MODULE1

1.Gener alPhar macol ogy

1.I ndi
cat et het ypeofact ionofadr ug,whi chis C.Wi
lldecr
ease
i
ntroduced or all
y,i s absor bed i ntot he blood in D.Wi
llnotchange
i
ntest i
neandact sont hecertai norgansort i
ssues: E.Wi
l
ldisappear
A.Gener al (Resor ptive)*
8.Thebioavai
labi
l
ityi
sdef
inedasanav
eragel
eveli
f
B.Ref lex
oneisequal:
C.Mai n
A.0-20%
D.Local (Topical )
B.40-70%
E.Indi rect
C.100%
2.Thef or mat i
onofas econdar ymedi atori
sobli
gatoryi
n D.>70%
membr ane- i
ntrac el
lularmec hani sm ofhormoneac ti
on. E.<40%*
Pointoutt hes ubs tancethatisunabl et obeas econdary
medi at
or : 9.Forpreventi
onr emot er elapsesof4- daysmal ariaa
A.Di acy lglycer ol 42y .
o.patientwasgi venpr imaqui ne.Onthe3- dday
B.Gl ycer ol* ofthet r
eatmentwi tht herapeut i
cdosesoft hedr ug
C.cAMP pati
entexper ienced abdomi nalpai n,cardi
ac pai n,
D.Ca2+ dyspepsia,gener ali
zedcy anosi s.Whati sther eason
E.Inosi tol-3.4.5-tr
iphosphat e oftheseadv er
seef fectsoft hedr ug?
3.Whi ch f rom t he speci fied par ameter
si s an A.Potenti
ati
onoft hedr ug’sac t
ionbyot hert
herapeuti
c
obligatory condi tion of f ast per meati
on of t he agent
medi ci
nal agent sthroughabl ood-brainbarri
er? B.Slowingdownofdr ug’ ssecr eti
onwi thuri
ne
A.Shor thal f-l
ife C.Decreasingofact ivi
tyofl iv
ermi crosomal
B.Wat ersol ubili
ty enzymes
C.Li pid-sol ubili
ty* D.Genet i
cdeficiencyofGl ucose- 6-phosphate
D.St rongbi ndi ngtopr oteins dehydrogenase*
E.Ioni zedst ate E.Cumul ati
onoft hether apeut i
cagent

4.Whichoft hedr ugsr

eadilypenetr
atei
ntot
heCNS? 10.Whi choneoft hef oll
owingi sTRUEf oradr ug
A. Hy dr ophili
c drugs wi th a non-uni
for
m whose el imi nati
on f r
om pl asma shows 1st- order
dist
ri
but ionofel
ectrons kinet
ics?
B.Polardr ugs A.Thehal f
-li
feoft hedr ugispr opor t
ionaltothedr ug
C.Lipi
d-sol ubl
e* concentrationinpl asma
D.Bindingdr ugstoplasmapr ot
eins B.Theamountel imi natedperuni tti
mei sconstant
E.Ioni
zeddr ugs C.The r ate ofel i
mi nat i
on is pr oporti
onaltot he
plasmaconcent ration
5. A 37 y .o. patient,suf f
eri
ng an obl i
terati
ng D.El imination inv olves a r ate-l
imiti
ng enzy mat i
c
endarteri
tisoft helegs,receivespheny l
i
ninadoseof react
ionoper ati
ngati t
smaxi mal veloci
ty(Vm)
60mg/ kg.Becauseofconv ulsi
ondev el
opment( brai
n E.Apl otofdr ugc onc entrat
ionv ersustimeisas trai
ght
tr
auma i sin anamnesi s),phenobar bi
talhad been l
ine
gi
ven,af t
ert he cancellati
on ofwhi ch the nasal
bl
eeding occur r
ed at t he pat ient. The gi ven 11.Whi choneoft hef oll
owingi sTRUEf oradr ug
compl i
cationisconnect edwi th: whose el i
mination f rom pl asma shows zer o-or
der
A.Conj ugati
onofpheny li
nwi thagl ucuronicacid kinet
ics?
B. I nhibiti
on by phenobar bit
al of enzy mes A.Thehal f-
li
feoft hedr ugispr opor t
ionalt
ot hedrug
microsomal oxidat
ionsinal i
ver concentrati
oninpl asma
C. I nduct i
on by phenobar bit
al of enzy mes B.Theamountel imi natedperuni tti
mei sconstant*
microsomal oxidat
ionsinal i
ver* C.Ther ateofel imi nati
ondoesnotdependont he
D.Oxidat i
vedeami nat i
onofpheny l
in plasmaconcent ration
E.Ali
phat i
chy droxylati
onofphenobar bi
tal D.El iminati
on i nvol v
es a r ate-l
imiti
ng enzymat i
c
6.Pharmacokineti
cs i
ncl
udes al
loft
he f
oll
owi
ng react
ionoper at
ingati tsmaxi mal veloci
ty
pr
ocessesEXCEPT: E.Apl otofdrugc onc entrat
ionv ersustimeisas tr
aight
A.Absorpti
on l
i
ne.
B.Dist
ri
buti
on
C.Bi
otransfor
mati
on 12.Whichoft hefoll
owingtimeperiodsmostcl osel
y
D.El
iminati
on descri
bestheclearancerat
eofadr ugt hatisinf
used
E.Cl
ini
caluse* atar at
eof4mg/ minandpr oducesast eady-
stat
e
concentr
ati
onof6mg/ Lintheplasma?
7.How phar macologi
calact
ivi
tyofadrugwithhi
gh A.27ml /min
af
fini
ty to pl as
ma pr otei
n will be al
ter
ed at B.40ml /min
hypoalbuminemia? C.24ml /min
A.Wil
lsli
ghtl
ydecrease D.667ml /min*
B.Wil
li
ncrease E.1.200ml /
min

1
13.Chooset hecor rectst atement : 20. Gi v
et he cor r
ect explanation for the term
A.Weakbasesar eabsor bedef ficientlyacr osst he “t
olerance” :
epi thelial cel lsoft hest omach A.Aconst antovermasteri
ngcr avi
ngfortakingadrug
B. Coadmi nist r
ation of at ropine speeds t he B. Ampl ifi
cati
on of dr ug act ion in r epeat
ed
absor pt ionofaseconddr ug i
ntroduction
C.Dr ugsshowi ngl ar geVdcanbeef fi
cientl
yr emov ed C.Lower i
ngofdr ugacti
oni nrepeatedi
ntroducti
on*
bydi aly sisoft hepl asma D.Increasedsensi bi
l
itytothedr ug
D.St ressemot ionscanl eadt oasl owingofdr ug E.Lower i
ngofdr ugabsor pti
on
absor pt ion*
E.Ift heVdf oradr ugi ssmal l
,mostoft hedr ugi sin 21.Whatistheacet yl
ati
onofdr ugs?К
theext rapl asmi cspace A.Conjugationwithglucuronicaci
d
14.Adr ug, gi veni na100mgsi ngledose, resultsina B.Oxi
dationwi thparti
cipat
ionofCYP-
450
peak pl asma concent ration of 20 μg/ ml . The C.Bi
ndingt oaceticacid*
appar entv ol ume di st ribut i
on i s( assume a r apid D.Hydrolysi
sofdr ugs
distribution and negl igible el i
mi nat i
on pr ior t o E.Bi
ndingt oglucuroni
caci d
measur i
ngt hepeakpl asmal ev el)
: 22.Whatisthegl ucur
onidationofdrugs?К
A.0. 5L A.Conjugat i
onwithglucuronicaci
d*
B.1L B.Oxidati
onwi thparti
cipati
onofCYP- 450
C.2L C.Bi
ndingt oaceticacid
D.5L* D.Hydrolysisofdrugs
E.10L. E.Cycli
zationofdrugs
15.Whati st hemai nmechani sm ofdr ugabsor ption
i
nt heGI T?
23.Whatdoest het erm« t
achyphylaxis»mean?
A.Strongwi shoft akingthedrug
A.Filtrat i
on
B. Ampl if
icati
on of dr ug act ion in r epeat
ed
B.Passi v edi ffusi on*
i
ntroduction
C.Act i
v et ranspor t
C.Lower ingofdr ugactioninrepeatedint
roducti
on
D.Pi nocy tosi s
D. Rapi d decr ease of t he ef fect in repeat
ed
E.Al labov e
i
ntroduct i
on oft hedr ug withi
n shortperiod of
16.Pr oser inei ncreasest het oneofskel etalmuscl es ti
me*
aftersy st emi cadmi ni st r
at on.Ft
i or otan (halothane) E.I
ncr easedsensi bi
li
tytothedrug
i
nduces skel et almuscl er el
axat ion and r educes
proser i
neef fect s.I ndi cat et hechar act erofpr oserine 24.Thecumul ati
onofdr ugsi spossible:
andf torotani nt eract i
on. A.Indecreasedreabsor ptioninkidney
A.Compet i
tiveant agoni sm B.Ini
ncreasedsecr etioninr enalt
ubules
B.Di rectf unct i
onal ant agoni sm C.Inl
ower ingofthegl omer ularfi
l
trat
ion*
C.Indi rectf unct ional ant agoni sm * D.Inact i
v at
ionofmi crosomalenzy mesoft
he
D.Independentant agoni sm l
iver
E.Uni lat er al antagoni sm E.I
nincreaseofbi otransformat i
on
17.How dowecal lt hedr ugact i
on,whi chcauses 25.A pat ientt ook PO a hal foft he gl ass of
congeni tal mal format ions? chlorophos (strong inhibitor of t he
A.Mut agenousact ion acetylcholinest erase) wi th t he ai m of sui cide.
B.Embr yot oxicact ion Besidesofgast riclav age,cl
eansi ngenema,i nfusion
C.Ter at ogeni c* therapy,t hei nject i
onofat ropinewasmade.Asa
D.Fet ot oxi c resultoft hesi gnsoft heintoxi cati
ondi sappear ed.
E.Al labov e Determi net het ypeofi nter
act i
onbet weenat ropi ne
18.How t o expl ai nt he r educt ion ofef fects of andchl orophos:
salicy l
atesi nt hei nt eract i
onwi thphenobar bital? A.Inhibi ti
onofenzy mesoft hel iv
er
A.Inhi bi tionofenzy mesoft hel i
v er B.Ant agoni stef fect*
B.Ant agoni stef fect C.Tachy phy l
axis
C.Tachy phy l
axis D.Tol erance
D.Tol er ance E.Act i
v ationofenzy mesoft hel i
ver
E.Act iv at ionofl iv erenzy mes* 26. A pat ient t ook t he long- l
asti
ng cour se of
19.Thebr eadt hoft her apeut i
cact ioni sar angeof antibi
ot i
ct her apy i n connect i
on wi t
h i nfectious
doses: disease.Dur i
ngt reat menthebegant ocompl ainof
A.Fr om av er aget her apeut icdoset omi nimum t oxic skinr ash,i t
chi ng,r hiniti
s.Aftert henexti njectionof
dose theant i
bioticasphy xi
a,edemaofl ips,increaseof
B.Fr om si ngl edoset ocour sedose bodyt o
wer e obser ved.The doct orabol ished t he
C.Fr om mi ni malt her apeut icdos et omi nimum t ox i
c antibi
ot i
ct her apy and i ndi
cat ed necessar y dr ugs.
dos e* Determi net het ypeoft hi
spathol ogicalcondi t
ion:
D.Fr om si ngl edoset odai l
ydose A.Inhibi ti
onofenzy mesoft hel iv
er
E.Fr om mi ni mum ef fect i
v edoset o av eraget oxic B.Sensi bilizat i
on*
dose C.Tachy phy l
axis

2
 D.Toler ance D.Phar
macologi
c*
E.Ant agoni steffect E.Compet
it
ive
27.Al ongcour seoft r
eatmentwi thcyancobal ami
n 33.Whi chofthef oll
owingphar macoki
neti
cv al
ues
was admi nistered I M t o t he pat ient wi t
h mostr eli
ablyr efl
ectst he tot
alamountofdr ug
megaloblasticanemi adevel opedaftergastroectomy. reachi
ngthetargettissueaft
eroraladmini
str
ati
on?
What adv ant age does a par enter
al way of A.Volumeofdist ri
buti
on
admini
strationhav eov eroral? B.Eli
minati
onrat econstant
A.Thedr ugi squi cklydeduced C.Peakbloodconcent rati
on
B.Thedr ugi squi cklyabsorbed D.Areaunderthebl oodconcentrati
on-
ti
mecur v
e*
C.Thedr ugci rculatesinbloodforalongert i
me E.Clear
ance
D.Thedr ugdoesnotdi sint
egrateintheliver
E. Thi s way i s ef fecti
ve in absence of 34.I ndi
catechemi calr
eact
ionofdr
ugmetabol
i
sm
gast r
omucopr otein* whichbel ongst othephaseofsynt
het
icr
eacti
ons
(conjugati
on):
28.Whi choft hef oll
owi ngst atement
sresulti
na A.Deamination
doubli
ngoft hest eady-st ateconcent r
ati
onofadrug? B.Dealkyl
ati
on
A.Doubl i
ngt her ateofi nf usion* C.Oxidat
ion
B.Mai ntaining the infusi on rate,butdoubl
ing t
he D.Glucuroni
dation*
l
oadingdose E.Reduction
C.Doubl i
ng ther ateofi nfusionand doubl
ing t
he
35.An agentwi th marked l
ipophi
l
ic pr
opert
ies i
s
concentrati
onoft heinfuseddr ug
admini
stered t o a pat i
ent
. What is t he main
D.Tri
plingt herateofi nf usi on
mechanism ofitsabsorpti
on?
E.Quadr upli
ngt her at
eofi nfusion
A.Activetransport
29.Azi t
hromyci n,an ant ibi
oti
c,has an appar ent B.Passi v
edi f
fusi
on*
volumeofdi str
ibution(Vd)ofappr oximatel
y30L/ kg. C.Fi
ltr
at i
on
Thecor r
ectinterpretati
onoft hisinformati
onisthat D.Pinocy t
osis
Azithromyci niswhi choft hefoll
owi ng? E.Bi
ndi ngtotranspor
tprot
eins
A.Ef fectiveonlywhengi venint
ravenously
36.Excr
etionofdr ugsortheirmet
abol
it
esacr
ossthe
B. Ext ensiv
ely di stri
buted to si tes outsi
de the
cel
lmembr aneoccur sbyt hefol
l
owingmechani
sm
vascul arandi ntersti
ti
alspaces*
onl
y:
C.El iminatedmai nlybyrenalexcret i
on,wit
houtprior
A.Passivedi f
fusion
met abol i
sm
B.Acti
v etransport
D.Unabl et o cr oss the blood-brain orplacental
C.Fil
tr
at i
on*
barriers
D.Pinocytosis
E.Notext ensivelyboundt oplasmapr ot
eins
E.Si
mpl ifi
eddiffusi
on
30.Whi ch oft he fol
l
owing admini
str
ati
on r
outes
37.I
fthedr ugsubst anceortoxi
ninhibi
tssynt
hesi
s
mostlikelysubjectadrugtoa“ f
ir
st-
pass”eff
ectin
ofATP,whatmechani sm ofpenet
rat
ionthr
oughthe
thel
iv
er ?
cel
lmembr anei sblocked?
A.Inhalati
on
A.Passivedi f
fusion
B.Intramuscular
B.Acti
vet ransport*
C.Intravenous
C.Fi
lt
ration
D.Or al*
D.Pi
nocy tosis
E.Subl i
ngual
E.Si
mpl i
fieddiffusion
31.Youar eplanningtoi nfuseadr ugI Vataconstant
38.Whatphar macoki net i
cproper
tyischaract
eri
sti
c
amountperuni ttime ( rate).Ithas a f i
rstorder
forl
i
pophili
cdrugsubst ance?
el
iminat
ionr ateconst ant( kel)of0. 35/h.Noloading
A.Iti
smet abol izedi nli
ver
*
dose wi l
l be gi ven. How l ong wi l
li tt ake
B.Lowbi oavailabili
tyinorali
ntr
oduct
ion
approxi
mat el
yf orbloodl ev elstor eachsteadystate
C.Quickrenal eliminat i
on
aft
ertheinfusionbegins?
D.Lowper meabi li
tyacrossti
ssuebar
rier
s
A.0.7hour s
E.Lowr enalreabsor pti
on
B.1.2hour s
C.9hour s* 39.Phar macol ogicalincompati
bil
ity ofmedici
nes,
D.24hour s whichi sfoundoutatal evelofspecifi
cef
fect(for
E.36hour s exampl e,admi nistrat
ion of adrenomimet
ics and
adrenoblockers),
isknownas:
32.Twodr ugsactont hesamet issueororganv i
a
A.Physical
acti
vat
ionofdi ff
erentreceptor
s,result
ingi
nef f
ects
B.Pharmacoki neti
c
thatarequal i
tat
ivel
yt heopposi t
eofoneanot her.
C.Chemi cal
Whatisthetypeofdr ugantagonism?
D.Pharmacody namic*
A.Chemi cal
E.Pharmaceut i
cal
B.Physiologi
c
C.Dispositi
onal 40.I
nfl
uence of cer
tai
n unf
avor
abl
efact
ors,i
n

3
parti
cular some medi calagents,which pr
ecede E.Mat
eri
alcumul
ati
on*
pregnancy ,enlar
ger i
skofabi r
thofthechil
dwith
46.Apat ientwhohasbeent r
eatedwi t
hdi azepam on
geneticdefects.Howt hi
sactioni
scal
led?
accountofneur osiscompl ai
nsoft oothache.Doctor
A.Embr yotoxi
ceffect
admi ni
stered him an anal geti
c,buti ts dose was
B.Mut ageniceff
ect*
l
ower t han av erage therapeut
ic dose. What
C.Teratogeniceff
ect
phenomenondi dt hedoct
ort akeintoaccountwhi l
e
D.Fetotoxiceff
ect
prescri
bingt hepat i
entanunderdose?
E.Blastomogeniceffect
A.Tolerance
41.I tis known t hatindiv
idual
s with genet
ically B.Cumul ati
on
caused def iciency of gl ucose-6-
phosphate C.Summat ion
dehydrogenase may dev el
op RBC hemol ysisi n D.Potent i
ation*
responsetot headmi ni
str
ati
onofsomeant i
malarial E.Drugdependence
drugs.Mani fest at i
onofadv ersereact
ionstot hese
2013 47.Dur ingsur gi
caloper at
ionwithadmi ni
str
ationofa
drugsiscalled: my orel
axant( neuromuscul arbl
ocker),adisturbance
A.Idi
osy ncr asy* ofbr eathingdev eloped.Admi ni
st r
atonofpr
i oseri
ne
B.Sensi bilization (neostigmi ne)hasi mprovedpatient’
scondit
ion.What
C.Allergicr eacti
on i
st henameoft histypeofdr ugi
nteracti
on?
D.Tachy phy l
axis A.Incompat i
bil
ity
E.Tolerance B.Ant agonism *
42.I
napat i
ent’
sliv
ertheprocessesofdetoxifi
cati
on C.Tachy phyl
axis
ofnaturalmetaboli
tes and xenobi
oti
cs is broken. D.Sy nergism
Acti
vi
tyofwhatcytochr
omecanber educed? E.Cumul ati
on
A.Cyt
ochromeB 48.Doct orpr escr i
bed5%ephedr inenasaldropstoa
B.Cyt
ochromeB- 1 patientsuf fering f r
om acut erhinit
is.The pati
ent
C.Hemoglobin startedtoputt hedr opsev ery30mi n.Asar esul
t
D.Cyt
ochromeoxidase there was shar p weakeni ng oft he eff
ectoft he
E.Cyt
ochromeP-450* preparati
on.I ndi catet her eason ofappearanceof
43.Thepat i
entwasgi v
enadr ug“A”.Aft
erafewdays tachyphylaxis:
theeffectoft hedr ugsignif
icant
lydroppedandfor A.Exhaust ionofsubst ratethr
oughwhi ch
rest
ori
ng oft he ini
ti
aleffectitwas necessar
yt o ephedr i
neact s*
i
ncreaset hedr ug’sdose.Whati st henameofthis B.Adapt ationofcel lr
eceptors
phenomenon? C.Increaseofact i
vit
yofhepat i
cenzy mes
A.Cumul ati
on D.Increaseofexcr eti
onofephedr i
ne
B.Tachy phylaxis E.Blockadeofr eceptors
C.Dependence 49.I
ndicat
et henumberofi nt
roduct
ionofadr
ugper
D.Tol er
ance* dayi
fitshalf
-li
feper
iod(
T1/2)i
s20hour s:
E.Idiosyncrasy A.2timesaday
44.Dur i
ng t he embr y onic per i
od met aboli
sm of B.3timesaday
medi cat
ionsi sconsi derablysl owedt haninanadul t C.4timesaday
organism.The speci fied f eature of an embr yo D.Oncedai l
y*
pharmacoki netics is caused,f i
rstof al l,by t he E.Every12hours
fol
lowing: 50.Whati shalf-
li
feperi
od( T1/2)ofadr ug?
A.The f uncti
onali mper fecti
on of enzy mes, A.Bloodpl asmav ol
ume,whi chi scl earedf
rom t
he
predomi nantlybyt heirabsence* druginaper i
odoft ime
B.The bi g permeabi lit
y of hi st
ohemat ologic B.Per i
oddur ingwhi chconcent rationofadr ugin
barri
ers bl
oodpl asmai sdecreasedby50%*
C.Essential vol
umeofext r
acellularli
quid C.Periodofcompl eteexcret ionofadr ugf
rom t
he
D.Abi l
it
yf orabsor ptionandal locati
onofwat er- organi
sm
solubl
edr ugsbyt heski n D.Speedofexcr eti
onoft hedr ugv iakidneys
E.Mat uri
ng”ofr ecept orsi nor gansi ndifferent E.Rat i
o bet ween speed ofexcr eti
on and bl
ood
t
erms pl
asmaconcent rat
ionofadr ug
45.Apat ientwi t
hchr oni
ccardiacinsuffi
ciencyhad 51.Benzylpenicill
in natri
um sal
tisi nject
ed t
ot he
been taking foxgl ove(Digi
tal
i
s)pr eparati
onsf ora pati
entwithpneumoni ai nadoze500, 000U6t imes
l
ongtime.Duet ot heviol
ati
onofintakeschedulethe perday.Justaf terani nj
ecti
onthepatientdev
eloped
woman got sy mptoms of i ntoxicati
on. These fev
er,spasms,l oss ofconsciousness.Whathas
symptomsr esul tfrom: happenedtot hepat i
ent ?
A.Tachy phylaxis A.Anaphy lacticshock*
B.Sensi bil
ization B.Idi
osyncr asy
C.Funct ional cumulat
ion C.Tachyphy laxis
D.Idiosyncr asy D.Cumul ation
4
 E.Tol
erance 58.Dur i
ng t he v i
sitt o a dent i
st,an at tack of
bronchospasm hasdev elopedi nthepatientwhohas
52.The pat i
entsuf fer
ing from epilepsyhasbeen
been t r
eat ed with 5 % ephedr i
ne hydr ochlor
ide
recei
vingdai ly0, 2gofphenobar bit
alcontinuously
.
solut
ioni njecti
on.I n20mi nt heat tackreoccur r
ed.
Recentlyat t
acksbecamemor efr
equent,suppressed
Theaddi tionalinj
ect ionofephedr i
nehadnoef f
ect
moodi sobser ved.Whi chpr ocessbecamet hecause
duet otachy phyl
axis.Whatmechani sm underli
esthis
ofdeteri
or ati
onoft hepatient’
sstate?
phenomenon?
A.Livermonooxy genaseenzy messy stem i
nduction*
A. Exhaust i
on of t he nor adrenali
ne depot i n
B.Livermonooxy genaseenzy messy stem i
nhibi
ti
on
presynapticendings*
C.Lipolysisactivation
B.Inhibi
ti
onofadr enal receptors
D.Gluconeogenesi sactivati
on
C.Activati
onofadr enal receptor s
E.Glycolysisinhibiti
on
D.Mat eri
al cumulationoft hedr ug
53.Adoct orhaspr escr i
bedt oa48y .
o.manwi t
ha E.Inductionofmi crosomalenzy mesy st
em byt he
stenocardiaatt
ackapi l
l ofnit
rogl
yceri
nesubl
ingual
ly
.
l
i
ver
Whyhast hedoct orchosenasubl ingualmethodof
themedi cineadmi ni
stration? 59.Wer epeatedlyadmi nist era dr ug oral
ly.Every
A.Badi nt
esti
nal absor pt
ion dosei s100mg;t hei nter v
albet weendosesi s8h,
B.Drugeliminationbygast ri
cjui
ce whichi si denti
calt ot hedr ugpl asmahal f
-l
if
e.The
C.Effectdevelopsf aster* bioavail
abili
tyis0. 5.Forasl ongasweconductt he
D.Iti
sact i
vatedbysal i
va experiment no i nteract ing dr ugs ar e added or
E.Onlybecausei tdamagest heli
ver stopped,and t here ar e no pat ient-r
elat
ed factors
(excreti
on, metabolism)t hatmi ghtchanget hedrug’s
54.Phenobar bi talwaspr escr ibedt oa54y .o.man,
pharmacoki neti
cs.
sufferi
ngf rom i nsomni a.Thesl eepr hyt
hm hasbeen
Howl ongwi lli
tt akef ort hedr ugt oreachsteady-
normal ized.Butgr adual l
y ,dur ing2mont hs, t
heef fect
stateserum concent r
at i
on( Css)?
of a medi ci ne has decr eased and i nsomni a
A.( 0.693xVd)/Cl
reoccur red.Whatf actorcauses t he reduct i
on of
B.0. 693/ke
somni faci entmedi cat ionef fect ?
C.T1/2xke
A.Badsol ubi lity
D.D/( FxT1/2)
B.Tol erance*
E.4. 5xT1/2
C.Badabsor ptioni nt hest omach
Abbreviat
ions:F=bi oav ai
labili
ty:
D.Accumul at i
oni nl ipids
ke=eliminati
onr ateconst ant;D=dose( mg);
E.Tachy phy l
axi s
Сl=cl ear
ance; T1/2=hal f-
li
fe( h)
55.Itisknown, thati npeopl ewi thgenet i
call
ycaused Vd=Vol umeofdi stribut ion.
i
nsuf fi
ciencyofgl ucose- 6-phosphat edehy drogenase
enzy meofr edbl oodcel l
s,l ysi sofst at
edcel l
smay 60.Apat ientwhohasbeent akingadr ugforalong
develop as a r eact i
on t o some ant imalari
al ti
mecannotabr upt l
yst opit
susebecauset hi
smay
medi cationsi nj ect ion.Howi ssuchunt ypicalreacti
on l
eadt opsy chi
candsomat i
cdy sfunct
ions.Namethe
tomedi cat ionsdesi gnat ed? syndromeofdi fferentdisor
der scausedbyadr ug
A.Sensi tizat ion withdrawal:
B.Idi osy ncr asy* A.Tachy phylaxis
C.Al ler gicr eact ion B.Cumul ati
on
D.Tachy phy laxi s C.Idiosyncrasy
E.Tol er ance D.Sensibili
zation
56.Anal cohol icwomanhasbor nagi r
lwi t
hment al E.Abst i
nence*
andphy sicaldev el opment all ag.Doct orsdi agnosed 61.Achi l
dsuffer sfrom dr ugi di
osyncrasy .Whati
s
thegi rlwi thf et alal coholsy ndr ome.Whatef f
ecti s thecauseofsuchr eaction? 2012

thecauseoft hegi rl’

sst ate? A.Hereditaryenzymopat hy*
A.Mal igni zat ion B.Exhaust i
onofsubst rateinter
actingwi t
h
B.Car cinogeni c phar
maceut icalsubst ance
C.Mechani c C.Accumul ati
onofphar maceut i
cal subst
ance
D.Ter at ogeni c D.Inhi
bit
ionofmi crosomal li
verenzy mes
E.Mut ageni c E.Associateddiseasesoft ar
getor gan
57.Thepat ientwi thhy per tensi onhasbeent akingan
anti
hy per tensi vedr ugf oral ongt ime,butsuddenl yhe 62.A50y .
o.pat ientwi thf oodpoisoningisonadrip
stoppeddoi ngi t.Af t
ert hatpat ient
’scondi ti
onhas of10%gl ucosesol ut i
on.I tnotonlypr ovi
desthebody
worsened,hy per tensi vecr isishasdev el
oped.What withnecessar yener gy,butal soper for
mst he
kindofasi deact ioni sit? functi
onofdet oxificati
onbyt hepr oducti
onofa
A.Cumul at ion met abol
it
et hatpar ti
cipat esinthef oll
owi
ng
2013
B.Wi thdr awal sy ndr ome* conjugati
onr eact i
on:
C.Tol er ance A.Met hylation
D.Sensi tizat ion B.Hydr oxylat i
on
E.Addi ct ion C.Glycosy lation*
D.Glucur onidation
5
 E.Sul
fat
ion E.Bi
smut
hsubni
tr
ate
2.Agent
saf
fect
ingt
heAf
fer
entNS 7.Bismuthsal t
sar ethoughtt obeeffecti
veadj
uncts
i
nmanagi ng,i fnotheal ing,r efr
act
orygastri
culcer
1.Whichofthef oll
owingcondit
ionsi
sNOT
becausetheyhav ebactericidal pr
oper
tiesagai
nst
:
char
acter
ist
icofcocai neoverdosage?
A.Staphylococcusaur eus
A.Dilati
onoft hepupil
B.Clostri
dium dif
fi
cile
B.Euphor ia
C.E.coli
C.Tachy cardi
a
D.Helicobacterpylori*
D.Per i
pheralvasodi
lat
ion*
E.Bacteri
cidesfragili
s
E.Hallucinati
ons
8.I
ndicatethemechani sm ofactionoflocal
2.Apat ientwasdel i
veredtothesur gicaldepart
ment
anestheti
cs:
i
n connect i
on wi th acute appendi ci
tis.He was
A.Format i
onofal
bumi nateswi thti
ssue’sprot
eins
proposed t o make appendect omyundert he l
ocal
B.Blockadeofsodi
um channel s*
anesthesia.Butf rom hismedicalhi storywasknown
C.BlockadeofM-cholinoreceptors
thathe had sev er
e aller
gicr eactions to drugs.
D.Inhibi
ti
onofnon-specifi
cexci t
ator
ysy st
emsof
Choose t he dr ug the most pr eferablef or the
CNS
i
nfil
tr
ationanest hesiainthissi
tuation:
E.Blockadeofal
pha- adrenoreceptors
A.Nov ocaine
B.Li docaine* 10.Adri
v erfeltsharppainintheeye.Hewas
C.Anest hesine admit
tedt othehospi t
al.Whichlocalanesthet
icmay
D.Di caine beappli
edf orremov alofaforeignbodyfrom theey
e?
E.Anyf rom indi
catedabove A.Anaest hesine(Benzocaine)
B.Nov ocain
3.Apat i
entwasadmi tt
edtoahospi talwithtrauma
C.Lidocaine*
oftheeyeasar esultofhitt
ingwithmet al
li
cshav i
ng.
D.Trimecai ne
Edemaandhy per emi aoftheey e,hyperl
acri
mat i
on,
E.Sov cai
num
painareobserved.Chooset helocalanesthet
ictouse
forremovalofthef orei
gnbody : 11Whatmor phol
ogi calel
ementsofskinandmucous
A.Procaine( Novocai
ne) membranesar einvolvedini
nteract
ionwitht
hedrug
B.Tri
mecai ne i
nter
mi nalanesthesia?
C.Anesthesine A.Sensi t
ivenervousendings*
D.Dicai
ne* B.Epi dermis
E.Anyfrom indicatedabove C.Fattyti
ssue
D.Capi l
l
arywal l
4.Nat
ural
l
yoccur r
ingl
ocal
anest
het
ici
s:
E.Derma
A.Nov ocaine(Pr
ocai
ne)
B.Anesthesine 12.I
ndicatethepr i
nci
pleofactionofcov er
ingdrugs:
C.Lidocaine A.Format ionofprotecti
velayeronthemucous
D.Cocaine* membr anes*
E.Trimecaine B.Blockadeofmucousmembr anesreceptor
s
C.Coagul ati
onofpr ot
einsofsuperfi
ciall
ayerof
5.A23y .o.womanwi t
hr edandi t
chyeczemat ous
mucousmembr ane
dermatit
isv i
sit
sadoct orof f
ice.Shehadadent al
D.Format ionofcompl exeswithtoxi
cagent s
procedureonedayear l
ierwithadmi ni
str
ati
onofa
l
ocalanaest hetic.Ther e were no otherf i
ndings, E.BlockadeofNa+- channels
al
though she indicated thatshe had a historyof 13.Foranest hesiadur i
ngt oothext racti
onsol ut
ionof
al
lergi
cr eacti
ons.Whi choft hefoll
owingdr ugsis novocain( pr ocaine)hasbeenused.Whyi twasnot
mostlikel
yinvolved? i
ntroducedi nt ogingivalti
ssue, butint hepr oj
ecti
on
A.Lidocaine ofnervef iberpat h?Becauseof :
B.Ultr
acaine A.Transmi ssionofpai nimpul sesi sblocked*
C.Bupivacaine B.Al
t er ationoft i
ssuepHi nanest hesiaarea
D.Nov ocaine(Procaine)
* C.Depr essionofaxonal tr
anspor t
E.Trimecaine D.Dist urbanceofact ionpot entialformationof
6.Apat ientwithrenalfai
lureundergoesaper i
odic thepainr ecept ors
hemodi alysi
swhi l
eawai ti
ngat r
ansplant.Between E.I
ncr easi ngofexci tabil
it
yoft hepai nreceptor
s
dial
ysis sessions we wantt or educe the body’s 14.Whynov ocai
ne( procai
ne)isnotusedf orter
minal
phosphat e load by r educing dietar
y phosphat e anaest
hesia?
absorptionandr emov i
ngsomephosphat ealr
eadyi n AIspoor l
yabsor bedthroughnor malski
nsurface
the blood.Whi ch compound shal lwe admi ni
ster andmucousmembr ane*
oral
ly? B.Doesn’tcausecov eri
ngact i
on
A.Al uminum hydroxi
de* CItiseasil
yabsor bedandi nhi
bitst
heCNS
B.Magnesi um hydroxide D.Ir
ri
tatesmucousmembr ane
C.Sodi um bi
carbonate E.Acti
vatesM- choli
noreceptors
D.Tanni n
6
15.Indicatethemai nef f
ectofthelocalanest
hetics: D.Tri
mecaine
A.Elimi nat
eallkindsofsensibil
ityduetoblockadeof E.Anaest
hesi Benzocai
ne( ne)*
actionpotential*
23.Whichdrughast ol
obeaddedt i
docai
nesol
uti
on
B.Eliminateallkindsofsensi bi
l
ityduetoparalysisof
topr
olongitsacti
on?
theCNS
A.No-spa
C.Decr easeofexci t
abili
tyofnerveendings
B.Caffei
ne
D.Decr easeofexci tabil
it
yandconduct i
vit
yoft he
C.Adrenali
ne*
afferentnervoussy st
em
D.Atr
opine
E.Select i
verel
ieveofpai nsensi
bili
tyi
nlocalacti
on
E.Anapril
i
ne(Propr
anol
ol)
16.Whataretheaimsoft her
apybyi rr
it
ativ
edrugs?
24.Whati st hemaini ndi
cati
onforadsor
bingdr
ugs
A.Refl
exst i
mulati
on
use?
B.Sli
m analgesi
cef f
ectasar esultofdist
ract
ing
A.Di
arrhea
act
ion
B.Hypoacidicgastri
ti
s
C.Dil
ati
onofski nvessel
s
C.Decreaseintrypsinact
ivi
ty
D.Improvementofinnerorgantrophici
ty
D.Decreaseinbilesecret
ion
E.All
abov e*
E.I
ntoxicati
on*
17.I
ndicat
et hemai nef fectofastri
ngentdrugs.
25.Anur seusedmust ar dplasterwit
hwat erofmore
A.Decreaseofner veendingsensi bi
li
ty*
B.Reduct i
onofhy peremiaofmucous than600Ct o
andappliedi tonpat i
ent’sback.I
n30
membr anesduet ov asoconstri
cti
on mi nshef oundt hatpatient’
sski nunderthemustard
C.Reli
efofpai n plast
erdi d notgetr ed.Whati st he reason f
or
D.Decreaseofsy nthesisofhistamine absenceofmust ar
dplastereffect?
E.Decreaseofgl andsecr eti
on A.Inactivati
onofmi r
osin*
B.I
nact ivati
onofchol i
neest er
ase
18.Whi
chdr ugf rom thegroupofl
ocalanaest
het
ics C.Act i
vat i
onofmi rosi
n
i
snotusedtoget herwithsul
fonami
des? D.Inactivati
onofmonoami neoxidase
A.Nov ocain(procai
ne)* E.Act i
vationofmet hyltr
anspherase
B.Sovcaine
C.Li
docai ne 26.Iti
snecessar ytocarryoutl ocalanesthesiaby
D.Tri
mecai ne l
idocai
neatext ract
ionofaf oreignbodyfrom aney e.
E.Ul
tracaine Whatistheact i
onmechani sm ofthisdr
ug?
A.BlocksNa+channel s*
19.Determi nethedrug,whichisusedf
oral
lty
pesof B.Breakst r
ansitofK+throughthemembr ane
anaest
hesi a. C.Decreasesdehy drogenaseacti
vit
y
A.Nov ocai n(pr
ocaine)
D.Activ eK+channel
at s
B.Anaest hesine(Benzocai
ne) +
E.Acti
vateNa channel s
C.Lidocai ne*
D.Trimecai ne 27.Itisnecessar yt opr ov i
del ocalanesthesiatoa
E.Di caine( t
etr
acai
ne) pati
entwi t
hski nbur nswhi chr ecei
vedasul fonamide
agentsul facyl-sodium ( sulfacetamide sodium)f or
20. A pat i
ent wi th i ncr
eased sensi
tiv
ity to
the prevention ofcont aminat i
on oft he wounds.
sul
fonamide needs t ooth extr
acti
on.Which local
Whichl ocalanest heti
ci sundesi rabl
et oadmi nist
er
anest
hetichast obeused?
simult
aneousl ywi thsulfonami des?
A.Anaest hesine(Benzocaine)
B.Dicaine( Tetr
acaine) A.Nov ocaine(Procai ne)*
B.Lidocai ne
C.Li
docai ne*
C.Tr i
mecai ne
D.Cocai ne
D.Ultracaine
E.Nov ocaine(Procaine)
E.Py romecai ne
21.Inj
ect
ionofal ocalanestheti
chastobegi
ventoa
28.A farmerhasbeenadmi tt
edt ohospitalwitha
pati
entfortoot hextracti
on.Whi chdr
ugshoul
dbe
sharppaininhisey e.Whatl ocalanestheti
cwillcause
used?
thestr
ongestanest hesiaatt er
mi nalanest
hesia?
A.Cocaine
B.Dicai
ne( Tetr
acaine) A.Nov ocaine( Procaine)
B.Li
docai ne
C.Anesthesine(Benzocaine)
C.Trimecaine
D.Ultr
acaine*
E.Ketamine
D.Dicaine(Tet racaine)*
E.Anaesthesi ne( Benzocaine)
22.Thisagenti spoorl
ysolublei
nwater
, soi
tisused
29.A26y .o.pati
entwi
thnumerousburnsoft heskin
for super
ficialanesthesia onlyint he for
m of
has been car ri
ed outsuperf
ici
alanesthesia with
oint
ment,past eandpowder .Whati
sthi
sdrug?
A.Sovcai ne
aerosol« Ampr ovi
zol
»t hatcontai
ns anaesthesine
B.Nov ocaine(Pr
ocaine) (benzocaine). What el
ements of the ski n and
mucosalmembr anesareaff
ectedbyanest heti
cat
C.Pyromecai ne
terminalanesthesi
a?

