be used. With this in
mind Esco has developed a highly specialized range
of cabinets designed especially for handling these
potentially dangerous drugs.
Sentinel Microprocessor Control System, Programmable When programmed ON • the start-up sequence confirms status with Air Safe and local time display.
• the Personal Identification Number (PIN) access restricts unauthorized adjustments.
• an airflow alarm warns of deviations from normal velocities.
With a range of specialist features This unique design allows contaminated • The easily removable multi-piece stain-
incorporated into our Cytoculture Cytotoxic filters to be removed easily, and all con- less steel work surface construction
Safety Cabinets (CYT), Esco brings you taminated areas to be sterilized without increases cleanability.
the ideal solution to your cytotoxic drug compromising safety.
preparation challenges. Our CYT cabinets Enhanced Filtration System
are designed to: Designed and Built for The enhanced filtration system is designed
Enhanced Usability to provide the highest level of air quality
• Maintain the highest level of cleanliness
All Esco Cytotoxic Safety Cabinets are within the work zone. 3
within the work zone ensuring the best
ergonomically designed for a high level of
possible level of patient safety and • Esco CYT cabinets provide ISO Class 3
usability and efficiency. They incorporate
product cleanliness. air cleanliness within the work zone (as
a number of features to ensure operator
• Provide the highest level of operator per ISO 14644.1), significantly “cleaner”
comfort and enhanced productivity.
safety to protect you and your personnel than the usual Class 5 classification on
from hazardous compounds used in • The ergonomic angled front improves cabinets offered by the competition.
cytotoxic drugs. reach into the work zone and prevents • A highly specialized Tri-Filter design
glare off the sliding sash. incorporates two standard ULPA filters
• Incorporate an advanced range of
additional safety features, including • The aesthetically pleasing stainless steel and an additional V-bank ULPA exhaust
a specialized Tri-Filter ™ design, to interior will never rust, chip or generate filter, providing a world class level of air
guarantee the highest possible levels particles, enhancing operator and cleanliness to protect the operator, the
of environmental, operator and product product protection. product and the environment.
protection. Contaminated air from the • The interior back and side walls are
work zone is immediately filtered by fabricated from a single piece of stainless
a HEPA filter below the work zone to steel, with no joints or sharp corners.
Mini-pleat Separatorless Filter (left) vs.
minimize the possibility of airborne This makes the cabinet exceptionally Conventional Aluminium Separator Filter (right)
contamination. easy to clean.
• Meet the requirements of all relevant • Built-in warm white, electronically bal-
safety standards for handling cytotoxic lasted, 5000K lighting provides excellent
drugs (see technical specifications for illumination of the work zone to reduce
details). operator fatigue. The reliable lighting
• Provide ISO Class 3 air cleanliness within system is zero-flicker and instant start.
the work zone. • The front sliding sash window is
With an additional HEPA filter placed motorized for movement, facilitating
Esco cabinets use Swedish Camfil Farr® mini-pleat
directly below the work zone, filters on easy transfer of reagents and equipment filters without aluminum separators to increase filter
our CYT cabinets can be changed without into and out of the work zone. efficiency, minimize the chance of leakage, and to
prolong filter life. Filters include a lightweight
exposing the ambient environment and • Spacious knee room is provided for the aluminum frame for structural stability and
elimination of swelling common to conventional
service personnel to potential hazards. operator in a sitting position, ensuring wood frames.
comfort during use.
Cytoculture Cytotoxic Safety Cabinet Airflow
Exhaust ULPA filter
Supply ULPA filter
ULPA-filtered air
Dynamic air barrier, inflow and forward
directed downflow air converge Unfiltered / potentially contaminated air
Room air / Inflow air
Secondary exhaust HEPA filter
Air enters the cabinet through perforations exhaust filter and 65% is forced evenly
located along the front of the work zone through the ULPA supply filter. This
before mixing with used downflow air sterilized air then passes through the
in a common chamber below the work main chamber as downflow air, flushing
zone (this inflow air does not mix with all contaminates from the work zone.
the filtered downflow air in the cabinets
At the work surface the downflow
main chamber). The mixed air then passes
airstream splits and enters the common air
through the HEPA filter located beneath
chamber beneath the work zone through
the work zone.
