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  • Nerve Signal Triggers Muscle Contraction

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    Syahrul Hadikusuma
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    This document summarizes the process of skeletal muscle contraction. It involves 3 key events: 1) A nerve signal triggers the release of acetylcholine (ACh) from the motor neuron, which then binds to receptors on the muscle fiber. 2) The binding of ACh causes ions to shift, generating an electrical signal that triggers further ion shifts and spreads within the muscle fiber. 3) The ion shifts activate calcium release within the muscle fiber, allowing myosin to bind to actin and cause sarcomere shortening and muscle contraction.

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    mekanisme kontraksi otot

    Original Title

    kontraksi 1

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    This document summarizes the process of skeletal muscle contraction. It involves 3 key events: 1) A nerve signal triggers the release of acetylcholine (ACh) from the motor neuron, which then binds to receptors on the muscle fiber. 2) The binding of ACh causes ions to shift, generating an electrical signal that triggers further ion shifts and spreads within the muscle fiber. 3) The ion shifts activate calcium release within the muscle fiber, allowing myosin to bind to actin and cause sarcomere shortening and muscle contraction.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    4 views1 page

    Nerve Signal Triggers Muscle Contraction

    Uploaded by

    Syahrul Hadikusuma
    This document summarizes the process of skeletal muscle contraction. It involves 3 key events: 1) A nerve signal triggers the release of acetylcholine (ACh) from the motor neuron, which then binds to receptors on the muscle fiber. 2) The binding of ACh causes ions to shift, generating an electrical signal that triggers further ion shifts and spreads within the muscle fiber. 3) The ion shifts activate calcium release within the muscle fiber, allowing myosin to bind to actin and cause sarcomere shortening and muscle contraction.

    Copyright:

    © All Rights Reserved
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    of 1

    Nerve signal

    1 Neuromuscular Junction
    Excitation of a skeletal muscle fiber
    Axon 2b The EPP initiates an
    Synaptic knob action potential
    Ca2+ along sarcolemma
    and T-tubules.
    1a A nerve signal triggers
    voltage-gated Ca2+ channels
    to open—Ca2+ enters
    synaptic knob and binds to
    synaptic vesicles.

    Voltage-gated
    Ca2+ channel

    ACh

    Synaptic
    1b ACh is released by vesicle
    exocytosis into
    synaptic cleft.
    ACh

    Synaptic cleft
    2a ACh binding causes
    Na+ to rapidly enter the
    ACh skeletal muscle fiber
    receptor K+ and K+ to slowly exit
    the skeletal muscle
    fiber, which may result
    in an end-plate
    potential (EPP).
    Na+
    1c ACh binds to
    ACh receptors.

    Motor end plate 3e Reset: ATP split and


    myosin head is reset.

    INTEGRATE CONCEPT OVERVIEW Pi


    ADP

    Figure 10.16 Skeletal Muscle Contraction. A summary


    of skeletal muscle contraction, which includes the events at (1) the
    neuromuscular junction, (2) the sarcolemma, T-tubules, and sarcoplasmic
    reticulum, and (3) sarcomeres.
    3d Release: ATP binds
    to myosin head
    releasing myosin
    head from actin.

    ATP

    350

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