7
 A.Epider
mi s choli
ner gi
cagoni stwithaphar macologicacti
on?
B.Wallsofcapil
lar
ies A.Proser i
ne: stimulatesatonicbl adder
C.Sensit
ivenerveendings* B.Car bachol:inducesr eleaseofepi nephri
nefrom t
he
D.Derma adrenal medul la
E.Subcutaneousfatt
yt i
ssue C.Acet y l
choline:decr easeshear trateandcar di
ac
output
30.Itisnecessaryf orpat i
enttocarr
youtpar
anephral
D.Pilocarpine: reducesintraocularpressure
blockadeaf terA.V. Vishnevsky.Whatconcent
rati
on
E.Phy sosti
gmi ne:decreasesi ntesti
nalmotil
it
y*
ofnov ocai
ne( pr
ocai ne)isr equi
redfori
ntr
oducti
on
forthi
spur pose? 4.Proserpine(Neosti
gmi ne):
A.0.125-0.5%* A.Iscontraindi
catedinglaucomaandmy astheni
a
B.0.5-1% B.Mayi nduceobst i
pati
on
C.1-2% C.Decreasest heacet yl
chol i
neconcent r
ationatthe
D.2-3% neur
omuscul arjuncti
on
E.5% D.Mayr esulti
nbowelhy permoti
li
ty,sal
ivati
on,and
sweating*
31.A pat ientsufferi
ng fr om chronic hyperacidic
E.Exacerbatestubocurarinepoisoni
ng
gastr
iti
s t akes an ant acid drug f or hear t
bur n
el
iminati
on.Af terit
singestionthepatientfeel
sbet ter 5.Whi
choft hef ol
lowi
ngsignsisNOTanexpect ed
butatthesamet i
mehehasasensat ionofst omach sympt
om ofpoi soningwihneost
t igmine(pr
oser
ine)?
swell
ing.Whi chdrugmi ghtbet hecauseofsuchsi de A.Increaseinskelet
almuscletonus
eff
ect?2012 B.I
ncr easedbronchi
alsecret
ions
A.Sodi um hydr
ocar bonate* C.Mi osi
s
B.Pepsi n D.Tachy cardi
a*
C.Al umini
um hydroxi de E.Conv ulsi
ons
D.Magnesi um oxide 6.Whi ch of t he following drugs INCORRECTLY
E.Magnesi um tr
isil
icate mat ches a chol inergic agoni st wi th a
32.Whichdrugf rom thegroupoflocalanest
het
icsi
s pharmacol ogical acti
on?
notusedtogetherwi thsul
fonamides? A.Pr oserine: sti
mul atesatonicbladder
A.Nov ocai ne(pr
ocaine)* B.Car bachol :inducesr eleaseofepinephri
nefr
om t
he
B.Bupi vacaine adrenal medul l
a
C.Lidocai ne C.Acet y
lchol ine:decr easeshear trateandcardi
ac
D.Trimecai ne output
E.Ultr
acai ne D.Pi l
ocar pine: r
educesi ntraocul
arpressur
e
E.Gal antami ne: decreasesi nt
est
inalmotil
it
y*
3.Agent
sAf f
ecti
ngtheEff
erentNS 7.Whi
chONEoft hef ol
lowi
ngdr ugswouldbeusef
ul
3.
1.Choli
nergi
cAgents i
nthel
ong-termtreatmentofmy astheni
agrav
is?
3.
1.1.M,N-
Choli
nergi
cAgents.Ant
ichol
inest
erases. A.Arduan
1.Det ermi ne t he phar macol ogi
calgroup ofdr ugs B.Atropi
ne
according t o t heir pr opert
ies: they i nhibi
t C.Proseri
ne( Neosti
gmine)*
acety
lcholinest erase, del ay t he hy drol
ysi
s of D.Scopolamine
acety
lcholine, f acilitate t he neur omuscular E.Lobeli
ne
conduct i
on, cause mi osi
s and spasm of 8. Det ermi ne t he dr ug. I t i s t he r ev er
sible
accommodat i
on,i ncreaset hetonici
tyofthesmoot h acetyl
cholinest eraseinhibitorandcausest heef f
ect s
musclesoft hei nneror gansandskel etalmuscl
es associated wi tht he ex cit
ation of par asy mpat hetic
A.Ant icholinest erases* nervoussy stem:i tnarrowst hepupi l
s,decreasest he
B.al pha- adrenobl ockers i
ntraocularpr essure,causes br adycardi
a,spasm of
C.bet a-adrenobl ockers accommodat ion;st imulates smoot h muscl es and
D.M- chol i
nobl ocker s gl
andsoft hegast roi
ntestinal
, r
espi r
atory,ur
inar ytr
act s
E.N- chol inobl ocker s and i n t he ey e; facilit
ates t he neur omuscul ar
2.Inexper
imentheterozy gousmiceamut ati
onofthe tr
ansmi ssion.Chemi callyi tisquat er
naryammoni um
gene codi
ng protein ofend pl ate ofthe skel
etal compound, hencei spoorlyabsor bedor all
y(oral dosei s
muscles, which fixes acet yl
choli
nest
erase in a 20-30t i
meshi ghert henpar enteraldose)andpoor ly
synapse, has been r eceived. Which way wi l
l penetratesintot heCNS.
neosti
gmine (pr
oserin)i nf
luenceonneur omuscul
ar A.Pheny lephri
ne
tr
ansmissi
onbechanged? B.Neost igmine( Proser i
ne) *
A.Willbesl
ightlyampl i
fi
ed C.Gal ant amine
B.Will
besignificantl
yampl i
fi
ed D.Pilocar pine
C.Willbenotchanged E.At ropinesul f
ate
D.Willbedecreased* 9.Pr oseri
n has been admi ni
ster
ed to a pati
ent
E.– suff
eringf r
om my ast
henia.Aft
eritsadmini
strati
on
3.Whi
choft
hef
oll
owi ugsi
ngdr ncor
rect
lymat
chesa thepatienthasgotnausea,di
arr
hea,twi
tchoftongue

8
andskel
etalmuscl es.Whichdr
ugwi
l
lel
i
minat
ethe B.Physosti
gmi ne*
i
ntoxi
cat
ion? C.Pil
ocarpine
A.Atropinesul f
ate* D.Dipi
roxim
B.Py r
idosti
gmi nebromi
de E.At r
opine
C.Isadrine 17.Afteruse ofneost i
gmine inthe patientwi t
h
D.Mesat on myasthenia,such sy mpt oms as nausea,di ar
rhea,
E.Phy sosti
gmi ne twi
tchi
ngofmuscl esoft ongueandskeletalmuscles
have appear ed. Whi ch agent can abor t the
10.A54y .o.mal ei sadmi ttedt ot heemer gencyr oom.
i
ntoxi
cation?
Hecompl ai nsdr ymout h, phot ophobi a,blur
redv i
si on.
A.Physostigmine
Hehashy per emi aanddr ynessofski n,my driasi s,
B.Methacin*
i
ncr easedi nt raoc ularpr es s ure.Thehear trateis140per
C.Mesatone( Phenylephr
ine)
mi nuteandBPi s100/ 70mm Hg.Whi chofdr ugs houl d
D.Tubocurari
ne
beadmi nister ed?
E.Py ri
dosti
gmi nebromide
A.Pr oser ine( Neost igmi ne)*
B.Pi locar pine 18.Toapat ientwi thgl aucomai tisnecessar yt o
C.Di piroxi m prescr i
be a medi cine. What ant i
cholinester ase
D.Dopami ne (ter
tiaryami ne)i snotusedi nopht halmicpr act i
ce
E.Adr enal i
ne becauseofsi gni f
icanti rri
tantact i
ononey e?
11.Al loft hef oll
owi ngdr ugsdonotcr osst hebl ood A.Ar mi ne
brai nbar rierexcept : B.Py ri
dost igmi nebr omi de
A.Pl aty phy l
lin C.Pr oser ine( Neost igmi ne)
B.Gast r osepi ne D.Gal antami ne*
C.Gal ant ami ne* E.Phy sost i
gmi ne
D.Neost i
gmi ne( Pr oser i
ne) 19.Apat ientwi t
hcompl aint sondr ynessi nmout h,
E.Pi renzepi ne phot ophobi aandv i
sualdi stur bancesi sadmi ttedt o
12.Thesubt y peofcar diacmuscar i
nicrecept ori s an admi ssion depar tment .He has r edness and
predomi nant l
y : drynessofski n,pupi ls’di l
ationandt achy cardiadue
A.M1 topoi soni ngwi thBel ladonnaal kal
oids.Whatagent
B.M2* shoul dbeused?
C.M3 A.Ar mi ne
D.M1andM3 B.Pi locar pi
ne
E.M1, M2andM3 C.Pr oser ine( Neost i
gmi ne) *
13.Phy sost igmi ne( Eser inisul fas)usedmai nl
yf ori ts D.Di pi roxi m
par asy mpat homi met icef fect s, i
nhi bit
s: E.Di azepam
A.Phosphodi est erase 20. At compl ex nar cosi s ( general anest hesia)
B.Acet y lchol inest erase* protocoldur i
ngst omachr esect ion,apat i
enthasgot
C.Cat echol -O- met hy ltr
ansf erase( COMT) an i njection of t ubocur arine chl ori
de as a
D.Monoami neoxi dase( MAO) my orelaxant( neur omuscul arbl ocker )
.Whatagent–
E.DOPAdecar boxy l
ase antagoni stshoul dbeadmi nister edtot hepat ientf or
14.Dur ingsur gicaloper ationwi thadmi nist
rationofa restorationofhi ssel f-drivenr espi r
ati
on?
my orelaxant( neur omuscul arbl ocker ),adi sturbance A.Pr oser ine( Neost i
gmi ne) *
ofbr eat hingdev eloped.Admi nistratonofpr
i oser ine B.Di thy lin(Succi nylchol i
ne)
(neost igmi ne)hasi mpr ov edpat ient ’
scondi t
ion.What C.At ropi ne
i
st henameoft hist ypeofdr ugi nt eracti
on? D.Et imi zol
A.I ncompat i
bi l
ity E.Benzohexoni um
B.Ant agoni sm * 21.Whatt he mostappr opr iate ant i
cholinester ase
C.Tachy phy l
axi s agent shoul d be gi ven t o combat t races of
D.Sy ner gism poli
omy eliti
s?
E.Cumul ation A.Pr oser ine
15.Adoct orhaspr escr ibedcy clodolf orPar ki
nson B.Gal ant ami ne*
disease. What i s t he mechani sm of i ts C.Phy sost i
gmi ne
ant iparkinsoni anact i
on? D.Ar mi ne
A.M chol i
nomi met icact ion E.Pl at yphy ll
in
B.M, N- chol i
nobl ocki ngact ion* 22.Whi choft hef ollowi ngdr ugsi ncorrect
lymat ches
C.St imul ationofdopami ner eceptors achol inergi cagoni stwi t
haphar macol ogicact i
on?
D.Bl ockadeofdopami ner ecept ors A.Pr oser i
ne: stimul atesat onicbl adder
E.bet a- adr enobl ockeract i
on B.Car bachol :inducesr eleaseofepi nephr i
nef rom t he
adrenal medul la
16.Thegl aucomai sdiagnosedin43y .
o.pati
entfor C.Acet y l
chol ine:decr easeshear trateandcar di
ac
the fi
rst t i
me. For t he treat
ment doctor has output
prescr
ibedanant i
cholinest
eraseagentineyedrops. D.Pi l
ocar pine: reducesi ntraocul arpressure
I
ndicatethisagent: E.Phy sost igmi ne: decr easesi ntest i
nalmot il
ity*
A.Сarbacholi
ne
9
23.Ther ecept orson t hes kel
etalmus cl
eend pl ate 29.
respondt o:
A.Acet ylcholineandni coti
ne*
B.Acet yl
chol i
ne, muscar i
neandni coti
ne
C.Ni cot i
ne
D.Muscar ine
E.Acet yl
chol i
ne
24.A82y .o.mani si ncr easinglyforgetful,andhi s 3.
1.2.M-
Chol
i
ner
gicAgent
s
wifeisaf raidofhei sdev elopingAl zheimer’sdisease. 1.Whi choft hef ol lowi ngcondi ti
onsi schar act eristic
Youconsi derpr escr ibinganant i
cholinesterasedr ug ofpar asy mpat het icst imul ation?
to see i ft hisdecr easeshi sf orgetfulness.Bef ore A.Decr easei ni nt est inal mot il
ity
writi
ngt hispr escription,y ouwantt obesur et hat B.Inhi bitionofbr onchi al secr et ion
thesedr ugsar esui table.Oft hepossi blepr eexi
sting C.Cont ract ionofsphi nct ermuscl ei nt hei ri
soft he
conditions l isted bel ow,y ou shoul d be t he least ey e( my osi s)*
concer nedabout : D.Cont ract i
onofsphi nct erofur inar ybl adder
A.At riovent ri
cul arblockade E.Incr easei nhear tr ate
B.Br ady car di
a
2.Sel ect t he most appr opr iate dr ug t o act at
C.Ast hma
peripher al and cent ral muscar inic chol iner gic
D.Obst ructionoft heGI T
recept or s:
E.Gl aucoma*
A.Pi renzepi ne
25.A 40y .o.mal ef arm wor kerisbr oughtt ot he B.Neost igmi ne
emer gencyr oom.He was f ound conf used i nt he C.Pl at yphy l
lin
orchardandsi ncet henhasl ostconsci ousness.Hi s D.Scopol ami ne*
HRi s45/ mi n;BPi s80/ 40mm Hg.Hei ssweat i
ng E.Ipr atr opi um br omi de
and sal iv at i
ng pr of usely.Whi ch dr ug shoul d be 3.Sel ectt he mostappr opr iate ant icholiner gicf or
admi nister ed? asthma:
A.Gal ant ami ne A.Pl at yphy l
lin
B.Nor adr enaline B.Pi renzepi ne
C.Pr oser ine C.Pi pecur oni um br omi de( Ar duan)
D.At ropi ne* D.At ropi ne
E.Pr ocai ne E.I pr atr opi um br omi de*
26.A pat ientsuf f
er ingf rom my astheniahasbeen 4.A20y .o.pat ientwasadmi ttedt oahospi talwi t
ha
admi nister ed pr oser in.Af teri tsadmi nistration the shar p pai ni nt he abdomen,v omi ting,i mpeded
patienthasgotnausea,di arrhea,t wi t
choft ongue breat hing,and dy spnoea.He has t he moi stski n,
and skel et almuscl es.Whatdr ug woul d hel pt o hyper sal ivat i
on, mi osi s, br ady car dia, muscul ar
eli
mi natet hei nt oxicat i
on? twitchi ng.I ti sknownf rom t heanamnesi st hatt he
A.Py ridost i
gmi nebr omi de patienti sat oxoman,hebr eat hedi nt heaer osolf or
B.I sadr ine extermi nat ionofi nsect s.Whatmechani sm ofact ion
C.Phy sost i
gmi ne hast heagent ,whi chhascausedpoi soni ng?
D.Mesat on A.M- chol inobl ocki ng
E.At ropi nesul fate* B.N- chol i
nobl ocki ng
27.A pat i
entwas admi t
ted t o a hospi talwi th C.M- chol inomi met i
c
compl aint s aboutqui ckf atigabilit
yand si gnifi
cant D.N- chol i
nomi met ic
muscl e weakness. Exami nation r eveal ed an E.M, N-chol inomi met ic*
autoimmunedi seaset hatcausesf unctionaldi sorder 7.Thepat ientwi thcompl aint sofconst antdr ymout h
ofrecept or si nt heneur omuscul arsynapses.Thi swill addr essedadent ist .Thedoct ormadet hedi agnosi s
resulti nt he di stur bed act iv i
ty of t he f ollowing «xerost omi a» .Tonor mal izet hesecr et i
onofsal ivahe
2012
medi ator: admi ni ster edPi locar pi ne5- 6dr ops3t imesaday .But
A.Acet ylchol i
ne* thepat ientv iolat edt hei nst ruct ionsandt ookt hedr ug
B.Dopami ne withoutf ollowi ngt hei ndi cat eddosage.Soonbesi des
C.Gl y cine thedi sappear anceofmout hdr ynesshef eltcr amps,
D.Ser ot oni n diarrhea,i ncr eased br onchi alsecr etion,sweat ing,
E.Nor adr enal ine tearing, br ady car di a, const riction i n t he chest ,
i
nv olunt ar yur inat ion,hy pot ensi on.Wi tht hehel pof
28.Apatientaf terdisrupt
edcerebralcir
cul
ati
onhas
whatdr ugcant hesi deef fect sbeeasi lyel i
mi nat ed?
devel
opedpar aly si
s.Chooset heant i
choli
nest
erase
A.Acecl idi ne
drugt
obepr escr ibedinthi
scase:
B.Cy t i
ton
A.Methaci n
C.Lobel ine
B.Hexamet honium (
Benzohexonium)
D.At ropi ne*
C.Proserine*
E.Pr oser ine
D.Cordiami n
E.Aceclidine 8.Det er mi net hedr ug.I ti st heal kaloi doft hesame
plantsasat ropi nei s.I texer tssi gni fi
canti nhibi ti
ng
10
i
nfluenceupont heCNS.I nt hecl i
ni calpr acti
cei ts from dr yness oft he mout ht hatappear ed af ter
i
nhibiti
ngact ionupont hecent ersconnect edwi tht he remov aloft onsi ls.Whi chef fectisnotchar acteristic
vesti
bul aranal yzeri s used f ort he t r
eat mentof forthisagent ?
mot i
onsi ckness. A.I ncr ease t he br onchismoot h muscl es
A.Met haci n tonicity
B.Scopol ami ne* B.My driasis*
C.Pi renzepi ne CSpasm ofaccommodat ion
D.Gal ant ami ne D.Br ady car dia
E.Pl aty phy ll
in E.Hy per sal i
v ation
9.Al lof f ollowi ng si de ef fect s ar e seen wi th 18.Int roductionofaphar maceut i
calsubst ancet oan
Ipr
atropi um br omi deexcept : exper i
ment al ani mal r esul ted i n r educt i
on of
A.Ur inar yr et ent i
on sali
v ation, pupi l my driasis. Next i ntravenous
B.Dr y nessofmout h i
nt r
oduct i
on of acet ylcholine di dn’tl ead t o any
C.Scr at chi ngi ntrachea signifi
cant changes of hear tr ate. Name t his
D.Mi osi s* subst ance:
E.Gl aucoma A.Proser ine
12.Apat ientwi thr enal colichasbeenadmi ni
stereda B.Adr enal ine
spasmol ytic agent f rom t he gr oup of M- C.Propr anol ol
choli
nobl ocker s.Speci f
yt hi sdr ug. D.At ropine*
A.Met haci n* E.Salbut amol
B.Ephedr ine 19. M- choli
nobl ocker s ar e wi dely used. Whi ch
C.Pi renzepi ne condi ti
oni scont raindi catedf ort heiradmi nistrati
on?
D.Gal ant ami ne A.At riov ent ri
cul arbl ockade
E.No- spa B.At onyofi ntest i
ne*
13.A pat ientr ecei ves Acecl idine af terabdomi nal C.Br onchi al ast hma
surgery. Hi s hear tr ate f all
s sl ight ly and she D.Li verandr enal colic
experiencessomewheezi ng.Thesepul monar yand E.Gast ricul cer
cardiacr esponsesr epresentorr eflect : 20.Apat i
enthasbeengi venat ropinesulf atef orrapi d
A.Expect edsi deef fect* reli
efofspast iccol onsy mpt oms.Theuseoft his
B.I diosy ncr asy drugi scont raindi cat eddur i
ngt hef ollowingdi sease:
C.Par asy mpat heticgangl ionact i
v ation 2016

D.Ref lex( bar orecept or)suppr essi onofcar diac A.Hy potensi on
rate B.Glaucoma*
E.Undi agnosedast hma C.Brady cardi a
14.Wegi vean‘ ef fect i
vedose’ ofat ropi net oaper son D.Bronchi al asthma
who i s poi soned wi t
h an acet ylchol inesterase E.Gastr i
cul cer
i
nhibitor. Whi ch st r
uct ure wi ll cont inue t o be 21.AM1- cholinobl ockerhasbeenadmi nist
eredtoa
overactedbyt heexcessacet ylcholineaf terthisdr ug patientf ort he t reatmentofgast ri
c pept i
c ulcer.
i
sgi ven? Indicatethi
sagent :
A.Ai rwaysmoot hmuscl e A.Pirenzepi ne*
B.S- Anodeoft hehear t B.Scopol ami ne
C.Sal i
v ar yandl acrimal glands C.Ipratropium br omide
D.Skel et al muscl e* D.Met haci n
E.Vascul arsmoot hmuscl e E.Platyphy l
lin
15.Whi chi samuscar i
ner ecept or-
bl ocki ngdr ugt hat 22.Awomanaskedt oadr ug-storemant osel lan
i
s admi nist er ed by i nhal ation t o cause eyedr opsAt ropine,butt helastoner efusedbecause
bronchodi l
ation f orpat i
ent s wi th emphy sema and Atropineiscont raindicatedatgl aucoma.Why ?
asthma? A.Di l
atespupi ls
A.Pl at yphy lli
n B.Increasesi ntraocul arpressure*
B.I prat ropi um br omi de* C.Causespar alysisofaccommodat i
on( cycl
oplegia)
C.Pancur oni um D.Nar rowsv iewf ield
D.Pi locar pine E.Causesmy opia
E.Sal but amol 23.Af teruti
li
zationofopht halmicdropspati
entwith
16. A dent ist pr escr ibed an agent st imulating gl
aucomahasmi osis,my opia,anddropofint
raocul
ar
sali
vationt oapat ientwi thxer ost omi a.I ndicatet he pressure.Whichphar macologicgroupcancausesuch
drug: effect
s?
A.Pi locar pine* A.M-cholinomi metics*
B.Di thy lin B.M-cholinoblockers
C.Ar mi ne C.N-cholinomi meti
cs
D.Scopol ami ne D.Ganglioblockers
E.At ropi ne E.al
pha-adr enoblocker s
17.Adoct orpr escr ibedacecl i
di net oamansuf fering
25.At
ropi
nei
susedasanant
idot
etot
reatpoi
soni
ng
11
with f ly agar ic. Whi ch mechani sm inherent to res tored.Whi c henz ymedef ic i
tpr ol ongst heac tionof
atr
opi ne l eads t o mushr oom t oxi
n muscar i
ne thismy or el ax ant ?
neutralization? A.Succi nat edehy dr ogenase
A.Enzy mat ic B.K- +
Na- +
adenosi net r i
phosphat ase
B.Phy sical-chemi cal C.Car boni canhy dr ase
C.Ant i-enzy mati
c D.Pseudochol inest er ase*
D.Met abol ic E.N- acet y ltransf er ase
E.Recept or* 5.Apat ientwi thf ract ureofl owerj aw wasadmi tt
ed
26.Choose t he agentused i n ophthalmology to toamaxi llof aci aldepar tment .Af t erI Vi nt roduct ionof
exami net hef undusofey e: my orelaxantt her ear osef ibr i
ll
arcont ract ionsoft he
A.At r opi nesul phate* pat ient’sf aci almuscl es. Whi ch my or elaxant was
B.Pr oser ine admi nist ered?
C.Met haci n A.Di azepam
D.Pi locar pine B.Tubocur ar inchl or ide
E.Ipr at r
opi um br omi de C.Pi pecur oni um br omi de
28.A pat ientwi thdr ugi ntoxicat
ionpr esent
edwi th D.Di thy l
in*
thedr ynessofor almucousmembr aneandmy dr
iati
c E.Mel lict i
n
pupil
s.Suchact ionoft hisdr ugisassociatedwiththe 6.Dur i
ngsur gicaloper at i
onwi thadmi nist r
at ionofa
fol
lowi ngef fect : my orelaxant( neur omuscul arbl ocker ),adi st ur bance
A.Adr enor ecept orblock ofbr eat hi ngdev el oped.Admi ni st rationofpr oser i
ne
B.Muscar i
ni cchol i
norecept orsti
mulation (neost igmi ne)hasi mpr ov edpat ient ’
scondi tion.What
C.Adr enor ecept orstimulation ist henameoft hi st ypeofdr ugi nt eract ion?
D.Muscar inicchol i
nor eceptorblock* A.I ncompat i
bi lity
E.Ni cotini cchol i
norecept orsti
mul at
ion B.Ant agoni sm *
29.A manwasi ntoxicatedwi thmushr ooms.They C.Tachy phy laxi s
contain muscar i
ne t hat stimulates muscari
nic D.Sy ner gi sm
chol
inor eceptors. What sy mptoms si gnali
ze E.Cumul at ion
i
ntoxicationwi thinediblemushr ooms?2012 7.Dur ing an oper ation a pat ientgoti nject ion of
A.Riseofar t
eri
al pressur
e muscl e r el axant di thylinum ( succi nylchol i
ne).
B.Bronchi dil
ation Rel axat ion ofskel et almuscl es and i nhi bit i
on of
C.Increasedhear trat
e respi rat i
onl ast ed2hour s.Thi scondi tionwascaused
D.My driati
cpupi l
s* byabsenceoft hef ollowi ngenzy mei nbl oodpl asma
2012
E.My oti
cpupi ls* :
A.But y rylchol ineest er ase*
3. 1.3.N- Chol iner gi
cAgent s B.Acet ylchol ineest er ase
1.Sel ectt hemostappr opr i
at edr ugt otreatthe C.Gl ucose6- phosphat ase
poi soningwi thdepol arizingmyor elaxant: D.Cat al ase
A.Di t
hy lin E.Gl ut at hioneper oxi de
B.Neost igmi ne 8.Dur i
ngsur gicaloper at i
onapat ienthasdev eloped
CFr eshbl oodt ransf usi on* sy mpt omsofdi thyl i
n( succi nylchol ine)over dosage.
DScopol ami ne Whatt reat menti snecessar yt opr ov idet ot hepat i
ent?
E.Iprat r
opi um br omi de A.Admi nist rat i
onofant i
chol inest erases
2.Ni cotinicr ecept or sar eseeni n: B.Admi nist rat i
onofM- chol inobl ocker s
A.Skel et al muscl e* C.Admi nist rat i
onofgangl i
obl ocker s
B.Viscer al smoot hmuscl e D.Bl oodt ransf usi on*
C.Car diacmuscl e E.Admi ni st rationofN- chol i
nobl ocker s
D.Sal ivarygl ands 9.A63y .o.pat ienthasgotani nject ionofpent ami ne
E.Adi posecel l forhy per tensi vecr isis.Whati si tsact i
onmechani sm?
3.A pat ientwi th a hi story ofas thma ex periences A.St imul at ionofM- chol inor ecept ors
signifi
cantbr onc hos pas m andur t
ic ari
a,andhistami neis B.I nhi bi tionofM- chol inor ecept ors
amai nmedi at ori nt hes er es pons es.Whi chdr ugmay C.I nhi bi tionofM- ,N- chol i
nor ecept or s
pos eex trar iskf ort hispat ient–notbec auseithasany D.St imul at ionofN- chol i
nor ecept or s
bronc hoc ons tri
c toref f
ec tsini tsownr i
ght,butbec auseit E.I nhi bi tionofN- chol i
nor ecept or s*
releaseshi s t
ami nef rommas tc el
l
s ? 10. The gangl iobl oc k er Benz ohexoni um has been
A.At ropine admi nister edt oapat ientwi t
hhy per tens ivec ri
ses . Which
B.Neost igmi nesul fat e effec ts shoul d doct orbe wor ried aboutaf tert he
C.Pr opr anol ol dr ug’si nj ect ion?
D.Pancur oni um A.Suppr essi onofr espi rat i
on
E.d-Tubocur arine* B.Di ar rhea
4.Di thyli
n( Li stenone)hasbeeni ntroducedt oapat i
ent C.Reboundsy ndr ome
bef oreanoper ation.Af tert heendofoper ationand D.I nf ringementoft ast esensat i
on
ces sati
onofanaes thes iathei ndiv
idual respi
rat
ionwas n’
t E.Or thost atic( post ur al)hy pot ensi on*

12
11.Cur ar
e-l
ik
emy orel
ax antsareus edf ordecreasi
ngand cardi
omy ocytes
cessationofimpulsetrans missi
onf r
om ner v
eendi ngto D.Directinf
luenceuponthecel
lwal
l
mus cularfi
ber.Whatist hemec hanism ofac ti
onoft hi
s E,Sti
mul ati
onofsy mpat
heti
cgangl
i
ons*
group?
18.Indicatet hemai nf eatureoflobelineaction:
A. Bl ockade N- choli
nor eceptors of post sy
napt i
c
A.Itst i
mul atesdi rect l
ytherespirator
ycent er
membr aneofneur omuscul arjunction
B.Itcausest her elaxati
onofbr onchialsmoot h
B.Inhibit
ionofacet y
lcholinesterase
muscles
C.InhibitonofNa+/K+pump
i C.Itisef fectiveaf terperorali
ntroduction
D. Reduct i
on of neur otr
ansmi tter r el
ease i nto D.Itact sbyr eflexwayst imul
atingt her ecept
ors
synapt i
ccleft ofcar otidzone*
E.Bl ockade ofCa2+ i nwardt hrough pr esy
napt i
c E.Itst i
mul atest her espirat
orymuscl es
membr
ane 19.Indicat et hedr ugwhi chexcitesbot hM-andN-
choli
nor ecept ors:
12.A y oung man hasbr oken hi sl eg in a skiing
A.Acet ylcholine*
accident ,causi ng sev er e muscul ar spasm t hat
B.Pent ami ne
necessi tated r elaxation of t he muscl e wi th a
C.Dithy l
in
compet i
tiveN- receptorant agoni stbef or ethef r
acture
D.Lobel ine
couldbeset .Att heendoft heor t
hopedi cprocedur e,
E.Tubocur arine
thedoct orr est oredneur omuscul art ransmi ssionby
admi nistering: 20.Indicatet hecl inical usesf orbenzohexoni um:
A.Phy sost igmi ne(Eser i
ne) A.Intestinalat ony
B.Neost i
gmi ne(Proser i
ne) * B.Vascul arhy pot ensi on
C.Gal ant ami ne C.My astheniagr av is
D.Car bachol i
ne( Car bachol ) D.Hy per t
ensi vecr i
sis*
E.Ar mi ne E.Respi ratoryar rest
13. A pat ient wi th a l i
mb f ract ure must be 21. Whi ch drug belongs to t
he compet
it
ive
admi nisteredadepol ar i
zingdr ugf rom t hegr oupof ant
agonistsofcholi
nor
ecept
ors?
myor elaxant sf ort hepur poseofashor t
-ti
mesur gery. A.Dithyli
n
Whatdr ugi si t? B.Tubocur ar
ine*
A.At ropi nesul fate C.Lobel i
ne
B.Di thylin* D.Cy t
iton
C.Tubocur ar i
nechl or i
de E.Nicotine
D.Cy ti
ton
22.Indicatethemechani sm ofdi thyli
nact
ion
E.Pent ami ne
A.I tbreaksneur omuscul artransmi
ssionduet o
14.Theef fect soft ubocur arinecanbeant agonized stable depol ari
zation of post synapt
ic
by: membr anesoftheskel etalmuscles*
A.Pi locar pi ne B.Itsti
mul atesM-cholinorecept or
s
B.Acecl idi ne C.ItblocksM- choli
norecept or
s
C.Cy ti
ton D.Itcompet iti
vel
yblockst heN-choli
norecept
ors
D.Neost igmi ne(Pr oser ine) * E.Itdir
ectlyactsuponmy ofi
bril
s
E.Lobel ine
15.A woman has t o pr oduce t r
achea i ntubati
on. 23.Indicatethesi
deef fectofgangl
ionblocker
s:
Whichdr ugshoul dbeadmi nistered? A.Increaseofbloodpr essur
e
A.At ropi nesul fate B.Intesti
nalat
onyandconst ipat
ion*
B.Di thylin* C.Salivati
on
C.Pr oser ine D.I rri
tati
ng i
nfluence on the gastri
c mucous
D.Cy ti
ton membr ane
E.Pent ami ne E.Diarrhea
16.I famanhasanat tackofbr onchospasm i tis 24.Cur ari
form substancesi ntroducedi ntoahuman
necessar yt or educet heef f
ectofv agusonsmoot h bodycauset herelaxationofal lskeletalmuscl es.
muscl esofbr onchi.Whatmembr anecy toreceptors Whatchangesi ntheneur omuscul arsy napsedoes
shouldbebl ockedf ort hispur pose? 2011
thi
sef ectcause?2013
f
A.α- adr enor eceptor s A.Depol ari
zati
onoft hepost synapticmembr ane
B.M- chol inor eceptor s* B.Impai r
edacet yl
cholinerelease
C.α-andβ-adr enor ecept or s C.Bl ockade ofCa2+ channel s oft he presynaptic
D.N- chol i
nor eceptor s membr ane
E.β-adr enor ecept or s D. Blockade of N- choli
nergic recept or
s of t he
17.Whatisthemechani sm oft
hei ncreaseofart
eri
al synapticmembr ane*
pr ebyni
essur coti
ne? E.Impai r
edcholinesterasesy nthesi
s
A.Di
rectst
imulat
ionofvascularadrenorecept
ors 25.Whi ch drug can be used t o decrease blood
B.St
imulat
ionofparasympatheticgangli
ons pressure?
C.St
imulat
ionofmembr anereceptor sof A.Cy t
it
on

13
 B.Tubocurar
ine C.Strophant hin
C.Lobeli
ne D.Adr enaline*
D.Atr
opine E.Nor adrenal i
ne
E.Pentamine* 6.Anaphy lacti
cshockhasdev el
oped in a pat i
ent
26.A 63y .o.mal epatientwi t
hbl adderatonyhad after nov ocain( pr ocaine) i njecti
on. What agent
beenadmini st
eredamedi cati
onwhi chhehadbeen suppr esseshi stami ner eleasef r
om mustcel lsand
arbi
tr
ari
l
yt aki
ng at a hi gher dose.The pat i
ent el
imi nat esmai nsy mpt omsofanaphy l
acticshock?
devel
oped hy perhydr
ation, sal i
vation, di
arr
hea, A.Ket oti
fen
musclespasms. B.Cromol i
nnat ri
um
Theadministereddrugrelatestothef oll
owi
nggroup: C.Adr enaline*
D.Mesat on
2016
E.Nor adrenal i
ne
A.Adrenergi
cbl ockers 7.A 26y .o.pat ienthasbr onchi alasthmaat tacks
B.Choli
nesteraser eact
ivat
ors appear ing usual l
y at ni ght accompany i
ng wi th
C.Gangli
onicblocker s brady car di
a,spast i
ci ntest i
ne pai n,and di ar
rhea.
D.Tocolyt
ics Whatki ndofagent si sthemostappr opriateforthis
E.Choli
nomi met i
cs patient ?
A.M- cholinobl ocker s*
3.
2.Adrenergi
cAgents
B.N-chol i
nobl ocker s
3.
2.1.Adrenomimet
ics
C.Bet a-
adr enomi met ics
1. Di
astoli
c pr essure i s incr
eased af
ter the D.Sy mpat homi met i
cs
admi
nist
rati
onofwhi choneofthefol
lowi
ngdrugs? E.Met hylxant hines
A.Nor adr enaline 8.Whi choft hef ollowingdr ugsst imulatescent r
al
B.Salbut amol presy napt i
calpha2- recept or s?
C.Isadrine A.Adr enalinehy drochl oride
D.Orciprenal ine( Al
upent
) B.Nor adrenal inehy dr otartrate
E.Terbut ali
ne C.Mesat one( Pheny lephr ine)
2.Sy stolicpr essur eisi ncreasedaf t
ert hei njectionof D.Clophel ine*
whichoff oll
owi ngdr ugs? E.Doxazosi n
A.Nadol ol 9.Thepat i
enthasabr upthy pot ensi on.Whi chdr ug
B.Dopami ne* that st i
mul ates adr ener gi cr ecept ors shoul d be
C.Reser pi ne i
nt roducedt onor mal i
zebl oodpr essur e?
D.Or nid A.Met opr olol
E.Met opr ol ol B.Mesat on( Pheny lephr ine)*
3.Dopami ne causes al lbutone oft he f oll
owing C.Xy l
omet hazol ine
act
ions? D.Clophel i
ne
A.I nhibit i
ngi nfluenceont hemot oneur onsof E.Doxazosi n
thespi nal chor d 10. A pat ient has dev el
oped br onchospasmi c
B.Di l
at esr enal vascul at
ure sy ndrome.St imul ators ofwhi ch r ecept ors wil
lbe
C.I ncr easesBP phy siologicallyreasonabl ef oremer gencyt r
eatment ?
D.I ncr easespr oduct ionofur i
ne A.alpha1- adr enorecept ors
E.Decr easescar diacout put* B.D-recept or s
4.All oft hef ollowi ngst atement sar et rueEXCEPT: C.M1- chol i
nocept ors
A.Amongt hephy siologicresponsescausedbyal pha D.alpha- andbet a-adr enor ecept or s
-recept or st imul ation ar e v asoconst ri
ct i
on, E.beta2-adr enor ecept ors*
my driasis, anddecr easedgast rointest i
nal mot il
i
t y
. 11 A 24 y .
o.pat ienthasbr onc hialas t hma.Fort he
B.Amongt hephy siologicr esponsescausedbybet a- treatmentofas thmaat tac kadoc torhaspr escri
bed
recept or st imul ation ar ev asodi lation,car diac salbutamol .Whati st hemec hanism ofc ur ati
veac t
ionof
stimul ation, andbr onchi alrel
axat ion. theagent ?
C.Nor adrenal inehasast rongeraf fini
tyf oral pha- A.alpha-andbet a-recept orsst imul ati
on
recept orscompar edt obet a-recept or s. B.beta2adr enor ecept orsbl ockade
D.Admi nistrat ionofat ropinepr iort onor adr enaline C.beta2adr enor ecept orsst imul at ion*
l
eads t o an i ncrease i n hear tr ate af ter D.beta1adr enor ecept orsbl ockade
nor adr enal i
neadmi nistr
at i
on. E.beta1adr enor ecept or sbl ockade
E.Dobut ami nei sapot entv asoconst rictor * 12.Al pha-1r ecept oract ionsar emedi at edt hrough:R