perforations located at the front and back
The HEPA filtered air then passes through of the main chamber, from where the
internal ducting in the back wall of the cycle is repeated.
cabinet to a common air plenum where
35% is exhausted through the ULPA
• Advanced minipleat separatorless HEPA User-Friendly Control System be operated by unauthorized personnel.
and ULPA filter technology maximizes The user-friendly Esco Sentinel micro- • Built-in solid state variable speed contro-
surface area. This energy efficient design processor-based control system, fitted to llers, with integral RFI and noise filters,
reduces operating costs, extends filter our CYT cabinets, supervises the operation are superior to conventional “step”
life, and delivers increased laminar air- of all cabinet functions. The controls controllers and offer infinite adjustment
flow uniformity, ensuring better product are easily configurable to meet your from zero to maximum setting.
protection than conventional filters. requirements and comes equipped with a
4 Cabinet Construction
• The high quality ULPA filt ers (per number of enhanced features to promote
IEST-RP-CC001.3) operate at typical cabinet usability and safety. All Esco products are manufactured to the
efficiency of >99.999% at 0.1 to 0.3 highest quality, using the finest materials,
• All critical cabinet airflow parameters
micron sizes, providing superior product for the most demanding laboratory
can be monitored using the built-in
protection. applications.
accurate true airflow velocity sensing
• For enhanced safety the first exhaust technology. Temperature compensated • All components are designed for
filter can be changed easily without sensors ensure increased accuracy. maximum chemical resistance and
time consuming decontamination. enhanced durability for a long service
• Audible and visual alarms ensure
• An integral metal filter guard protects product protection by alerting the user life, making Esco’s CYT cabinets one
the ULPA filters from accidental in the event of low airflow. of the most cost effective solutions on
damage. the market.
• Password-protected administration
• Unique U-channels in work surface can be set to restrict access to the main • The main body of the cabinet is constructed
construction protect the main filters menu ensuring that the cabinet cannot of industrial-grade electrogalvanized steel
from liquid spills and small parts. for durability and enhanced safety.
Antimicrobial Powder-Coating
All exterior painted surfaces are powder-coated with
Bacterial Population (10 folds)
2
�
1
7 2
(18.7")
3
ING
475 mm
MAX. OPEN
4
13 8
2190 mm (86.2")
5
670 mm (26.4")
9
14
(8")
10
6
203 mm
OPENING
CESS
15
AC
16 11
760 mm (30.0")
12
1. Exhaust ULPA filter 6. Electrical outlet Retrofit Kit provision 10. Stainless steel multi-piece work tray 15. Single-piece stainless steel back wall
2. Blower (two single outlets in workzone) 11. Stainless steel armrest and side walls
3. Downflow ULPA filter 7. Electrical and electronics panel 12. Exhaust ULPA filter 16. Removable side panel for plumbing
8. Fluorescent lamp access
4. Standard UV light Retrofit Kit™ 13. Esco Sentinel microprocessor 5
provision 9. Plugged service fixture provisions control system
5. Standard IV bar Retrofit Kit provision (2 on each side) 14. Motorized laminated glass sliding
sash window
General
Air Quality Filtration Electrical Safety
Requirements
Standards
EN-1822 (H14), Europe UL-C-61010A-1, USA
Compliance ISO 14644.1, Class 3, Worldwide
IEST-RP-CC001.3, USA CSA C22.2, No.1010-92, Canada
EN 12469, Europe IEST-G-CC1001, Worldwide
IEST-RP-CC007.1, USA EN-61010-1, Europe
IEST-G-CC1002, Worldwide
IEST-RP-CC034.1, USA IEC61010-1, International
• All cabinet components are cleanroom loaded, ensuring optimum efficiency or UL recognized, ensuring superior
compatible. and product protection without the electrical safety for the operator.
• The external structure of all our cabinets need for constant manual adjustment.
