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  • The Neuromuscular Junction

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    Karthik Vee
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    1. The document discusses the neuromuscular junction, including the motor unit, synapse, endplate, and synaptic transmission. 2. At the neuromuscular junction, acetylcholine is released from the presynaptic neuron into the synaptic cleft and binds to receptors on the postsynaptic muscle fiber membrane. 3. Acetylcholine is then broken down by acetylcholinesterase in the synaptic cleft to terminate the signal and prevent overstimulation of the muscle fiber.

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    Short intro to the Neuromuscular Junction

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    1. The document discusses the neuromuscular junction, including the motor unit, synapse, endplate, and synaptic transmission. 2. At the neuromuscular junction, acetylcholine is released from the presynaptic neuron into the synaptic cleft and binds to receptors on the postsynaptic muscle fiber membrane. 3. Acetylcholine is then broken down by acetylcholinesterase in the synaptic cleft to terminate the signal and prevent overstimulation of the muscle fiber.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    7 views9 pages

    The Neuromuscular Junction

    Uploaded by

    Karthik Vee
    1. The document discusses the neuromuscular junction, including the motor unit, synapse, endplate, and synaptic transmission. 2. At the neuromuscular junction, acetylcholine is released from the presynaptic neuron into the synaptic cleft and binds to receptors on the postsynaptic muscle fiber membrane. 3. Acetylcholine is then broken down by acetylcholinesterase in the synaptic cleft to terminate the signal and prevent overstimulation of the muscle fiber.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    of 9

    Neuromuscular

    Junction
    Karthik V
    Objectives
    1. Motor unit
    2. Synapse: Neuromuscular junction (NMJ)
    3. End plate
    4. Synaptic transmission
    5. Calcium channels: N-type
    6. Drug-targets at the NMJ
    7. Quiz!
    Revision: Muscle Structure
    Motor Neurone
    • Neurone: alpha-motoneurone
    Motor Unit
    • Definition: Group of muscle fibres (i.e. cells)
    innervated by a single alpha-motoneurone.
    Synapse: NMJ & Endplate
    Not typical of brain synapses!

    SYNAPSE!
    Neurone Neurone / Muscle fibre

    Endplate:
    Large and complex end
    formation by which the axon of a
    motor neuron establishes
    synaptic contact with a skeletal
    muscle fibre

    Sort of like a ‘handprint’ onto


    the muscle!
    Synaptic Transmission
    Synaptic Transmission
    • Acetylcholine: Rapidly broken down and
    inactivated
    • Synthesis: Acetyl-CoA + Choline → Acetylcholine
    (Enzyme: Cholineacetylase; Site: Terminal bouton)
    • Breakdown: Acetylcholine → Acetic acid + Choline
    (Enzyme: Acetylcholinesterase; Site: Synaptic cleft)
    Recycled into terminal
    bouton by uptake pumps!
    Synaptic Transmission
    • Synaptic vesicles
    ACTION POTENTIAL!

    Vesicle

    Synaptobrevins

    Syntaxins
    Pre-synaptic
    membrane

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