5.A doct ordi agnosed hypoglycemic coma ina A.сAMP

pat
ient with diabetes melli
tus and admi ni
ster
ed B.сGMP
gl
ucose solut
ion IV.Patient’
s conditi
on improved. C.Ca2+ ions*
Whichdrugcanbeusedaddi ti
onall
yasachemi cal D.ADP
ant
agonistofinsuli
n? E.K+Channel s
A.Dopami ne 13.Wi th exci tation of whi ch r ecept or s aret he
B.Mesaton following ef fect s associ ated – st i
mul ation oft he
14
heartwor k,i ncr easei ncar di acout putandHR,AV D.bet a2-adr enor ecept ors
conduct ion accel er ati
on, i ncr ease i n hear t E.M- chol i
nor ecept or s
automat ism? 20.A 42 y .o.pat i
enthas been suf f
ering fr
om
A.M1-chol i
nor ecept or s bronchi alast hmaandt achy cardiaf oral ongt i
me.
B.M2-chol i
nor ecept ors Admi nist er t he opt imal dr ug f or r emov ing of
C.bet a1--adr enor ecept ors* bronchospasm:
D.bet a2-adr enor ecept ors A.Adr enal ine
E.al pha1--adr enor ecept ors B.Ephedr ine
14.Wi th exci t
at ion of whi ch r ecept ors ar et he C.Or ci prenal ine
foll
owing ef fect s associ ated – di lation ofbl ood D.I sadr i
n
vessels, decr easeoft onici t
yoft hebr onchi al muscl es E.Sal but amol *
andmy omet ri
um, stimul at ionofgl y cogenol ysis? 21.Apat ienthasanaphy lac ti
cs hock .Nameadr ugof
A.al pha1-adr enor ecept ors choice.
B.al pha2-adr enor ecept ors A.Mesat one( Pheny l
ephr i
ne)
C.bet a1-adr enor ecept or s B.Adr enal ine
D.bet a2-adr enor ecept or s* C.Ephedr ine
E.bet a3-adr enor ecept or s D.Nor adr enal ine
15.Anambul ancewascal ledf ora22y .o.pat ient E.Fenot er ol
with st atus ast hmat i
cs.Whatr out e ofadr enal ine 22.Tot hepat i
entwi thanacut erhiniti
s5% sol uti
on
admi nistrat ionwi llbet hemostappr opr i
at ei nt his of ephedr i
ne has been pr escr i
bed.Howev er,the
case?R patienti nst i
lledt hedr ugi nt henoseeach20- 30mi n.
A.I nt rav enous* Becauseofdev elopmentt achyphyl axis,effectofthe
B.I nhal ati
on drug shar pl y decr eased. What mechani sm of
C.Subcut aneous under liesdev elopmentoft hisphenomenon?
D.Subl ingual A. Depl et i
on of medi ator depot i n pr esynaptic
E.I nt ramuscul ar endings*
16.I ndi cat et he br onchol ytic agentwhi ch act ion B.Act i
v ationofadr enor ecept ors
mechani sm i ssel ectivest imul ationofbr onchi al2- C.Bl ockadeofadr enor ecept ors
adrenor ecept or s: D.Mat er ial cumul at i
on
A.At ropi ne E.Induct ionofmi cr osomal enzy mesbyl i
ver
B.Fenot er ol
* 23.An opht halmol ogi stwi th diagnost ic purpose
C.Ami nophy lli
ne( Euphyl line) (di
lationoft hepupi lforey ebot tom obser vat i
on)has
D.I sadr ine used1% Mesat on ( Phenyl ephrene)sol uti
on.Whi ch
E.Adr enal ine mechani sm under liesmy dr iasiscausedbyt heagent ?
17.A 63 y .o.man wi th col lapse sy mpt oms was A.Act i
v at i
onofal pha1- adr enor eceptor s*
admi tt
edt ot heemer gencyhospi tal.Aphy si cianhas B.Act i
v ationofal pha2- adr enor eceptors
chosennor adr enal inagai nsthy pot ensi on.Whati sits C.Bl ockadeofbet a1-adr enor eceptors
D.Bl ockadeofal pha1-adr enor eceptors
mechani sm ofact ion?2012
E.Act iv ationofM- chol inor ecept ors
A.Act ivat i
onofal pha1- adr enor ecept ors*
B.Act i
v at i
onofser otoni nr ecept ors 24.Chooset hedr ugwi t
hf ollowingchar acteristi
cs:a
C.Act ivat i
onofdopami ner ecept ors synt het i
ccat echol ami ne,st i
mul atesbot h1-and2-
D.Bl ockofM- chol inor ecept or s adr enor ecept ors,i ncr easescar diaccont ractil
ityand
E.Act iv at i
onofbet a-adr enor ecept or s hear tr ate,decr easesdi ast olicAPandi nhibitl abor
18.Apat i
enti llwi t
hbr onchi alast hmadi dn’ ti nform act i
vity. I t i s phar macol ogical ant agoni st of
hisdoct ort hathehadat tacksofst enocar di a.Doct or propr anol ol.
admi nister edhi m amedi cat ion, whi cht akingr esul ted A.Sal butamol
i
nl ess f requentat tacks ofbr onchi alast hma,but B.Pi locar pine
stenocar di a at t
acks became mor ef requent .What C.I pratropi um br omi de
medi cationwasadmi nister ed? D.Acecl idine
A.Sal but amol E.Isadr i
ne*
B.Ami nophy lli
ne 25.Apat ienthasmar keddr oppi ngofbloodpr essur e
C.I sadr in* dur i
ng sur gical oper ation wi h hy
t gronium
D.Cr omol insodi um admi nistr
at ion. Repr esent atives of whi ch
E.Phenot herol phar macol ogi calgr oupcoul dnor malizeBPi ngi ven
19.Apat i
entwi thbr onchi alast hmahasbeengi v en si
t uat i
on?
0.5% sol ut ion of i sadr i
n ( isopr ot erenol )
. A.N- chol inomi met ics
Bronchospasm wasr emov ed,butt hepat i
entst arted B.al pha- adrenomi met ics*
tocompl ainofapai ni ncar di acar ea.I ti sl inkedt o C.bet a1-adr enobl ocker s
sti
mul at i
onof : D.bet a2-adr enomi met ics
A.Acet ylchol i
nesy nt hesi s E.M- cholinomi met ics
B.al pha1- adr enor ecept or s 26.Af tertoot hext ractionpat ienthasdev elopedl ocal
C.bet a1-adr enor ecept ors bleedi ng.Adent istappl iedspongewi t
hamedi cine
15
andbl eedingsubsi ded.Whatmedi cinedidthedentist B.Act ivat i
onofal pha2- adr enor ecept ors
use? C.Bl ockadeofal pha1-adr enor ecept ors
A.Isadri
ne D.Bl ockadeofbet a1-adr enor ecept ors
B.Salbutamol E.Act i
v ationofbet a2-adr enor ecept ors*
C.Adrenal ine* 34.A12y .o.chi ldhasav i
ral infect i
oncompl i
cat edby
D.Prazosi n obst r
uctiv e br onchi tis. Br onchospasm can be
E.Timolol eli
mi natedbyi nhal ationofadr ugf rom t hef ollowing
27.Acut ear t
erialhy pot ensionhasdev el
opedina phar macol ogi cal gr oup: 2013

pati
entdue t o oct adine ( guanethidi
ne)over dose. A.Anal ept i
cs
Whichagentshoul dbeusedt onormal i
zeAP? B.M- ant ichol iner gics
A.Ephedr ine C.N- chol inomi met ics
B.Noradr enal ine* D.bet a1-adr ener gicbl ocker s
C.Caffeine E.bet a2-agoni sts*
D.Cordiami n( Nikethamide) 35.Apat ientwi thbr onchi alast hmahadbeent aking
E.Dopami ne orallyanagent ,whi chcausedi nsomni a,headache,
28.Apat ientwithchr onicbr onchitishasbeent aki
ng i
ncr eased AP. What medi ci ne can cause such
wihephedr
t i
nef oral ongt ime.Whati st hedrug’s compl icat i
on?
acti
onmechani sm? A.Ephedr i
ne*
A.Stimul ati
on ofnor adrenali
ner eleaseintos y
naptic B.I sadr in
cl
eft
* C.Pr az osi n
B.Blockadeofnor adr enali
ner eleasei ntosynaptic D.Adr enal i
ne
cl
eft E.Dopami ne
C.Stimul ati
onofal pha- adrenorecept or
s 36.Apat ientwi thbr onchi alast hmahasbeengi ven
D.Blockadeofbet a-adr enoreceptors 0.5% sol ut on of i
i sadr inum ( i
sopr oterenol).
E.Directspasmol yticact ion Bronchospasm wasr emov ed,butt hepat i
entst art
ed
29.Indi
catet he st ate which r
equi
res ephedr
ine tocompl ainonapai ni ncar diacar ea.Whati sthe
i
ntr
oducti
on: reason?
A.Tachy cardia A.I nhi bitionofacet ylchol inesy nthesis
B.I
nsomni a B.Act ivat ionofal pha1- adr enor ecept ors
C.Caff
ei nepoi soning C.St imul at ionofbet a1-adr enor ecept ors
D.Art
erial hypotension* D.St imul at ionbet a2-adr enor ecept ors
E.Art
erialhy pertensi
on E.Act ivat i
onofM- chol i
nor ecept ors
37.Ambul ancehasbeen cal led t o a 22- y.o.man
30.A pat i
entwi thobst ruct
ivebronchit
ishasbeen becauseofbr onchi alast hmaat tack.Whatwayof
t ng ephedr
aki i
ne f ora l ong ti
me withoutdoctor’
s adrenal i
neadmi nist r
at ioni st hemostappr opriatein
contr
ol.Whatsi de effectcan be observed i
nt he thiscase?
pati
ent? A.I nt rav enous*
A.Apat hy B.I nt r
amuscul ar
B.Sleepiness C.I nhal ation
C.Excitationoft heCNS* D.Subcut aneous
D.Brady cardia E.Subl ingual
E.Hy potension
38.A 63- y.o.pat ientwi thcol lapsesy mpt omswas
31.Mesaton (Phenylephrine)was i ntroduced toa admi tt
edt ot heemer gencyhospi tal .Aphy sicianhas
pat
ientwit
hcol lapseforBPcor rection.Whati sthe chosen nor adr enal inf orhy pot ensi on.Whati si t
s
mechani
sm ofact ionofthedr ug? mechani sm ofact ion?
A.Activati
onofM- cholinorecept or
s A.Act ivat i
onofal pha1-adr enor ecept or s*
B.Activ
at i
onofalpha2-adrenor eceptors B.Act i
v ationofser ot oni nr ecept ors
C.Blockadeofbet a1-adrenorecept ors C.Act ivat i
onofdopami ner ecept ors
D.Blockadeofalpha1-adr enor eceptors D.Bl ockofM- chol i
nor ecept ors
E.Acti
vat i
onofalpha1-adrenor eceptors* E.Act i
vat ionofbet a–adr enor ecept or s
32.Col
laps ehasdev elopedinapatientduet
odecr
ease 39.Dur
inglocalanesthetizat
ionthepat i
enthasgone
i
n peri
pher alvess el
st one.Which agentshoul
d be i
nto anaphy l
actic shock. What dr ug must be
admini
stered? admini
ster
edt othepatient?
A.Met oprolol A.Propranolol
B.Mesat on( Pheny l
ephr
ine)* B.Atropinesulf
ate
C.Xy l
omet hazol i
ne C.Nitrogly
ceri
ne
D.Proserine( Neostigmi
ne) D.Epinephrinehydrochl
oride*
E.Prazosin E.Diazepam
33.Fenot
erolwasi nt
roducedtoa32y .o.pregnant 40.
woman wi th threat
ened abort
ion. I
ndicat
e i ts
A.
mechani
smofacti
on:
B.
A.Acti
vat
ionofM- chol
i
nor
ecept
ors
16
 C. havemedi atort ypeofact ion,decr easet hestr
ength
D.* ofhear tcont ractionsandHR,i nhi
bitautomat i
sm of
E. myocar dium, increaseper i
pher alvascularresi
stance.
Thedr ugsar eusedt ot reatangi napect ori
s,cardi
ac
40.
arr
hythmi as,ar t
er i
alhy pertension.Thei rmai n si
de
3.
2.2.Adr
enobl
ocker
s eff
ects ar e br onchospasm, di sorders of AV
conduct i
on,i nhibiti
onofcont r
acti
lef uncti
onoft he
1.A pat i
ent 50 y .
o.wi th compl aints of hear t
myocar dium.
palpitation,paini nt hehear tar ea,headache,v erti
go
A.al pha- adrenomi met icks
wasdel i
veredt oahospi tal.Dur i
ngt heexami nati
on
B.al pha-adr enoblocker s
angina pect oris,car di
ac ar rhy thmia( paroxysmal
C.det a1-adr enomimet i
cks
tachy cardia, at rium f i
bril
lation) and ar ter
ial
D.bet a2-adr enomimet i
cks
hyper tension( 180/ 90mm Hg)wer er evealed.Make
E.bet a-adr enoblocker s*
ther ationalchoi ceoft hedrugi nt hissituati
on.
A.Propranol ol (
Anapril
ine)* 8.Amal epat ientwhohasbeen‘ surfingt heWeb’i n
B.Epinephr ine sear ch ofan aphr odi siac orsome ot heragentt o
C.Ephedr ine enhance’ sex ualper for mance’ di
scov ersy ohi mbine.He
D.Neost igmi ne consumest hedr ugi nex cessanddev elopssy mpt oms
E.Reserpi ne oft ox i
cityt hatr equi rey ouri ntervent ion.Youconsul t
2.A 60 y .
o.ast hmat i
c man compl ains ofsome yourdr ug r ef er ence and l earnt haty ohi mbine i sa
diff
icul t
yi n« startingt ourinate» .Hehasasl i
ghtly select i
ve α2- adr ener gic ant agonist .Whatwoul dy ou
enlargedpr ostate.BP160/ 100mm Hg. .Whichoft he ex pectasar es ponset ot hisdr ug?
foll
owi ngagent sshoul dbeadmi nist
ered? A.Tachy car di a
A.Phent olami ne B.Br ady car di a
B.Reser pine C.Reducedcar diacout putf rom r educedl eft
C.Ephedr ine vent r icul arcont r
act i
lit
y
D.Doxazosi n* D.Hy per tensi on*
E.Propr anol ol E.Br onchoconst r
iction
9.Al lthef ol lowi ngdr ugsar eusedt opi call
yi nt he
3.A35y .o.mal ewor kerisbr oughtt otheemergency
treatmentofchr oni c wi de-angl e gl aucoma.Whi ch
room.HR150/ mi n,BP180/ 100mm Hg.Whi chdr ug
oner educesi nt raocul arpr essur ebydecr easi
ngt he
shouldbeadmi ni stered?
for mat i
onoft heaqueoushumor ?
A.Neost igmi ne
A.Ti mol ol *
B.Phent ol ami ne
B.Pi l
ocar pi ne
C.At ropine
C.Phy sost igmi ne
D.Pr opranol ol*
D.Neost igmi ne
E.Pr azosi n
E.Acecl idi ne
4.A 38 y .
o.f emal e has t aken unknown dr ug to
10. A 40 y .o. pat ient compl aints of i ntensive
decreasehi ghBP.Af t
eri tsadmi nist
rati
onsy stoli
c
hear tbeat s,sweat ing, nausea, v
isioni mpai r
ment ,arm
pressuredecr easedbutt achy cardi
aappear ed.What
tremor ,hy per t ensi on.Fr om hi sanamnesi s:2y ears
drughadbeenadmi nist
ered?
ago he was di agnosed wi th pheochr omocyt oma.
A.At enol ol
Whathy pot ensi v eagentshoul dbeadmi ni ster
ed?
B.Reser pine
A.Capt opr il
C.Phent ol ami ne*
B.Pr azosi n*
D.Pr opranol ol
C.Dr ot av er ine
E.Pr azosi n
D.Ni fedi pine
5.A pat ient wi th hy pertension i sr egi
ster
ed at E.Pl at y phy llin
prophylactic cent er.He has concomi t
antdisease
12.Thedr ugf rom t hegr oupofbet a-adr enoblocker s
bronchialasthma.Hei stoadmi ni
sterabeta-bl
ocker .
has been admi ni st er ed t o 47 y .o.pat ientfort he
Whatdr ugwi lly ouchoose?
treatmentofi schemi chear tdi sease.Whenar eβ-
A.Ti mol ol
adr enobl ocker sabsol utel ycont raindi cated?
B.Met opr ol ol*
A.Ar ter ial hy per tension
C.Sal but amol
B.Br onchi al ast hma*
D.Reser pine
C.Hy per trophi ccar diomy opat hy
E.Pr opranol ol(Anapr il
ine)
D.Thy rot oxi cosi s
6.Bet
a-block
erwi ththeleas
tentryc
ros
sbl
oodbr
ain E.Hi st or yofmy ocar dialinf arction
bar
ri
er:
13.A 64y .o.womanwi t
htoxi
cgoit
erc
ompl ai
nsof
A.Propranolol
(Anapri
li
ne)
per
manent pal pi
tati
on. Whi
ch agent should be
B.Carvediol
admini
ster
ed?
C.Nadolol *
A.Isadr i
n
D.Timolol
B.Sal butamol
E.Oxprenolol
C.Pent ami ne
7.Det
ermi
net
hephar
macol
ogi
cgr
oupofdr
ugs.They D.Pr opranolol(
Anapri
l
ine)
*
17
 E.Fenot
erol adr
enoblockers:
A.Glaucoma
14. The pat ient suf f
eri
ng f rom i diopat
hic
B.Int
estinal
at ony
hypertension had been admi nistered the compl ex
C.Arter
ialhypertensi
on*
tr
eatment .Laterhebegant ocompl ainofpai nsinthe
D.Int
estinalatony
epigastri
cr egion,diarrhea,hear t
bur n.Whi chagent
E.Bronchialasthma
couldpr ovokethel i
stedadv er
seef fectsinthepat i
ent?
A.beta-Adrenoblockers(Anapr il
ine) 21.Indicat
et hemechanism ofactonofpr
i azosi
n:
B.Ganglioblockers(Pentamine) A. Bl ockade of al pha- and bet a-
C.Sy mpatholyti
cs(Reserpine) *) adrenoreceptors
D.aalpha1-adrenoblockers(Pr azosin) B.Blockadeofalphaadrenorecept
ors
E.Spasmol yti
cs(Papaver i
ne) C.Blockadeofalpha1-
adrenoreceptors*
D. Bl ockade of al pha1- and al pha2-
15.A patientsuf feri
ngf r
om hy pert
ensionhadt he
adrenoreceptors
accompany i
ng di seases:cor onary heart di
sease,
E.Blockadeofbeta1-
adrenoreceptors
atr
ium fi
bril
lat
ion,chr oni
cbr onchi
ti
s.Thephy sici
an
hasdecidest ouseanagentf rom thegroupof- 22.I
ndi
catethemechanism ofactionofanapr il
i
ne:
adrenobl
ockers.Whi chagentshouldbeused? A.Bl
ockadeofalpha1adrenoreceptors
A.Timolol B.Bl
ockadeofbeta1-adr
enoreceptors
B.Anapr i
l
ine C.Bl
ockadeofbeta1-andbeta2-adrenoreceptors*
C.Met oprolol
* D.Bl
ockadeofalpha-andbeta-adrenorecept
ors
D.Reserpine E.Bl
ockadeofbeta2-adr
enoreceptors
E.Clopheline(Cloni
dine)
23.Indicat
et hemechanism ofact onofmet
i opr
olol:
16.A patientwhohadbeensuf f
eri
ngfrom arterial A.Blockadeofalpha1-adrenoreceptors
hypert
ension was t reat
ed with an agent whi ch B.Blockadeofbeta1-adrenoreceptors*
mechanism ofact ionisconnect
edwithexhaust
ionof C. Bl ockade of bet a1- and bet a2-
norepi
nephr i
necont entinsympathet
icnerveending. adrenoreceptors
I
ndicatethisagent : D. Bl ockade of al pha- and bet a-
A.Clopheline(Cloni
dine) adrenoreceptors
B.Anapr il
i
ne E.Blockadeofbeta2-adrenoreceptors
C.Prazosin
24.I
ndicat
et hecl i
nicalusef orbet
a-adr
enobl
ocker
s:
D.Met oprolol
A.Arterialhypotension
E.Reser pi
ne*
B.Arterialhypertension*
17.Elongati
onofP- Qi nt
erv
alwasr eveal
edonECG. C.Bronchi alasthma
I
ndicatethedrug,whichcancausethiseff
ect
: D.Atrioventri
cularblockade
A.Prazosin E.Obliterati
ngendar teri
ti
s
B.Atenolol*
25.I ndicat ethe pr i
nciple oft he sy mpat hol
yti
cs’
C.Reserpine
act
ion:
D.Octadine(Guanethi
dine)
A.Blockadeofal pha-adrenoreceptors
E.Phentolamine
B.Blockadeofexci tati
ont r
ansmi ssionont helevelof
18.A patientsuf feri
ngf r
om hy pert
ensionhadt he theadr energicnerveendings*
accompany i
ng di seases:cor onary heart di
sease, C.Act i
vation of exci tat
ion on t he l evelof t he
atr
ium fi
bril
lat
ion,chr oni
cbr onchi
ti
s.Thephy sici
an adr ener gi
cner v
eendi ngs
hasdecidest ouseanagentf rom thegroupof- D.Blockadeofal pha-andbet a-adrenoreceptors
adrenobl
ockers.Whi chagentshouldbeused? E.I
nhi bi
tionoft heenzy meswhi chdest royadrenali
ne
A.Timolol 26.Indicatethephar macol ogi cal eff
ectsofr eserpine:
B.Anapr i
l
ine A.Reduct ioni nthegast ricjuicesecretion
C.Met oprolol
* B.Excitati
onoft heCNS
D.Reserpine C.Diarrhea
E.Clopheline(Cloni
dine) D.Increasei nt hegast roi ntesti
nalmot il
ity
19.A pat i
entwhohasbeensuf feri
ngf rom severe E.Decr easeoft hear ter ialpressureand
for
m ofar teri
alhy pert
ension was di agnosed with bradycar dia*
pheochromocy toma( tumorofadr enalmedul l
awhich 27.A 60y .
o.mal epat ienthasa9- yearhi storyof
i
s accompani ed by i ncreased sy nthesi
s of diabetes and t akes i nsul in Semi lente f or t he
epi
nephrine).Indicat et he drug group tot r
eatthe correcti
onofhy per glycemi a.10day sagohebegan
pati
entbeforesur gical t
reatment: t ng anapr
aki ili
ne f orhy per tensi on.One houraf ter
A.alpha-adrenobl ockers* admi ni
strati
on of t he ant i
hy pertensive dr ug t he
B.Alpha-adr enomi meticks patientdev el
opedhy pogl ycemi ccoma.Whati st he
C.Gangl i
oblocker s mechani sm ofhy pogl ycemi ai n caseofanapr i
line
D.Sy mpat homi met i
cs use?2013
E.beta-adrenobl ockers A.Decr easei ngl ucoseabsor pti
on
20.I
ndi
cat
ethecl
i
nicalappl
i
cat
ionf
oruseofal
pha- B.Increasei nbi oav ailabi l
it
yofi nsuli
n
18
Semilente B.Act i
v ati
ngant i
thrombi nI I
I,inhi
biti
ngt hrombin
C.Increasei ninsul i
nSemi lentehalf-
li
fe C.Bl ockingpl a
t el
e taggr e
gat i
onbypr eventingbridgi
ng
D.Inhibiti
onofgl y cogenolysis* be t
we en gl ycopr otei
n I I
b/II
Ia r ecept or
s on
E.Reduct ionofgl ucagonhal f
-l
if
e neighbour i
ngpl at el
ets
28.Apat i
entwi tharteri
al hypert
ensionhasbeent re
ating D.I nhibiti
ng hepat icv i
tami n K-dependentcl otti
ng
withr
es er
pinef oralongper i
odoftime.2-3week sagohe factorsy nthesis
devel
opeds tomac hache, heart
burn,nausea.I
ndicat
et he E.Prev entingpl ateletaggr egat i
onbyi nhibiti
ng
group ofdr ugs whi chi s abl
et o antagonizet hese thromboxaneA2sy nthesi s*
symptoms ?
A.M- cholinoblocker s* 5.Aspi r
in causes si gnifi
cantbr onchospasm and
B.Astringentdr ugs bronchospasm i n patients who ar e subsequently
C.Ant acids descr i
bedas‘ aspi r
in-sensiti
ve’.Whi chmechani sm is
D.Prot onpumpi nhi bi
tors i
nv olved?
E.H2-histami noblockers A.Bl ockedepi nephrinebi ndingt obeta2-r
eceptorson
air
waysmoot hmuscl ecells
29.Whi ch drug inter
feres wi
ththe c
ycl
ooxy
genase B.Dr ug- medi atedhy persensiti
vityofH1 receptorson
pat
hwayofpr os tagl
andinssynt
hes
isbynonsel
ect
ivel
y air
waysmoot hmuscl es
i
nhi
bit
ingbothCOX- 1andCOX- 2? C.I nhibitedsy nthesisofendogenousPGst hathav e
A.Meloxicam bronchodi lat
oract i
vit
y*
B.Celecoxib D. Dr ug- medi at ed hy persensi t
ivi
ty of muscar i
nic
C.Paracetamol e receptor sonai rwaysmoot hmuscl ecells
D.Indomet hacin* E.Enhancedf ormat i
onofant ibodiesdirectedagainst
E.Naltr
exone thesal icylateonai r
waymastcel ls

3 6Whi chsy mpt om woul dbesuggest i

vet hatplasma
l
ev el
s ofaspi rin ar e get ti
ng t oo hi gh – supr a-
4.TheAgentsAffect
ingtheCNS therapeutic?
4.1Non-opi
oidAnalgesi
cs A.Const ipat i
on
1.A58y .
o.pat i
entwit
har t
hr i
ti
scomplainsofnausea, B.Cough
di
stressinepi gastr
ium duringtreat
mentwithaspiri
n. C.Tinnitus*
Thedoct orhascancel l
edi tandpr escr
ibedaNSAI D D.My opi a
fr
om t he gr oup of sel ect
ive cycl
ooxygenase-
2 E.Hyper tensi on
i
nhibit
ors.Indicatei
t: 7.A pat ientt akesanacut e,massi veov erdoseof
A.Anal gi
n( Metamizole) aspiri
n, whi ch may be f atal wi thout pr oper
B.But adion(Phenyl
but azone) i
ntervention.Whi choft hef ol
lowingcondi t
ionswoul d
C.Tr amadol e youexpecti ntheadv anced( l
ate)st agesofaspi r
in?
D.Indomet haci
n A.Met abol i
cal kal osi s
E.Mel oxicam* B.Respi ratoryal kalosi s
C.Respi rator yalkal osis+met abolicacidosis*
2.Whi ch dr ug inter
fer
es wit
hthe cy
clooxy
genase D.Hy pother mi a
pat
hwayofpr os
taglandi
nssynt
hes
isbynonsel
ect
ivel
y E.Vent i
lator ystimul ation
i
nhi
bit
ingbot hCOX- 1andCOX-2?
8.I naddi ti
ont opr ov idi ngsy mpt omat i
c,suppor ti
ve
A.Meloxi cam
care,whichoft hef ollowi ngdr ugswoul dbeahel pf
ul
B.Celecoxi b
adjuncttomanagesev er easpi ri
npoi soning?
C.Naloxone
A.Acet ami nophen
D.Diclofenac-natri
um *
B.Acet yl
cy steine
E.Naltrexone
C.Diazepam
3.Whichoft hefoll
owingaspiri
nef f
ectsisexpected D.Sodi um bi carbonat e*
i
nusual ther apeuti
cdoses? E.Unithiol
A.Inhi bitedgrowt hofbacteriathatcausef ever 9.I naddi ti
ont opr ov idi ngsy mpt omat i
c,suppor ti
ve
asasy mpt om ofi
nfecti
on care,whichoft hef ollowi ngdr ugswoul dbeahel pf
ul
B.Inhibitionofuricaci
dsy nt
hesis adjunct t o manage sev ere Par acetamol
C. Pr otecti
on agai nst br onchospasm i n (Acetaminophen)poi soni ng?
asthmat ics A.Nal oxone
D.Ef ficacygr eaterthanpar acetamoleasant i
- B.Acet yl
cy steine*
i
nflammat oryagent* C.Diazepam
E.Ef f
icacyl essthanacetaminophenf orrel
ievi
ng D.Sodi um bi carbonat e
simpl eheadache E.Unithiol
10.Whi choft hef ollowi ngcondi ti
onsi sthepr imary
4.Which of t he f ol
lowing aspir
in desi
red (
and cause of deat h f rom massi ve Par acetamol
someti
mesunwant ed)ef fect
sonbl oodclot
ti
ngis (Acetaminophen)over doses?
i
nvol
ved? A.Acut enephr opat hy
A.Bl
ockingpl
ateletreceptorsforADP B.Statusepi lepti
cus
19
 C.St
atusasthmat
icus *
D.AVconducti
ondist
urbances
E.Li
verf
ail
ure* 17.Painint hebackdev elopedafterthelif
ti
ngof
heavy loads, and l umbosacral radi
cul
it
is was
11. How do Met hotr
exate, gol d sal ts,
di
agnosed.Itisknownf r
om t heanamnesist hata
Hydroxychl
oroqui
ne ( Pl
aquenil
), or Penici
ll
ami ne
pati
entwassuf f
eri
ngfrom ulceroft
heduodenum f or
di
fferfr
om ‘t
radit
ional
’NSAIDsasDi cl
ofenac-
natr
ium
alongper i
odoft ime.Maket herati
onalchoiceof
orIndomethacininthecontextofmanagi ngart
hriti
c
NSAID:
i
nflammator ydisease?
A.Butadion
A.Acti
vatethei mmunesy stem responses
B.Dicl
ofenacsodium
B.Areremar kablyfr
eef rom seri
oust oxi
cit
ies
C.Indomethaci
n
C.Ar e pri
mar yt herapies forhy perur
icemia,gout,
D.Meloxicam *
goutyart
hri
tis
E.Aspir
in
D.Provi
demuchqui ckerreli
efofarthri
ti
ssy mptoms
E.Slow st op,possi blyr ever
se jointpat hol
ogy i
n 18.Gum bl eedingar oseint hepat i
entafterextract
ion
rheumatoi
dar thri
ti
s* ofthet ooth.Itwasr evealedf rom anamnesi sthatthe
pati
enti ssuf f
er i
ng fr
om r heumatoid arthri
ti
s,and
12.Themai nr easonf orusingcelecoxib(selecti
ve wast reatedwi thaspiri
n.Indicatethereasonofar i
sen
COX-2i nhibitor)r athert han a nonsel ect
ive COX bl
eedi ng:
i
nhibi
tor(aspirin)isthatcel ecoxi
b: A.Suppr essionofsy nthesisofuricacid
A.Curesar t
hritis,r
athert hanjustgivesymptom reli
ef B.Promot i
onoft hr
ombol ysi
s
B.Eff
ecti
v el
yi nhibit
sur icacidsynthesis C.Inhibit
ionofhaemopoi esi
s
C.Hasal owr iskofcar diot
oxicit
y D.Decr easingofbloodcoagul ati
on
D.Is associ ated wi thal owerr i
sk ofgast ri
c or E.Suppr essionofthromboxanesy nt
hesis*
duodenalulcer ati
on*
19.Ut i
l
izati
onofar achi
donicaci
dvacy
i cl
ooxygenase
E.Hassignifi
cantf ast eronsetofact i
on
pathway r esultsinf ormati
on ofsome bioacti
ve
13.A 46 y .o.pat i
enthas been di agnosed wit
h substances.Namet hem:
rheumat oi
dpol y
arthr
iti
s.Whi chagentisappropr
iat
e A.Biogenicami nes
forthispati
ent? B.Insul
in-l
ikegrowthfact
ors
A.Dicl
ofenac(Voltaren) C.Thy r
oxine
B.Aspir
in* D.Prostaglandi
ns*
C.Butadi
on( Phenylbutaz
one) E.Somat omedins
D.Paracetamol
20.Forthet reatmentofchroni
cr heumatoidarthri
ti
s,
E.Tramadole
thepat i
enthast akenamedi cinef oral ongt i
me.
14.A60y .
o.pati
entwithrheumat oidpoly
art
hri
ti
shas Lateron,weakness,mal aise and necrotic angi
na
beentakingindomethacinforal ongtime.Whatist
he havedev eloped.Thereisadecreaseofgr anulocyt
es
mechanism ofactionofthisdr ug? i
nbl oodanal ysi
s.
A.Blockadeofl i
poxygenase Whatdr ugcouldcausesuchcompl i
cat
ion?
B.Blockadeofacet y
lcholinester
ase A.Paracetamol
C.Blockadeofcy cl
ooxy genase* B.Aspiri
n
D.Blockadephosphodi esterase C.Pi
roxicam
E.Blockadeofphosphol ipase D.Analgin(Metamizol
e)*
E.Meloxicam
15.Achi ldwi thfeverwasgi venadrugwi t
hstrong
anti
pyreti
c act i
on and no infl
ammatoryactiv
ity
.I t 21.A pat ientwi th gouthas t aken a dr ug,whi
ch
undergoes i nacti
vati
on through conj
uncti
on wi t
h decreased a j ointpain.I naf ew day s,nausea,
gl
utathione. At t oxi
c doses i t can damage vomiting,diarr
hea,abdomi nalpai n,andedemahav e
hepatocytes. Dur ing poisoning antidot
es ar e developed.
Acetyl
cysteineandMet hioni
ne.Defi
nethi
sagent: Whichdr ughasbeent akenbyt hepatient?
A.Par acetamol * A.Paracetamol
B.Aspi ri
n B.Meloxicam
C.Ni mesul i
de C.Celecoxib
D.Cel ecoxib D.Butadion(Phenylbutazone)*
E.Mel oxicam E.Naltr
exone
16.Ataspi ri
noverdose,met hodofur i
nealkal
izati
on 22. A pat i
ent wi t
h r heumat oi
d arthri
ti
s was
i
sused.Thi smet hodisdirect
edt o: prescri
bed aNSAI D – Di cl
ofenacsodium.Af tera
A.St i
mul at
e a secretion oft he aci
di n pr
oximal peri
odoft i
met hepatientexper i
encedaggravati
onof
tubul
es aconcomi tantdiseaset hatf orcedtowithdraw t
he
B.Neutrali
zeacidinblood drug.Whatconcomi tantdi seasecouldleadt othe
C.Stimulatereabsor
ptionoftheacidintubules drug’swithdrawal?
D.Suppr ess a secretion oft he aci
di n pr
oximal A.Diabetesmel l
it
us
t
ubules B.I
schaemi chear tdi
sease
E.Suppressr eabsor
ptionoft heacidinrenaltubul
es С.Pepticulcerofast omach*
20
 D.Br
onchi
alast
hma respir
atorydiseaseandt emperat
ur eriseupto39oC
E.Hy
pert
ensi
vedisease hascal l
edi nadoct or.Thedoct ori nsi
stedonher
23.Aspir
incausesant i-
inf
lammat or
yacti
oni nresul
t avoidi
ngt akingparacetamol,becausei nthi
sper
iod
2016
ofdepr
essi onoft hecyclooxygenaseact
ivi
ty.Lev
elof ofpregnancyt herei
sar iskofit
s:
whatbiol
ogi call
yactiv
esubstancewi l
ldr
op? A.Fetotoxi
cit
y
A.Biogeni camines B.Embr yot
oxici
ty
B.Prost aglandi
ns* C.Teratogeni
city*
C.Iodthy r
onines D.Hepat ot
oxici
ty
D.Leukot ri
enes E.All
ergenici
ty
E.Catechol amines 30.Apatientwhohadbeent akingdi cl
ofenacsodium
24.A f emal e consul ted a doct
oraboutpai n and forart
hri
tisofmandi bularjointdev el
opedanacut e
l
imitedmov ement si nt hekneejoint
s.Whichoft he condi
ti
onofgast ri
culcer.Suchsi deef fectofthis
fol
lowingNSAI Dsshoul dbeadminist
eredtaki
nginto medici
ne i s caused byi nhibit
ion oft he fol
lowing
2016
considerationt hatthepat i
enthasahistor
yofchronic enzyme:
gastroduodeni tis?2011 A.Phosphodi esterase
A.Promedol B.Lipoxy genase
B.Butadi on C.Cy clooxygenase-1(COX- 1)
*
C.Acet ylsali
cyli
caci d D.Cy clooxygenase-2(COX- 2)
D.Diclofenacsodi um E.Monoami neoxidase
E.Celecoxi b*
4.
2Opi
oidAnal
gesi
csandAnt
agoni
sts
25.Apat i
enthasbeendi agnosedwi t
hinfl
uenza.Hi s
conditi
on became dr asti
cally wor
se after taking 1.I ndi
cat
e a sy nthet
ic opi oi
d analgesi
c,whi
ch
anti
py ret
icdr ugs.Hi
sconsci ousnessisconfused,AP i
ncreasesmy ometri
um cont racti
onandr el
axest
he
i
s80/ 50mm Hg,psi s140/ mi
n.Bodytemper ature neckofuterusandisadministeredinl
abour:
dropped down t o 35. 8°C. What compl i
cation A.Omnopon
developedi nt hi
spati
ent?2012 B.Promedol Tr
( i
meperidine)*
A.Hy perthermi
a C.Mor phi
ne
B.Hy povolemia D.Fentanyl
C.Al kalosis E.Fenoterol
D.Aci dosi s 2.Aper sonwhowasphy si
call
ydependentonher oi
n
E.Col lapse* buysadr ugint hestr
eet.Hetakesitandrapidl
ygoes
26.Apatientwitharthr i
ti
sandv ar
icoseveinshas i
ntowi thdr
awal .Whichofthef ol
lowi
ngdr ugsdidhe
beentaki
ngaNSAI Df oralongti
me, whi
chcaused take?
thrombosisofskinv eins.Whichofthefoll
owing A.Heroin
drugsmighthav ecausedt hi
scompl i
cat
ion? B.Pentazocine*
A.Indomet hacin C.Morphine
B.Ibuprof
en D.Promedol (Tr
imeperi
dine)
C.Celecoxib* E.Omnopon
D.Pheny l
butazone 3.Apatientwi t
hsev ere,acutetraumapainrequi
res
E.Aspiri
n anal
gesia.Thephy si
cianprescrbesmor
i phi
ne.Which
27.Apat i
enthasbeenadmini
ster
edanant i
- ofthefollowingconcomi t
antcondi t
ionswoul
dpose
i
nflammat or
ydrugthatbl
ockstheacti
vi
tyof thegr
eatestriskfrom morphine’
suse?
cyclooxy
genase.Speci
fyt
hisanti
-i
nfl
ammat or
yagent
: A.Acut epulmonaryedema
2013 B.Hy pert
ension
A.Analgi
n C.Closedheadi njury*
B.All
opurinol D.Opi oi
dabuse
C.Thiamine E.Recentmy ocardiali
nfarct
ion
D.Creati
ne 4.Allofthef oll
owingst at
ement sconcer ngf
ni entanyl
E.Aspir
in* arecorrectexcept :
28.Apat ientwi tharthri
tisandv ari
coseveinshas A.I thasl esspot entanalgesi
cact i
vit
ythant hat
beent akinganon- steroidalanti-
inf
lammatorydrug ofmor phi
ne*
foralongt ime,whi chcausedt hrombosi
sofskin B.I thasshor terdur at
ionofact i
ont hanthatof
veins.Whi choft hef ol
lowingdr ugsmighthave mor phine.
causedt hiscompl icaton?2013
i C.Itisef fecti
vepar enteral
ly
A.I ndomet hacin D.Itcausesami lderwi t
hdrawalsyndromethan
B.Ibupr ofen mor phine.
C.Aspi rin E.Ithast hegr eatestact i
ononμr eceptor
s
D.Cel ecoxib* 5.Whichst
atementaboutpent
azocineisincor
rect
?
E.Pheny l
butazone A.I
tisamixedagonist
-ant
agoni
st
29. An 8-
week pr
egnant woman wi
th acut
e B.I
tmaybeadmi ni
ster
edPOorpar enteral
ly
21
C.Itproduceslesseuphori
athanmorphi
ne D.Inhi bitionofcy clooxy genase
D.Itisof tencombinedwi t
hmor phi
neformaxi
mal E.Inhi bitionofpr ost aglandinsy nthesi
s
analgesi
cef f
ects* 13.A dr ug- abuserwi thsy mpt omsofov erdosage
E.Highdosesofpent azoci
neincr
easeAP withnar cot i
canal gesi cshasar ri
vedatr esusci
tation
6. In the post operati
ve perod pr
i omedol was unit
. Compl et ed emer gency act i
ons appear ed
admini
steredcont i
nuouslyt
oapat i
ent.Cancel
l
ati
on i
nefficient .Whatwast hemostl ikelycauseofdeat h?
ofthemedi cati
oncausedheav ymentalandsomati
c A.Renal failure
di
sorders.Whatisthisphenomenondesignat
ed? B.Liv erf ai l
ur e
A.Cancel l
ati
onsy ndr
ome C.Col l
apse
B.Idiosyncr
asy D.Inhi bitionofr espi ratorycent er*
C.Tachy phyl
axis. E.Br onchospasm
D.Steali
ngsy ndrome 14.Mor phi neunder goesgl ucuronidati
onint heli
v er.
E.Abst i
nentsyndrome* Bindingoft hedr ugwi t
hgl ucuronicaciddur i
ngi t
s
bi
ot r
ansf or mat ionwi ll:
7.Morphinehydr
ochlori
dehasbeengi ventoreduc
epain A.I ncr easei tsphar macody nami cacti
vi
ty
attr
aumat i
cshock.Indi
catethemec hani
sm ofacti
onof B.Incr easei tswat ersol ubil
ity*
thedr
ug: C.Reducei tswat ersol ubili
ty
ABl ockofperipheralsensati
onreceptors D.Notchangei tsphar macody namicactiv
ity
B.Inhibi
ti
onofpr ostaglandi
nssy nt
hesis E.InduceCYP- 450sy stem
C.Blockadeofopi oidreceptor
s
15. The pat i
ent was admi nistered a nar cot i
c
D.St i
mulati
onofopi oidreceptor
s*
analgesic, agoni st-
ant agoni stofopi oi
dreceptorsthat
E.Blockadeofadr enoreceptor
s
i
sweakert hanmor phi ne.Whati stheagent ?
8.Indicatet hedr ugs ti
mul atingt heopi oi
dr eceptorsin A.Nal t rexone
theCNS, whi chl eadst oi nhibiti
onoft het rans missi
onof B.Fent any l
painimpul ses. C.Pent azoci ne*
A.Indomet haci n D.Codei nephosphat e
B.Bupr enor phi ne* E.Nal oxone
C.Acet y l
salicy l
icaci d
16.A 4y .
o.chi l
dwasadmi tt
edt otheorthopedi
c
D.Anal gin
depart
ment wi t
h shi n f ractur
e t oget
her wi t
h
E.Nal oxone
di
splacement .Bone f r
agment sreposit
ion r
equir
es
9.Nal t
rexonewasadmi nisteredt oa23y .
o. mant ot r
eat prel
i
mi nary anal gesia. What dr ug should be
heroinmani a.Indi catet hemechani sm ofact i
onoft he administ ed?2010
er
drug: A.Mor phi
nehy drochl
oride
A.St imul ationofopi oidr ecept ors B.Pr omedol *
B.Bl ockadeofbenzodi azepi ner ecept ors C.Panadol
C.Bl ockadeofadeny lcy clase D.Anal gin
D.Bl ockadeofGABAr ecept or s E.Nal oxone
E.Bl ockadeofopi oidr ecept ors*
10.Apat i
enthass ignsofac utepoi soningwi thmorphine: 17.Whyisitundesirablet ousemor phi
neinpat
ient
s
mios is,los s ofc onsc ious nes s,dec r
eas ed BP and wit
hheadinjur
y?
Chey ne-Stok es r
espi rati
on. Admi nister the A.I
tprovokescar diacarrhythmias
pharmac ological antagoni st: B.I
treducesbloodpr essure
A.Nal orphine C.I
ncreasesint
racr anialpressur
e
B.Pr omedol D.I
tcausesphy siologicaldependence
C.Pent azoci ne E.I
tsuppressesr espirati
on *
D.Nal oxone * 18.A30y .
o.manhasbeenadmi tt
edt othehospit
al
E.Tr amadol e receptionaftercaracci
dentwit
hhipfractur
e.Hehas
11.A dr ug addi ctwas admi tt
ed t ot he emer genc y decreasedBP,t hr
ead-l
i
kepulse,l
ocaltendernessof
depar t
menti nc omawi t
hs ignsofpoi soningwi thopioi
ds. thebr okenhi p.Whatisnecessar
ytoadmi nisterf
or
Whatadv erseef fectofmor phi
ne cont ributed tot he traumat i
cshockpr ev
enti
on?
poisoning? A.Promedol
A.Const i
pat ion B.Naltr
exone
B.Euphor i
a C.Fentany l*
C.Reduct i
onofdi ur esis D.Naloxone
D.Tachy phy laxis E.Aspiri
n
E.Tol erance*
19.A 65 woman wi th breastc ancerhas r
ecei
ved
12.Fent anylhasbeenadmi ni
steredt or educet he
morphi
neforal ongt i
me.Whatdoesnotbel ongtothe
pain atcar diogeni c shock.Whati st he anal gesic
phar
macologi
c al
effectsofmor phi
ne?
actionmechani sm oft hedr ug?
A.Constipati
on
A.Bl ockadeofNa+channel s B.I
nhibit
ionofr espir
atorycent er
B.St imul ationofGABAr ecept ors C.Spasm ofOddi sphincter
C.St imul ationofopi oidr eceptor s* D.Decreaseofr ateofr espir
ation
22
 E.My
dri
asi
s* C.Morphi
ne *
D.Ni
mesulide
20.Whi chstatementaboutPent azocineisincor
rect
?
E.Di
clof
enacsodi
um
A.I
tisami xedagoni st
-antagonist
B.I
tisadmi nist
eredorall
yorpar enteral
ly
C.I
tpr oducesl esseuphoriathanmor phi
ne
4.
3Neur
olept
ics,
Tranqui
l
izer
s,Sedat
ives
D.Itisoftencombi nedwithmor phineformaximal
analgesi ceffect
s* 1.A 42 y .
o.man who hasbeen i nj
ured in a car
E.Highdosesofpent azocineincreaseBP accidentis br oughtt ot he emer gency r oom.Hi s
blood alcoholl evelon admi ssi
on i s 250 mg/ dL.
21.Exami nat ion ofa pat i
entr eveal
ed extremel y
Hospitalrecor ds show a pr iorhospi t
alizati
on for
my otic pupi ls,l abour ed Chai n-
Stock’
sr espir
ation,
al
coholr elatedseizures.Hi swi f
econf irmst hathe
uri
nar yretent ion,sl owi ng-downofHR,l ow BP and
hasbeendr i
nkingheav i
l
yf or3weeks.
enhanced spi nalr eflexes.Whatagentcaused t he
Whatt r
eat mentshoul dbepr ovidedtot hepatient
poisoning?
i
fhegoesi ntowithdrawal?
A.Nar cot icanal gesics*
A. Diazepam *
B.Non- nar cot i
canal gesi cs
B. Phenobar bi
tal
C.Muscur inicr ecept orblockers
C. Pentobarbital
D.Local anaet het i
cs
D. Diphenin(Pheny toi
n)
E.Beta- adr enobl ocker s
E. None
22.A pat i
enthasbeendi agnosedwi thtransmur al
my ocardiali nfar ction.Whatdr ugshoul dbegiv ent o 2.A17y .
o.pati
entc onsultedadoc toraboutins omni a
preventcar diogeni cshock?2012 manifes tedinhar df all
ingas leept hatl edtof atigue,
A.Phent olami ne weaknes s,and di ffi
culty of l earning. The c li
nical
B.Anal gin examinat ion revealed irri
tabil
i
ty,emot ionalinstabili
ty
,
C.Promedol * puls
eandBP al terati
on.Thedoc tordet erminedt hat
D.Oct adi ne i
nsomni awasassoci atedwi thneur osis-li
kestateand
E.Reser pi ne vegetov asculardi stonia.Choose t he mostr ati
onal
23.Apat ientdi agnosedwi thmor phi
nism hasbeen agentf orcor r
ectionoft hiscondi ti
on.
admi tt
edt ot henar cologicaldepar tment.A doct or A.Dr operidol
noted a decr ease i n phar macol ogi
calactivi
ty of B.Ni tr
azepam *
mor phine.Repet iti
v euseoft hedr ugmayr esulti n C.Ami nazine( Chlorpromazi ne)
tol
erancet oi tsef fect ,andt hisphenomenoni scalled: D.Phenobar bital
2012 E.Hal operidol
A.Cumulati
on 3. A pat i
ent has been t aking a mi xt
ure for
B.All
ergy neurasthenia for a week. He f el
t bett
er, but
C.Antagoni
sm conj
unct i
vit
is,r ash,inert
ia,decrease of memor y
D.Addict
ion* appeared.He has been di agnosed wit
h bromi
sm.
E.Tachyphyl
axi
s Whatshoul dbeadmi ni
ster
ed?
24. A pat i
ent wi t
h ur ol
i
thiasis has unbearabl
e A.Nal oxone
spasmodi cpain.Topr eventpainshock,hehasbeen B.At r
opine
gi
venani njecti
onofat r
opi
neal ongwi
thanar coti
c C.Panangi n
anal
gesichav i
ngant ispasmodi cef f
ect
s.Whatdr ug D.Sodi um chlori
de*
wasit?2013 E.Pilocarpine
A.Tr amadol e 4. Choose dr ug combi nat
ion produci
ng
B.Pr omedol (Trimeper i
dine)* neur
oleptanal
gesia.
C.Mor phi
nehy dr ochl
oride A.Haloperi
dol+Paracet
amol
D.Et hylmorphinehy drochlori
de B.Droperi
dol+Naloxone
E.Nal orphi
ne C.Dicl
ofenac-
nat
ri
um +Hal operi
dol
25.A pat ienti s diagnosed wi th acut
e mor phine D.Droperi
dol+Fentanyl
(Innovar
)*
hydrochlor
ide intoxi
cati
on.Admi ni
steran oxidi
zi
ng E.Aminazine+Nimesuli
de
2016
agentforgast ri
clavage: 5.A 45 y .
o.pat i
entdev eloped the sympt
oms of
A.Potassium permanganat e* par
k i
nsonism dur ing ps ychosis treat
ment. Whi
ch
B.Sulfocamphocai ne( Pr
ocaine+ ant
ipsychoticdrughaspr obablybeenused?
Sulf
ocamphoricacid) A.Sul piri
de(Eglonil
)
C.Chloramine B.Ti apride
D.Cerigel C.Cl ozapine
E.Chlorhexidi
ne(bi)gluconate D.Ami nazine(Chlor
promazi ne)*
E.Di azepam
26.Due t o sever
e pain syndrome a pat
ientwas
prescr
ibedanarcoti
canalgesic.Namethedrug: 6.A40y .
o.pat
ientwasadmi t
tedt
ot hepsychi
atr
ic
A.Met ami
zole(Analgi
n) cl
ini
cinastateofexcit
ati
on,aggressi
on,del
ir
ium.
B.Indomethaci
n Whatdr
ugshoul
dbeadmi ni
ster
edtothepati
ent?