Warranty
is coated with Esco Isocide antimicrobial
Designed and Built to Exceed Esco Cytotoxic Safety cabinets include
coating to protect against contamination
Safety Criteria an extended 3 year warranty, excluding
and inhibit bacterial growth. Isocide
eliminates 99.9% of surface bacteria At Esco safety is of paramount importance. consumable parts and accessories. Contact
within 24 hours of exposure to further We take extra care in the design and your local Sales Representative for specific
ensure the cleanliness of the work zone. construction of all cabinets to ensure all warranty details.
components used in our products meet or
Blower Efficiency exceed all applicable safety requirements.
• Esco Cytotoxic Safety Cabinets incorpo- • Each cabinet is individually factory
rate permanently lubricated direct drive tested for safety and performance in
centrifugal blowers. The energy efficient accordance with international standards.
external rotor motor design reduces Each unit is shipped with a documen-
operating costs and has extremely low tation outlining the tests undertaken
vibration. and the units individual results for each
• The blower system automatically cabinet.
maintains airflow as the filters become • All electrical components are UL listed
General Specifications, Cytotoxic Safety Cabinets
Note to customer: Insert electrical voltage number into last model number digit _ when ordering.
Model CYT-4A_ CYT-6A_
Internal Work Area, Dimensions 1270 x 603 x 670 mm 1870 x 603 x 670 mm
(W x D x H) 50.0" x 23.7" x 26.4" 73.6" x 23.7" x 26.4"
Internal Work Area, Space 0.60 m2 (6.4 sq.ft.) 0.90 m2 (9.7 sq.ft.)
ULPA Filter Typical Efficiency >99.999% for particle size between 0.1 to 0.2 microns
Fluorescent Light Intensity At Zero Ambient >1300 Lux (>121 foot candles) >1200 Lux (>111 foot candles)
Cabinet Construction 1.5 mm (0.06") 16 gauge electrogalvanized steel with Isocide white oven-baked epoxy powder-coating
Model Voltage
Customized to Meet Your Esco Centrifugal Fan with External Rotor Motor (left) vs.
Specific Needs Conventional Fan with Standard Motor (right)
Esco CYT cabinets can be configured to
Esco cabinets use German made ebm-papst®
meet unique needs including: permanently lubricated, centrifugal motor/
blowers with external rotor designs.
• Lead shielding for nuclear medicine
Integrated blades narrow the profile and
applications. eliminate need for a motor shaft.
• An optional carbon filter impregnated Motors are selected for energy efficiency,
compact design, and flat profile. The
with KI (potassium iodide) in place of the completely integrated assembly optimizes
additional HEPA filter (this configuration motor cooling.
does not protect service technicians All rotating parts are unitized and balanced
for smooth, quiet, vibration-free operation.
when changing contaminated filters).
Since 1978, Esco has emerged as a leader in the development of controlled environment, laboratory and pharmaceutical
equipment solutions. Products sold in more than 100 countries include biological safety cabinets, compounding pharmacy
equipment, containment / pharma products, ductless fume hoods, in vitro fertilization workstations, lab animal research
products, laboratory fume hoods, laboratory ovens and incubators, laminar flow clean benches and PCR products and
instrumentation. With the most extensive product line in the industry, Esco has passed more tests, in more languages,
for more certifications, throughout more countries than any biosafety cabinet manufacturer in the world. Esco remains
dedicated to delivering innovative solutions for the clinical, life science, research and industrial laboratory community.
www.escoglobal.com.
Biological Safety Cabinets • Cytotoxic Safety Cabinets • Laminar Flow Clean Benches • Pharmacy Isolators
products and specifications without notice. All trademarks and logotypes in this material are the property of Esco and the respective companies.
Esco can accept no responsibility for possible errors in catalogues, brochures and other printed materials. Esco reserves the right to alter its
9010031_Compounding Equipment_CYT_Brochure_A4_vB1_02/12
Esco Technologies, Inc. • 2940 Turnpike Drive, Units 15-16 • Hatboro, PA 19040, USA
Toll-Free USA and Canada 877-479-3726 • Tel 215-441-9661 • Fax 215-441-9660
www.escoglobal.com • usa@escoglobal.com
Esco Micro Pte. Ltd. • 21 Changi South Street 1 • Singapore 486 777
Tel +65 6542 0833 • Fax +65 6542 6920 • mail@escoglobal.com
www.escoglobal.com
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