DRUG NAME MECHANISM OF INDICATION/ ADVERSE EFFECT NURSING

ACTION CONTRAINDICATION RESPONSIBILITY

GENERIC: Aminoglycosides like INDICATIONS: Common side effects of -Observe the 12 rights in
Gentamicin gentamicin For treatment of serious infections gentamicin include: giving medication
"irreversibly" bind to caused by susceptible strains of the
specific 30S-subunit following microorganisms: P. Neurotoxicity (spinning sensation -Give by IM route if at all
BRAND: proteins and 16S rRNA. aeruginosa, Proteus species (indole- [vertigo], loss of control of bodily possible; give by deep IM
- Specifically gentamicin positive and indole-negative), E. coli, movements) injection
binds to four Klebsiella-Enterobactor-Serratia Gait instability
THERAPEUTIC: nucleotides of 16S species, Citrobacter species and Ototoxicity (auditory, vestibular) -Use 2mg/ml intrathecal
Antibiotic rRNA and a single Staphylococcus species (coagulase- Kidney damage (decreased CrCl) preparation without
amino acid of protein positive and coagulase-negative). Kidney damage if trough greater preservatives for
PHARMACOLOGI S12. This interferes than 2 mg/L intrathecal use
C: with decoding site in the CONTRAINDICATIONS: Swelling (edema)
Aminoglycosides vicinity of nucleotide Rash -Avoid long-term therapies
1400 in 16S rRNA of Patients with dementia-related Itching because of increased risk
DOSAGE AND 30S subunit. This region psychosis who are treated with Stomach upset of toxicities, Reduction in
ROUTE interacts with the antipsychotic drugs are at increased risk Injection site reactions (pain, dose may me clinically
wobble base in the for death, as shown in short-term irritation, and redness) indicated.
Adult and Pediatric anticodon of tRNA. controlled trials; deaths in these trials Patients with edema or
Dosage Forms and This leads to appeared to be either cardiovascular Less common side effects of ascites may have lower
Strengths interference with the (e.g., heart failure, sudden death) or gentamicin include: peak concentration due to
initiation complex, infectious (e.g., pneumonia) in nature. expanded extracellular
Injectable solution misreading of mRNA so Drowsiness fluid volume.
incorrect amino acids This drug is not approved for treatment Headache
10 mg/ml are inserted into the of patients with dementia-related Pseudomotor cerebri -Cleanse area before
40 mg/ml polypeptide leading to psychosis. Photosensitivity application of
nonfunctional or toxic Allergic reaction dermatologic preparations
peptides and the This medication contains gentamicin. Skin redness
breakup of polysomes Do not take Modecate, Modecate Loss of appetite -Ensure adequate hydration
into nonfunctional Concentrate, Moditen, Prolixin, or Nausea/vomiting of patient before and
monosomes. RhoGentamicin if you are allergic to Weight loss during therapy.
gentamicin or any ingredients contained Increased salivation -Monitor renal function
in this drug. Enterocolitis tests, CBCs, serum drug
Granulocytopenia levels during long-term
Keep out of reach of children. In case of Agranulocytosis therapy
overdose, get medical help or contact a Low platelet counts
Poison Control Center immediately. (thrombocytopenia) -Consult with prescriber to
Elevated liver function tests adjust dosage
(LFTs)
Burning
Stinging
 Tremors
Muscle cramps
Weakness
Shortness of breath

Serious side effects of gentamicin

include:

Ringing or roaring sounds in the

ear
Hearing loss
Dizziness
An unusual decrease in the amount
of urine while using gentamicin
injection (pediatric)

DRUG NAME MECHANISM OF INDICATION / ADVERSE NURSING RESPONSIBILITIES

ACTION CONTRAINDICATION EFFECT
GENERIC:
Streptomycin This medication is used with
BRAND: other medications to treat
Streptomycin sulfate active tuberculosis (TB)
CLASS: infection if you cannot take
Aminoglycoside Antibiotics other drugs for TB or if you
have a type of TB that cannot
DOSAGE: be treated with other drugs
PEDIA=400mg/Ml (drug-resistant TB).
Adult= 1g Streptomycin belongs to a
class of drugs known as
aminoglycoside antibiotics. It
ROUTE: works by killing the
IM stored at 2-8°C organisms that cause the
infection.
DRUG NAME MECHANISM OF
ACTION
INDICATIONs:
This medication is an
aminoglycoside indicated for
the treatment of moderate to
severe infections caused by
susceptible strains of
mycobacterium tuberculosis
and other bacteria.
CONTRAINDICATION:
Contraindicated in patients
with known hypersensitivity.
INDICATION /
CONTRAINDICATION
Nausea, vomiting, - Ask for allergies.
stomach upset, loss Ask patient if she is pregnant or
of appetite breast-feeding.
dizziness, rash,
fever, burning - Ask patient if he have
sensation of face, recently taken any drugs that
hives, rapid can cause nerve, kidney, or
swelling of the hearing problems.
dermis and high
eosinophil count. - Do not use longer than you
have been told. A second
infection may happen.
ADVERSE EFFECT NURSING
RESPONSIBILITIES
GENERIC: Tobramycin binds INDICATION: - Assess for baseline
Tobramycin irreversibly to one of two 1-10% status
aminoglycoside binding sites For the treatment of - Question for history
BRAND: on the 30 S ribosomal pseudomonas aeruginosa lung - Ototoxicity of allergies esp.
Tobrex subunit, inhibiting bacterial infections. Also being - Nephrotoxicity aminoglycosides.
protein synthesis. investigated for use in the - Establish baseline for
CLASS: Tobramycin may also treatment of sinus infections. - Neurotoxicity hearing acuity.
destabilize bacterial (neuromuscular - Obtain baseline lab
Pharmacotherapeutic: membrane by binding to 16 S CONTRAINDICATION: blockade) test esp. renal
Aminoglycoside 16 S r-RNA. An active function.
transport mechanism for A hypersensitivity to any <1% - Monitor I&O,
Clinical: aminoglycoside uptake is aminoglycoside is a urinalysis, renal
Antibiotics necessary in the bacteria in contraindication to the use of - Hypotension function.
order to attain a significant Tobramycin. A history of - Monitor results of
- Drug fever
DOSAGE & ROUTE: intracellular concentration of hypersensitivity or serious peak/trough blood
IV: 1mg/L tobramycin. toxic reactions to - Drowsiness tests.
ADULT & PEDIA: injectable aminoglycosides may also - Headache - Be alert to ototoxic,
solution contraindicate the use of any neurotoxic symptoms.
- Paresthesia
- 10mg/mL other aminoglycoside because - Evaluate IV site for
of the known cross-sensitivity - Tremor phlebitis.
- 40mg/mL
of patients to drugs in this - Rash - Assess for rash.
IM class. - Be alert for supper
- Nausea
Inhalation infection, particularly
- Vomiting anal or genital
Ophthalmic
- Anemia pruritis, changes of
Topical oral mucosa, diarrhea
- Eosinophilia
- Report any hearing
- Arthralgia
visual balance,
- Weakness urinary problems
- Eyelid edema even after therapy is
completed.
- Itching eyes
- Keratitis
- Lacrimation
- Dyspnea