23
 A.Reserpine D.Fl umazeni l*
B.Ami nazine(Chl
orpr
omazi
ne)
* E.Al l
oxi m
C.Diazepam 13.Whi chgr oupofdr ugsi susedasmoodst abili
zer s
D.Dicl
of enacsodi
um i
nmani cdepr essi vepsy chosi s?
E.Sodium oxybutyr
ate A.Ant idepr essant s
7.A pat i
ent ,get ti
ng t r
eatmentf orneur osis with B.Sedat iv es
Diazepam compl ains of a t oothache.A doct or C.Neur ol ept ics
prescribedananal gesicinal essdos ethanav erage D.Tr anqui lizer s
ther
apeut ic
.Whatphenomenon di d doc t
ortakei nto E.Li thi um sal t s*
conside r
ati
onwhi l
edec r
easingthedos e? 14.Whi chdr ugshoul dbeadmi nisteredt oapat i
enti n
A.Summat ion thecaseofpoi soni ngwi thdr oper i
dolt ost abi li
zeBP?
B.Cumul at ion A.Pl at yphy llin
C.Tol erance B.St rophant hin*
D.Addi ti
veef fect C.Adr enal ine
E.Pot ent i
at i
on* D.Mesat on
8 A woman wi th an act ivel i
fe-sty l
e consul
ted a E.Met opr ol ol
doctorcompl ai
ni ngofbadmood, migr ai
ne,emotional 15.The maj or i
tyofdr ugsf rom t hisgr oup pr oduc e
l
iabil
ity,and chestpai n.Whi ch dr ug should be expres seds edat ive-hy pnot icandmy orelaxantac t
iont hat
admi nistered t aking i nto accountt hatthe woman i
swhyt heydec reas ec onc ent rationandr eac tiont i
meof
spendsal otoft imeatwor k? thecur edpat ient s .Det ermi net hi sgr oup:
A.Gi dazepam * A.Tr anqui lizer s*
B.Phenazepam B.Bet a-adr enomi met ics
C.Tr if
tazi ne C.Sy mpat homi met ics
D.Phenobar bital D.Sal i
cy l
at es
E.Ami nazi ne( Chlorpromazi ne) E.Monoami nooxi dasei nhi bitors
16. Ther e i s a necessi ty t o admi nist er an
9Apat i
entv i
sit
edadoct orcomplainingofemot i
onal
anti
psy chot icdr ugt oapat ientwi thpar ki nsoni sm.
i
nstabili
ty,f eel
ingofpsy cho-emot i
onaltensi
onand
Whichneur olept ichast hel eastr iskf ort hepat ient?
fear on meet i
ng hi s chi ef accompani ed by
A.Ami nazi ne( Chl orpr omazi ne)
tachycardia,hy peremi a oft he face,hand t r
emor,
B.Dr oper i
dol
sweat i
ng.Thedoct ordi agnosedv egetat
iveneurosi
s.
C.Tr iftazi ne
Whi chdrugshoul dbeadmi ni
ster
ed?
D.Cl ozapi ne( Leponex) *
A.Sul pir
ide(Eglonil
)
E.Hal oper idol
B.Tiapr i
de
C.Lor azepam * 17.Ami naz ine was admi nis tered t o a pat ientwi th
D.Sodi um bromi de schizophr eni a. Whi c h phar mac ody nami c ef f
ec t of
E.Lithium carbonat e aminaz i
nei st hebas icfort hispat ient ?
A.Anxi ol y ti
c
10.Aneurolept icwithexpress
edhypotensi
veact
ivi
tyhas B.Ant ipsy chot ic*
been admi nis t
ered to a pat ient suff
eri
ng f r
om C.My or el axant
schi
zophrenia ac companied by art
eri
alhypert
ensi
on. D.Hy pot ensi ve
I
ndicat
ethisdr ug: E.Hy pot her mi c
A.Hal oper i
dol 18. A 45 y .o. pat i
ent suf f
ers f rom neur osi s
B.Risper idone charact er ized by i rritability, sl eepl essness, and
C.Ami nazine(Chlorpr
omazine)* mot i
v elessanxi et y.Whatdr ugwoul del i
mi nat eal lthe
D.Di azepam sympt oms?
E.Tr i
ft azine A.Lev odopa
11.At ruckdr i
verconsul
tedadoct oraboutemotional B.Py racet am
tension,anxiety
.Thedoct ordiagnosedneur ast
henia. C.Val er ianext ract
Chooset hedayt imetranquil
izerf
ort hi
spatient
: D.Di azepam *
A.Phenazepam E.Caf f einesodi um benzoat e
B.Mezapam * 19.Amet hodofgener alhy pot her mi aisnecessar yto
C.Chlozepide(chlor
diazepoxide) use f orper for mi ng an oper ative measur e.Whi ch
D.Diazepam agent i n combi nat ion wi th phy sicalcool ing wi l
l
E.Lorazepam providet heexpr essedhy pot her mi a?
A.Sul piride( Egl onil)
12.A26y .o.f emalehastakennozepam forneurosis B.Ti apr ide
foralongt i
me.Onedayshedev elopedweakness, C.Chl or diazepoxi de( Chl ozepi de)
nausea,sl urred speech,discoor
dinati
on,unsteady D.Li t hium car bonat e
gait
.Sheconsul ted adoctorand headmi nistered E.Ami nazi ne*
benzodiazepi neantagoni
st.Det
erminethi
santidote:
20.I ndi cat e a dr ug wi th st rong,qui ck butshor t
A.Isoni tr
ozine
neurol ept icact ion.I tpot ent at esact ionofanal gesi cs,
B.Nal trexone
hypnot ics,and al cohol ,possesses ant i
shock and
C.Nal oxone
24
anti
emet i
cact ion, bel
ongst obut yr
ophenones: 27.Impai r
mentofmov ementcoordi
nati
on,shiv
ering
A.Clozapi ne ofthehandsandsl eepi nessdevel
opedinapat i
ent
B.Dr operidol* suffer
ingfrom schi zophr eni
aandtakingpsychot
ropic
C.Sul pir
ide drugs.Indi
catet hisgr oupofdrugs.
D.Ami nazine( Chlorpromazi ne) A.Neur oleptics*
E.Lor azepam B.Analgesi cs
21.Apat ientaskedadoct orf orhelptoovercomehi
s C.Tranqui l
izer s
fearbef oredent almani pul at
ion.Whi chdrugdidt
he D.Antidepr essant s
doctorrecommend? E.Psycost imul ants
A.Sul piri
de 28.Introduct onofami
i nazinet oapatientsuffer
ing
B.Ami nazine( Chlorpromazi ne) fr
om chr oni
c al coholism f or eli
mi nati
on of
C.Dr oper i
dol aggression and del iri
um, caused l oss of
D.Diazepam * consciousness.I ndicatet hepr obabler
easonoft his
E.Lithium car bonat e compl i
cat i
on.
22.Glut
amat edecarboxy
lat
ionr
esul
tsi
nfor
mat
ionof A.Or t
host ati
ccollapse*
i
nhibi
torytr
ansmi tt
eri
nCNS.Nameit: B.Inhibi
tionoft heret i
cularformat ion
A.Serotonin C.Suppr essionoft hel i
mbi csy stem
B.GABA* D.I mpairmentofoxi dativepr ocessesint hebrain
C.Glutathi
one ti
ssue
D.Histamine E.Impairmentofcor onarycirculati
on
E.Asparagines 29.Indicatet hedrug foreli
minati
on oftheacute
23.Adoc torhasadmi nisteredanagentI Vt othepat i
ent psychosis f rom t he group of der i
vati
ves of
withac uteps ychos is,whi c hac compani edbydel i
ri
um phenothiazine:
andhal l
uc inations .Sy mpt omsofps ychos ishav ebeen A.Ami nazine(
Chlor
promazine)
*
el
imi nat ed, butwhent hepat i
enthasr isenf rom abed, he B.Dr operidol
bec ame pal e and l ostc ons ci
ous nes s.The doc tor C.Cl ozapine
di
agnos edor thos tati
c( post ural)collaps e. Whi chagentis D.Sul piri
de
mos tlikel
yt oinv olve? E.Tiapr i
de
A.Reser pine 30.Determine t he group ofdr
ugs,whi
ch doesn’
t
B.Ami nazi ne* causedrugdependence.
C.Di azepam A.Neuroleptics*
D.Dr oper idol B.Tranquil
izer s
E.Cl ozapi ne C.Barbit
urates
24.A35y .o.pat ientwi t
hschi zophr eni acompl ai
nsof D.Opioidanal gesics
di
scoor di
nat i
on of mov ement ,t remor of hands, E.Phenylal
ky lamines
drowsi ness. Thepat ienthasbeent ak i
ngapsy chotr
opic
agentf oral ongt i
me.Whi chgr oupi smostl i
kel
yt o 31.A doct oradmi nister ed ami nazine t o apat i
ent
i
nv olv e? sufferingf rom schi zophr eni at oel i
minatedel ir
ium,
A.Tr anqui lizers hall
uci nat i
ons, t o decr ease aggr ession and
B.At y pical neur oleptics psychomot orexci tement .Whati st hemechani sm of
C.Ty pical neur oleptics* antipsy chot icact onofami
i nazi ne?
D.Ant idepr essant s A.St imul ationofM- chol inor ecept orsi ntheCNS
E.Psy chost imul ant s B.St i
mul ationofopi oidr ecept ors
C.Bl ockadeofD2r ecept or si nt heCNS*
25.Lor azepam hasbeenadmi nister edt oapat ient
D.St imul ationofadr ener gicanddopami ner eceptors
with hy per exci tabilit
y, i rri
tabi li
ty , t earful
ness,
i
nt heCNS
sl
eepl essness.Whati sthemechani sm i t
sact i
on?
E.Inhibi ti
onofMAO
A.Bl ockadeofGABA- recept or s
B.Bl ockadeofbenzodi azepi ner ecept ors 32.Aneur olept icfrom t hegr oupofbut yr
ophenones
C.St imul ationofbenzodi azepi ner eceptors* wasadmi nister edt oapat i
entwi thal cohol psychosis.
D.St imul ationofGABA- recept or s Deter mi net hedr ug:
E.Bl ockadedopami ner ecept ors A.Ti apr i
de
B.Chl ozepi de( Chl or diazepoxi de)
26.Hal oper i
dolhasbeenadmi ni
ster
edfordel
i
ri
um and C.Sul piri
de
hal
lucination.Whati st hemec hanismofit
santi
psy
choti
c D.Hal oper idol*
act
ion? E.Ami nazine( Chl or pr omazi ne)
A.Blockadeofr eupt akeofcat echolami
nes 33.A 32 y .
o.woman wi th compl aintsoft emper,
B. St i
mul ati
on of adr energic and dopaminer
gic ti
redness,i nsomni a,int er nalt ensi onhasdi agnosed
processesi ntheCNS with neur osi s and admi nistered a t ranquili
zer
C. Inhi bition of adr energic and dopami ner
gic (di
azepam) .Whi ch ef fect of t he dr ug i s mor e
processesi ntheCNS* i
mpor tanti nt hi
ssi tuation?
D.BlockadeofM- chol i
nor5eceptors A.Ant ipsy chot i
c
E.Sti
mul ationofM- cholinoreceptor
s B.Anxi oly t
ic*
25
 C.Anticonv ulsi
v e ofbenzodiazepinerow hasbeenusedforanal
gesia.
D.My orelaxant Which agenthasbeen admi ni
ster
ed f
oranalgesi
a
E.Antiemet ic pot
enti
ation?
2014

34.A dent i
sti nt roduced diazepam t o a 47 y .o. A.Carbamazepine
woman bef or e ext r
action of t ooth.I ndicatet he B.Trif
tazine
anxi
oly
ticactionmechani sm ofthedr ug: C.Droper i
dol
A.Stimul at ionofopioidr eceptors D.Diazepam *
B.I nhibi tion of dopami ne receptor s and E.Imizi
ne
adrenor ecept or
s
C. St imul ati
on dopami ne recept ors and
adrenor ecept or
s
D.Agoni stofbenzodi azepi nerecept ors*
E.Inhibitionofbenzodi azepiner eceptors
35.A pat i
entv i
si ted a doct orwith compl aint
sof
3.
4Hy
pnot
ic,
Anti
epi
l
epti
cDrugandPharmacol
ogi
c
i
rri
tabi
li
ty,i
nsomni a,f ati
gue.Adoct oradmi nister
eda
ManagementofPar
kinsoni
sm
sedati
vedr ugtohi m.I naweekt hepatientbegant o
complainofcough,sl eepiness,decreaseofmemor y, 1.Whichoneoft hefoll
owingst atementsiscor
rect?
symptoms of r hi niti
s, conj unct
ivi
ti
s, der mati
tis. A.Aminazinei si
ndicatedintreatingthenausea
Whichgr oupoft hedr ugswasadmi nister
edbyt he B.Vit
aminB6i ncreasest heeffectiv
enessoflev
odopa
doctor
? C. Admi ni
strati
on of dopami ne is an effecti
ve
A.Neurolept ics tr
eatmentofPar kinson΄sdisease
B.Tranquilizer s D.Levodopa-inducednauseai sr educedbycarbidopa
C.Lit
hium E.Nonspecifi
cMAO- inhi
bitor
s, suchasnialami
de,are
D.Bromides* ausefuladjuncttolevodopat herapy
E.Non-ster oidalanti-
inflammatoryagent s
2. Whi ch one of t he foll
owing st atements is
36.Whicheffecti snotdev elopedaferami
t nazi
ne
I
NCORRECT?
(chl
orpr
omazine)admi ni
st r
ati
on?
A.Treatmentwi hsel
t egeli
ne(deprenyl)candelaythe
A.Anti-
emet i
caction
parkinsoniansympt oms
B.Hypothermia
B.OvertreatmentofPar ki
nson΄sdiseasecanr esul
tin
C.Art
erialhypotension
thesy mt omsofpsy chosis
D.Anti-
hist
ami neact i
on
C.Dietsr i
chinpr otei
nmaydecr easet heef f
ectsof
E.St
imul at
ionoft hebraincor
tex*
levodopa
37.A man dev el
ops akat hisi
a,a Par ki
nson-
li
ke D. Vitami n B6 decr eases the ef fecti
veness of
syndrome,gal act
orrhea,andamenor rheadur i
ngthe levodopa
therapy.Whi ch of t he foll
owing mechani sms is E.Par kinsoni
an pat i
ents are char acter
ized by a
i
nv olv
ed? increased r atio of dopami nergic/
choli
nergi
c
A.Bl
ockadeofM chol i
noreceptors activit
yintheneost ri
atum.
B.Sti
mul at
ionofdopami ner eceptors
C.Bl
ockadeofal pha-adrenergicreceptor
s 3.A v eryagitatedy oungmal ewasbr oughtt othe
D.Blockadeofdopami nereceptors* emer gency r oom by t he police. Psy chi
atri
c
E.Bl
ockadeofNchol inoreceptors exami nati
onr evealedthathehadsnor t
edcocai ne
severaltimesint hepastfewday s;thelastti
mewas
38.Apati
entwhohasbeent r
eatedinaneur alcli
nic
12hour sago.Hewasgi venadr ug,whichsedat ed
andhasbeentaki
ngasedat i
vef oralongt i
megot
him,andhef ellasleep.Thedr ugveryli
kelyusedt o
thefol
l
owingcompli
cat
ion:cough,rhi
nit
is,epiphora
countert hi
spat ient’
sappar entcocainewi t
hdrawal
(l
acr
imati
on)
.Whatdrugcausedthesedistur
bances?
2011 was:
A.Phenobar bit
al*
A.Sodium br omi de*
B.Lorazepam
B.Phenazepam
C.Cocaine
C.Reser pine
D.Diazepam
D.Diprazi
ne( Pipol
phen)
E.Fluoxet
ine
E.Valeri
an
39.A pat ienthas r ecur
rentattacks ofepi lepti
c 4.Dr
ugofchoi cef orpsychomot
orepi
l
epsyi
s:
seizur
esandst ay sunconsciousbet weent hem.I n A.Valproicaci d
ordertostopconv ul
sionsthedrugsoft hef
ollowing B.Carbamazepi ne*
groupshoul dbeusedi nthefir
stpl
ace: 2013 C.Ethosuxi mide
A.Sedat ives D.Barbiturate
B.Neur olept i
cs E.Di
pheni n
C.Muscl er elaxants 5.Whi ch anti-
epi
lepti
c acts by augmentati
on of
D.Tr anquilizer
s* rel
easeofinhi
bitor
yt r
ansmitt
erGABAbyi nhi
bit
ingi
ts
E.Anal eptics degradati
on (by GABA- t
ransaminase) as wellas
40.Anopi
oidanal
gesi
cincombi
nat
ionwi
thanagent probablybyi
ncreasingit
ssynthesi
s?
26
 A.Valproi
cacid* E.Bl
ockscent
ral
chol
i
nor
ecept
ors
B.Carbamazepi ne
13.Thedoct orhaspr escrbedcy
i cl
odolforPar
kinson
C.Dipheni
n( Phenytoi
n)
di
seaset r
eat ment.Whati sthemechani sm ofanti
D.Ethosuximide
parki
nsonianactionoft hedrug?
E.Barbi
turates
A.M cholinomi meti
caction
6.Whi chant i
-epi
lepti
cact sbypr olongatonofNa+
i B.M cholinoblockeracti
on*
channelsinacti
vati
onaswel l asbyinhibi
ti
ngki
ndl
ing? C.Stimulati
onofdopami nerecept
ors
Thedr ugal so hasant i
diureti
cact ion,pr
obabl
yby D.Blockadeofdopami nereceptor
s
enhancingADHact i
ononr enal t
ubules. E.beta-Adrenoblockeracti
on
A.Car bamazepine* 14.A 56 y .
o.pat i
enthas t aken phenobarbi
talin
B.Phenobar bit
al connecti
onwi thinsomnia.Aft
eracancel l
ati
onoft he
C.Dr operi
dol drugthepat i
enthasdi f
fi
cult
yi nfal
li
ngasleepagai n,
D.Val pr
oatesodium fr
equentl
ywakesupatni ght;sleepisaccompani ed
E.Ethosuximide bydreadfuldreams.Whati st hereasonoft hegiven
7Whichant i
convulsantisnotusedi
ngener
ali
zed undesi
rableeffectofphenobarbit
al?
t
oni
ccloni
cconv ulsi
on? A.Dependence
A.Phenobar bi
tal B.Idi
osy ncrasy
B.Ethosuximide* C.Tachy phylaxi
s
C.Diphenin D.Reboundsy ndrome*
D.Diazepam E.Tolerance
E.Sodium oxybutyrat
e 15.A pat ientdef i
ed hi sdoctor
’si nst
ructi
onsand
8.Al
lareusedi nthetr
eat
mentofepi
l
epsyexcept
: conti
nued t o use phenobar bit
al over 3 weeks.
A.Ethosuximide Meanwhi l
e,he was f or
ced toincrease the drug’
s
B.Reserpine* dose.Howt oexplainfall
ingofphenobarbit
aleff
icacy?
C.Lamot r
igine A.Activat
ionoflipolysis
D.Diazepam B.Inhi
biti
onofmonooxy genasesyst
emsoft heli
ver
E.Sodium oxybuty
rat
e C.Inducti
onofmonooxy genasesystemsoft heli
ver*
D.Inhi
biti
onofl i
polysis
9.Drug,whichdecr easesexcit
ingneurot
ransmi
tt
er E.I
nduct i
onofgl ycolysis
aminoacids(glutamate,aspar
tate)l
evel
inbrai
n:
A.Diazepam 16. A 56 y .o. man wi th insomnia was gi ven
B.Phenobar bit
al phenobar
bital.Thesl eepwasnor mali
zed.Howev er
,
C.Sodium v al
proate aft
er2weekst heeffectofPhenobar bitalfel
ldown.
D.Carbamazepi ne Whatreasoncauseddecr easi
ngofhy pnoticacti
onof
E.Lamot r
igine* phenobar
bital?
A.It
spoorsol ubi
lit
y
10.A maj orpr obl em thatmustbe f aced when B.Tolerancedev elopment *
administeri
ng ant i
convulsant
s wi th many ot her C.It
spoorabsor ptioninthestomach
medicati
ons ( i
ncl uding other antiepi
lept
ic drugs) D.It
sf i
xationinlipi
ds
i
nvolvesdr uginteract i
onsduet oalteredmet abol
ism. E.Tachy phylaxi
sdev elopment
Which oft he fol lowing drugs isl i
kelyto cause
excessiv
eort oxicef f
ect
sf rom someot herdrugsby 17.A pat i
entwi th epilepsywas r ecommended a
i
nhibit
ingmet abol ism? medi ci
neknown asa pr opylval
eri
caci d deri
vati
ve
A.Et hosuximi de thatinhibitsGABA- tr
ansf eraseandi ncreasesGABA
B.Car bamazepi ne l
ev elint he br ain;inhibits excit
abili
tyand sei zure
C.Phenobar bital capabili
tyofmot orzoneoft heCNS.I tcanbeused
R
D.Pheny t
oin foralltypesofepi lepsy.Namet hi
smedi cine:
E.Val proi
caci d* A.Reser pine
B.Di azepam ( Seduxen)
11.Determine t he hypnoti
c drug,whi
ch doesn’
t
C.Di pheni n
i
nfl
uencethest r
uct ur
eofsleep:
D.Sodi um bromi de
A.Barbit
al
E.Sodi um v alproate*
B.Phenobar bit
al
C.Nit
razepam * 16.Admi nistert oapat i
entwi t
hi nsomni aamoder n
D.Thiopentalsodi Aet
um ( haminal
um-
nat
rum) hypnotic.Iti sani midaz opyri
dineder i
vativ
e;ac t
ivat
es
E.Secobarbital benzodiazepi ner eceptorsi nt heCNS;doesnotal t
er
eit
hers l
eeps tr
uctureorac t
ivi
tyofliv
erenz y
mes ,does
12.A pat i
enthas been admi nist ed l
er evodopa i
n notcaus edependenc e:
complex t her
apy of Par kinson di sease. What A.Phenobar bit
al
changesthisdrugproducesint heCNS? B.Ni t
razepam
A.Enhancesdopami nemedi ati
on* C.Zol pidem *
B.Decreasesdopami nemedi at
ion D.Chl oral hydrate
C.Stimulat
esdopami ner eceptors E.Flumazeni l
D.Blocksdopaminer eceptors
27
17.Anat tac kofgener ali
z edt oni c-clonicc onv ulsi
ons C.Ni trazepam*
ac compani ed byl os sofc ons cious nes sand gener al D.Ami nazi ne( Chl orpr omazi ne)
suppr es s i
onoft heCNSdev elopedi napat ientaf ter E.Sodi um br omi de
trauma.Whi chagents houl dbeadmi nister
edt ot his 24.Di pheni n( Phenyt oi n)hasbeenadmi ni
steredt oa
pat i
e nt? pati
entf orepi lepsywi tht oni c-cloni cat tacks.Whati s
A.Et hosuxemi de theact ionmechani sm oft hedr ug?
B.Car bamazepi ne A.Act iv ationofGABAsy st em
C.Phenobar bit al B.Bl ockadeofCa2+channel s
D.Sodi um oxy but yrate* C.St i
mul ationofdopami ner ecept ors
E.Tr imet hine( Tr imet hadi one) D.Bl ockadeofdopami ner ecept or s
18. Sy mpt oms of poi soni ng wi th der iv ativ e of E.Bl ockadeofNa+channel s*
bar bitur icaci dar er ev eal edi napat i
ent.Whatdr ug 25. A pat i
ent s uf
fer s f rom Par ki
nson’ s disease
can i ncr ease excr et i
on ofbar bitur ates f rom t he accompani edwi thmus c leri
gi dity,c ons t
rainedmot ions,
or gani sm? andc ons t
antt remorofar ms .Whatdr ugs houldbe
A.Nat rium chl or ide admi ni
s tered?
B.Sodi um hy dr ocar bonat e* A.Phenobar bital
C.Pot assi um chl oride B.Lev odopa*
D.Magnesi um oxi de C.Di azepam
E.Magnesi um sul fate D.Di pheni n
19.Whatphenomena may be dev eloped i nl ong E.Et hosuxi mi de
takingofbar bi t
ur at es? 26.Apat ientsuf feringwi thpar kinsoni sm hasbeen
A.Dr ugt ol erance* taki
ng f or a l ong t ime t he agent wi t
h cent ral
B.Dr ugdependence cholinoly ticact i
onmechani sm whi chef fi
ciencyhas
C.Ext rapy rami dal sy ndr ome gradual l
ydecr eased.I ndicat edr ugwhi chshoul dbe
D.Sensi bili
zat i
on admi nister edi nst eadofusedone?
E.I nhi bitionofenzy mesofl iver A.Cy clodol (Trihexypheni dyl )
20.A pat i
ent has consul ted t he dent ist about B.Lev odopa*
hy per trophyandpai ni nt hegumsandhy perpl astic C.My docal m( Tol perizon)
gingi v i
tis was di agnosed.I thas been est abl ished D.Tr opaci n( Diphenyl tropi n)
from t heanamnesi s,t hatt hepat ienthast akenan E.Bel l
at ami nal
ant iepi lept icagentf oral ongt ime.Speci f
ythi sdr ug: 27.A76y .o.pat ienthasappeal edt ot hedoct orwi t
h
A.Phenobar bit al compl aint sofsuper fici alshor t -
ter m sl eepwi thof t
en
B.Hexami di ne awakeni ngs caused by sense ofi nternalt ension,
C.Di pheni n( Phenyt oin)* anxiety,f ear .Seni lesl eeplessnesswasdi agnosed.
D.Car bamazepi ne Makear at ionalchoi ceofahy pnot i
ci nthegi ven
E.Tr imet hine( Tr imet hadi one) sit
uat i
on:
21.Apat i
entwi thcr ani ocer ebr alinj uryhasgotbr ain A.Phenobar bital
edemaandhy poxi ccr amps.Whatagentshoul dbe B.Chl or al hy dr
at e
admi ni st er ed? C.Ni trazepam*
A.Cor diami n D.Lamot rigine
B.Anapr i
line( Pr opr anol ol) E.Car bamazepi ne
C.Bemegr ide
D.Sodi um oxy but ir
at e* 28.Apat i
entwi t
hconv ulsionswasadmi tt
edt ot he
E.Pi racet am hospi talwher e st atus epi l
epticus was di agnosed.
Indicatet hef i
rstchoi cedr ugt otreatthepat ient:
22.A57y .o.mani nacomahasbeendel iv eredt o
A.Car bamazepi ne
hospi tal .I ti sknown f r
om hi sanamnesi st hathe
B.Di azepam *
suf fer edf rom i nsomni a.Ati nspect i
ont hef ol lowing
C.Phenobar bital
i
s r ev eal ed: r espi rator y depr essi on, f al len BP,
o D.Lev odopa
pr ogr essi ngcar diacweakness,decr easeofbodyt ,
E.Chl oralhy dr
ate
i
nhi bi tionoft endonr ef l
exes.Whatdr ugcoul dcause
poi soni ng? 29.I ndicatet hechar act erofchangesi nthest r
ucture
A.Fl uoxet ine ofsl eepundert heact i
onoft hehy pnot i
cagent sfrom
B.Phenobar bital* thegr oupofbar bitur
ates:
C.Ti nct ur eofVal erian A.Deepeni ng ofsuppr ession oft he CNS dur ing
D.Lev odopa UNREM sl eepphase
E.Sodi um br omi de B.Shor teningoft helat entper iodthef i
rstepisodeof
theREM- sleep
23.A hy pnot icdr ug wi tht ranqui llizing ef fectwas
C.Ext ensi onofREM- sleep( paradoxical)phase
pr escr ibedt oapat i
entwhosuf fer sf r
om i nsomni a
D.Shor teningofREM- sleep( paradoxical)phase*
causedbyemot ionaldi sor der .Whathy pnot icwas
E.Lengt heningoft hedur at i
onofepi sodesoft heREM-
pr escr ibed?2010
sleep
A.Thi opent al sodi um
B.Phenobar bital 30.A17y .o.girlt
ookahi ghdoseofphenobar bi
talto
commi tasui cide.Anambul ancedoct orcleansedher
28
stomachandgav eheranI Vi njectionofbemegr ide E.Dr
oper
idol
andsodi um bi carbonat esol uti
on.Whatwassodi um
5.A doct oradminist
eredami tr
ipty
li
net oapat i
ent
bicarbonat ei njectedf or?
wit
hendogenousdepr ession.Explai
nthemechanism
A.Fori ncr easingr enal excretionofphenobar bit
al *
ofactionoft hi
sdrug:
B.Forbr i
ngi ngt hepat ienttoconsci ousness
A. I nhibiti
on of t he neur onal reuptake of
C.Forbr eathingst imul ati
on
noradrenal i
ne
D.Forphenobar bital i
nact i
vat i
on
B.I
nhi bi
tionoftheneuronalreuptakeofserot
oni
n
E.Forar ter i
al pressur enor mal i
zati
on
C.MAOi nhibit
or
31. Apatientpr e sentswi t
hdys functi
onofc erebralc
ortex D.I
ncr easeofr el
easeofnoradrenali
neandserotoni
n
ac c
ompani ed by epi l
eptics eiz
ures .He has been E. I nhibiti
on of t he neur onal reuptake of
admi ni
stered a bi ogeni c ami ne s ynthesized f r
om nor adrenali
neandser ot
onin*
glutamateandr es pons ibl
ef orc entralinhibit
ion.What
subs t
anc eisi ?2012
t 6 A man was addr essed t ot he psy chi atri
stwi t
h
A.Acet y l
chol ine compl aint s and desper ation,t endency t o sui ci
de.
B.Hi stami ne Det ermi net hegr oupofdr ugsf ort het reatmentof
C.Gamma- ami nobut y ri
caci d* thispat ient ?
D.Ser otoni n A.Ant idepr essant s*
E.Dopami ne B.Sedat ives
32.A66y .o.pat i
ents uff
erswi t
hPar ki
ns on’
sdi seas e C.Neur olept i
cs
shows an i mpr ov ementi nl ocomot orac t
ivi
ty after D.Tr anqui li
zer s
prolongedus eofac ertai
ndr ugwhi c hisc onvert
edt o E.Li t hium
dopami nebydec ar box yl
ati
on.Whatdr ughast hepat i
ent 6.Thi sgr oupofdr ugi ncludespsy chot r
opi cagent sof
taken?2013 plantor igin.Thesedr ugsar eusedi nast henicst ates
A.Cel ecoxi b after sev erei nfect i
ous di seases.They i ncr
ease
B.Lev odopa* gener al v i
tal t oni city of t he or ganism and i ts
C.Chl orpromazi ne resist ancet oi nf ectiousdi seases.Thesedr ugsar e
D.Dr oper i
dol used i nt he f or m oft inctur es orl i
qui d ext r
act s.
E.Nal oxone Chooset hi sgr oupofdr ugs:
4.
5.CNSSt
imul
ant
s A.Sedat ive
B.Adapt ogens*
1.MAOi nhi bitorsar econt raindicatedwi thal lofthe C.Psy chost imul ant s
fol
lowingEXCEPT: D.Ant idepr essant s
A.Indi rectadr energicagent s,suchasephedr i
ne E.Noot ropi cagent s
B.Tr icy clicant i
depressant 7.48.A 36y .o.manhasacr ani ocer ebr alt r
auma.
C.Par acet amol * Obj ect ivel y:di mi nishedbr eat hsounds,t hr eadypul se,
D.Beerandcheese andnor eflexes.Whatwayofpy racet am i ntroduction
E.Dopami ne willbet hemostappr opr i
atei nt hiscase?
2.Av eryupsetmot herbr ingsi nher12y .
o.sont o A.I nhal ation
askhel pi ndeal i
ngwi thhisbed- wet ti
ng.Whi choft he B.Subcut aneous
fol
lowingdr ugsmi ghtalleviatethispr oblem? C.Rect al
A.Fl uoxet ine D.I nt rav enous*
B.Imi zine( Imiprami ne)* E.Per oral
C.Di azepam 8.Thi sdr ughasst imul atingact i
onpr omot ing
D.Pi racet am synt hesi sofpr ot einsandATP, incr easest hecapaci ty
E.Zol pi dem forphy sical andment alper formance.I tisusedf ora
3.Awomant riedt ocommi tsuicide,herpsy chiatr
ist l
ongt i
meandshoul dnotbet akenbef oresl eep.
madet hedi agnosi sofendogeni cdepr ession.What A.Gi nsengt inct ure*
drugshoul dbegi venforhert r
eat ment ? B.Val eriant inct ure
A.Ami tripty l
ine* C.Zol pidem
B.Noot ropi l D.Ni al ami de
C.Sy dnocar b(Mesocar be) E.Ami tr
ipt y l
ine
D.Et imi zol 9.Ananal ept icofr eflectivet ypef rom t hegr oupofN-
E.Caf feine chol inomi met icswasgi vent oapat i
entf orbr eathing
4.Apat ientaddr es sedtoadoc t
orwi thc ompl aintsabout restor at ion af terpoi soni ng wi th car bon monoxi de.
badmood,t hatwasac compani edbyex pressedf eeli
ng Whatagentwasadmi nisteredt ot hepat ient ?
of fear,anx iety.The c l
i
nicalex aminat ion r eveal
ed A.Adr enal ine
psychical depr es si
on.Whatdr ugs houldbeadmi nister
ed B.Lobel i
ne*
tothispat ient ? C.Mesat on
A.Caf feine D.Nal oxone
B.Sul focamphocai ne E. Caf feine
C.Py racet am 10.I ndi cat et hemechani sm ofact ionofcaf f
eine.
D.Ami tripty l
ine* A.Bl ockadeofMonoami noox i
dase( MAO)
29
B.I
nhi
bit
ionoftheneuronalcaptureofnoradr
enal
ine B.Sodi um oxybutyr
ate
C.I
nhi
biti
onofphosphodiester
ase( PDE) C.Sy dnocarb
D.Bl
ockadeofadenosi
ner eceptors. D.Mer idil
E.Bl
ockadeofadenosi nereceptorandinhibi
ti
onof ECor diamin( Ni
kethami de)
phosphodi
ester
ase* 19.A pat i
entwi thposttraumat i
cencephal
opathyis
admitt
ed t o the neur ological depar
tment with
11.Indi cat et hecondi tionf ort heuseofPi r
acet am: complaints of di sorders of memor y,i nt
ell
ect
,
A.Angi napect oris headache,v er
ti
go.Chooset hegroupofdrugsforthe
B.Ment al i
nsuf ficiency* pati
enttreatment:
C.Conv ul sions A.Psy chostimulants
D.Hy per tensi vecr isis B.Anal epti
cs
E.Congest i
v ehear tf ailure C.Noot ropicagents*
12.Indi cat et heanal ept i
cofmi xedt ypeofact ion: D.Ant i
depressants
A.Cor diami n( Niket hami de) * E.Adapt ogens
B.Caf f eine
20.Specif
yt hemai nef
fectofPyracet
am (Nootr
opil
).
C.Lobel i
nehy drochl or i
de
A.Stimul ati
onofmy ocar
dium act
ivi
ty
D.Bemegr i
de
B.Tranqui l
izi
ngeff
ect
E.Et imi zol
C.Inhibiti
onuponexcitat
ionintheCNS
13.Indi cat et heanal ept i
cofdi r
ectt ypeofact i
on: D.Impr ovestheprocessesofmemor izi
ngand
A.Cor diami n( Niket hami de) thi
nki
ng*
B.Cy titon E.Decr easestheneuronalst
abil
it
ytohypoxia
C.Lobel i
ne
D.Bemegr i
de* 21.A28y .o.patienti
sdeliv
er edtotheint
ensi
vecare
E.Sul focamphocai ne unitwiththedi agnosisofpoisoningwihbar
t bi
tur
ates
14.Apat ient ’sr espi r
at i
oni ssi gni f
icant l
ydepr essed of moder ate degr ee.Admi ni
ster a st
imul
ant of
during t he oper ation under gener alanaest hesia. respir
ati
onwhi chwillbeper
tinentinthi
scase:
Whi ch agentshoul d be used wi thoutpausi ng the A.Eti
mi zol
gener al anest hesi a? B.Bemegr i
de*
A.Et imi zol * C.Sydnocar b
B.Sy dnocar b D.Pir
acet am
C.Mer i
di l E.Cordiami n
D.Cy ti
ton 22.Thiopentalnatr
ium wasint
roducedtothepat i
ent
E.Lobel ine fori
niti
algeneralanesthesi
athatcausedthear t
erial
15.I ndi cat et he dr ug possessi ng anal eptic and hypotensi
onandr espir
ator
ydepression.Selectthe
psychost imul at ingact i
v i
ty: drugtorestorebreathi
ngandbloodcir
culat
ion:
A.Caf feine* A.Lobeline
B.Bemegr ide B.Dipi
roxim
C.Et imi zol C.Naloxone
D.Cor diami n( Niket hami de) D.Cyti
ton
E.St r ychni ne E.Bemegr i
de*
16.Speci f ycl ini cal usef orBemegr ide: 23.I
ndicatethecharacteri
sti
csi
deef
fectof
A.Par kinsoni sm bemegride.
B.Hy per tensi vecr ises A.Gast r
it
is
C.Ov erdoseofgener alanest hetics* B.Bronchiospasm
D.Br ai nhy poxi a C.Hepat i
ti
s
E.Conv ulsi ons D.Ar t
eri
alhypotension
17. The CNS st imul ation pr oduced by E.Conv ul
sions*
met hy lxant hi nes,suchascaf feine,ismostl i
kel ythe
resultoft heant agoni sm wi tht hef ollowingr ecept ors: 24.Achildwasbor
nasphyxi
ated.Whatdrugmustbe
A.M- chol inor ecept or s admini
steredt
othenewborntosti
mulatebreat
hing?
2016
B.N- chol inor ecept or s
C.Al pha1- adr enor ecept ors A.Proserine(
Neosti
gmi
ne)
D.Adenosi ner ecept or s* B.Naloxone
E.GABA- recept ors C.Prazosin
D.Atropine
18.Apat ienti sadmi ttedt ot heneur ologydepar tment
E.Aethimizol
um *
duet ocompl aint sofdecr easeofmemor y,ment al
and wor kcapaci ty,sl eepl essnessand v ertigo.Hi s 25.A68y .o.pati
entisdel
iv
er edtotheint
ensiv
ecar e
sympt omsar econnect edwi thabr ainconcussi on, uni
twi ththediagnosisofpoisoningwit
hbarbit
urates
taki
ngpl ace2y ear sagoasar esul tofanaut omobi le ofami lddegree.Specif
yast i
mulantofrespi
rati
on,
accident .Whi chdr ugshoul dbeadmi ni
steredt othe whichwi ll
beper t
inenti
nthi
scase.
patient ? A.Instenon
A.Pi racet am ( Noot ropi l
)* B.Sydnocarb

