GENERIC NAME AND BRAND NAME (10%) GENERIC: Gentamicin sulfate
DOSE, STRENGTH & FORMULATION (10%) ORDERED: TIMING:
INDICATION/ MECHANISM OF DRUG ACTION (15%)
ADVERSE/SIDE EFFECTS DRUG INTERACTION (15%)
CLIENT TEACHING (20%)
CLASSIFICA TION: Aminoglycoside; antibiotic
INDICATIONS: Serious infection caused by sensitive strains of Pseudomonas aeruginosa, Escherichia coli, Proteus, Klebsiella, Serratia, Eneterobacter, Citrobacter, Staphylococcus. M.O.A.: Chemical effect: Inhibits protein synthesis by binding to ribosomes. Therapeutic effect: Kills susceptible bacteria (many aerobic gramnegative
OTHER FORMS: Injection: 40 mg/ml (adults), 10 mg/ml (pediatrics), 2 mg/ml (intrathecal) IV Infusion (premixed): 40 mg, 60 mg, 80 mg, 90 mg, 100 mg, 120 mg, 160 mg, 180 mg available in saline
ADVERSE REACTION: CNS: headache, lethargy, numbness, paresthesia, peripheral neuropathy, neurotoxicity, seizures, twitching EENT: ototoxicity GU: nephrotoxicity Hematologic: agranulocytosis, leucopenia, thrombocytopenia Other: hypersensitivity reactions DRUG INTERACTIONS: Drug-drug: Acyclovir, amphotericin B, cisplatin, methoxyflurane, other aminoglycosides, vancomycin: May increase ototoxicity and nephrotoxicity. Use
ASSESSMENT: 1. Assess patient’s infection and hearing before starting therapy and regularly thereafter. 2. Obtain specimen for culture and sensitivity tests before giving the first dose. 3. weigh patient and review baseline renal function studies before therapy and regularly during therapy 4. therapy usually continues for 7 to 10 days. If no response occurs in 3 to 5 days, therapy maybe stopped
Use together only when necessary. Parenteral ampicillins: May inactivate gentamicin in vitro. Don’t mix together. Drug may act against some aminoglycosideresistant bacteria. Avoid use together.
. Avoid use together.
together cautiously. General Anesthetics: May increase effects of non-depolarizing muscle relaxant. Diuretics: May increase ototoxicity.solution
organisms and some aerobic gram-positive organisms). Neurotoxic drugs: May increase neurotoxicity. including prolonged respiratory depression.