TRIAZOLAM

CLASSIFICATIONS AVAILABLE FORMS ACTION INDICATION CONTRAINDICATIONS SIDE EFFECTS ADVERSE REACTIONS
AND DOSSAGE
CENTRAL NERVOUS 0.125 mg, 0.25 mg Acts at many levels in the Triazolam is Patients with known Get emergency medical Risks from
SYSTEM AGENT; tablets CNS, producing generalized indicated for the hypersensitivity to help if you have signs of Concomitant Use with
BENZODIAZEPINE; depression. Effects may be short-term Triazolam, any of an allergic reaction: hives; Opioids
ANXIOLYTIC; Oral mediated by gamma- treatment of component of difficult breathing;
SEDATIVE-HYPNOTIC Give immediately aminobutyric acid (GABA), insomnia Triazolam tablets, or swelling of your face, lips, Abuse, Misuse, and
before bed; onset of an inhibitory (generally 7 to 10 other tongue, or throat. Addiction
drug action is rapid. neurotransmitter. days) in adults. benzodiazepines.
Do not exceed Therapeutic Effects: Relief Reactions consistent Triazolam can slow or stop Dependence and
recommended of insomnia. with angioedema your breathing, especially Withdrawal Reactions
doses. (involving the if you have recently used
Store at 15°–30° C tongue, glottis, or an opioid medication or Persistent or
(59°–86° F). larynx), dyspnea, and alcohol. A person caring Worsening Insomnia
throat closing have for you should seek
been reported and emergency medical “Sleep-driving” and
may be fatal. attention if you have slow Other Complex
breathing with long Behaviors
Concomitant pauses, blue colored lips,
administration of or if you are hard to wake Central Nervous
strong cytochrome up. System
P450 (CYP 3A) Manifestations
enzyme inhibitors
(e.g., ketoconazole, Effects on Driving and
itraconazole, Operating Heavy
nefazodone, Machinery
lopinavir, ritonavir)
Patients with
Depression

Compromised
Respiratory Function
 FLUTICASONE
CLASSIFICATIONS AVAILABLE FORMS ACTION INDICATION CONTRAINDICATIONS SIDE EFFECTS ADVERSE REACTIONS
AND DOSSAGE
SKIN AND MUCOUS 44 mcg, 110 mcg, Potent, locally acting anti- Maintenance and Primary treatment of CNS: headache, dizziness. Oropharyngeal
MEMBRANE AGENT; 220 mcg aerosol; inflammatory and immune prophylactic status asthmaticus or candidiasis infection
ANTIINFLAMMATORY; 0.05%, 0.005% modifier. Therapeutic treatment of other acute episodes EENT: dysphonia,
CORTICOSTEROID cream; 0.005% Effects: Decreases asthma. May of asthma where hoarseness, Immunosuppression
ointment frequency and severity of decrease intensive measures oropharyngeal fungal and risk of infections
Therapeutic: anti- asthma attacks requirement for or are required infections, nasal stuffiness,
inflammatories inhalation aerosol avoid use of rhinorrhea, sinusitis. Hypercorticism and
(steroidal) (CFC free 110 systemic Hypersensitivity to adrenal suppression
mcg/inh; CFC free corticosteroids and any of the Resp: bronchospasm,
Pharmacologic: 220 mcg/inh; CFC delay pulmonary ingredients cough, upper respiratory Reduction in bone
corticosteroids free 44 mcg/inh); damage that tract infection, wheezing. mineral density
occurs from
inhalation powder chronic asthma. GI: diarrhea. Growth effects
(100 mcg/inh; 113
mcg/inh; 232 Endo: adrenal suppression Glaucoma and
mcg/inh; 250 (high-dose, long-term cataracts
mcg/inh; 50 therapy only), decreased
mcg/inh; 55 growth (in children),
mcg/inh; furoate Cushing's syndrome.
100 mcg; furoate
200 mcg; furoate 50 MS: muscle pain.
mcg)
Misc: CHURG-STRAUSS
SYNDROME, fever.
 NOEIPINEPHRI
N
CLASSIFICATIONS AVAILABLE FORMS ACTION INDICATION CONTRAINDICATIONS SIDE EFFECTS ADVERSE REACTIONS
AND DOSSAGE
Alpha adrenergic Injection: 4 mg/4 increase blood pressure treatment of Hypovolemic shock Blurred vision. Tremors,
agonist (stimulates α1 mL (1 mg/mL and cardiac output by severe unless fluid hypertension,
and α2 receptors) Norepinephrine stimulating alpha- hypotension and resuscitation has chest pain or discomfort. palpitations, reflex
base) sterile, adrenergic receptors in the shock already been bradycardia
Beta adrenergic colorless to pale blood vessels, established lightheadedness,
agonist (stimulates β1 yellow solution in a demonstrates minor beta Produces dizziness, or fainting. Headache,
receptors) single-dose amber activity vasoconstriction Peripheral or convulsions
glass vial. and myocardial mesenteric vascular pounding in the ears. Blurred vision,
Therapeutic: Stimulates alpha- stimulation, which thrombosis photophobia
vasopressors Adult: IV Start with adrenergic receptors may be required slow, fast, or irregular
8–12 mcg/min, located mainly in blood after adequate Safety during heartbeat. Extravasation results
Pharmacologic: titrate to vessels, causing fluid replacement pregnancy or in tissue necrosis.
adrenergics maintenance dose constriction of both in the treatment of lactation not
of 2–4 mcg/min capacitance and resistance severe established (Category
AUTONOMIC vessels. Also has minor hypotension and D).
NERVOUS SYSTEM Child: IV Start with 2 betaadrenergic activity shock.
AGENT; ALPHA- AND mcg/min, titrate to (myocardial stimulation).
BETA-ADRENERGIC maintenance dose Therapeutic Effects:
AGONIST of 0.1 mcg/kg/min Increased blood pressure.
(SYMPATHOMIMETIC) Increased cardiac output.
 TORSEMIDE
CLASSIFICATIONS AVAILABLE FORMS ACTION INDICATION CONTRAINDICATIONS SIDE EFFECTS ADVERSE REACTIONS
AND DOSSAGE
ELECTROLYTE AND 5 mg, 10 mg, 20 mg, Long-acting potent Edema due to CHF; Hypersensitivity to frequent urination CNS: Headache,
WATER BALANCE 100 mg tablets; 10 sulfonamide "loop" diuretic Hepatic or renal torsemide or headache dizziness, fatigue,
AGENT; LOOP mg/mL injection that inhibits reabsorption disease; sulfonamides; anuria, cough insomnia.
DIURETIC of sodium and chloride Hypertension. fluid and electrolyte sore throat
primarily in the loop of depletion states; hearing loss CV: Orthostatic
Therapeutic: CHF, Chronic Kidney Henle and also in the hepatic coma; ringing in your ears hypotension.
antihypertensives Failure proximal and distal renal pregnancy (category upset stomach
Adult: PO/IV 10–20 tubules. Binds to the B). constipation Endocrine:
Pharmacologic: loop mg once daily, may sodium/potassium/chlorid diarrhea Hypokalemia,
diuretics increase up to 200 e carrier in the loop of weakness hyponatremia,
mg/d as needed Henle and in the renal excessive thirst hyperuricemia.
tubules. Lower potassium-
Hepatic Cirrhosis wasting effects than GI: Nausea, diarrhea.
Adult: PO/IV 5–10 furosemide and a longer Skin: Rash, pruritus.
mg once daily half-life.
administered with Body as a Whole:
an aldosterone Muscle cramps,
antagonist or rhinitis.
potassium-sparing
diuretic, may
increase up to 40
mg/d as needed