30
 C.Cordi
ami n* E.Caf
fei
ne-
benzoat
esodi
um
D.Pir
acetam
33.Thisdr ugi susedforthet reat
mentofdi sor
ders
E.Encephabol
ofmemor y,cerebr
alatheroscl
erosis,aftercerebr
al
26.A pati
entwithdepressi
onhasbeenpr escr
ibed i
njur
ies,al coholencephalopathy,and dement i
a.It
Nial
amide.Thedoctorhaswarnedthepati
entabout i
mpr oves t he processes of memor izi
ng and
necessi
tyt o excl
ude from hid di
et dur
ing the cognit
ively.Determi
nethegr oupofdr ug.
tr
eatment: A.Ami tr
ipt
y l
i
ne
A.Cheese* B.Py racetam *
B.Apples C.Par acetamol
C.Potato D.Bemegr ide
D.Cabbages E.Di azepam
E.Pears
34.Apat i
entwi t
htraumat i
cencephalopathywas
27.Impairmentofl earni
ng,ret
ardati
onofintel
l
ectual admitt
edt ot heneur ologicaldepar
tmentwi th
devel
opmenti sr ev
ealedat9y .
o.chil
d.Whichgroup complaint
sofdi sordersofmemor y,i
ntell
ect,
admini
strati
oni sappr opri
ateinthi
scase? headache,v erti
go.Chooset hegroupoft he
A.Neur oleptics tr
eatmentoft hepatient.
B.Noot rops* A.Psy chost imulants
C.Tranqui l
izers B.Anal eptics
D.Ant i
depr essants C.Noot ropi cagent( cognit
iveenhancers)*
E.Adapt ogens D.Ant i
depr essants
E.Adapt ogens
28.Thepat i
entabusesamphet
amines.Devel
opment
ofwhateffectisunusual
aft
eri
ntakeofthi
sagent
? 35.Apat ientt ookaf ewtabletsofphenobarbi
talt
o
A.Anor exia fal
lasleepf ast er
.Soonhisr espi
rati
onwas
B.Dependence suppressedandi twasdiff
icultt
owakehi m up.Hi
s
C.Brady cardia* wif
ecal l
edf oranambul ance.Whi chspeci
fi
c
D.Ri
si ngofAP antagonistshoul dbeused?
E.Arrhythmi as A.Bemegr ide*
B.Caf f
eine
29. For restor
ati
on of t he CNS f uncti
on aft
er
C.Lobel ine
i
schaemic stoke a 63 y .o.woman wer et aki
ng
D.Cytiton
pi
racet
am.Shei mprovedsi gnifi
cant
ly.Whati sthe
E.Atropine
mechanism ofacti
onofgivendr ug?
A.Blockageofmonoami neoxidi
ze 36.Phar macol ogi
cal effect
sofantidepressantsare
B.Blockageofcholi
nesterase baseduponi nhibit
ingt heenzymet hatactsasa
C.Blockageofcatechol–O-met hyl
transfer
ase catalystfort hebreakdownofbi ogenicami nes
D.Improvementofmet abolism i
ntheCNS* noradr enali
nandser otonininthemi tochondri
aof
E.Blockageofdopaminehy droxyl
ase cephal icneur ons.Whatenzy mestakepar tint
his
process?
30.Anant i
depr essant,whi
chi scapabletoi
nvokea
A.Ly dase
stat
eofagi tat
ionandsl eeplessnessinhumans,has
B.Tr ansami nase
beenpr escr i
bedt othe22y .o.pati
ent
.Namet hi
s
C.Pept idase
drug.
D.Decar boxylase
A.Fl
uoxet i
ne
E.Monoami neoxi dase*
B.Amitript
y l
ine
C.Mocl obemi de(Auror
ix)* 37.Whi l
eunderbar bitur ateanaest hesi
aa65 y .o.
D.Haloperidol male pat ient dev eloped r espirator
y i nhibi
ti
on.
E.Caffeine Anaesthesiologisti ntroduced hi m 10 mlof0. 5%
bemegr i
de sol uti
onI V.Thepat ient’
scondi t
iongot
31.Apat ientwithrespir
atorydepr
essi
onwasamitted
bet
ter,thepul monar yv ent i
l
ationv ol
umei ncreased.
tot he hospi t
al.Agent s ofwhi ch phar
macol
ogic
Whatphenomenonunder liestheinteract
ionoft hese
groupshoul dbeadmi nister
ed?
A.Neur ol
eptics medicatons?2012
i
B.Tranquil
izers A.Directant agoni sm
C.Analepti
cs* B.Directsy nergism
D.Ant i
depressants C.Indirectant agoni sm *
E.Analgesics D.Indirectsy nergism
E.Unilateralantagoni sm
32.A patientneedsadr ugthatimpr
ovesmemory
and cogni
t i
vef uncti
oni
norganicdamagesofthe 38.Apat i
entwi thepil
epsyanddepressiv
ereacti
on
brai
n.Sel
ecti tout: hasbeenadmi ni
ster
edadr ugthatr
educedepil
epsy
A.Nitr
azepam manifestati
on and i mproved t
hatpatient
’spsychi
c
B.Pyracet am * condi
tion.2012
C.Mezapam A.Ami triptyl
ine*
D.Diazepam B.Pheny toin
31
 C.Sodium val
proat
e B.Thiopentalsodi
um
D.Ethosuxemide C.Diethylet
her
E.Phenobarbi
tal D.Sombr evin
E.Fl
uor ot
ane( Hal
othane)
3.
6.Gener
alAnest
het
ics.Et
hyl
Alcohol
6.Thi opentalsodi um was IV admi nister
ed toa
1.Apat ientwi thcraniocerebrali nj
urywasadmi t
ted
pati
entf oran i ntr
oducti
on narcosi
s.Wi thi
naf ew
toahospi tal.Pr ogressiv
ei ncreaseofneur ologi
cal
minutes l ar
yngospasm and hy per
salivati
on have
sympt omsal lowedt omaket hedi agnosi
sofbr ain
devel
oped.Whi chdr ugcouldhav epr eventedsuch
contusion,whi chbecamet her easonofi ncreasing
eff
ects?
brai
nedemaf ol
lowedbyhy poxi aofi t
sst r
uct ur
es.
A.Ni tr
azepam
Admi nistera gener alanaest het i
c,which produces
B.Adr enali
ne
beneficialinfluencei nbrainhy poxia:
C.Al l
oxim
A.Ft orotan( Halothane)
D.At ropi
ne*
B.I soflurane
E.Pr oseri
ne( Neost
igmine)
C.Pr opani dide(Sombr evine)
D.Ket ami ne 7.Thecombi nationofader i
vati
veoft hebarbit
uri
c
E.Sodi um Oxy butyr
ate( GOBA) * aci
d and i nhaled anaest heti
c was used dur i
ng a
surgi
caloper ati
onf ort hegener alanaesthesi
a.What
2.To anaest het i
ze t he mani pul
ation related toa
combinat i
onhasbeenused?
burnedsurfacet reatment , apati
entwasI Vi njecteda
A.Phenobar bit
al+Ket alar(Ketamine)
short-
acti
ng anaest het ic.Wi t
hin 1 mint he pat i
ent
B.Thiopental+Ft orotan( Halothane)*
being under anaest hesia had an i ncreased AP,
C.Ketalar(Ketamine)+Ft orotan(Halot
hane)
tachycar
dia,i ncr eased t one ofskel etalmuscl es;
D.Hexenal +Pr opanidide
refl
exesremai ned.Af t erawakeni ngthepat ienthad
E.Ftorotan(Halothane)+Hexenal
disori
ent
ationandv i
sualhal luci
nati
ons.Whatagent
wasadmi nister ed? 8.Pr oserine increasesskel etalmuscl et onewhen
A.Nitrousoxi de giv
en sy stemi call
y. Ftorotan ( hal
othane) i
nduces
B.Thiopent alsodium rel
axationofskel etalmuscl esandr educesproseri
ne
C.Diethyl ether eff
ects.Whati st henat ureofpr oser i
nandhalothane
D.Sombr ev in i
nteraction?2011
E.Ketami ne* A.Directfunct i
onal antagoni sm
3.A23y .
o.patientwi thhumerusabscesshasbeen B.Noncompet i
tiveantagoni sm
admitted t
o a sur gicaldepart
ment .Whatki
nd of C.Indirectfunct i
onalant agoni sm *
anesthesi
a and whi ch agentto usear et
hemost D.Independentant agonism
appropri
ateforthispatient
? E.Unilateralantagonism
A.Ethernarcosis 9.I n a pat ientdur ng f
i t
orotan nar
cosi
s BP has
B.Spinalanesthesiawithnovocai
ne abruptlydecr eased.Whichdr ugshouldbeusedfor
C.Hexenal narcosis restorati
onofBPl evel
?
D.Localanest hesiawit
hli
docaine* A.Adr enaline
E.Ketaminenar cosis B.Isadrine
4.Det erminet hedr ugf orIVanest hesi
awi thquick C.Mesat one(Phenyl
ephri
ne)*
onset and shor t dur at
ion of act i
on. Gener al D.Nor adrenali
ne
anesthesiai sdev elopedi n20- 40secandl ast
s3- 5 E.Ephedr ine
min.Thest ageofexci tementi sabsent.Thisdr ug 10.Gener al anaest het
icwit
hul t
rashortaction(5mi n)
doesnotcauseaf t
er-anaestheti
csleep.Itpracti
cally wasi ntr
oducedt oapat i
entI
Vf oranalgesi
aofbi opsy.
doesnoti nhi bi
tt hemy ocardium acti
vit
y.Iti
susedi n I
tcaused a muscul artwitchi
ng,decr ease ofAP,
ambul antpr acticef oriniti
alanesthesiaandi nshor t respir
atory ar rest for a shor t peri
od of t i
me.
operations. The possi bl
e compl i
cat
ion i s Determinet hi sdr ug.
hyperventil
at i
onf oll
owedbyr espi
rati
ondepr essi
on, A.Ketami ne
tachycardia,hy per t
ension,andhy peremiaalongt he B.Natrium oxy buty
rat
e
vein C.Pent azoci ne
A.Nitrousoxi de D.Propani dide*
B.Thiopent al sodium E.Ftorot an( Halot
hane)
C.Sombr evin( Propanidide)
D.Nat ri
um oxy butyrate 11.Propani
dide i
s of t
en used i n dent
alpracti
ce.
E.Ketami ne* Det
erminethecontrai
ndicat
ionf oruseofthi
sdrug.
A.Reposi
tionofjawbonef ragments
5.A25y .
o.pati
entwit
hpolytr
aumai nunconscious B.Shock*
statewasadmitt
edtothehospi
tal
.AP95/70mm Hg, C.Reposi
tionofdisl
ocationsofjaw
pulse75/min,r
espir
ati
onsuperfi
ci
alwit
hf requency D.Taki
ngoutt hesti
tches
30/min.Whatagentshoul d be used f
orgener al E.Di
ssecti
onofpul pcavity
anesthesi
a?
A.Ket
amine* 12.Expressedbradycar
dia,
fall
ofAPappearedduri
ng
ft
orotananesthesia.Whatdrugiscont
rai
ndicat
edto
32
st
abil
izehemody namicsdur
ingftor
otananest
hesi
a? B.Ft orotan( Halot hane)*
A.Prednisol
one C.Sodi um oxy butirate
B.Atropi
ne D.Et herpr onar cosi s
C.Mesaton( Phenyl
ephr
ine) E.Pr opanidide
D.Caffei
ne 20.I nwhatconcent r ati
oni set hylal
coholusedf or
E.Adrenali
ne* anti
mi cr
obial processi ngofskin:
13.Themostappr opriateanaest
het
icusedmai
nlyi
n A.96%
obst
etri
cpr acti
ce: B.70%*
A.Met hoxyfl
urane* C.40%
B.Ftorotan D.50%
C.Ketami ne E.60%
D.Natrium oxybutyrate 21.A 35y .
o.pat ientwhoof tenconsumesal cohol
E.Etherpronar cosis wast reatedwi thdi ur et
ics.Ther eappearedserious
muscl eandhear tweakness,v omiti
ng,diar
rhea.AP
14.Thi opent alsodium was I V administered t
oa 100/ 60mm Hg,depr ession.Thisconditi
oniscaused
pat
ientf orani nit
ialnarcosi
sandt henlaryngospasm byint ensif
iedexcr etionof :
andhy persalivati
onhav edevel
oped.Introducti
onof A.Cal cium
whatagentcoul dpreventundesir
ableeffects? B.Pot assium*
A.Adr enal i
ne C.Chl orine
B.Neost igmi ne(Proseri
ne) D.Phosphat es
C.Pl aty
phy ll
in* E.Sodi um
D.Dobut amine
E.Isadrine 22.Witht hepurposeofwar mingaft
ercooling,the
pati
entusedsol ut
ionofet hanol.How doesethanol
15.A pat ienthad an acut el esi
on ofthe l
i
ver i
nfl
uenceont hermor egulation?
(hepatit
is)afterrepeatedsur gi
caloper
ati
ons.What A.Incr
easesheatrelease*
generalanaest hetic mostlikel
yhas caused gi
ven B.Decreasesheatrelease
pathology? C.Incr
easesheatpr oduction
A.Nitr
ousoxi de D.Decreasesheatpr oduction
B.Ftorotan(Halothane)
* E.Decreasesheatpr oductionandheatrelease
C.Ketami ne
D.Sodium oxy butyr
ate 23.A pat i
entsuf f
ersf rom chr onical coholi
sm wi th
E.Etherpronar cosi
s the f oll
owi ng sy mpt oms:pai ni n ar ms and l egs,
i
mpai rmentofski n sensi tivit
y ,muscl e weakness,
16.Apat i
entt r
eatedwithclopheli
ne(cl
onidi
ne)due edemas.Whi chv itami nshoul dbepr escri
bedt ot he
toar t
erialhy pert
ensi
on,hadt akenanalcohol
icdri
nk pati
ent ?
thatcausedashar pi
nhibi
ti
onoft heCNS.Whatisthe A.Er gocal ciferol
nameoft hi
si nt
eract
ion? B.Thi ami ne*
A.Pot entiat
ion* C.Ret inol
B.Summat i
on D.Rut in
C.Cumul ati
on E.Vi casol (Menadi one)
D.Intoxicati
on
24.Fl ushingoccur swhenal cohol i
st akenalongwi t
h:
E.Idiosyncrati
creacti
on
A.Uni thiol
17.Asuddenf allofAPar osei napat i
entwhowas B.Met ronidazol e*
bei
ng oper ated under gener alanaest hesi
a.The C.Gl ibencl ami de
doct
orintroducedepi nephri
nef oll
owingbyv ent
ri
cl
e D.Dr ot av erine( No- spa)
fi
bri
l
lat
ion.Indicategeneralanaest het
ic,whi
chcoul
d E.Itraconazol e
mostli
kelyinducet hi
scompl i
cation: 25.I nsev er eal coholi ntoxi cation,thebl oodet hanol
A.Nitri
coxide exceeds:
B.Propanidide A.0. 5g/ L
C.Ftorotan(Halothane)
* B.1g/ L
D.Ketami ne C.2g/ L
E.Thiopental-
sodium D.3g/ L
18.I
ndicatet hegener alanaestheti
c,whichcausesa E.4g/ L*
l
ongandexpr essedst ageofexcitement: 26.Thesamedoseofal coholi nvokesadi f
ferent
A.Etherpr onar cosis* degreeofal coholi ntoxicat ioni ndifferentpeople.Itis
B.Propani dide l
inkedwi th:
C.Ftorotan( Halothane) A.Hi ghpl asmal evel ofbet a- l
ipoproteins
D.Ketami ne B.Inhi bi
tionofi nsul i
nsy nt hesi s
E.Thiopent al-
sodium C.Genet ical l
ydet ermined i nsuf f
i encyofal
ci cohol
19.Indi
cat et he gener alanaesthet
ic dur
ing whi
ch dehydr ogenasesynt hesis*
appl
icat
ionadr enalinemustnotbeused: D.Inhi bit
ionofhepat icmi crosomal enzy mes
A.Nitrousoxi de E. Low act iv
ity of pseudochol inesterase
(butyrylchol in-est erase)
33
27.Indicat et heemet icagentexci tingvomi ti
ngcenter
dir
ect l
y,whi chi susedi nav ersiont her
apyofchr onic
al
cohol i
sm:
A.Ipecacuanha
B.Apomor phi ne*
C.Disul firam ( Tet uram)
D.Met roni dazol e
E.Nal trexone
28.Adoct orhaspr escribedTet ur am (Disulf
iram)for
al
cohol i
sm.Whati st hemechani sm ofact i
onoft he
drug?
A.Act i
v ationofv omi ti
ngcent er
B.Augment ationofacet yl
chol inest er
ase
C.Inhibitionofacet yl
choli
nest er ase
D. Augment ation of al dehy de dehy drogenase
acti
v i
ty
E.Inhibitionofal dehy dedehy dr ogenase*
29.Anal cohol i
chasal coholicpsy chosiswi t
hev i
dent
psychomot or agi t
ation. Whi ch neur olepti
c dr ug
shoul dbeadmi nisteredf oremer gencyai d?2015
A.Sodi um br omi de
B.Diazepam
C.Hal ot hane
D.Ami nazi ne
E.Reser pine
30.Dur i
nganest heti
zati
onapat i
entpresentedwith
sympt oms oft onus increase ofpar asympatheti
c
nervous sy stem such as hy persali
vati
on and
l
aryngospasm.What dr ug could hav e prev
ented
theseundesirableef f
ects?2011
A.Atropinesul phate*
B.Pyracetam
C.Analgin
D.Adrenalinehy drochl
or i
de
E.Neostigmi ne
31.A 55 y .o.man had been admi tted tot he
resusci
tat
ion uni tunconscious.Rel at
ives reported
himt ohavemi stakenlydrunkanal coholi
csol uti
onof
unknown or i
gin.On exami nat i
on the patientwas
diagnosedwithmet hanolint
oxi cat
ion.Whatant idote
shouldbeusedi nt hiscase?2016
A.Protaminesul f
ate
B.Ethanol *
C.Disulf
iram (Teturam)
D.Acetylcystein
E.Naltr
exone
32.Sev eralmi nutes aftera dent istadmi nist
ered
novocainef orlocalanaest hesiaofapat ient’
st ooth,
the fol
lowing sy mptoms shar plydev el
oped i nt he
pati
ent:fati
gue,ski nitchi
ng,Obj ecti
velythef oll
owing
can be obser ved:ski n hyperemi a,tachy cardi
a,BP
droppeddownt o70/ 40mm Hg.Whatki ndofal l
ergi
c
react
ionisthi spathology?
A.Cy t
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edi mmuner eact i
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C.Stimul at
ing
D.Anaphy l
actic*
E.Immunecompl ex

34
 Module 2 (fever, hypotension, tachycardia, oliguria, confusion). What
5.1. Cardiotonic and AAD hemodynamic support would be helpful?
A. Fluid administration
1. Dopamine causes all but one of the following actions?
B. Dobutamine infusion
A. Increases cardiac output
C. Fluid and dobutamine infusion *
B. Dilates renal vasculature
D. Atropine administration
C. Dilates bronchi *
E. Antibiotic administration
D. Increases BP
E. Increases production of urine 10. The action of electric current on the excitable
2. A patient suffering from CHF develops the typical signs myocardial cell caused depolarization of its membrane.
of acute heart failure: dyspnea, cyanosis, tachycardia, pulse Movement of what ions through the membrane caused
96/min, BP 100/60 mm Hg. Indicate the drug to be used to depolarization?
treat the patient: A. Сa2+
A. Propranolol B. K+
B. Epinephrine С. Cl-
C. Enalapril D. Na+ *
D. Nifedipine E. HCO3
E. Digoxin* 11. Treatment of digitals toxicity can include all except:
3. During the ambulant tooth extraction a patient who had been A. Potassium
suffering from chronic congestive heart failure showed the B. Phenytoin
typical signs of acute heart failure: dyspnea, cyanosis, C. Lidocaine
tachycardia, ps 96 per minute, BP 100/60 mm Hg. Indicate the D. Dialysis *
drugs to be used to treat this patient. E. Unitiol
A. Strophanthine + Verospirone 12. A 45 y.o. patient has been prescribed Digoxin to treat
B. Lisinopril + Furosemide chronic heart failure. What is its mechanism of action?
C. Anapriline + Sulfacamphocaine A. Inhibition of Na+/K+- ATPase*
D. Strophanthine + Furosemide* B. Decreases intracellular Na+ concentration
E. Anapriline + Furosemide C. Decreases release of Ca2+ from the sarcoplasmic
reticulum
4. The side effects of Digitalis are all except:
D. Increases the intracellular level of ATP
A. Ventricular Tachycardia
E. Stimulates production of cAMP
B. Ventricular Bigeminy
C. Vasodilatation* 13. A patient with a cardiac arrhythmia is being treated for a
D. AV blockade long time with amiodarone. This drug can cause biochemical
E. Vomiting changes and clinical signs and symptoms that resemble those
associate with which of the following disease?
5. All of the following mechanisms of action correctly
A. Diabetes mellitus
match a drug EXCEPT:
B. Addison's disease
A. Quinidine: Blocks Na+ channels
C. Hypothyroidism*
B. Amiodarone: Blocks K+ channels
D. Diabetes insipidus
C. Verapamil: Blocks Ca2+ channels
E. Cushing’s syndrome
D. Propranolol: Blocks β adrenoreceptors
E. Novocainamide: Blocks K+ channels* 14. Which antiarrhythmic drug has relatively few
electrophysiological effects on normal myocardial tissues, but
6. A drug of choice for supraventricular tachycardia in
suppresses the arrhythmogenic properties of ischemic tissues?
patients with decreased BP is:
A. Digoxin
A. Diphenin
B. Propranolol
B. Amiodarone
C. Lidocaine*
C. Propranolol
D. Amiodarone
D. Digoxin *
E. Phenytoin
E. Lidocaine
7. A drug of choice for supraventricular tachycardia in 15. Which one of the following statements is incorrect?
patients with increased BP is: A. Lidocaine must be given parenterally
A. Digoxin B. Lidocaine is used mainly for atrial arrhythmia*
B. Propranolol * C. Novocainamide is associated with a reversible lupus
C. Lidocaine phenomenon
D. Amiodarone D. Quinidine is active orally
E. Diphenin E. All antiarrhythmic drugs can suppress cardiac contractions
8. Which statement about dopamine is correct? 16. Specify the mechanism of antiarrhythmic action of
A. Used in congestive cardiac failure Amiodarone:
B. Its plasma half-life is 6 hours * A. Blockade of Na+ channels of the cardiomyocyte
C. Therapeutically useful in parkinsonism membranes
D. Acts only on dopaminergic receptors B. Blockade of Ca2+ channels of the cardiomyocyte
E. Therapeutically useful in tachycardia membranes
9. A 35 y.o. male has undergone surgery for necrotic bowel. C. Blockade of K+ channels of the cardiomyocyte
Despite having been treated with antibiotics, on the 5th membranes*
postoperative day, he develops symptoms of septic shock D. Blockade of β–adrenoreceptors

1
E. Blockade of α–adrenoreceptors E. Summation
18. In terms of therapeutic usefulness, the most important 26. In homozygous mice with defect of the gene-coding frame
pharmacologic action of digoxin in congestive heart of beta1 adrenoreceptors, it has been probed action of an agent
failure is: on inotropic function of heart. What agent will lose the activity
A. The reduction of cardiac size in these conditions?
B. The increase in ventricular contractile force* A. Dobutamine *
C. The slowing of heart rate B. Mesatone (Phenylephrine)
D. The diuretic effect C. Strophanthin
E. The increase in blood pressure D. Caffeine
E. Digoxin
19. A patient with a cardiogenic shock has been delivered into
an emergency room. Which drug should be administered for 27. A patient has been prescribed a water-soluble cardiac
hemodynamics restoration? glycoside. What concomitant pathology can promote the
A. Dopamine * cumulation of water-soluble cardiac glycosides?
B. Propranolol A. Renal failure *
C. Cordiamin B. Liver failure
D. Adrenaline hydrochloride C. Hyperacid gastritis
E. Enalapril D. Hypoacid gastritis
E. Hypothyroidism
20. The drug of choice in anaphylactic shock is:
A. Dopamine 28. A lipid-soluble cardiac glycoside has been prescribed to a
B. Propranolol patient. What concomitant pathology can promote a cumulation
C. Cordiamin of lipid-soluble cardiac glycosides?
D. Adrenaline hydrochloride* A. Renal failure
E. Enalapril B. Liver failure*
C. Hyperacid gastritis
21. The half life of digoxin is:
D. Hypoacid gastritis
A. 12 hrs
E. Hypothyroidism
B. 24 hrs
C. 36 hrs* 29. A patient suffering from heart insufficiency was treated
D. 5 days with digoxin. He took diuretic dichlothiazide without the
E. 2 weeks doctor’s knowledge and after 2 days he felt worse and was
obliged to address to the doctor. Doctor administered the
22. A patient complained of unpleasant sensations in the
treatment including unitiol. Indicate its mechanism of its
heart region, and attacks of weakness and loss of
action.
consciousness. Inspection of the patient’s ECG had
A. Decreases oxygen consumption
revealed the presence of II degree atrioventricular block.
B. Increases oxygen consumption
Specify a drug, which should be used:
С. Promotes retention of K+ ions
A. Isadrin *
D. It has got free sulfhydril groups which bind to the
B. Novocainamide
molecules of digoxin*
C. Nitroglycerine
E. Promotes retention of Ca2+ ions
D. Strophanthin
E. Anapriline 30. Indicate the mechanism of anti arrhythmic action of
23. A cardiotonic drug has been prescribed to a 50 y.o. novocainamide.
patient with chronic cardiac insufficiency and A. Blockade of Na+ channels of the cardiomyocyte
tachyarrhythmia. What drug was prescribed? membranes *
A. Dobutamine B. Blockade of Ca2+ channels
B. Amiodarone C. Blockade of beta–adrenoreceptors of the myocardium
C. Dopamine D. Blockade of alpha– and beta– adrenoreceptors of the
D. Digoxin * myocardium
E. Mildronate E. Blockade of M-cholinoreceptors
24. What medication should be administered to a patient 31. Specify the cardiac glycoside, which possesses the
with chronic left-ventricular failure? 2010 fastest onset of the action:
A. Reserpine A. Strophanthin *
B. Bemegride B. Celanide (Lantoside)
C. Piracetam C. Digitoxin
D. Etimizol D. Digoxin
E. Digoxin * E. Adoniside
25. Digitoxin (1 tab. tid) had been prescribed to a patient 32. Indicate the group of drugs which is the most expedient to
with congestive heart failure. In 15 days, the signs of treat atrial fibrillation in patients with low BP:
intoxication developed: bradyarrhythmia, disturbance of A. M- Cholinoblockers
AV conduction, upset of colour vision. What could cause B. Cardiac glycosides *
the specified phenomena? C. Na+– channels blockers
A. Functional cumulation D. Beta – adrenomimetics
B. Material cumulation * E. Alpha – adrenomimetics
C. Potentiation 33. Indicate the group of drugs, overdosage of which is
D. Tolerance accompanied by following sings: nausea, vomiting,
2
diarrhea, infringement of heart activity (extrasystoles, 41. Symptoms of cardiac glycosides toxicity have been
delay of atrioventricular conductivity), headache, vision developed in a patient with chronic congestive heart
impairment (xanthopsia, diplopia): failure. What agent should be administered to decrease
A. Calcium channels blockers adverse effects of cardiac glycosides?
B. Organic nitrates A. Etimizol
C. Cardiac glycosides * B. Dipiroxim
D. Beta - adrenoblockers C. Potassium chloride*
E. Angiotensin converting enzyme inhibitors D. Atropine sulfate
E. Novocainamide
34. A patient suffers from allergic reaction to iodine.
Indicate an anti-arrhythmic agent, which is absolutely 42. A 55 y.o. patient with continuing ventricular
contraindicated to him. arrhythmia was admitted to the hospital. The patient is
A. Amiodarone * taking Timolol drops for glaucoma, daily insulin injections
B. Verapamil for diabetes mellitus, and an ACE inhibitor for
C. Novocainamide (Procainamide) hypertension. You have decided to use Phenytoin
D. Ornide (Bretylium) (Diphenin) instead of Procainamide (Novocainamide).
E. Quinidine sulfate What is the reason?
A The anticholinergic effect of procainamide would
35. What antiarrhythmic preparation does not belong to
aggravate glaucoma *
membrane stabilizers?
B. The cholinergic effect of procainamide would
A. Diphenin (Phenytoin)
aggravate the diabetes
B. Amiodarone *
C. The hypertensive effect of procainamide would
C. Novocainamide (Procainamide)
aggravate hypertension
D. Quinidine sulfate
D. The local anesthetic effect of procainamide would
E. Lidocaine
potentiate diabetes
36. A 64 y.o. patient suffering from bronchial asthma E. The local anesthetic effect of procainamide would
develops atrium fibrillation. What antiarrhythmic agent is aggravate hypertension
contraindicated to this patient?
A. Quinidine 43. Ventricular arrhythmia has developed in a patient with
B. Verapamil myocardial infarction. An antiarrhythmic drug with local
C. Anapriline (Propranolol) * anesthetic activity was administered to normalize the
D. Ethmozin (Moracizin) cardiac rhythm. What is the drug?
E. Novocainamide (Procainamide) A. Verapamil
37. A patient develops a lengthening P-Q interval during B. Quinidine
the treatment with an antiarrhythmic drug. What agent C. Sotalol
could cause it? D. Propranolol
A. Lidocaine E. Lidocaine hydrochloride *
B. Isadrin
C. Atropine 44. A patient has developed paroxysmal ventricular
D. Propranolol * tachycardia against the background of cardiac infarction.
E. Phenytoin (Diphenin) What antiarrhythmic drug should be chosen to avoid
lowering cardiac output? 2015
38. A 65 y.o. patient with chronic heart failure has been
A. Lidocaine hydrochloride *
taking digitoxin in self-administered dosages for a long
B. Procainamide
time. She was admitted to the hospital for general health
C. Propranolol
aggravation, arrhythmia, nausea, reduced dieresis,
D. Potassium chloride
insomnia. What is the primary action to be taken? 2012
E. Verapamil
A. To administer digoxin
B. To withhold digitoxin * 44. An atrioventricular blockade has been revealed in a 25
C. To administer strophanthine IV y. o. patient during inspection. Name the agent used for the
D. To reduce digitoxin dose treatment of AV blockade:
E. To give an IV injection of calcium gluconate solution A. Amiodarone
B. Proserine (Neostigmine)
39. Indicate the drug and its group, which is used for the C. Verapamil
treatment of atrioventricular blockade. D. Metoprolol
A Cardiac glycoside Digitoxin E. Isadrin *
B. Beta-adrenomimetic Isadrin (Isoprenaline) * 45. A patient has an attack of tachycardia. What type of
C. Sympatholytic Ornide (Bretylium) membrane receptors of cardiomyocytes is wise to block for
D. Beta –adrenoblocker Anapriline (Propranolol) stopping of the attack?
E. Blocker of slow Ca2+ channels Verapamil A. M-cholinoreceptors
40. Indicate the group of drugs used to treat total B. Beta–adrenoreceptors *
atrioventricular block: C. N- cholinoreceptors
A. M-Cholinoblockers* D. Alpha- adrenoreceptors
B. Membrane-stabilizing agents E. M-and N- cholinoreceptors
C. Local anesthetics 46. For correction of the arrhythmias caused by poisoning
D. Beta –adrenoblocker with cardiac glycosides, the antiepileptic agent diphenin
E. Potassium channels blockers
3
(phenytoin) can be used. What effect is typical for diphenin 53. A patient complaining of rapid pulse, dyspnea and
(phenytoin)? bluish color of mucosa has been admitted to the
A Quickens repolarization and reduces the cardiological department. The objective symptoms are as
efficient refractory period * follows: edema of lower extremities, ascites. Which of the
B. Blocks beta- adrenoreceptors given medicines should be administered intravenously to
C. Decreases contractility of myocardium improve the patient’s general state? 2016
D. Suppresses contractility of heart A. Cordiamin
E. Prolongs Phase 3 repolarization B. Digitoxin
47. The permeability of the irritable cell membrane has C. Corglyconum *
been increased for potassium ions during an experiment. D. Drotaverine
What changes of membrane electric status can occur? E. Adrenaline hydrochloride
A. Depolarization 54. During local anesthetization the patient has gone into
B. Action potential anaphylactic shock. What agent must be administered to
C. No changes the patient?
D. Local response A. Propranolol
E. Hyperpolarization * B. Epinephrine hydrochloride *
48. Which one of the following statements is C. Atropine sulfate
INCORRECT? D. Nitroglycerin
A. Quinidine prolongs repolarization and the effective E. Diazepam
refractory period
B. Lidocaine shortens repolarization and decreases the 1
effective refractory period
C. Amiodarone prolongs repolarization
D. Anapriline (Propronalol) increases Phase 4
depolarization
E. Verapamil shortens the duration of the action
potential * 5.2. Agents Normalizing Coronary and
Brain Blood Flow. Antianginal Agents
49. A cardiotonic drug from the group of cardiac glycosides 1. All of the following statements concerning
has been administered PO to a patient with chronic cardiac nitroglycerine are correct EXCEPT:
insufficiency. What drug is it? A. It causes an elevation of intracellular cGMP
A. Strophanthine B. It undergoes significant first-pass metabolism in liver
B. Corglycon C. It may cause significant reflex tachycardia.
C. Digoxine * D. It significantly decreases AV conduction
D. Cordiamin E. It can cause postural hypotension.
E. Amiodarone
2. Which of the following adverse effects is associated
50. A patient with coronary heart disease and arrhythmia
with nitroglycerine?
had been administered a drug that blocks K+ channels and
A. Hypertension
prolongs the action potential. What drug is it?
B. Throbbing headache
A. Dobutamine
C. Bradycardia
B. Corglycon
D .Sexual dysfunction
C. Nitroglycerin
E. Anemia
D. Lisinopril
E. Amiodarone * 3. Which drug is appropriate and generally regarded as
most effective for relieving and preventing ischemic
51. During a surgery with the use of hygronium the patient
episodes in patients with variant angina?
had an abrupt fall in blood pressure. Blood pressure may be
A. Aspirin
normalized by the representatives of the following drug
group: 2013 B. Metoprolol
C. Propranolol
A. N-cholinergic agents
D. Nifedipine*
B. Ganglionic blockers
E. Nitroglycerine
C. M-cholinergic agents
D. α- adrenergic agonists 4. Nitrites used in management of angina have all the
E. α-blockers following actions EXCEPT:
A. Increase total coronary blood flow
52. A patient with acute heart failure was administered non- B. Decrease cardiac O2 consumption
glycoside cardiotonic drug stimulating myocardial beta1 C. Decrease preload and after load
adrenoreceptors, increasing blood circulation and diuresis. It is D. Redistribution of blood into subendocardial vessels
used only as IV infusion due to fast inactivation in the body. E. Dilatation of cerebral vessels
Which drug is it?
A. Digoxine 5. In a patient with angina pectoris who is taking insulin
B. Corglycon to treat diabetes, which of the following drugs is to be
C. Dobutamine * used with extra caution and advice to the patient?
D. Anapriline A. Aspirin
E. Adrenaline B. Verapamil
C. Propranolol

4
 D. Diltiazem 12. Ca2+ channel blocker with maximum peripheral action is:
E. Nitroglycerine A. Verapamil
6. Beta-blockers are used in all cases except: B. Nifedipine *
A. Thyrotoxicosis C. Diltiazem
B. Mild hypertension D. Papaverine
C. Glaucoma E. Molsidomine
D. Variant angina * 13. Hyperlipidemia is caused by:
E. Atrial arrhythmias A. Nifedipine
7. Determine the drug. This drug is the main agent for the B. Propranolol*
arrest of angina pectoris attacks. The onset of its action C. ACE Inhibitors
develops in 2-3 min, and lasts up to 30 min. The drug D. Methyldopa
increases the coronary circulation (especially in E. Theophylline
subendocardial zones). The main mechanism of antianginal 14. In a patient with myocardial infarction, if congestive
action is relaxation of vascular smooth muscle by their cardiac failure develops, the dose of digoxin should be:
intracellular conversion to nitrate ions and then to nitric A. Reduced *
oxide, which in turn activates guanylate cyclase and B. Increased
increases the cells’ cyclic GMP. Elevated cGMP ultimately C. Unaltered
leads to dephosphorylation of the myosin light chain D. None of the above
resulting in vascular smooth muscle relaxation. It causes a 15. Drugs that may precipitate vasospastic angina pectoris
decrease in myocardial O2 consumption because of are:
decreased cardiac work. A. Beta blockers
A. Aspirin B. Nitrates
B. Verapamil C. Alpha blockers
C. Propranolol D. Calcium channel blockers
D. Diltiazem E. Benzodiazepines
E. Nitroglycerine 16. After tooth extraction the patient experienced
8. Which drug can relieve angina pectoris by decreasing persistence chest pain. In result of sublingual use of an
myocardial work, but may precipitate congestive heart failure? antianginal agent the chest pain disappeared, but patient
A. Phentolamine complained on headache and dizziness. What agent did the
B. Strophanthine patient use?
C. Propranolol A Anapriline (Propranolol) *
D. Atropine B. Validol
E. Enalapril C. Nitroglycerine *
9. We want to compare and contrast the cardiac and D. Verapamil
hemodynamic properties of immediate-acting E. Metoprolol
dihydropyridine-type Ca2+ channel blockers Nifedipine and 17. A 37 y.o. patient complains of chest pain at excitement
non-dihydropyridines, benzothiazepines Verapamil and and exercise stresses. He has been diagnosed with IHD
Diltiazem. The most striking difference is that compared (ischaemic heart disease). What agent will you use to treat
with Nifedipine and Diltiazem, Verapamil: the patient?
A. Cause significant dose-dependent slowing of AV A. Asparcam
nodal conduction velocity* B. Isradipine (Lomir)*
B. Cause a much higher incidence of reflex tachycardia C. Doxazosin
C. Cause significant vasodilation, leading to profound D. Vinpocetin (Cavinton)
orthostatic hypotension E. Amiodarone (Cordarone)
D. Have significant positive inotropic effects 18. Indicate the antianginal agent, which does not cause
E. Are suitable for use in conjunction with a β blocker or decrease of BP for a patient suffering from angina pectoris
digoxin accompanied by arterial hypotension:
A. Enalapril
10. The advantages of metoprolol over propranolol include B. Pentoxiphylline (Trental)*
all of the following except: C. Nitroglycerine
A. More likely to be effective in sinus tachycardia * D. Anapriline (Propranolol)
B. Less likely to produce sudden rises in BP after physical E. Nifedipine
exertion
19. Indicate the nitrate of prolonged action:
C. More likely to be effective in sinus bradycardia
A Sustac-forte *
D. Less likely to produce temporary rise in peripheral
B. Validol
resistance at the start of therapy
C. Dipyridamole
E. Less likely to provoke bronchoconstriction
D. Talinolol
11. All the following statements are true about enalapril E. Amlodipine
except:
20. A 27 y.o. man with angina pectoris was admitted to a
A. A prodrug
cardiologic department. A phosphodiesterase inhibitor was
B. Used to treat hypertension
included to the complex therapy. Concentration of what
C. Used to treat CHF
substance will increase in the cardiac muscle?
D. Inhibits ACE
A. ATP
E. Blocks Angiotensin-1
B. Cyclic-AMP *
5
 C. ADP cramps. What is the pathogenetic mechanism that
D. GMP underlines these signs?
E. AMP A. Formation of the reduced hemoglobin
21. After a serious psychoemotional stress a 48 y.o. patient B. Formation of an oxyhemoglobin
suddenly developed acute heart ache irradiating to the left arm. C. Formation of a carbhemoglobin
Nitroglycerine relieved pain after 10 minutes. What is the D. Formation of carboxyhemoglobin
leading pathogenetic mechanism of this process development? E. Formation of a methemohlobin*
2012
28. After a psycho-emotional stress a 45 y.o. patient
A. Spasm of coronary arteries * suddenly felt constricting heart pain irradiating to the left
B. Increase in myocardial oxygen consumption arm, neck and left scapula. His face turned pale, the cold
C. Dilation of peripheral vessels sweat stood out on it. The pain attack was stopped with
D. Compression of coronary vessels nitroglycerine. What process has developed in this patient?
E. Obstruction of coronary vessels A. Stenocardia*
22. A patient suffering from stenocardia has been taking B. Myocardial infarction
nitroglycerine which caused restoration of blood supply to C. Psychogenic shock
myocardium and relieved pain in the cardiac area. What D. Stroke
intracellular mechanism provides restoration of energy E. Stomach ulcer perforation
supply to insulted cells? 2012 29. A patient with myocardial infarction was admitted to
A. Intensification of RNA generation the cardiologic department. For pain relief it was decided
B. Intensification of oxygen transporting into to potentiate fentanyl action with a neuroleptic. What
the cell neuroleptic is the most suitable for neuroleptanalgesia?
C. Intensification of ATP resynthesis A. Haloperidol
D. Increased permeability of membranes B. Triftazine
E. Reduction of ATP resynthesis C. Aminazine
23. A 48 y.o. patient with ischaemic heart disease is getting D. Sulpiride
medical treatment. Specify the antianginal agent that has E. Droperidol*
benefits to improve endocardial circulation: 30. A patient with coronary artery disease was admitted to
A. Anapriline (Propranolol) the cardiology department. For stenocardia prevention a
B. Sustac-forte* drug from the group of beta-adrenoreceptor blockers was
C. Prazosin administered. What drug is it?
D. Papaverine A. Morphine hydrochloride
E. Euphylline (Theophylline) B. Oxytocin
24. In a 29 y.o. man a stenocardia attack has appeared. A C. Metoprolol *
physician gave tablet of nitroglycerine sublingually. The D. Furosemide
doctor chose this route of nitroglycerine administration E. Atropine sulfate
because of: 31. Acetylsalicylic acid 75 mg a day has been administered
A. Poor intestinal absorption to a patient with myocardial infarction. What is the purpose
B. Instability in gastric medium of this administration?
C. Activation in saliva A. Coronary vessel dilatation
D. Sublingual route provides fast onset of action * B. Temperature reduction
E. Hepatotoxicity C. Reduction of platelet aggregation*
25. After a tooth extraction a patient felt persistent pain behind D. Inflammation relieve
his breastbone. After sublingual intake of an antianginal drug E. Pain relief
the pain behind the breastbone disappeared, but the patient 32. A patient suffering from coronary artery disease had taken
complained of headache and dizziness. What drug are these a certain drug many times a day in order to arrest stenocardia
properties typical for? attacks. Overdose with the drug finally produced intoxication.
A. Propranolol Objectively: cyanotic skin and mucous membranes, dramatic
B. Metoprolol fall in the AP, tachycardia, and respiration inhibition. Blood
C. Validol has increased concentration of met-Hb. The drug the patient
D. Verapamil had taken relates to the following group:
E. Nitroglycerine * A. Ca2+ channel blockers
26. A patient who had been treated with a vitamin agent for B. Adenosine drugs
the prophylaxis of brain vessel constriction complained of C. Myotropic spasmolytics
unpleasant sensations: flushing of upper part of the body, D. Organic nitrates *
vertigo, flushing of blood to the head. What agent exerts E. α- adrenoblockers
this effect? 33. A patient suffers from stenocardia takes isosorbide
A. Tocopherol acetate mononitrate. He was administered a complementary drug
B. Thiamine bromide with disaggregating effect. What drug is it? 2012
C. Riboflavin A. Nitroglycerine
D. Nicotinic acid* B. Propranolol
E. Anapriline (Propranolol) C. Validol
27. A 3 y.o. child is admitted to the hospital reception with D. Nifedipine
signs of the nitrates poisoning such as cyanosis, dyspnoea, E. Acetylsalicylic acid *

6
34. A patient with ischemic heart disease has been A. Hydroxy-Methyl-Glutaril-CoA reductase *
administered an anti-antianginal drug that reduces the B. Glucose-6-phosphatase
myocardial oxygen consumption and improves blood C. Acetyl CoA carboxylase
supply of myocardium. What drug is it? D. Pyruvate kinase
A. Propranolol * E. Acetylcholinesterase
B. Nitroglycerine 6. Antihypertensive with not central action:
C. Validol A. Clonidine
D. Retabolil B. Methyldopa
E. Promedol C. Propranolol
35. A patient has arterial hypertension. What long-acting D. Amlodipine *
drug from the group of Ca2+ channel blockers should be E. Reserpine
administered? 2016 7. A patient, who has been treating with clopheline
A. Amlodipine * (clonidine) due to arterial hypertension, has taken an
B. Reserpine alcoholic drink that has caused the sharp inhibition of the
C. Pyrroxanum CNS. What is the name of this interaction?
D. Atenolol A. Potentiation *
E. Octadine B. Summation
C. Cumulation
36. A 68 y.o. patient consults a cardiologist, complaining D. Intoxication
of high arterial BP, pain in the heart region, intermittent E. Idiosyncratic reaction
pulse. Administer the beta1 adrenoreceptor blocker for the 8. What is true about Minioxidil?
treatment of the described pathology: 2016 A. Increase hair growth
A. Nootropil
B. Antihypertensive
B. Morphine hydrochloride C. Peripheral vasodilator
C. Metoprolol * D. All above *
D. Benzylpenicillin E. None above
E. Fenoterol
9-18. Listed below are short descriptions of various
patients, all of whom have been recently diagnosed Stage
5.3. Antihypertensive and Lipid-Lowering Drugs II essential hypertension. You are to start oral therapy for
the hypertension. Your goal is to select the
1. A 55 y.o. man comes in for a check-up and complains antihypertensive agent with a profile that makes it the best
that he is having some difficulty in «starting to urinate». choice – or, in other stated instances, the worst choice – for
Physical examination indicates that the man has a BP of the patient described.
160/100 mm Hg and a slightly enlarged prostate. Which of A letter may be used once, more than once, or not at all.
the following medications would be useful in treating both A. β-adrenergic blocker
of these conditions? B. Nifedipine
A. Doxazosin * C. Verapamil
B. Labetalol D. Angiotensin-converting enzyme inhibitor
C. Enalapril E. Thiazide diuretic
D. Phentolamine
E. Propranolol 9. Best choice for a 45 y.o. man with well-controlled type
2. Which drug is a Ca2+ blocker selective on cerebral blood 2 diabetes and normal renal function- D
vessels? 10. Most likely to trigger a gout attack or worsen
A. Nifedipine asymptomatic hyperuricemia - E
B. Amlodipine 11. Best choice for a patient who has a history of
C. Nimodipine * vasospastic (variant, or Prinzmetal’s) angina pectoris - B
D. Diltiazem 12. Best choice for a patient who is tachycardic and has
E. Verapamil chronic open-angle glaucoma - A
13. Worst choice for a patient with vasospastic angina
3. Cough has appeared in a patient with hypertension at
because it may worsen the condition - A
regular use of an antihypertensive agent. Which agent can
14 Most likely to exacerbate tachycardia in a patient who
cause the given adverse effect?
is already taking sublingual nitroglycerine for chronic-
A. Prazosin
stable (exercise-induced) angina pectoris -B
B. Verapamil
15. May cause breathing difficulty for an asthmatic patient
C. Clopheline (Clonidine)
by thickening airway mucus secretion and so obstructing
D. Dichlothiazide
the airway with viscous mucus – E
E. Enalapril *
16. Most likely to exacerbate asthma by facilitating or
4. One of the following signs is not a side effect of causing bronchoconstriction -A
captopril: 17. Worst choice for a pregnant woman -D
A. Cough 18. Poorest choice for a patient with poorly controlled
B. Renal dysfunction insulin-dependent diabetes mellitus because it will mask a
C. Hyperkalaemia symptom of severe hypoglycemia and delay recovery from
D. Haemolytic anaemia * a hypoglycemic episode – A
E. Fever
5. Statins decrease activity of:
7
19. All of the following drugs produce a significant B. Clofeline and Furosemide *
decrease in peripheral resistance except: C. Captopril and Verospirone
A. Chronic administration of diuretics D. Atenolol and Verospirone
B. Hydralazine E. Anapriline and Amiloride
C. beta-blockers * 28. A patient with arterial hypertension has some
D. ACE inhibitors accompanying diseases: chronic bronchitis with asthmatic
E. Clopheline component, chronic gastritis with increased acid-producing
20. Which of the following drugs should not be given to a function. Indicate the antihypertensive drug(s), which is
pregnant, hypertensive women? (are) contraindicated in this situation.
A. Hydrochlorothiazide A. Propranolol
B. Propranolol B. Captopril
C. Aminophylline C. Reserpine
D. Enalapril * D. Octadine
E. Verapamil E. All above *
21. Which drug is not used in hypertensive emergency? 29. Drug of choice in hypertensive crisis in a patient with
A. Dibazole pheochromocytoma is:
B. Pentamine A. Clofeline
C. Captopril * B. Capoten
D. Sublingual Nifedipine C. Amlodipine
E. Aminophylline D. Phentolamine *
E. Drotaverine
22. Cough is a side effect with intake of:
A. Captopril * 30. All of the following antihypertensives decrease plasma
B. Prazosin renin activity except:
C. Nifedipine A. Clonidine
D. Thiazide B. Methyldopa
E. Euphylline C. Atenolol
D. Hydrochlorothiazide *
23. A 54 y.o. man suffering from hypertension complains
E. Enalapril
of severe tachycardia after administration of
antihypertensive drug. Which one is most likely to cause 31. What is true about Minioxidil?
reflex tachycardia? A. Increase hair growth
A. Prazosin B. Antihypertensive
B. Verapamil C. Peripheral vasodilator
C. Hydralazine* D. All above*
D. Propranolol E. None above
E. Captopril 32. Sodium nitroprusside causes hypotension mainly by:
24. A 45 y.o. hypertensive male has manifested A. Arterial dilatation*
hypoglycemia after administration of antihypertensive B. Vein dilatation
drug. Select the one most likely to lower plasma sugar. C. Central action
A. Captopril D. Negative inotopic effect on heart
B. Prazosin E. Alpha-receptors’ blockade
C. Nifedipine 33. A 40 y.o. patient complains of intensive heartbeats,
D. Propranolol * sweating, nausea, vision impairment, arm tremor,
E. Verapamil hypertension. From his anamnesis: 2 years ago he was
25. A 17 y.o. young man presents the symptoms of the diagnosed with pheochromocytoma. What hypotensive
familial hypercholesterolemia. He was prescribed an agent agent should be administered?
inhibiting enzyme 3-hydroxy-3-methylglutaryl-CoA A. Captopril
reductase. What was the agent? B. Prasozine *
A. Simvastatin * C. Drotaverine
B. Nicotinic acid D. Nifedipine
C. Gemfibrozil E. Platyphyllin
D. Cholestiramine 34. A patient with hypertensive disease has been taking a
E. Probucol hypotensive medication. After a while arterial pressure
26. Drug which reduced afterload but not preload: decreased, but the patient started complaining of flaccidity,
A. Captopril sleepiness, indifference. A bit later he felt stomach pain. He
B. Isosorbide dinitrate was diagnosed with gastric ulcer. What hypotensive
C. Nitroglycerine medication has the patient been taking?
D. Hydralazine * A. Furosemide
E. Furosemide B. Verapamil
27. A 55 y.o. patient suffering from arterial hypertension C. Reserpine *
develops hypertensive crisis: he felt acute headache, D. Dibazole
darkening in the eyes, nausea, pulse 64/min, BP 210/110 E. Captopril
mm Hg. Administer the agents to stabilize hemodynamics: 35. A 35 y.o. patient, who had been suffering from
A. Anapriline and Captopril idiopathic hypertension, was treated by an antihypertensive
8
drug. After 4 days his AP decreased, but he started mechanism of action is the inhibition of the vasomotor center
complaining of sleepiness and psychological suppression. activity due to excitation of alpha 2-adrenoreceptors and I1-
What drug was the patient treated with? imidazoline receptors of nucleus tractus solitarius zone of
A. Clopheline (Clonidine) * medulla oblongata. Indicate this drug:
B. Prasozine A. Phentolamine
C. Captopril B. Reserpine
D. Enalapril C. Hydrochlorothiazide
E. Apressin D. Clopheline (Clonidine) *
36. A patient had been suffering from hypertonic disease E. Captopril
had been treated for a long time with the drug from the 43. It was observed primary short-term increase of BP in a
group of Rauwolfia alkaloids and began to complain of patient after IV administration of a hypotensive agent.
heartburn, pain in the epigastrial area and bad mood. Indicate this drug:
Indicate the drug which caused these complications: A. Clopheline (Clonidine) *
A. Octadine B. Reserpine
B. Reserpine * C. Prasozine
C. Clopheline (Clonidine) D. Anapriline
D. Prasozine E. Hydrochlorothiazide
E. Enalapril 44. Hypertensive crisis characterized by sharp headache,
37. A patient who had been suffering from arterial dizziness, hyperemia of face, pains in the region of heart,
hypotension had taken a hypotensive drug, but in an hour rapid pulse, AP 220/110 mm Hg has developed in a patient
his BP increased and 2 hours after it decreased. Indicate suffering from essential hypertension. What agent is
this antihypertensive agent: necessary to introduce to the patient?
A. Nifedipine A. Enalapril
B. Prasozine B. Clopheline (Clonidine) *
C. Captopril C. Prasozine
D. Anapriline D. Anapriline
E. Octadine* E. Hydrochlorothiazide
38. A patient had been suffering from hypertonic disease 45. Indicate the antihypertensive agent which can cause
accompanied by chronic bronchitis with asthmatic such adverse effects as dryness in the mouth, constipation
component. Indicate the drug which is contraindicated due and water retention:
to its action on the bronchi: A. Hydralazine (Apressin)
A. Anapriline * B. Enalapril
B. Captopril C. Verapamil
C. Prasozine D. Clopheline (Clonidine) *
D. Nifedipine E. Hydrochlorothiazide (Dichlothiazide)
E. Dichlothiazide
46. Stable arterial hypertension has developed in a patient
39. A doctor has administered clonidine (clopheline) to a suffering from chronic glomerulonephritis. Indicate the
patient to combat hypertensive crisis. What group does the most effective group of drugs to treat this patient:
named agent belong to? A. Ganglioblockers
A. Agonists of central alpha 2 adrenoreceptors B. Peripheral vasodilators *
B. Antagonists of central alpha 2 adrenoreceptors C. Alpha-adrenoblockers
C. Agonists of central L1 –imidazoline receptors D. Beta-adrenoblockers
D. Antagonists of central L1 –imidazoline receptors E. Angiotensin converting enzyme inhibitors
E. Non-selective agonists of central alpha 2-
adrenoreceptors and imidazoline receptors * 47. A patient with a hypertensive crisis was admitted to
the cardiologic department. He was given an IV injection
40. A doctor has administered clonidine (clopheline) to a of an antihypertensive drug – alkali-earth metal salt. What
patient to treat hypertensive crisis. What class of drug was injected?
antihypertensive drugs does the named agent belong to? A. Benzohexonium
A. Drugs affecting the renin-angiotensin system B. Calcium lactate
B. Peripheral neurotropic C. Potassium chloride
C. Diuretics D. Sodium hydrocarbonate
D. Central neurotropic * E. Magnesium sulfate *
E. Peripheral vasodilators 48. Which is the most common side effect of
41. Indicate the drug which inhibits activity of vasomotor antihyperlipidemic drug therapy?
centre: A. Decreased blood pressure
A. Hydralazine (Apressin) B. Headache
B. Clopheline (clonidine) * C. Neurological problems
C. Verapamil D. Heart palpitation
D. Enalapril E. Gastrointestinal disturbances *
E. Hydrochlorothiazide (Dichlothiazide) 49. Which drug binds bile acids in the intestine, thus
42. A woman addressed to a doctor complaining of headache, preventing their return to the liver via the enterohepatic
fatigue, insomnia. Examination revealed high level of BP circulation?
(200/100 mm Hg). The doctor administered a drug whose A. Nicotinic acid
9
 B. Gemfibrozil 56. A patient who had been continuously taking drugs
C. Cholestiramine* blocking the production of angiotensin II developed
D. Lovastatin bradycardia and arrhythmia. A likely cause of these
E. Probucol disorders is: 2013
50. A patient suffering from initial hypertension has been A. Hyperkalemia *
taking an antihypertensive drug for a long time. Suddenly B. Hypokalemia
he stopped taking the preparation. After this his condition C. Hypernatremia
became worse and this led to hypertensive crisis D. Hypercalcemia
development. This by-effect can be classified as: E. Hypocalcemia
A. Cumulation 57. A patient has arterial hypertension. What long-acting
B. Dependence drug from the group of calcium channel blockers should
C. Sensibilization be prescribed? 2013
D. Tolerance A. Pyrroxanum
E. Abstinence syndrome B. Atenolol
51. Which drug causes a decrease in liver triglyceride C. Reserpine
synthesis by limiting available free acids needed as D. Octadine
building blocks for this pathway? E. Amlodipine *
A. Nicotinic acid 58. A patient with arterial hypertension was administered
B. Clofibrate an antihypertensive agent. Arterial pressure normalized but
C. Cholestiramine the patient began complaining of persistent dry cough.
D. Lovastatin Which agent has the given adverse effect? 2014
E. Probucol A. Reserpine
52. If the patient is given clofibrate to treat hyperlipidemia B. Anapriline
what enzyme or receptor activity will be most increased? C. Clopheline
A. Cytochrome P 450 D. Nifedipine
B. Lipoprotein lipase E. Lisinopril *
C. 3-hydroxy-3-methylglutaryl-CoA reductase 59. A 47 y.o. patient developed intestinal colic against the
D. Low density lipoprotein receptors background of essential hypertension. In this situation it
E. High density lipoprotein receptors would be most efficient to arrest the colic by using drugs
53. A 66 y.o. female got IV injection of MgSO4 for the of the following group: 2016
purpose of elimination of hypertensive crisis. But AP A. Myotropic antispasmodics *
didn’t go down and after repeated administration of the B. Anticholinesterase agents
same drug there appeared sluggishness, slow response, C. M-cholinomimetics
inhibition of consciousness and respiration. What D. Sympathomimetics
preparation is an antagonist of MgSO4 and can eliminate E. Adrenomimetics
symptoms of its overdose? 2012
A. Potassium permanganate
B. Calcium chloride*
C. Potassium chloride 6. Drugs Affecting the Respiratory System
D. Sodium chloride 1. A patient suffering from bronchial asthma had been
E. Activated charcoal taking tablets which caused insomnia, headache, increased
AP. What medicine can cause such complication?
A. Cromolyn sodium
54. A patient with essential hypertension has a high rate of B. Ephedrine *
blood rennin. Which of antihypertensive drugs should be C. Euphylline
preferred? 2011 D. Adrenaline
A. Prazosin E. Isadrine
B. Dichlothiazide
C. Propranolol * 2-4. A 12 y.o. boy with history of asthma complained of
D. Lisinopril cough, dyspnea and wheezing. His symptoms became so
E. Nifedipine severe that his parents brought him to the emergency room.
Physical examination revealed diaphoresis, dyspnea,
55. For relief of hypertensive crisis a doctor administered tachycardia and tachypnea. His respiratory rate was
to a patient a drug that apart from antihypertensive effect 42/min, pulse rate was 110 beats per minute and AP was
has also sedative, spasmolytic and anticonvulsive effect. 130/70 mm Hg. From the list below choose:
The drug was administered parenterally. When it is 2. The most appropriate drug to reverse the
administered enterally it acts as a laxative and cholagogue. bronchoconstriction rapidly.- C
What drug was administered? 3. The drug most likely to provide sustained resolution
A. Magnesium sulfate * of the patient’s symptoms. - A
B. Apressin 4. A drug contraindicated in this patient. - H
C. Dibasolum
D. No-spa A. Methylprednisolone
E. Reserpine B. Salmeterol

10
 C. Salbutamol C. Libexine*
D. Ipratropium D. Glaucine
E. Cromolyn E. Bromhexine
F. IV Methylprednidsolone
13. During a surgical operation on the patient in deep
G. Inhaled Beclomethasone
general anesthesia a danger of apnea was developed. To
H. Anapriline (Propranolol)
prevent this complication 1 ml of cytitonum was introduced
5. Indicate the mechanism of broncholytic action of to the patient intravenously, but the beneficial effect wasn’t
ipratropium bromide. reached.
A. Direct spasmolytic action Indicate the analeptic which should be used in this
B. Blockade of M-cholinoreceptors* situation:
C. Stimulation of β-receptors A. Cordiamin
D. Inhibition of phosphodiesterase B. Coffeinum
E. Activation of adenyl cyclase C. Bemegride *
D. Sulphocamphocaine
6. Indicate the mechanism of Euphyllin action:
E. Lobeline
A. Stimulation of β-receptors and
activation of adenyl cyclase 14. Determine the drug. This drug is a derivative of
B. Inhibition of phosphodiesterase nicotinic acid. It occurs stimulant effect upon the
C. Inhibition of phosphodiesterase and respiration and blood supply. The increase of respiration is
blockade of adenosine receptors * associated with the direct action upon the respiratory center
D. Blockade of β-receptors as well as with the reflex action upon it – through
E. Blockade of M-receptors chemoceptors of the Sino carotid zone.
A. Cordiamin *
7. Indicate the mechanism of Salbutamol action:
B. Caffeine
A. Stimulation of β-receptors
C. Etimizol
B. Activation of adenyl cyclase
D. Bemegride
C. Stimulation of β-receptors and
E. Cytiton
activation of adenyl cyclase*
D. Inhibition of phosphodiesterase 15. Determine the drug. This drug is an alkaloid, derivative
E. Blockade of adenosine receptors and of methylxanthine. It exerts significant psychostimulating
inhibition of phosphodiesterase action associated with the excitation of the brain cortex. It
activates respiratory and vasomotor center directly, and
8. Indicate the strategy to treat pulmonary edema and left
also possesses a direct cardiotonic effect. The direct action
ventricular failure.
upon the blood vessels is accompanied by their dilation and
A. Strophanthin IV
the action upon vasomotor center leads to the increase of
B. Furosemide IV
the vascular tonicity. As a result the vessels of the
C. Euphyllin IV
abdominal cavity narrow and the cardiac, cerebral,
D. Strophanthin, Furosemide, Euphyllin IV
pulmonary, renal, skeletal muscles blood vessels dilate.
E. Strophanthin, Mannitol, Euphylline IV infusion
A. Cordiamin
9. Indicate the stimulant of respiration with sedative effect B. Caffeine*
and anti-inflammatory properties: C. Etimizol
A. Bemegride D. Bemegrid
B. Etimizol * E. Cytiton
C. Caffeine
16. A 20 y.o. woman treated for asthma develops a skeletal
D. Cordiamin
muscle tremor that is drug-induced. Which of the following
E. Lobeline
medications is the most likely cause?
10. Indicate the antitussive agent with central non-narcotic A. Beclomethasone
type action: B. Theophylline
A. Codeine C. Cromolyn
B. Ethylmorphine D. Salbutamol*
C. Lobeline E. Ipratropium
D. Glaucine*
17. An adult patient with COPD is being managed with
E. Bromhexine
several drugs, one of which is inhaled ipratropium
11 Indicate the antitussive agent with central non-narcotic bromide. What is the main effect that accounts for the
type action: beneficial effects of this drug?
A. Codeine A. Blockade of endogenous bronchoconstrictor
B. Ethylmorphine mediator action*
C. Lobeline B. Enhanced release of epinephrine from the adrenal
D. Tusuprex* medulla
E. Bromhexine C. Inhibition of cAMP breakdown via
phosphodiesterase inhibition
12. Indicate the antitussive agent of peripheral action:
D. Stimulation of adenylyl cyclase
A. Codeine E. Prevention of antigen-antibody reactions that lead
B. Ethylmorphine
to mast cell mediator release
11
18. A young boy with asthma receives montelukast. What bronchospasm development during its administration.
is the main mechanism by which this drug produces its Which drug has been administered?
beneficial effects? A. Sodium bicarbonate
A. Prevention of antigen-antibody reactions that B. Thermopsis grass
lead to mast cell mediator release C. Bromhexine
B. Enhanced release of epinephrine from the D. Acetylcysteine *
adrenal medulla E. Libexine
C. Stimulation of adenylyl cyclase
26. The child was born asphyxiated. What drug should be
D. Blockade of receptors for pro-inflammatory
administered to the newborn to stimulate breathing? 2014
and bronchoconstrictrictor mediators *
A. Aethimizolum *
E. Inhibition of cAMP breakdown via
B. Atropine
phosphodiesterase inhibition C. Prazosin
D. Proserine
19. The most potent bronchoconstrictor is:
E. Lobeline
A. Histamine
B. Bradykinin 27. A child patient has dry cough. What non-narcotic
C. Leukotriens * antitussive drug will relieve the patient’s condition? 2016
D. Acetylcholine A. Codeine phosphate
E. Adenosine B. Morphine hydrochloride
C. Althea officinalis root extract
20. Use of adrenaline is in:
D. Glaucine hydrochloride *
A. Bronchospasm
E. Potassium iodide
B. Hypotension
C. Anaphylactic shock
D. Bradycardia
E. All of above *
7. Drugs Affecting the Gastrointestinal Tract
21. To the patient with psychomotor excitation 2 ml of
2,5% solution of aminazine (chlorpromazine) was injected 1. Determine the drug that is not used as an antiemetic in
IM. AP felt down (pre collapse state). Which drug should motion sickness:
be administered? A. Scopolamine
A. Anaprilin (Propranolol) B. Aeron
B. Atropine C. Validol
C. Cordiamin * D. Suprastine
D Domperidone E. Metoclopramid*
E. Pentamine
2. Determine the drug that is not used as an anti emetic in
22. To the patient with acute bronchitis has been administered motion sickness:
an agent that caused vomiting. What agent could most likely A. Validol
cause such action? B. Ondansetron*
A. Acetylcysteine C. Aeron
B. Potassium iodide D. Dimedrol
C. Bromhexine E. Scopolamine
D. Salbutamol
3. Indicate the pharmacological group that inhibits the
E. Thermopsis grass infusion
motility of the stomach and intestine:
23. A patient suffering from chronic bronchitis takes a A. M-cholinomimetics
synthetic mucolytic drug that facilitates the sputum B. M-cholinoblockers*
thinning. What drug is it? C. Cholinesterase inhibitors
A. Diazepam D. N-cholinomimetics
B. Enalapril E. β1-adrenomimetics
C. Acetylcysteine*
4. Indicate the pharmacological group that stimulates the
D. Heparin
motility of stomach and intestine:
E. Furosemide
A. Ganglioblockers
24. In order to stimulate breathing in a child born with B. M-cholinoblockers
asphyxia, the doctor gave him a drug injection into C. Anticholinesterases *
umbilical vein. What drug might have been injected? 2013 D. Myorelaxants
A. Sulfocamphocaine E. β1-adrenomimetics
B. Cordiamin
5. A 35 y.o. woman was admitted to the surgical department
C. Etimizol
with the symptoms of acute pancreatitis: vomiting, diarrhea,
D. Coffeinum *
bradycardia, hypotension, weakness, dehydration of the
E. Labetalol
organism, amylase of the blood plasma – 128U. What agent
25. A patient with chronic bronchitis has been administered should be used first of all?
an expectorant acting by splitting the disulfide bonds of A. Pirenzepine
glycosaminoglycan of sputum, decreasing its viscosity. B. Platyphyllin
The physician has warned the patient about possible C. Contrical (Aprotinin)*
12
 D. Methacin B. Prostaglandin E2
E. Atropine C. Sucralfate
D. Al3+-containing antacids
6. Indicate the mechanism of the emetic action of
apomorphine: 24. Hypothalamic ventromedial nuclei stroke was
A. Stimulation of the parasympathetic ganglions diagnosed in a 50 y.o. woman. Her behavior is
B. Activation of chemoreceptors of trigger zone characterized by unsatisfied hunger, weight gain. Which
of the emetic center in medulla oblongata * drug may be used to reduce her appetite?
C. Irritation of the gastric mucus A. Etimizol
D. Increase in the tonicity of smooth muscles B. Phepranone *
E. Increase in hydrochloric acid secretion C. Piracetam
D. Lipostabil
7. A doctor has administered Metoclopramide to a 37 y.o. man E. Caffeine
with the symptoms of acute pancreatitis and severe vomitus. 25. An anticholinesterase drug has been administered to a
Indicate the mechanism of action of this drug. patient in postoperative period to stimulate intestinal
A. Blocks M-cholinoreceptors peristalsis and tonus of urinary bladder. Which drug is it?
B. Blocks dopamine D2-receptors * A. Propranolol
C. Stimulates M-cholinoreceptors B. Reserpine
D. Blocks histamine H2-receptors C. Dichlothiazide
E. Stimulates β-adrenoreceptors D. Mannitol
8-13. Select the most appropriate drug from the following E. Proserine*
list, which is: 26-29. Select the most appropriate drug to induce the
8. Given in combination regiment to enhance numbered adverse effects from the following list:
antiemetic potency- C* A. Sodium bicarbonate
9. Highly effective against cytotoxic drugs induced B. Cimetidine
emesis – A* C. Loperamide (Imodium)
10. Can cause extrapyramidal side effects – F* D. Metoclopramide
11. Approved for managing postoperative nausea and
vomiting – B* 26. Gynecomastia – B*
12. Useful in managing nausea and vomiting due to 27. Metabolic alkalosis – A*
motion sickness – D* 28. Extrapyramidal symptoms – D*
13. Low antiemetic potency – E* 29. Toxic megacolon – C*
A. Granisetron 30. An agent, capable to inhibit essentially 100% of gastric
B. Ondansetron acid secretion in a single daily dose was administered to a
C. Dexamethasone patient suffering from the ulcer of the stomach with the
D. Suprastine increased acid-producing function. What agent is it?
E. Lorazepam A. Atropine
F. Metoclopramide B. Ranitidine
14-19. Select the most appropriate drug from the C. Famotidine
following list, which: D. Omeprazole*
14. It softens the stool – C* E. Platyphyllin
15. It may adsorb intestinal toxins – F* 31. Agents, which dissolve cholesterol stones, are:
16. It diminishes fluid secretion in the bowel – A* A. Chenodeoxycholic acid*
17. It irritates the gut and causes increased peristalsis – B. Clofibrate
B* C. Cholestiramine
18. It retains water and produces intestinal distension – D. A and B are correct
E* E. Lipoic acid
19. It inhibits peristalsis – D* 32. Which of the following drugs is useful in dissolving
A. Bismuth subsalicylate Gall bladder stone:
B. Phenolphthalein (Purgen) A. Clofibrate
C. Docusate sodium (Norgalax) B. Chenodeoxycholic acid*
D. Loperamide (Imodium) C. Lactulose
E. Magnesium sulfate D. Gemfibrosil
F. Activated charcoal E. Lipoic acid
33. A patient with severe arthritis will be placed on long-
20-23. Select the most appropriate drug from the term therapy with indomethacin. Which of the following
following list: drugs is the most appropriate choice to administer as an
20. It is approved for prevention of NSAID-induced add-on (adjunct) to prevent gastric ulcers caused by this
gastric ulcers – A * NSAID?
21. It diminishes gastric acid production by inhibiting A. Misoprostol*
adenyl cyclase – B * B. Celecoxib
22. It can alter absorption of other drugs – D * C. Nimesulide
23. It binds to mucus forming physical barrier to HCl D. Cimetidine
and pepsin – C * E. Meloxicam
A. Misoprostol
13
34. A liquidator of a breakdown at a nuclear power plant B. Nicodinum
who was irradiated complained about vomiting that C. Allochol
occurs all of a sudden. What medication should be D. Cholenzyme
prescribed? E. Magnesium sulfate
A. Metoclopramide* 41. A doctor prescribed trasylol (contrical, gordox) to the
B. Reserpine patient to prevent attacks of acute pancreatitis. The drug is
C. De-Nol an inhibitor of:
D. Atropine A. Gastriscin
E. Aeron B. Phospholipase
35. Which agent has properties not only to stimulate bile C. Carboxypeptidase
formation but also bile migration? D. Elastase
A. Cholosas E. Trypsin
B. Oxaphenamid * 42. A 65 y.o. female patient has chronic constipation due
C. Cholecystokinin to the colon hypotonia. What drug should be chosen in
D. Cholenzym this case? 2013
E. Allochol A. Bisacodyl *
36. A 60 y.o. man presents with weakened peristaltic B. Magnesium sulfate
activity of the bowels. Which of the following foodstuffs C. Metoclopramide
would stimulate peristalsis most of all? D. Neostigmine methylsulfate
A. Tea E. Castor oil
B. Lard 43. A 40 y.o. female patient diagnosed with acute
C. Meat pancreatitis has been admitted to the admission department
D. White bread of a regional hospital. What drug should be administered to
E. Brown bread* the patient in the first place?
37. A patient with chronic hyperacid gastritis takes an A. Contrical *
antacid for heartburn. After its ingestion he feels better but B. Pirenzepine
at the same time he has a sensation of stomach swelling. C. Platyphyllin
Which of the following drugs might be the cause of such D. Atropine
side effect? E. Methacin
A. Sodium hydrocarbonate * 44. A 40 y.o. patient with hyperacid gastritis suffers from
B. Aluminium hydroxide night hunger pains. Administer him a histamine H2 receptor
C. Magnesium trisilicate
blocker of the III generation which will decrease
D. Magnesium oxide
E. Pepsin hydrochloric acid secretion (especially at night) and
increase mucus formation:
38. A patient has multiple gastric ulcers but has done A. Platyphyllin hydrotartrate
nothing about them. Shortly after consuming a large meal B. Pirenzepine
he experiences significant GI distress. He takes a remedy C. Famotidine *
for heartburn. Within a minute he develops ‘bad bloating D. Atropine sulphate
feeling’. Several of the ulcers have begun to bleed and he E. Methacin
experiences severe pain. The patient becomes profoundly
45. What drug will be most appropriate for the patient who
hypotensive from upper GI blood loss and is transported to
has chronic gastritis with increased secretion? 2016
the hospital. Endoscopy confirms multiple bleedings. The
A. Pancreatin
endoscopist remarks that it appears as if the lesions had
B. Chlorphentermine
been literally stretched apart, causing additional tissue
C. Pepsin
damage that led to the hemorrhage. The drug the patient most
D. Aprotinin
likely took was:
E. Pirenzepine *
A. Aluminum hydroxide
B. Magnesium hydroxide
C. Sodium bicarbonate *
D. Tannin
E. Bismuth subnitrate
39. An elderly patient has chronic obstipatons induced by
large intestine hypotonia. Which drug should be 8. Drugs affecting the Kidney and Uterus
administered? 2014
1. Which effect can hydrochlorothiazide produce?
A. Proserine
A. Hyperkalemia
B. Aceclidine
B. Hyperuricemia*
C. Sodium sulphate
C. Hypertension
D. Bisacodyl *
D. Hypoglycemia in diabetic patients
E. Castor oil
E. Hypolipidemia
40. A patient with biliary dyskinesia and constipations has
2. The alternative usage of dichlotiazide, etacrinic acid and
been prescribed a cholagogue having also a laxative
furosemide did not cause a marked diuretic effect in the
effect. What drug has been administered? 2013
patient with developed peripheral edema. The aldosterone
A. Cholosas
14
level in the plasma is increased. Which diuretic would be B. Furosemide
most effective in this case? C. Hydrochlorthiazide
A. Amilorid D. Bumetanide
B. Spironolactone* E. Ethacrinic acid
C. Mannit
11. A 35 y.o. patient who often consumes alcohol was
D. Clopamide
treated with diuretics. There appeared serious muscle and
E. Urea
heart weakness, vomiting, diarrhea. AP 100/60 mm Hg,
3. A doctor administered allopurinol to a 37 y.o. man with depression. This condition is caused by intensified
the symptoms of gout. What pharmacological action of excretion of:
allopurinol ensures therapeutical effect? A. Calcium
A. Increasing uric acid excretion B. Potassium*
B. Inhibiting leukocyte migration into joint C. Chlorine
C. Inhibiting uric acid synthesis* D. Phosphates
D. Increasing uric acid biotransformation E. Sodium
E. General anti-inflammatory effect
12. Choose a drug to stimulate myometrium in a pregnant
4. Which of the following enzymes is responsible for the woman, taking into account that she has inclination to
ultimate formation of uric acid, which contributes to arterial hypertension:
hyperuricemia and the pathophysiology of chronic and A. Oxytocin *
acute gout? B. Pituitrin
A. 5’-Lipoxygenase C. Fenoterol (Partusisten)
B. Xanthine oxidase* D. Dinoprost
C. Phospholipase E. No-spa
D. Cyclooxygenase-1
13. A doctor has administered pituitrin to a 35 y.o.
E. Cyclooxygenase-2
parturient woman with the weakness of labor activity.
5. The diuretic, which causes hypercalcemia, is: Which concomitant disease is a contradiction for this drug
A. Hydrochlorothiazide* administration?
B. Lasix A. Hypotension
C. Bumetanide B. Bronchial asthma
D. Indapamide C. Peptic ulcer
E. Mannitol D. Diabetes mellitus
6. Which diuretic promotes Ca2+ reabsorption? E. Hypertension *
A. Verospirone 14. A vitamin-containing therapy was administered to a
B. Lasix pregnant woman with a history of habitual abortion. Select
C. Amiloride vitamin promoting maintenance of pregnancy:
D. Indapamide A. Tocopherol*
E. Hydrochlorothiazide* B. Pyridoxine phosphate
7. There is a pregnant woman in a delivery room that on term C. Folic acid
of gestation should already have labors. The uterus cervix is D. Rutin
not opened at inspection. Indicate an agent for acceleration of E. Cyanocobalamine
uterus cervix ripening and for parturition activity stimulation: 15. A 34 y.o. woman with threatened (habitual) abortion has
A. Progesterone admitted to the obstetrician department. Which tocolytic
B. Dinoproston (PGE2) * should be administered to the patient?
C. Estrone A. Dinoproston
D. Testosterone B. Fenoterol (Partusisten) *
E. Ergometrine C. Cotarnine
8. A parturient woman has uterine bleeding in connection D. Ergometrine
with disturbances of contractility of the myometrium in E. Drotaverine
postpartum period. Which drug should be administered to 16. A tocolytic agent was administered IM to a pregnant
stop bleeding? woman to prevent preterm delivery. The drug is also known
A. Partusisten (Terbutaline) as anticonvulsive, hypotensive, antiarrhythmic, cholagogic
B. Atropine and laxative. Which agent had been used?
C. MgSO4 A. Oxytocin
D. Adrenaline B. Dinoprost
E. Ergometrine * C. Fenoterol
9. A 32 y.o. parturient woman is suffering from severe pain. D. Magnesium sulfate *
Which medicine should be administered to reduce the pain? E. Partusisten
A. Codeine phosphate 17. Despite the administration of cardiotonics and a
B. Morphine hydrochloride thiazide diuretic a patient with chronic heart failure has
C. Promedol (Trimeperidine) * persistent edemas and the risk of ascites arose. What
D. Analgin (Metamizole) medication should be administered in order to enhance the
E. Paracetamol diuretic effect of the drugs used? 2015
10. Examination of a patient revealed hyperkaliemia and A. Amiloride
hyponatremia. What diuretic was administered? B. Spironolactone *
A. Verospirone * C. Furosemide
15
 D. Clopamide 9. Drugs affecting Blood
E. Mannitol
1. There is an inhibited coagulation in the patient with the
18. A 65 y.o. female suffers from chronic renal failure bile ducts obstruction, bleeding due to the low level of
accompanied by evident edemata caused by chronic absorption of a vitamin. What vitamin is in deficiency?
glomerulonephritis. What diuretic should be administered A. A
for forced diuresis? 2010 B. D
A. Cyclometazide C. E
B. Acetazolamide D. K*
C. Hydrochlorothiazide E. Carotene
D. Chlorthalidone
E. Furosemide 2. A 2 y.o. child has got intestinal dysbacteriosis, which
19. Which of the following agents WILL NOT have results in hemorrhagic syndrome. What is the most
diuretic effect on a patient with Addison’s disease? probable cause of the hemorrhage in the child?
A. Spironolactone * A. Vitamin K deficiency*
B. Triamterene B. PP hypovitaminosis
C. Furosemide C. Activation of tissue tromboplastin
D. Hydrochlorothiazide D. Hypocalcaemia
E. Ethacrynic acid E. Fibrinogen deficiency
20. A 26 y.o. pregnant woman at 40 weeks of pregnancy 3. Inhibition of leucopoiesis is observed in a 43 y.o.
has been taken to the maternity ward. Objectively: the radiologist. The amount of leukocytes equals 3.5x109/L.
uterine cervix is open, but contractions are absent. The Specify the agent for correction of leucopoiesis:
doctor administered a hormonal drug to her to stimulate the A. Ferroplex
labour. Name this drug: 2013 B. Folic acid
A. Oxytocin * C. Cyanocobalamin
B. Estrone D. Ascorbic acid
C. ACTH E. Pentoxyl *
D. Testosterone
4. A patient with hypochromic anemia suffers from
E. Hydrocortisone
splitting and loss of hair, increased nail fragility and taste
21. A hypertensive patient had been keeping to a salt-free alteration. What is the mechanism of the symptoms
diet and taking antihypertensive drugs together with development?
hydrochlorothiazide for a long time. This resulted in A. Vitamin K deficiency
electrolyte imbalance. What disorder of the internal B. Vitamin A deficiency
environment occurred in the patient? 2013 C. Iron-containing enzymes deficiency *
A. Hypochloremic alkalosis * D. Decreased production of thyroid hormones
B. Metabolic acidosis E. Vitamin B12 deficiency
C. Hyperkalemia
D. Increase in circulating blood volume 5. A patient with acute myocardial infarction has been
E. Hypermagnesemia administered heparin as a part of complex therapy. Some
time after heparin injection the patient developed
22. A woman with kidney disease accompanied by marked hematuria. What heparin antagonist should be injected to
edema was administered a diuretic inhibiting Na+ and water remove the complication? 2015
reabsorption and enhancing K+ and Mg2+ excretion by the A. Protamine sulfate*
kidney, induces hyperuricemia and powerful diuretic effect B. Aminocaproic acid
. Indicate this agent: C. Vicasol
A. Spironolactone D. Fibrinogen
B. Triamterene E. Neodicumarin
C. Furosemide *
D. Allopurinol 6. Indicate the alkylating drug used for the treatment of
E. Diacarb leucosis:
23. A patient with chronic heart failure with edema has A. Fluoracil
increased level of blood aldosterone. Which diuretic would B. Mercaptopurine
be most effective in this case? 2016 C. Methotrexate
A. Triamterene D. Cyclophosphamide*
B. Spironolactone * E. Vincristine
C. Hydrochlorothiazide 7. Indicate the mechanism of the heparin action:
D. Furosemide A. Inhibition of synthesis of the clotting factors in the liver
E. Acetazolamide B. Inhibition of thrombin
C. Inhibition of the conversion of prothrombin to
thrombin*
D. Activation of profibrinolysin
E. Causes proteolysis of plasminogen to plasmin
8. Indicate the clinical use of cyanocobalamin:
A. Leucopoenia
B. Malignant megaloblastic anemia*
16
 C. Acute leucosis C. Vicasol
D. Gout D. Deferoxamine *
E. Thyrotoxicosis E. EDTA
9. Indicate the properties of sodium citrate: 17. Examination of a 43 y.o. anephric patient revealed
A. It activates proteolysis anemia symptoms. Which agent should be administered?
B. It binds to Ca2+ ions A. Epoetin alpha *
C. It inhibits the conversion of prothrombin to thrombin B. Vitamin B12
D. It is used for blood preservation C. Vicasol
E. B and D* D. Folic acid
E. Fercoven
10. Indicate the mechanism of aspirin antiplatelet action:
A. Inhibition of PDE that promotes the accumulation of 18. A 27 y.o. woman suffers from hypochromic anemia in
cAMP connection with significant blood loss after thyroidectomy.
B. Stimulation of adenyl cyclase in thrombocytes Which drug should be administered to the patient?
C. Inhibition of cyclooxygenase and prevention of A. Cyanocobalamine
synthesis of thromboxane* B. Coamide
D. Block of adenosine uptake C. Folic acid
E. Increase of prostacyclin synthesis D. Pentoxyl
E. Ferrum-lek*
11. Indicate the drug used locally to stop bleeding from the
small vessels. 19. During a competition there are the indirect proofs of the
A. Calcium chloride forbidden drug erythropoietin usage in the sportsmen-
B. Contrical skiers by results of the dope-control. Define, what is not
C. Amben typical for erythropoietin?
D. Thrombin * A. It is produced by recombinant technologies
E. Vicasol B. It decreases level of erythrocytes in blood*
C. It is synthesized by the kidney in hypoxemic
12. Indicate the mechanism of the streptokinase action:
environment
A. Inhibition of synthesis of the clotting factors in the liver
D. It stimulates erythropoiesis
B. Inhibition of thrombin
E. It can be used for the treatment of anemia due to
C. Inhibition of the conversion of prothrombin to thrombin
chronic renal failure
D. Activation of profibrinolysin
E. Causes proteolysis of fibrin *
20. To the patient suffering from stenocardia and taking
13. Indicate the mechanism of the cytostatic action of isosorbide mononitrate, has been given an agent with
Methotrexate: antiplatelet activity. Indicate this agent:
A. Inhibition of dihydrofolate reductase - blocking the A. Anapriline (Propranolol)
conversion of dihydrofolic acid to tetra hydrofolic acid* B. Acetylsalicylic acid*
B. Inhibition of the conversion of inosine monophosphate C. Nifedipine
to adenine and guanine nucleotides D. Nitroglycerine
C. Inhibition of thymidilate synthesis and selective failure E. Validol
of DNA synthesis 21. The patient with myocardial infarction had been
D. Production of highly reactive carbonium ion receiving each 6 hours an anticoagulant IV. In a few days,
intermediates, which transfer alkyl groups to he has developed bleeding gums, nasal bleeding;
macromolecules by forming covalent bonds erythrocytes in urine have appeared. What drug was
E. Block of adenosine uptake introduced to the patient?
14. A 45 y.o. patient is admitted to the hospital in A. Aminocaproic acid
connection with thromboembolism of pulmonary artery, B. Neodicumarin
which developed after physical exertion. Choose the drug C. Vicasol
of choice for this patient: D. Calcium gluconate
A. Aspirin E. Heparin*
B. Dipyridamole 22. Symptoms of internal bleeding developed at a patient
C. Abciximab of gynecologic department. What agent should be given for
D. Streptokinase * inhibition of fibrinolysis and arrest of hemorrhage?
E. Clopidogrel A. Calcium chloride
15. The anticoagulant activity of neodicumarin can be B. Dicynon
potentiated by all of the following drugs EXCEPT: C. Vicasol
A. Rifampicin * D. Contrical*
B. Aspirin E. Fibrinogen
C. Pentoxifylline 23. The patient was admitted to the traumatologic
D. Cimetidine department due to fracture of chin bones, damages of soft
E. Disulfiram tissues and massive bleeding. Examination revealed
16. Indicate the pharmacological antidote for the iron paleness of the skin, pain in palpation of area of trauma,
preparations: swelling of the skin, bleeding on the whole surface of the
A. Ascorbic acid wound. Specify a drug for local use to stop the bleeding:
B. Protamine sulfate A. Vicasol