Hypertension
Adult: PO/IV 5 mg
once daily, may
increase to 10 mg/d
if no response after
4–6 wk
 PENTOSTATIN
CLASSIFICATIONS AVAILABLE FORMS ACTION INDICATION CONTRAINDICATIONS SIDE EFFECTS ADVERSE REACTIONS
AND DOSSAGE
adenosine deaminase intravenous powder Inhibits adenine deaminase Pentostatin for Pentostatin for Most people will not CNS: CNS toxicity,
inhibitor for injection (10 mg) (ADA), an enzyme that injection is injection is experience all of the fatigue, headache,
blocks the synthesis of indicated as single- contraindicated: In pentostatin side effects weakness.
Antineoplastic IV injection: DNA, especially in T cells of agent treatment patients who have listed.
(antibiotic) A single dose over 1 the lymphoid system. for both untreated demonstrated EENT: epistaxis,
minute. Therapeutic Effects: and alpha- hypersensitivity to Pentostatin side effects keratoconjunctivitis,
Decreased signs and interferon- pentostatin. are often predictable in pharyngitis, rhinitis,
Infusion: symptoms of hairy-cell refractory hairy cell terms of their onset, sinusitis, vision
A single dose over leukemia (recovery of leukemia patients duration and severity. changes. Resp:
20 to 30 minutes. hematologic parameters, with active disease
organomegaly, and as defined by Pentostatin side effects PULMONARY
lymphadenopathy). clinically significant will improve after therapy TOXICITY, bronchitis,
anemia, is complete. dyspnea, pneumonia,
neutropenia, cough, pulmonary
thrombocytopenia, Pentostatin side effects edema.
or disease-related may be quite manageable.
symptoms. There are many options to CV: MI, angina
minimize or prevent the pectoris, arrhythmias,
side effects of pentostatin. thrombophlebitis. GI:
anorexia, diarrhea,
hepatotoxicity,
nausea, vomiting,
constipation,
flatulence, abdominal
pain, stomatitis.

GU: renal toxicity.

Derm: itching, skin
rash, dry skin. Hemat:
anemia, leukopenia,
thrombocytopenia.
MS: arthralgia,
myalgia.
Misc: ALLERGIC
REACTIONS,
INCLUDING
ANAPHYLAXIS, fever,
flu-like syndrome,
weight loss.

SUBMITTED BY: FIGUEROA, JOHN KYLE PHILLIP