17
 B. Calcium chloride A. Pentoxyl *
C. Thrombin * B. Methotrexate
D. Aminocaproic acid C. Mercaptopurine
E. Amben D. Cyanocobalamin
24. Anticoagulants are used for the prevention and E. Prednisolone
treatment of thrombosis. Specify an anticoagulant which 32. A patient has myocardial infarction with thrombosis of the
antagonist is protamine sulfate. left coronary artery. What pharmacological preparation group
A. Phenylin should be used to reestablish blood flow? 2012
B. Neodicumarin A. Glucocorticoids
C. Warfarin B. Angiotensin-converting enzyme inhibitors
D. Sodium citrate C. Narcotic analgetics
E. Heparin* D. β-adrenoblockers
25. A 38 y.o. woman has been on a slim diet consisted of 2 E. Fibrinolysis activators *
cups of coffee without sugar, 3 crackers from white bread, 33. Examination of a child who hasn’t got fresh fruit and
2 eggs or 2 sausages a day for a mouth. She lost 5 kg her vegetables during winter revealed numerous subcutaneous
weight but developed headaches, often nasal bleedings, hemorrhages, gingivitis, carious cavities in teeth. What
bleeding sickness of gums, shaking of teeth, shelling of vitamin combination should be administered? 2012
skin and shedding of hair. What vitamin drug is expedient A. Ascorbic acid and rutin *
in this case? B. Folic acid and cobalamin
A. Ascorbic acid* C. Thiamine and pyridoxine
B. Cyanocobalamin D. Calciferol and ascorbic acid
C. Folic acid E. Riboflavin and nicotinamide
D. Vicasol (Menadione) 34. A patient has a slowly healing fracture. Which medicine can
E. Retinol acetate be used to accelerate formation of connective tissue matrix? 2012
26. Specify the antagonist of anticoagulants with indirect A. Cyclosporine
type of action. B. Prednisolone
A. Vicasol * C. Cyclophosphan
B. Fercoven D. Methotrexate
C. Pentoxyl E. Methyluracil *
D. Protamine sulfate 35. As a result of home injury, a patient suffered a
E. Contrykal significant blood loss, which led to a fall in BP. Rapid
27. Specify the coagulant agent available for local use blood pressure recovery after the blood loss is provided by
only (to stop bleedings from small blood vessels). the following hormones: 2013
A. Aminocaproic acid A. Oxytocin
B. Vicasol B. Adrenaline, vasopressin
C. Calcium chloride C. Sex hormones
D. Hemostatic sponge * D. Cortisol
E. Fibrinogen E. Aldosterone
28. Specify the thrombolytic agent with direct action 36. A 46 y.o. female is scheduled for a maxillofacial
which belongs to plasm proteins. surgery. It is known that the patient is prone to high blood
A. Contrical coagulation. What natural anticoagulant can be used to
B. Streptokinase prevent blood clothing? 2013
C. Fibrinolysin * A. Fibrinolysin
D. Urokinase B. Hirudin
E. Streptodecase C. Sodium citrate
29. After a disease a 16 y.o. boy presents with a decreased D. None of the listed substances
function of protein synthesis in the liver as a result of E. Heparin *
vitamin K deficiency. This may cause disorder of: 37. A 20 y.o. male patient complains of general weakness,
A. Blood coagulation rapid fatigability, irritability, decreased performance,
B. Osmotic blood pressure* bleeding gums, petechiae on the skin. What vitamin
C. Erythrocyte sedimentation rate deficiency may be a cause of these changes? 2013
D. Anticoagulant production A. Ascorbic acid *
E. Erythropietin production B. Retinol
30. Before tooth extraction a patient was administered a C. Riboflavin
drug for haemorrhage prevention. Which drug was it? D. Folic acid
A. Asparcam E. Thiamine
B. Vicasol * 38. A 40 y.o. man was diagnosed with hypochromic
C. Dimedrol anaemia. Which agent should be administered? 2014
D. Heparin A. Vicasol
E. Magnesium sulfate B. Fercoven *
31. A 54 y.o. patient took levomicetin (chloramphenicol) C. Pentoxyl
for a long time without doctor permission. The patient D. Cyanocobalamine
examination revealed leucopenia. Which drug should be E. Heparin
administered for stimulation of leucopoiesis?
18
39. A 30-y.o. patient with a past history of virus B hepatitis 8. Best preparation of insulin for intravenous injection is:
complains of prolonged nosebleeds. Which drug will be A. Lente Insulin
most efficient in remedying this condition? 2016 B. Semilente Insulin
A. Folic acid C. Regular insulin *
B. Dipyridamole D. Humulin
C. Vicasol * E. Ultralente Insulin
D. Asparcam 9. Which drug decrease insulin release?
E. Fraxiparin A. Glibenclamide
B. Carbamazepine
C. Sodium valproate
11. Hormones and Antihormones D. Diazoxide*
1. A 32 y.o. woman visited gynecologist with the E. Butamide
complaints of the usual abortions during the first months of 10. The following states are adverse reactions of oral
pregnancy and the disorders of the menstrual cycle. The contraceptives except:
doctor established the diagnosis of pituitary insufficiency. A. Thromboembolism
Administer the hormonal drug to treat this patient: B. Weight gain
A. Corticotrophin C. Carbohydrate intolerance
B. Glibenclamide D. Galactorrhea *
C. Oxytocin E. Hyperlipidemia
D. Gonadotropin menopausticum * 11. A 42 y.o. woman taking an oral contraceptive (estrogen
E. Pituitrin + progestin) for 3 years is diagnosed epilepsy and started
2. A patient had been suffering from atopic bronchial on phenytoin (diphenin). Which state is the most probable
asthma for a long time. Last time he was treated with consequence of adding phenytoin?
prednisolone due to worsening of his state. Long treatment A. Reduced contraceptive efficacy*
with prednisolone produced the development of edemas, B. Increased risk of craniofacial abnormalities in the fetus
increase in glucose concentration, increased excitability D. Aplastic anemia
and sleeplessness. Indicate hormone drug, which should be E. Seizures
administered for prevention of this complication: B. Thromboembolism
A. Androcur (Cyproterone acetate) 12. A 32 y.o. man has complained of a headache, fatigue,
B. Retabolil thirst, pains in the spine and joints for the last 2 years.
C. Glibenclamide Clinically it was observed disproportional enlargement of
D. Tocopherol acetate hands, feet, nose, superciliary arches. He noted that he
E. Corticotropin* needed to buy 3 times bigger shoes. What is the main
reason of such disproportional enlargement of different
3. Determine the drug for hyperprolactinemia: parts of the body?
A. Bromocriptine* A. Increased sensitivity of the tissues to growth hormone
B. L-Dopa B. Increased sensitivity of the tissues to insulin
C. Oxytocin C. Cartilaginous tissue proliferation under growth
D. Pituitrin hormone influence*
E. Estradiol D. Joint dystrophy development
4. Glucocorticoids are contraindicated in all cases except: E. Joints chronic inflammation development
A. Organ transplants*
B. Peptic ulcers 13. A patient has been taking glucocorticoids for a long
C. Hypertension time. When the preparation was withdrawn he developed
D. Diabetes mellitus the symptoms of aggravation, decreased blood pressure and
E. Tuberculosis weakness. What is the reason of this condition?
5. The corticosteroid without any glucocorticoid activity is: A. Sensibilization
A. Triamcinolone B. Adrenal insufficiency *
B. Dexamethasone C. Cumulation
C. DOCA (Desoxycorticosterone acetate)* D. Hyperproduction of ACTH
D. Cortisol E. Idiosyncrasy
E. Hydrocortisone 14. A 2 y.o. child has experienced tetanic convulsions due
6. What is not true about Beclomethasone? to lowering Ca2+ concentration in the plasma. Administer
A. Indicated for chronic use the hormonal drug to treat the patient:
B. Inhalation steroid A. Prednisolone
C. Effective in acute asthma * B. Insulin
D. Predispose to fungal infections C. Calcitrin
E. All above D. Calcium chloride
7. Inhaled corticosteroid is: E. Parathyroid hormone *
A. Dexamethasone 15. A 17 y.o. female suffers from tachycardia at rest,
B. Beclomethasone* weight loss, excessive sweating, exophthalmus, irritability,
C. Triamcinolone elevated thyroxine in her serum. What treatment should be
D. Prednisolone administered to the patient?
E. Hydrocortisone A. Thyrotropin
19
 B. Calcitonin 25. Testosterone and its analogs increase volume of
C. Reserpine skeletal muscles that makes this drug useful for the
D. Mercazolyl (Methimazole)* treatment of myodystrophy. Interaction with what cellular
E. Prednisolone substrate determines this action? 2011
A. Membrane receptors
16. Taking oral contraceptives containing sex hormones
B. Ribosomes
inhibits endogenous pituitary secretion. Select the hormone
C. Nuclear receptors *
which secretion is inhibited while taking oral
D. Chromatin
contraceptives containing sex hormones.
E. Protein-activator of transcription
A. Follicle-stimulating hormone *
B. Oxytocin 26. A 35 y.o. woman suffering from chronic polyarthritis
C. Pituitrin has been treated for a long time with some drugs. She is
D. Growth hormone complaining on rising of BP, redistribution of fat tissues,
E. Thyroid-stimulating hormone disturbances of menstrual cycle. Which drug
administration are these complaints related to?
18. Best drug of stopping fibrosis: A. Beclomethasone
A. Antibiotics B. Phenylbutazone (Butadion)
B. Aspirin C. Meloxicam
C. Steroids * D. Prednisolon *
D. Enzyme preparation E. Diclofenac-natrium
E. Nimesulide
27. A 32 y.o. woman was taking tri-regol for a long time. What
19. Which of the following is true of propylthiouracil? does not belong to the adverse effects of this drug?
A. It is used in the treatment of hypothyroidism A. Thrombosis
B. It has a long half-life in the circulation B. Pyelonephritis
C. It increases proteolysis of thyroglobulin C. Weight gain
D. It inhibits thyroid hormone synthesis * D. Hepatotoxicity
E. It enhances thyroid hormone synthesis E. Osteoporosis *
20. Somatostatin inhibits all except: 28. A pregnant woman has been admitted to a obstetrician
A. Insulin department. Indicate the agent of the hormonal nature to
B. Growth hormone intensify parturition activity.
C. Thyroxine A. Progesterone
D. Epinephrine * B. Oxytocin *
E. Glucagon C. Methandrostenolone
21. Hyperglycemia is caused by all preparations except: D. Hydrocortisone
A. Glucocorticoids E. Aldosterone
B. Thiazide diuretics 29. A gynecologist has recommended to a 24 y.o. woman a
C. Glucagon * peroral contraceptive, which should be applied
D. Propranolol immediately after the sexual intercourse for the prevention
E. Contraceptives of undesirable pregnancy. Specify this drug:
22. Stress increases all hormones level except: A. Rigevidon
B. Triziston
A. ACTH C. Levonorgestrel (Postinor) *
B. Noradrenalin D. Estradiol
C. Insulin E. Proginova
D. Glucagon *
E. Adrenalin 30. A 27 y.o. woman who from time to time uses peroral
contraceptives has addressed to the doctor with a question
23. A patient with diabetes mellitus type II glibenclamide on composition of these agents. What steroid substances
was administered by endocrinologist. Indicate the main are included to postcoital peroral contraceptives?
mechanism of its action: 2016 A. Gonadotropins
A. Promotes glucose utilization by peripheral tissues B. Progestins *
B. Stimulates beta-cells isles of Langerhans * C. Androgens
C. Suppresses beta-cells isles of Langerhans D. Anabolic steroids
D. Facilitate glucose transport through cellular membranes E. Glucocorticoids
E. Inhibits glucose absorption in the intestine
31. A 27 y.o. woman has arrived to the obstetrician
24. A 68 y.o. patient that complains of thirst and frequent department because of threatened (habitual) abortion. What
urination has been diagnosed with diabetes mellitus and hormonal agent should be administer?
was administered metformin. What is the mechanism of A. Folliculin
action of this agent? B. Progesterone *
A. Promotes glucose utilization by peripheral tissues * C. Ethinylestradiol
B. Stimulates beta-cells isles of Langerhans D. Gonadotropin menopause
C. Suppresses beta-cells isles of Langerhans E. Estradiol
D. Inhibits glucose transport through cellular membranes
E. Inhibits glucose absorption in the intestine 32. Many kinds of pathology (inflammation, pulmonary
edema, shock of different origin) are accompanied by
20
violation of permeability of vessels. Which drug can be used caused spastic pain of skeletal muscles. What medication
for elimination of the reaction at any of the termed states? should be used in order to correct potassium exchange?
A. Dimedrol (Diphenhydramine) A. No-spa
B. Acid acetylsalicylic B. Dithylin
C. Indomethacin C. Asparcam *
D. Prednisolone * D. Thyrocalcitonin
E. Beclomethasone E. Diazepam
33. Continuous use of a drug can result in osteoporosis, 40. Parents of a 10 y.o. boy consulted a doctor about
erosions of stomach mucosa, hypokaliemia, retention of extension of hair-covering, growth of beard and
Na+ and water, decreased concentration of corticotropin in moustache, low voice. Intensified secretion of which
blood. What drug is it? hormone must be assumed?
A. Indomethacin A. Cortisol
B. Prednisolone * B. Oestrogen
C. Digoxin C. Somatotropin
D. Hypothiazide D. Testosterone *
E. Reserpine E. Progesterone
34. A patient with infectious mononucleosis has been 42. It is required to administer hormonotherapy for the
taking glucocorticoids for two weeks. This resulted in purpose of immunosuppression to prevent the transplant
remission but the patient got exacerbation of chronic rejection after organ transplantation. What hormones are
tonsillitis. This complication is induced by the following used for this purpose?
effect of glucocorticosteroids: 2010 A. Sexual hormones
A. Immunosuppressive * B. Glucocorticoids *
B. Anti-inflammatory C. Catecholamine
C. Antitoxic D. Mineralocorticoids
D. Antishock E. Thyroid
E. Antiallergic
43. A patient suffers from diabetes mellitus. After the
35. A 3 y.o. child has convulsions as s result of lowered regular insulin injection his condition became worse: there
concentration of Ca2+ in blood plasma. What hormone appeared anxiety, cold sweat, tremor of limbs, general
should be administered concomitantly with Ca2+ agent? weakness, dizziness. What preparation can eliminate these
A. Calcitrin symptoms? 2010
B. Parathyroid hormone * A. Noradrenaline
C. Miacalcic B. Caffeine
D. L - Tyroxine C. Glibutide
E. Prednisolone D. Butamide
36. Inhabitants of territories with cold climate have high E. Adrenaline hydrochloride *
content of an adaptive thermoregulatory hormone. What 44. Examination of a 70 y.o. patient revealed insulin-
hormone is meant? dependent diabetes. What drug should be administered? 2011
A. Insulin A. Insulin *
B. Somatotropin B. Glibenclamid
C. Glucagon C. Cortisone
D. Cortisol D. Parathyroidin
E. Thyroxin * E. Mercazolil
37. A 45 y.o. woman suffers from Cushing’s syndrome –
steroid diabetes. Biochemical examination revealed: 45. A patient has been given high doses of hydrocortisone
hyperglycemia, hypochloremia. Which of the undermentioned for a long time. This caused atrophy of one of the adrenal
processes is the first to be activated? cortex zones. Which zone is it? 2011
A. Glycogenolysis A. Fascicular *
B. Glycolysis B. Glomerular and reticular
C. Gluconeogenesis * C. Reticular
D. Glucose reabsorption D. None
E. Glucose transport to the cell E. Glomerular
46. A 60 y.o. male patient has type II diabetes mellitus. A
38. A 60 y.o. male has type 2 diabetes mellitus doctor administered him a long-acting synthetic
accompanied by obesity, atherosclerosis, and coronary hypoglycemic drug that is a sulphonylurea derivative.
artery disease. Basal hyperinsulinemia is also present. What drug was it? 2016
Which drug would be the most appropriate? A. Metformin
A. Glibenclamid * B. Glibenclamide *
B. Retabolil C. Butamide
C. Amlodipine D. Acarbose
D. Insulin E. Actrapid (soluble insulin)
E. Lovastatin
47. A nurse accidentally injected a nearly double dose of
39. A patient with collagenosis has been taking insulin to a patient with diabetes mellitus. The patient
prednisolone for a long time. Hypokaliemia development

21
lapsed into a hypoglycemic coma. What drug should be synthesis of one of the following substances. Choose the
injected in order to help him go out of coma? 2012 correct answer.
A. Glucose * A. Leukotriens*
B. Lydase B. Prostacyclin
C. Somatotropin C. Prostaglandins
D. Nor5adrenaline D. Thromboxanes
E. Insulin E. Platelet-activating factor
48. Parodontitis is treated with calcium preparations and a 2. A 23 y.o. man suffers from allergic seasonal coryza
hormone that stimulates tooth mineralization and inhibits caused by the ambrosia blossoming. Which medicine
tissue resorption. What hormone is it? 2012 stabilizing adipose cells can be used for prevention of this
A. Calcitonin c disease?
B. Aldosterone A. Phencarol
C. Thyroxin B. Diazolin
D. Adrenaline C. Dimedrol
E. Parathormone D. Tavegyl
E. Ketotifen*
49. A 20 y.o. patient complains of morbid thirst and
hyperdiuresis (up to 10 L daily). Glucose concentration in blood 3. A patient has mild cutaneous and systemic
is normal and it is absent in urine. The patient has been manifestations of an allergic response. Before you
diagnosed with diabetes insipidus. What hormonal drug is the prescribe a short course of dimedrol (diphenhydramine) for
most appropriate for management of this disorder? symptoms relief, you should realize, that this drug has one
A. Insulin mechanism of action, causes many side effects similar to,
B. Thyroxin and share many contraindications that are applied to one of
C. Vasopressin * the prototypic ‘autonomic’ drug. What is it?
D. Cortisol A. Atropine*
E. Oxytocin B. Epinephrine
50. A comatose patient was admitted to a hospital. He has a C. Norepinephrine
history of diabetes mellitus. Objectively: Kussmaul breathing, D. Propranolol
low blood pressure, acetone order of breath. After the E. Ephedrine
emergency treatment the patient’s condition improved. What 5. A woman with an allergic disorder experiences significant
drug had been administered to the patient? 2013 bronchoconstriction and urticaria, and histamine is a main
A. Adrenaline mediator in these responses. Which of the following drugs may
B. Isadrin pose extra risk for this patient – not because it has any
C. Furosemide bronchoconstrictrictor effects, but because it quite effectively
D. Glibenclamide releases histamine from mast cells?
E. Insulin A. Atropine
51. A female patient with bronchial asthma had taken B. Neostigmine
prednisolone tablets (1 tablet 3 times a day) for 2 months. C. Propranolol
Due to a significant improvement of her condition the D. Pancuronium
patient suddenly stopped taking it. What complication is E. d-Tubocurarine*
likely to develop in this case? 6. A 30 y.o. woman with a 3-year history of chronic renal
A. Hypotension failure requiring dialysis consents to transplantation. A
B. Upper body obesity donor kidney becomes available. She is given cyclosporine
C. Withdraw syndrome to prevent rejection. Which of the following states is the
D. Gastrorrhagia most probable adverse effect of the drug?
E. Cushing’s syndrome A. GIT ulceration
52. A woman with rheumatoid arthritis began complaining B. Seizures
of intermissions in the heart work after three-week C. Hepatotoxicity
treatment with prednisolone. What is the reason of such an D. Nephrotoxicity *
adverse effect development? E. Bone marrow depression
A. Hyperkalemia 7. A woman working as railway traffic controller suffers
B. Hypoglycemia from seasonal vasomotor rhinitis. She was prescribed an
C. Hypokalemia antihistamine that has no effect upon the CNS. What drug
D. Hyperglycemia is it? 2010
E. Hyperuricemia A. Diprazin (Promethazine)
B. Dimedrol (Diphenhydramine)
C. Suprastine
D. Loratadine*
E. Tavegil (Clemastine)
11. Antihistamine Drugs. Immunopharmacology 8. A 22 y.o. woman has a runny nose and itching eyes from
a bout with the common cold. dimedrol (diphenhydramine)
1. Arachidonic acid is metabolized by two main pathways: provides symptomatic relief. Indicate the mechanism of
cyclooxygenase and lipooxygenase. The latter, initially action that is most likely associated whis the named drug:
involving 5’- lipooxygenase, is responsible for the
22
 A. beta-adrenoreceptors blockade C. Beclomethasone
B. α-adrenergic stimulation D. Ephedrine hydrochloride
C. Histamine (H1) receptor blockade* E. Loratidine *
D. MAO inhibition 14. A patient suffering from chronic generalized parodontitis
E. Muscarinic receptor blockade requires the treatment with an immunostimulant which also
9. An asthma patient has symptoms flare-ups during hay possesses anthelmintic activity. Indicate this drug.
fever season. He visits the local superstore and buys an A. Thymalin
over-the-counter antihistamine/allergy remedy containing B. laferon
dimedrol (diphenhydramine). After a few days of using it, C. Cycloferon
his breathing becomes worse. You examine him and D. Cyclosporin
conclude that what the patient viewed as the allergy cure E. Levamisole
was actually the cause of the problems. Which of the 15. Dimedrol (diphenhydramine) is administered to a patient
following is the most likely mechanism by which the with urticaria to reduce itching rashes on the skin. What
dimedrol worsened this patient condition? mechanism provides its efficiency in this case?
A. Enhancing metabolic clearance of other asthma agents A. Competitive blockade of H1-histamine receptors *
(lowering their serum levels) B. Inhibition of synthesis of histamine
B. Drying the airways, increasing mucus viscosity* C. Suppression of release of histamine
C. Releasing histamine D. Acceleration of histamine
D. Causing bronchoconstriction by releasing more Ach in E. Blockade of H2- histamine receptors
the airways 16. Which drug should be administered to the patient who
E. Blocking the endogenous bronchodilator effects of suffers from rashes due to allergic reaction accompanied by
circulating epinephrine reddening, edema, and strong itch of skin which causes
sleeplessness?
10. A 25 y.o. man has had a kidney transplant. He receives A. Nitrazepam
cyclosporine as part of the immunosuppressant regimen. B. Dimedrol (Diphenhydramine) *
What is the main mechanism of cyclosporine’s C. Chloral hydrate
immunosuppressants effects? D. Sodium oxybutyrate (oxybate sodium)
A. Inhibits calcinurenin and IL-2 synthesis that is E. Phenobarbital
necessary for B and T cell proliferation *
B. Inhibits antigen-activated lymphocytes, reduces 17. The patient with allergic rhinitis has taken antihistaminic
responsiveness of T-lymphocytes to IL-1, reduces drug PO. In half an hour the patient felt dryness in mouth,
IL-2 production by lymphocytes and monocytes retardation and sleepiness. Indicate this drug:
C. Directly inhibits B and T lymphocyte proliferation A. Phenobarbital
D. Directly destroys proliferating B and T lymphocyte B. Diazolin (Mebhydroline)
proliferation C. Dimedrol (Diphenhydramine) *
E. Blocks the CD3 site on T lymphocytes, blocks all T D. Diazepam
cell functions E. Paracetamol
18. Indicate “day time” antihistaminic agent (with the least
11. A 35 y.o. patient suffering from bronchial asthma is expressed sedative and hypnotic activity).
hospitalized in a state of anaphylactic shock. Which agent A. Dimedrol (Diphenhydramine)
is the drug of choice to treat anaphylaxis? B. Diprazin (Promethazine)
A. Dimedrol (diphenhydramine) C. Tavegil (Clemastine)
B. Adrenaline * D. Suprastin (Choloropyramine)
C. Chromoglicic-acid E. Diazolin (Mebhydroline) *
D. Salbutamol
E. Ephedrine 19. A 40 y.o. patient is hospitalized with expressed Quinke’s
12. A 21 y.o. man with aspirin asthma experiences severe edema after stung of a bee. Indicate an antihistaminic drug to be
bronchospasm in response to even small doses of the drug. introduced without sedative and hypnotic action:
The most likely explanation for this is that the aspirin. A. Suprastin (Choloropyramine)
A. Induces hypersensitivity of H1 receptors on airway B. Phencarol (Quifenadine)*
smooth muscles C. Diprazin (Promethazine)
B. Suppresses airway inflammatory processes D. Prednisolone
C. Blocks synthesis of endogenous prostaglandins that E. Dimedrol (Diphenhydramine)
have bronchodilator activity* 20. A girl was treated with antibiotic from the group of
D. Prevents or reduce epinephrine binding to β2-adrenergic semisynthetic penicillins due to acute bronchitis. On the 3
receptors rd day of treatment allergic dermatosis has developed.
E. Induces hypersensitivity of muscarinic receptors on Indicate an antiallergic drug which should be administered
airway smooth muscles t the patient.
A. Suprastin (Chloropyramine) *
13. A girl receives antibiotics of the penicillin group for B. Levamisole
acute bronchitis. On the 3d day of treatment she developed C. Aspirin (Acetylsalicylic acid)
allergic dermatitis. Which drug should be administered? 2013 D. Cyclosporin
A. Levamisole E. Dexamethasone
B. Cromolyn sodium

23
21. A 27 y.o. patient has been diagnosed with allergic
dermatitis. A blocker of H1-histamine receptors was
administered. Indicate this drug:
A. Cromolyn sodium
B. Diprazin (Promethazine)*
C. Prednisolone
D. Adrenaline
E. Hydrocortisone
22. Indicate the group of antiallergic agents which
Loratadine belongs to:
A. Glucocorticoids
B. Membrane stabilizers
C. Antagonists of leukotriene receptors
D. Blockers of histamine receptors *
E. Blockers of serotonin receptors
23. Treatment by anti-inflammatory drugs was
administered to the patient with rheumatic endocarditis.
After a while hyperglycemia was developed. Which group
of drugs is capable to provoke such side effect?
A. Nonsteroid anti-inflammatory agents
B. Antibiotics of the group of Penicillins
C. Ascorbic acid
D. Sedatives
E. Glucocorticoids *
24. The immunodepressive effect of Prednisolone is cause by:
A. Inhibition of protein synthesis due to activation of
gluconeogenesis *
B. Inhibition of collagen synthesis
C. Activation of synthesis of inhibitors pf proteases
D. Inhibition of synthesis of mucopolysaccharides
E. Diminution of activity of plasmin
25. A patient develops anaphylactic shock after
intracutaneous test on sensitivity to penicillin. Doctor
administered a drug which eliminated bronchospasm and
arterial hypotension. Indicate this drug:
A. Mesatone (Phenylephrine)
B. Noradrenaline
C. Adrenaline *
D. Atropine
E. Salbutamol
27. Indicate the drug which is the most expedient to use
topically to treat allergic dermatitis?
A. Sea buckthorn oil
B. Solution of furacilinum (nitrofuran)
C. Liniment of methylsalicylate
D. Ichthyol ointment
E. Hydrocortisone ointment *
29. The doctor has administered a glucocorticoid
Synaflanum (fluocinoline) in the form of ointment to the
patient with dermatitis. What pharmacological effect is not
characteristic for this drug?
A. Magnification of hyperemia *
B. Diminution of itch
C. Diminution of edema
D. Deceleration of wound repair
E. Inhibition of skin immune response
30. Fluocinolone acetonide is administered to the patient,
suffering from allergic cheilitis for smearing of lipline and
mucous of the lips. Indicate the group which this drug
belongs to?
A. Antagonists of histamine H1 receptors
B. Antagonists of histamine H2 receptors
C. Glucocorticoids *
24
D. Membrane stabilizers
E. Antagonists of leukotriene receptors
31. To prevent bronchial asthma attacks, a doctor
administered cromolyn sodium (cromoglycate) to the
patient suffering from bronchial asthma. Indicate the
principle of action of this drug:
A. Decrease of immunoglobulins level
B. Binding of free histamine
C. Stabilization of membranes of mast cells *
D. Inactivation of histamine
E. Blockade of histamine receptors
32. A 45 y.o. woman suffers from allergic seasonal coryza
caused by ambrosia blossoming. Which drug from the
group of stabilizers of mast cells can be used for prevention
of the disease?
A. Ketotifen *
B. Phencarol
C. Tavegil
D. Dimedrol
E. Diazolin
33. Ketotifen was administered to a patient with bronchial
asthma. Indicate the mechanism of its action:
A. Blocks H2-histamine receptors
B. Blocks H1-and H2-histamine receptors
C. Inhibits synthesis of histamine
D. Blocks H1- histamine receptors *
E. Activates enzymes which cleave histamine
34. Which adrenomimetic is the most effective for topical
administration in allergic rhinitis?
A. Mesaton (Phenylephrine)
B. Naphthyzine (Naphazoline)
C. Phencarol
D. Salbutamol
E. Ephedrine *
36. A patient with chronic infectious disease requires
treatment with non specific immunomodulating agent.
Indicate this drug.
A. Mercaptopurine
B. Methyluracil *
C. Azathioprine
D. Cyclophosphamide
E. Azathioprine
37. A 48 y.o. woman who is suffering from exacerbation of
chronic pneumonia requires treatment with an
immunomodulating agent. Indicate this drug.
A. Sulfocamphocaine
B. Thymalin *
C. Biseptol (co-trimoxazole)
D. Dimedrol
E. Cyclosporin
38. Indexes of immune response are worsened in a patient
during chemotherapy of malignant tumour. What drug
should be administered in this state?
A. Thymalin *
B. Cyanocobalamin
C. Iron preparations
D. Prednisolone
E. Acetylsalicylic acid
39. A drug from the group of immunomodulators which is
an analogue of natural biogenic substrate and almost
devoid side effects after topical administration is
administered to a 4 y.o. child. Indicate this drug:
A. Thymalin
 B. Prodigiosan A. Vitamin A*
C. Interferon * B. Vitamin B6
D. Pyrogenal C. Vitamin C
E. Levamisole D. Vitamin E
40. It is necessary to administer an antihistamine agent to a E. Vitamin K
woman suffering from seasonal vasomotor rhinitis, who 3. Fat-soluble vitamins, compared with their water-soluble
works as a dispatcher on the railway. Indicate the drug to forms, generally have a greater potential toxicity as they are:
treat the patient: A. Involved in more essential metabolic pathways
A. Cromolyn sodium (cromoglycate sodium) B. Involved in less essential metabolic pathways
B. Diprazin (promethazine) C. Avidly stored by the body *
C. Prednisolone D. Capable of dissolving membrane phospholipids
D. Telfast* E. Administered in larger doses
E. Hydrocortisone
41. A female patient was administered loratidine for 4. Which is not a fat-soluble vitamin?
allergic cheilitis treatment. What is the mechanism of the A. Vitamin A
drug’s action? 2011 B. Vitamin D
A. It stimulates the activity of monoamine oxidase C. Vitamin K
B. It inhibits the activity of Na+, K+-ATP-ase D. Vitamin E
C. It blocks the activity of H1 histamine receptors * E. Vitamin C *
D. It inhibits the activity of choline esterase 5. The patient should be told to avoid taking supplemental
E. It blocks the adrenergic receptors vitamin B6 (pyridoxine) if he is being treated with one of
42. A patient developed Quincke's edema after penicillin these drugs:
introduction. Which agent should be administered? 2014 A. Digoxin for heart failure
A. No-spa B. Haloperidol
B. Prednisolone * C. Niacin for hypertriglyceridemia
C. Ascorbic acid D. Levodopa for Parkinson’s disease *
D. Sulfacyl sodium E. Phenytoin for epilepsy
E. Rifampicin 6. You have a patient who has been consuming
43. A patient with insomnia induced by allergic rash and extraordinarily large amounts of alcohol for several years.
itch has been administered the drug that has antihistamine He goes into acute withdrawal and manifests nystagmus
and hypnotic effect. Specify this drug: 2016 and bizarre ocular movements and confusion (Wernicke’s
A. Analgin encephalopathy). Although this patient’s alcohol
B. Benadryl * consumption pattern has been accompanied by poor
C. Loratidine nutrient intake overall, you specifically manage the
D. Prednisolone encephalopathy by administering one of these drugs.
E. Acetylsalicylic acid Choose the correct answer.
A. Vitamin A
16.
B. Folic acid
A.
C. Vitamin B12 (Cyanocobalamin)
B.
D. Vitamin E (alpha-tocopherol)
C.
E. Vitamin B1 (Thiamine)*
D.
E. 7. Indicate the main feature of trisaminum (trometamol)
that sodium bicarbonicum is unable:
A. It is available for taking orally
B. It is available for IV infusion
C. It penetrates into the cell, binding to hydrogen
ions outside and inside the cell*
D. It does not penetrate into the cell that is why it
eliminates extracellular acidosis only
12. Vitamins. Enzymes and Enzymatic inhibitors. E. It increases BP
Agents, regulating fluids and electrolytes balance
8. You are doing summer volunteer work at health clinic in
1. Hydroxylation of the endogenous substrates and a very poor region of the world. A 19 y.o. woman is
xenobiotics requires a donor of protons. Which of the diagnosed vitamin D-resistant rickets. Apart from a high-
following vitamins can play this role? dose of vitamin D and oral phosphate, an additional
A. Vitamin A therapeutic approach might be used. What agent should
B. Vitamin B6** you choose?
C. Vitamin C A. Estrogen
D. Vitamin E B. Hydrochlorothiazide
E. Vitamin K C. Folic acid
D. Calcitriol*
2. Which vitamin or nutrient, also an ingredient in some
E. Vitamin B12
prescription medications for severe, refractory acne
vulgaris, is “highly” teratogenic and should not be 9. A 57 y.o. postmenopausal woman develops weakness,
administered pregnant women? polyuria, polydipsia, and significant increases of palsma
25
creatinine concentration. A computed tomogram (CT scan) D. Tocopherol
indicates nephrocalcinosis. A drug is considered to be the E. Acetylsalicylic acid
cause. Which drug is the most relevant? 17. Radiation therapy is performed to the patient. What
A. Prednisolone vitamin drug with antioxidant properties is to administer to
B. Estrogen increase stability of tissues?
C. Vitamin D* A. Thiamine chloride
D. Metformin B. Vitamin B6
E. Progesterone C. Ascorutin *
10. Which drug is used for the treatment of megaloblastic D. Cyanocobalamin
anemia? E. Folic acid
A. Vitamin A 18. Define a vitamin, which participates in oxidative
B. Folic acid* phosphorylation:
C. Riboflavin A. Nicotinic acid *
D. Vitamin E (alpha-tocopherol) B. Thiamine
E. Vitamin B1 (Thiamine) C. Ascorbic acid
D. Tocopherol
11. Which drug is used to inhibit pancreas function? E. Ergocalciferol
A. Urokinase 19. The patient treated with a vitamin for prophylaxis of
B. Pancreatin vasospasm of the brain complains of the unpleasant
C. Alteplase sensations related to the drug administration: reddening of
D. Contrical (Gordox)* the face and the upper half of a trunk, giddiness, sense of
E. Lydazum flush of blood to a head. Which drug was administered?
12. A patient with symmetric dermatitis of open-area-skin A. Tocofecol acetate
consults a doctor. Which vitamin deficit is the most B. Nicotinamidum
possible in this patient? C. Thiamine bromide
A. Calciferol D. Nicotinic acid *
B. Folic acid E. Calcium pangamate
C. Nicotinic acid * 20. Diarrhea, dementia and dermatitis are observed in a
D. Vitamin E (alpha-tocopherol) patient. Which vitamin should be included into a complex
E. Ascorbic acid treatment?
13. Indicate the vitamin, which deficiency can produce A. Thiamin
sterility in experimental animals, and which is applied to B. Cyanobalamine
complex treatment of female infertility: C. Nicotinamide (vitamin PP) *
A. Vitamin A D. Calcium pantothenate
B. Vitamin K E. Cyanocobalamine
C. Vitamin B1 21. Bioflavonoids (rutin, quercetin) possess all listed below
D. Vitamin D pharmacodynamic effects, except for:
E. Vitamin E * A. Antioxidant activity
B. Dilation of capillaries *
14. A 45 y.o. patient was admitted to the hematological C. Inhibition of hyaluronidase activity
department with acute anemia: RBCs 1.5 x 1012/L, Hb D. Protections of ascorbic acid, assistance to its transport
80g%, colour index 1.3. Hyperchromic anemia was and accumulation
diagnosed. Which drug should be administered to the E. Decrease of capillary wall permeability
patient?
A. Hemostimulin 22. A woman suffers from hemeralopia (disturbance of vision
B. Ergocalciferol in darkness). What vitamin should be recommended?
C. Cyanocobalamine * A. Riboflavin
D. Ferrum-Lek B. Tocoferol acetate
E. Folic acid C. Pyridoxine
D. Ascorbic acid
15. Which acid decreases permeability of connective tissue E. Retinol acetate *
structures, possesses antioxidant activity due to ability to 23. What vitamin promotes growth and development of
be transformed from the oxidized from into reduced and on epithelial cells, including epidermal ones?
the contrary? A. Retinol *
A. Aspirin (acetylsalicylic acid) B. Ergocalciferol
B. Hydrochloric acid C. Ascorbic acid
C. Mefenamic acid D. Nicotinic acid
D. Ascorbic acid * E. Lipoid acid
E. Aminocaproic acid
24. A 37 y.o. patient suffers from hyperkeratosis, disturbance of
16. For synthesis of the basic substances of connective vision in darkness, frequent infectious diseases. Which vitamin
tissue (mucopolysaccharides and collagen) an essential should be administered?
agent is: A. Pyridoxin
A. Nicotinic acid
B. Retinol B. Retinol acetate *
C. Folic acid *
26
 C. Riboflavin A. Pyridoxine
D. Ergocalciferol B. Vicasol
E. Tocopherol acetate C. Tocopherol acetate
25. The patient had been taking vitamin D for a long time D. Thiamine chloride
for rickets. The phenomena of intoxication have developed: E. Retinol acetate *
depression of appetite, nausea, headache, fatigue, disorders 33. A 64 y.o. woman has impairment of twilight vision
of sleep, increase of body temperature, changes in urine – (hemeralopy). What vitamin should be recommended in the
hyaline cylinders, protein, leucocytes. What vitamin drug first place?
should be administered to weaken arisen symptoms? A. Vitamin E
A. Vicasol (Menadione) B. Vitamin A
B. Vitamin B12 C. Vitamin C
C. Vitamin A (Retinol acetate) * D. Vitamin B6
D. Vitamin PP E. Vitamin B2
E. Riboflavin
26. What vitamin is formed in skin under influence of 34. A sportsman was recommended to take a medication
ultraviolet radiation? that contains carnitine in order to improve his results. What
A. Ascorbic acid process is activated by carnitine the most?
B. Retinol acetate A. Synthesis of ketone bodies
C. Calcium pantothenate B. Synthesis of steroid hormones
D. Riboflavin C. Synthesis of lipids
E. Cholecalciferol * D. Tissue respiration
E. Fatty acids transport to mitochondrions *
27. Parasthesia, xeroderma and sticking out fontanel are
observed at the 6 months child under the treatment by a 35 Examination of a man who hadn’t been consuming fats
vitaminic drug. Specify this drug. but had been getting enough carbohydrates dermatitis, poor
A. Retinol acetate wound healing, vision impairment. What is probable cause
B. Pyridoxine of metabolic disorder?
C. Riboflavin A. Lack of oleic acid
D. Ergocaiciferol * B. Low caloric value of diet
E. Tocoferol acetate C. Lack of palmitic acid
28. What of the listed below vitaminic drugs possesses D. Lack of vitamins PP, H
expressed radioprotctive property? E. Lack of linoleic acid, vitamins A, D, E, K *
A. Ergocaiciferol 36 Removal of gall bladder of a patient has disturbed
B. Thiamine chloride processes of Ca2+ absorption through the intestinal wall.
C. Riboflavin What vitamin will stimulate this process?
D. Tocoferol acetate * A. PP
E. Folic acid B. B12
29. The dentist administered to his patient liposoluble C. C
vitamin with antioxidant activity for treatment of D. K
parodontitis. Indicate this vitaminic drug: E. D3 *
A. Ascorbic acid
B. Tocoferol acetate * 37 A patient diagnosed with focal tuberculosis of the upper lobe
C. Rutin of the right lung receives isoniazid as a part of combination
D. Nicotinic acid therapy. After some time the patient reported of muscle
E. Ergocaiciferol weakness, decreased skin sensitivity, blurred vision, impaired
motor coordination. Which vitamin preparation should be used
30. What enzymatic drug is used with the purpose of to address these phenomena? 2013
reduction of density and rising of permeability of A. Vitamin C
connective tissue structures? B. Vitamin B6 *
A. Amylase C. Vitamin E
B. Lipase D. Vitamin D
C. Cocarboxylase E. Vitamin B12
D. Cholinesterase
E. Lydase * 38. A 66 y.o. woman had intravenous injection of
magnesium sulfate solution to stop hypertensive crises.
31. According to clinical indications a patient was However her arterial pressure did not decrease and after
administered pyridoxal phosphate. What processes is this repeated introduction of the same preparation she
medication intended to correct? developed sluggishness, slow response to stimuli; the
A. Dissemination of purine nucleotide patient is unconsciousness and her respiration is inhibited.
B. Synthesis of purine and pyrimidine bases What preparation is antagonist of magnesium sulfate and
C. Transamination and decarboxylation of aminoacids * can remove the symptoms of its overdose? 2015
D. Protein synthesis A. Sodium chloride
E. Oxidative decarboxylation of kenotic acids B. Potassium chloride
32. A patient suffers from vision impairment – hemeralopy C. Potassium permanganate
(night blindness). What vitamin preparation should be D. Activated carbon
administered to the patient to restore his vision? E. Calcium chloride*
27
39. A patient addressed to a doctor with complaints of acute Hydrogen Peroxide to be cleaned from the pus. Foam was
worsening of vision in the evening time and the conditions not observed. What caused inefficiency of the drug?
of a dull light, sensation of dryness and cutting pain in eyes, A. Pus in the wound
dryness and peeling of the skin. In patient’s examination: B. Shallow wound
eye conjunctiva is dull, with whitish spots, hyperkeratosis C. Inherited insufficiency of catalase*
of the skin. Indicate the type of hypovitaminosis and the D. Low concentration of H2O2
drug, which should be used for the treatment. E. Inherited insufficiency erythrocyte’s
A. Vitamin D phosphatdehydrogenase
B. Vitamin C
C. Vitamin E 2. Determine the drug: it possesses antiseptic and
D. Vitamin B12 deodorizing action. In the presence of organic compounds
E. Vitamin A * it releases oxygen, which provides antiseptic and
deodorizing effects. In high concentrations it exerts
40. How can you explain the fact that the isoniazid doze for
irritative and cauterizing action. The drug is administered
the treatment of tuberculosis is selected individually with
in the form of solution for rinsing, syringing, washing of
the obligatory control of concentration of the medication in
wounds, disinfection of burns, gastric lavage in poisonings
urine after its first application?
by morphine and other alkaloids.
A. Development of hemolytic anaemias
A. Silver nitrate
B. Hyperglycemia after drug administration
B. Furacilinum
C. Development of renal insufficiency
C. Potassium permanganate *
D. Irritating effect of the drug
D. Hydrogen peroxide
E. Genetically caused methylation of the drug*
E. Iodophormum
41. A 10 y.o. girl has a history of repeated acute respiratory
3. Burned skin surface has been treated with a preparation
viral infection. After recovering she presents with multiple
which antiseptic properties are provided by atomic oxygen
petechial hemorrhages on the sites of friction from clothing
that is formid in presence of organic substances. What
rubbing the skin. What kind of hypovitaminosis has this
preparation was applied? 2010
girl? 2011
A. Sodium hysrocarbonate
A. B1
B. Alcoholic iodine solution
B. B2
C. Furacilin
C. A
D. Chlorhexidine
D. C *
E. Potassium permanganate *
E. B6
4. A 23 y.o. patient addressed to an ophthalmologist with
42. In order to accelerate healing of a radiation ulcer a
complaints of eye discomfort, discharge of purulent
vitamin drug was administered. What drug is it? 2011
exudate, disorders of vision. Specify the antiseptic to rinse
A. Retinol acetate
the eyes:
B. Retabolil
A. Lugol’s solution
C. Prednisolone
B. Potassium permanganate
D. Levamisole
C. Ammonium solution
E. Methyluracil
D. Silver nitrate*
43. Obstructive jaundice and biliary fistulas are often E. Chlorhexidinum
accompanied by prothrombin deficiency. Which vitamin 5. What is the most important influence of Iodophormum
deficiency is it connected with? on the microorganisms?
A. E A. Bactericidal and sporicidal effect*
B. K * B. Bacteriostatic and sporicidal effect
C. A C. Fungistatic effect
D. C D. Bactericidal effect
E. B6 E. Sporicidal effect
44. A patient complaints of photoreception disorder and 6. Indicate the antiseptic, which belongs to the group of
frequent acute viral diseases. He has been administered a oxidizers.
vitamin that affects photoreception processes by producing A. Silver nitrate
rhodopsin, the photosensitive pigment. What vitamin is it? B. Furacilin
2016
C. Potassium permanganate
A. Cyanocobalamine D. Hydrogen peroxide
B. Tocopherol acetate E. C and D*
C. Pyridoxine hydrochloride
7. A doctor used 5% spirituous solution of iodine for
D. Thiamine
operation field cleaning. Indicate its mechanism of action:
E. Retinol acetate *
A. Inhibition of dehydrogenase
B. Interaction with amino groups of microbes
proteins that promotes to their denaturation*
13. Antiseptics and Disinfectants C. Dehydration of protoplasm’s proteins
D. Binding to enzymes’ sulfhydryl groups
1. A patient with the abscess of the cut wound applied to E. Formation of albuminates
the traumatologist. The wound was washed with 3%
28
8. What is the most important influence of iodine on the 17. Chloramine possesses all following effects, except:
spore? A. Antiseptic
A. Bacterial effect B. Deodorizing
B. Inhibition C. Spermicidal
C. Absorption to bacterial membranes D. Fading
D. Sporicidal effect* E. Antiallergic*
E. Fungistatic effect
18. 70% solution of ethyl alcohol is used for surgeon’s
9. What is the most important influence of iodophor on hands cleaning before operation. Explain the mechanism of
the microorganism? action of the drug:
A. Bactericidal and sporicidal effect * A. Protein dehydration of microbes’ protoplasm*
B. Bacteriostatic and sporicidal effect B. Interaction with hydroxyl groups of microbes’ enzymes
C. Bactericidal effect C. Interaction with aminogroups of protoplasm proteins of
D. Fungistatic effect microbes
E. All above D. Blockade of sulfhydryl groups of enzymes
E. Oxidation of organic components of microbes
10. What are the sporicidal concentrations of hydrogen
protoplasm
peroxide?
A. 10-25% *
19. Which antiseptic is used for surgical tools cleaning?
B. 0,5-1,5%
A. Furacilin
C. 60-90%
B. 70% solution of ethyl alcohol
D. 40-45%
C. 95% solution of ethyl alcohol*
E. 0.001-0,005%
D. Ethonium
12. Indicate the antiseptic which is used for disinfection of E. Resorcin
operation field and surgeon’s hands:
14. Antibiotics
A. Furacilin
B. 70% solution of ethyl alcohol* 1. Choose the drug for 6 months old child with mycoplasma
C. 95% solution of ethyl alcohol infection:
D. Ethonium A. Tetracycline
E. Resorcin B. Streptomycin
C. Clotrimazole
13. A 57 y.o. patient with varicose dilation of veins
D. Erythromycin *
develops the trophic ulcer of the leg. The bacteriological
E. Penicillin
examination of the ulcer discharge has revealed
Staphylococcus infection. Determine the antiseptic in the 2. Which antibiotic is not used in myasthenia gravis?
form of ointment from the group of detergents for local A. Tetracycline
treatment of the ulcer: B. Gentamicin*
A. Ethonium* C. Clarithromycin
B. Brilliant green D. Ceftriaxone
C. Furacilin E. Azithromycin
D. Potassium permanganate 3. A 20 y.o. patient was hospitalized to the surgical
E. Ethacridin lactate department due to infection caused by blue pus bacillus
(Pseudomonas aeruginosa), which is sensitive to penicillin
14. Determine the drug: it contains a halogen, exerts antibiotics. Indicate which penicillin has a marked activity
antimicrobial and deodorizing action, is used for on the Pseudomonas aeruginosa?
disinfection of non-metal instruments, domestic use items A. Benzylpenicillin
and premises; as an antiseptic – for processing of hands: B. Methicillin
A. Chloramine * C. Phenoxymethylpenicillin
B. Hydrogen peroxide D. Carbenicillin *
C. Formaldehyde E. Oxacillin
D. Phenol
E. Resorcin 4. A patient with pneumonia was treated with antibiotics
for a long period. After the treatment the patient complains
15. All antiseptics possess all following properties except: of frequent and watery stools, abdominal pain. What is the
A. Selective antimicrobial action* reason of intestinal disorder?
B. Versatile antimicrobial action A. Hereditary enzyme defect
C. Are not introduced parenterally B. Bacteria toxins influence
D. Highly toxic for human C. Intestinal dysbacteriosis development *
E. Bactericidal action D. Antibiotics toxic influence on the GIT
16. Formaldehyde solution is used for disinfection of non- E. Allergic reaction
metallic surgical tools. Indicate the name of drug group of 5. Purulent endometritis developed in a woman after delivery.
formaldehyde: Treating with antibiotics inhibitors of murein synthesis was
A. Aromatic agent ineffective. Wide spectrum bactericidal antibiotic was
B. Aliphatic agent* administered. In 6 hours to rapidly increased up to 40oC with
C. Alcohols shiver. Muscle pains have appeared. BP dropped down to
D. Halogen-containing agents
E. Detergents
29
70/40 mm Hg, oliguria. What is the reason for the 12. Which of the following drugs is the most effective agent
development of this condition? in the treatment of rickettsia, mycoplasma, and chlamydia
A. Toxic effect of preparation infections?
B. Endotoxic shock* A. Penicillin
C. Anaphylactic shock B. Gentamicin
D. Bacteremia C. Erythromycin
E. Internal bleeding. D. Chloramphenicol
E. Tetracycline*
6. Choose the drug of choice for cholera prophylaxis:
A. Chloramphenicol 13. Streptomycin and other aminoglycosides inhibit
B. Benzylpenicillin bacterial protein synthesis by binding with one of the
C. Doxycycline * following substances.
D. Erythromycin A. 30S ribosomal particles*
E. Streptomycin B. DNA
C. mRNA
7. Antibiotic, which acts by inhibiting cell wall synthesis
D. Peptidoglycan units in the cell wall
A. Penicillin*
E. RNA polymerase
B. Gentamycin
C. Doxycycline 14. Which cefalosporin would have increased activity
D. Chloramphenicol against anaerobic bacteria such as Bacteroides fragilis?
E. Tetracycline A. Cefaclor
B. Cephalexin
8. All of the following clinical indication may require a
D. Cephalotin
combination of antibiotics (rather than a single agent)
D. Cefoxitin *
EXCEPT:
E. Ceftriaxone
A. Treatment of mixed infections
B. Treatment of gonorrhea * 15. A child who previously was healthy develops bacterial
C. Treatment of tuberculosis meningitis. Assuming no specific contraindications, which
D. Treatment of meningitis of the following drugs will you prescribe?
E. Treatment of bacterial endocarditis A. Erythromycin
B. Tetracycline
9. A 50 y.o. woman who had underwent chemotherapy for
C. Doxicycline
lymphoma a week ago was brought to the emergency room.
D. Ceftriaxone*
She had a fever of 40.3oC and was confused. Respiration
E. Novocain penicillin
was rapid, BP 75/40 mm Hg. She was neutropenic. Gram’s
strains of the urine and sputum are negative. Which of the 16. A patient being treated for springtime allergies with
following actions is the most beneficial to the patient? loratadine develops an upper respiratory problem. He
A. Send a clinical sample to the laboratory for receives an antibiotic and develops a cardiac arrhythmia.
identification and then administer an appropriate Which antibiotic it was?
antibiotic. A. Cefaclor
B. Administer a combination such as Clindamycin and B. Oxacillin
an aminoglycoside * C. Cefalotin
C. Administer a broad-spectrum antibiotic like D. Erythromycin*
Tetracycline E. Amoxicillin
D. Administer Clindamycin
17. Which of the following drugs is both penicillinase-
E. Administer Tobramycin
resistant and effective by oral administration?
10. A 60 y.o. alcoholic male with poor dental hygiene is to A. Methicillin
have his remaining teeth extracted for subsequent dentures. B. Carbenicillin
He has mitral valve stenosis with mild cardiac insufficiency C. Ceftriaxone
and is being treated with captopril, digoxin and furosemide. D. Amoxicillin plus clavulanic acid*
The dentist decides that his medical history warrants E. Procaine penicillin
prophylactic antibiotic therapy prior to the procedure and
18. The penicillin that is effective against Proteus and
prescribes:
Pseudomonas aeruginosa is:
A. Vancomycin
A. Ampicillin
B. Amoxicillin*
B. Amoxiclav
C. Tetracycline
C. Amoxicillin
D. Co-trimoxazole
D. Carbenicillin*
E. Imipenem
E. Oxacilline
11. A 35 y.o. man has an infection with Legionella.
19. Chronic ulceration would most likely occur after
Assuming no contraindications, which of the following
administration of:
drugs should you choose?
A. Carbenicillin
A. Penicillin
B. Clindamycin *
B. Gentamicin
C. Chloramphenicol
C. Erythromycin *
D. Gentamycin
D. Chloramphenicol
E. Doxycycline
E. Tetracycline
30
20. The penicillin with the longest duration of action is: 28. Determine the drug that is able to penetrate to bone
A. Benzylpenicillin-natrium tissue and bone marrow to treat bone infections:
B. Amoxicillin A. Gentamicin
C. Procaine penicillin B. Neomycin
D. Bicillin-5* C. Clindamycin*
E. Ampicillin D. Oleandomycin
E. Erythromycin
21. Inhibition of protein chain initiation at the ribosomal
level is the principal mechanism of antibacterial action of. 29. Staphylococcus aureus resistant to methicillin and other
A. Chloramphenicol beta-lactam antibiotics has revealed in bacteriological
B. Amikacin blood test of a 27 y.o. woman with puerperal sepsis. Which
C. Erythromycin * drug should be administered?
D. Tetracycline A. Vancomycin*
E. Benzylpenicillin-natrium B. Tetracycline
C. Cefazoline
22. Acute enterocolitis was developed in a three-month
D. Gentamycin
baby upon artificial feeding. What drug should be
E. Amphotericin
administered to the patient?
A. Polymyxine M* 30. A patient with diminished hearing has severe bacillary
B. Tetracycline infection. Which pharmacological group is
C. Erythromycin contraindicated to the patient?
D. Oxacillin A. Tetracyclines
E. Streptomycin B. Macrolides
C. Tetracyclines
23. Most serious adverse effect of penicillins is:
D. Aminoglycosides*
A. Skin rashes
E. Fluoroquinolones
B. Jarish Hexheimer reaction
C. Anaphylaxis * 31. Infectious agent determined by lab tests is known to be
D. Convulsions sensitive to third generation cephalosporins. Choose the
E. Urticaria drug for treatment:
A. Cefazolin
24. Mechanism of action of Chloramphenicol in B. Cefalotin
prokaryotes: C. Cefalexin
A. Interferes DNA synthesis D. Cefoperazone
B. Interferes with cell wall synthesis E. Ceftriaxone *
C. Binds with 50S ribosome *
D. Causes m-RNA misreading 32. A patient with stomach ulcer has been treated with an
E. Interfere RNA syntesis antacid drug almagel. For acute bronchitis treatment he was
prescribed antibiotic methacycline. However within next 5 days
25. To treat an exacerbation of chronic pyelonephritis the fever didn’t fall, cough and sputum nature remained unchanged.
doctor has prescribed a drug from the group A physician came to the conclusion that the drugs were
fluoroquinolones. What is the mechanism of antimicrobial incompatible. What type of drug incompatibility is the case?
action of fluoroquinolones? A. Pharmaceutical
A. Inhibition of DNA-gyrase B. Pharmacodynamic
B. Inhibition of synthesis of peptidoglycan C. Pharmacokinetic, absorption stage *
C. Inhibition of protein synthesis by binding to 30S D. Direct antagonism
ribosomes E. Pharmacokinetic, biotransformation stage
D. Inhibition of protein synthesis by binding to 50S
ribosomes 33. As a result of durative antibiotic therapy a 37-y.o.
E. Increasing of bacterial wall permeability patient developed intestinal dysbacteriosis. What type of
drugs should be used in order to normalize intestinal
26. A patient suffers from severe postoperative microflora?
pseudomonades infection. Which antibiotic should be A. Sulfanilamides
administered in this case? B. Vaccines
A. Amikacin sulfate * C. Bacteriophages
B. Benzylpenicillin D. Vitamins
C. Erythromycin E. Eubiotics *
D. Cephazolin
E. Doxycycline 34. A 5 y.o. child has been diagnosed with acute right side
pneumonia. Sputum inoculation revealed that the causative
27. An antibiotic with ability to penetrate to bone tissues agent is resistant to penicillin, but is sensitive to
and cumulate there was administered to 25 y.o. patient macrolides. Which drug should be administered? 2012
with osteomyelitis. After 3 weeks of using it the patient A. Tetracycline
felt much better. Indicate the drug: B. Streptomycin
A. Chloramphenicol (Levomicetin) C. Ampicillin
B. Oxacillin D. Azithromycin *
C. Ampicillin E. Gentamycin
D. Penicillin
E. Lincomycin*
31
35. A patient underwent appendectomy. In the be drug-induced: cough, dyspnea, and pulmonary
postoperative period he has been administered an infiltrates; neutropenia and bleeding tendencies. Which of
antibiotic. The patient complains about hearing impairment the following can most likely cause this patient’s
and vestibular disorders. What group of antibiotics has symptoms?
such by-effects? 2012 A. Amoxicillin
A. Tetracyclines B. Ciprofloxacin
B. Macrolides C. Azithromycin
C. Penicillins D. Furadonin (Nitrofurantoin)*
D. Aminoglycosides* E. Isoniazid
E. Cephalosporins
3. Hypokalemia is not caused by:
36. Administration of doxycycline hydrochloride caused A. Amphotericin B
an imbalance of the symbiotic intestinal microflora. B. Enalapril *
Specify the kind of imbalance caused by the antibiotic C. Etacrinic acid
therapy: 2016 D. Furosemide
A. Dysbacteriosis * E. Hydrochlorthiazide
B. Superimposed infection
4. Which of the following drugs is primarily used in
C. Bacteriosis
amebiasis and leishmaniasis as well as anaerobic bacterial
D. Idiosyncrasy
infections?
E. Sensibilization
A. Сo-Trimoxazole (Biseptol)
37. A 50 y.o. patient has been administered levomicetin B. Ciprofloxacin
for the treatment of typhoid fever, but the next day the C. Azithromycin
patient’s condition worsened, the temperature rose to D. Metronidazole*
39.6o C. The deterioration of the patient’s condition can be E. Carbenicillin
explained by: 2013
A. Secondary infection 5. A patient requires an antibiotic that is the most effective
B. Insensitivity of the pathogen to levomicetin against Pseudomonas aeruginosa. Which of the following
C. Effects of endotoxins of the causative agent * drugs is the quinolone of choice?
D. Re-infection A. Ofloxacin
E. Allergic reaction B. Ciprofloxacin*
C. Lomefloxacin
38. A 26 y.o. female patient with bronchitis has been D. Norfloxacin
administered a broad spectrum antibiotic as a causal E. Enoxacin
treatment drug. Specify this drug: 2016
A. BCG vaccine 6. Which property or mechanism of action is shared by the
B. Doxycycline * penicillins, the cephalosporins, and Amphotericin B?
C. Dexamethasone A. Act, though various mechanisms, on cell walls or
D. Ambroxole membranes of susceptible organisms*
E. Interferon B. Contraindicated in immunocompromised patients
39. A patient with acne has prescribed doxycycline C. Interact with many drugs by inducing their hepatic
hydrochloride. What recommendations should be given to metabolism
the patient while he is taking this drug? 2016 D. Interact with many drugs by inhibiting their hepatic
A. The course of treatment should not exceed 1 day metabolism
B. Avoid long stay in the sun * E. Nephrotoxicity precludes use in patients with impaired
C. Take before meal renal function
D. Take with large quantities of liquid, preferably milk
E. Do not take with vitamins 7. A 37 y.o. woman complains of itching in the vulval area.
Hanging-drop examination of the urine reveals
trichomonads. Which of the following drugs is preferred
for the treatment of trichomoniasis?
A. Amoxicillin
B. Ciprofloxacin
15. Sulfonamides, Fluoroquinolones,
C. Azithromycin
Nitrofurans, Quinoxalines, and Antifungal agents D. Furadonin (Nitrofurantoin)
E. Metronidazole *
1. A 25 y.o. man with acquired immunodeficiency
syndrome (AIDS) develops cryptococcal meningitis. He 8. A 28 y.o. patient with an opportunistic infection with
refuses IV medication. Which of the following antifungal Pneumocystis carinii is receiving a combination of
agents is the best choice for the oral therapy of meningitis? sulfamethoxazole and trimethoprim. What is the
A. Fluconazole * mechanism by which this combination exerts its desired
B. Amphotericin B effects – and does it better than if just one of the drugs was
C. Ketoconazole administered?
D. Metronidazole A. The combination exerts significant antiviral activity
E. Nystatin B. Sulfamethoxazole permeabilizes bacterial cell walls,
allowing better penetration of trimethoprim
2. A patient on antimicrobial therapy develops the
C. Trimethoprim inhibits normal transmission of resistance
following signs and symptoms that ultimately are found to
factors directed aginst Sulfamethoxazole
32
D. They inhibit sequential steps in bacterial synthesis of E. Ceftriaxone
tetrahydrofolic acid* 17. A patient consulted a dentist about itching and burning
E. Trimethoprim kills gut flora that otherwise would in the oral cavity, high temperature. The patient was
reduce oral bioavailability of the Sulfamethoxazole diagnosed with trichomonal gingivostomatitis. Whoch
drug should be chosen for his treatment? 2012
9 A patient has been diagnosed with gonorrhea after A. Ampicillin
bacterioscopy of the smear from urethra. Taking into B. Nystatin
account that agents of choice for the treatment of gonorrhea C. Gentamicin sulfate
are fluoroquinolones the patient is necessary to administer: D. Doxycycline hydrochloride
A. Erythromycin E. Metronidazole*
B. Ciprofloxacin* 18. Some infectious diseases caused by bacteria are treated
C. Furazolidone with sulfonamides which block the synthesis of bacteria
D. Clarithromycin growth factor. What is the mechanism of their action? 2013
E. Rifampicin A. They are allosteric enzyme inhibitors
10. Trimethoprim: B. They are involved in redox processes
A. Is less potent that sulfamethoxazole C. They inhibit the absorption of folic acid
B. Inhibits formation of dihydrofolic from PABA D. They are antivitamins of para-amino-benzoic acid
C. Inhibits dihydrofolate reductase * E. They are allosteric enzyme
D. Resistance has not been observed in microorganisms.
E. Stimulates purine synthesis 19. The diagnosis of sepsis has been made to a patient. It
was decided to use a drug from the group of
11. A patient with pneumonia has intolerance to antibiotics. fluoroquinolones. Determine this drug.
Which combined sulfonamide preparation should be A. Erythromycin
administered for the treatment of this patient? B. Ciprofloxacin
A. Sulfadimezine C. Gentamycin
B. Sulfadiazine D. Tetracyclines
C. Co-trimoxazole* E. Amikacin
D. Sulfasalazine
E. Sulfamethoxazole 16. Antituberculous and Antiviral drugs
12. Maximum endocrinal side effects (gynecomastia, 1. .A bactericidal antitubercular drug is:
impotence) are seen with: A. Streptomycin*
A. Ketoconazole * B. Ethionamide
B. Fluconazole C. Pyrazinamide
C. Myconazole D. Thioacetazone
D. Nystatin E. Ethambutol
E. Ampicilline
2. As part of multidrug attack on patient’s infection with
13. Determine the drug: it is for the treatment and Mycobacterium tuberculosis, a physician plans to use an
prophylaxis of gonorrheal infection of eyes in newborns aminoglycoside antibiotic. Which drug is the most active
and adults, in conjunctivitis, blepharitis, and corneal ulcers. against the tubercle bacillus and seems to be associated
It is well dissolved in water. The mechanism of action is with the fewest problems with resistance or typical
competitive antagonism with PABA. aminoglycoside-induced adverse effects?
A. Ceftriaxone A. Streptomycin*
B. Sulfacyl-sodium * B. Kanamycin
C. Griseofulvin C. Neomycin
D. Aethazolum D. Amikacin
E. Furacilin E. Tobramycin
14. Nalidixic acid is useful in: 3. Primary mechanism of action of zidovudine is:
A. Urinary tract infection* A. Proliferation of B and T cells
B. Bacillary dysentery B. Inhibition of reverse transcriptase *
C. Enteric fever C. Activation of macrophages
D. Malaria D. Stimulation of lymphocytes
E. Clamidiosis E. Blockade of leukotriene receptors
15. Sulfanilamides act by: 4. A 35 y.o. man under the treatment for pulmonary
A. Covalent modification tuberculosis has acute-onset of right big toe pain, swelling,
B. Non competitive inhibition * and low-grade fever. The gouty arthritis was diagnosed and
C. Allosteric modification high serum uric acid level was found. Which drug is known
D. Competitive inhibition to cause high uric acid level?
E. Covalent connection A. Rifampicin
16. All the following antibiotics act on cell wall except: B. Para-aminosalicylic acid
A. Ampicillin C. Thiacetazone
B. Carbenicillin D. Pyrazinamide*
C. Amphotericin B E. Cycloserine
D. Griseofulvin* 5. Neuropsychiatric side effect is a manifestation of:
33
 A. Ethosuximide and a Hb of 9.0 mg/dL. Which of the following drugs most
B. Cycloserine* likely caused the hematological abnormalities?
C. Pyrazinamide A. Rimantadine
D. Rifampicin B. Midantane
E. Ampicillin C. Acyclovir
D. Foscarnet
6. Primary mechanism of action of indinavir is:
E. Zidovudine*
A. Proliferation of B and T cells
B. Inhibition of transcriptase 13. A patient with AIDS is treated with a combination of
C. Activation of macrophages agents, one of which is Zidovudine. This drug exerts its
D. Stimulation of lymphokines main effects by inhibiting:
E. Inhibition of HIV-proteases* A. Viral proteases
B. Viral particle assembly
7. A patient with tuberculosis is being treated with
C. RNA synthesis
isoniazid. He develops paresthesias, muscle pain, and
D. Non-nucleoside reverse transcriptase
unsteadiness. Which vitamin needs to be given in order to
E. Nucleoside reverse transcriptase*
reverse these symptoms – or used from the outset to prevent
them in high-risk patients? 14. All of the following drugs are bactericidal except:
A. Vitamin A A. Cephalexin
B. Vitamin C B. Rifampicin
C. Vitamin K C. Isoniazid
D. Vitamin B1 (thiamine) D. Tetracycline *
E. Vitamin B6 (pyridoxine)* E. Ceftriaxone
8. A 59 y.o. man is diagnosed tuberculosis. Before prescribing 15. Blue vision is caused by:
a drug regimen, you take a careful medication history because A. Digoxin
one of the drugs commonly used to treat tuberculosis induces B. Rifampicin
microsomal cytochrome P-450 enzymes in the liver. Which C. Ethambutol *
drug is it? D. Chloroquine
A. Rifampicin* E. Nystatin
B. Vitamin B6 (pyridoxine)
16-20. Determine the drug or drug group:
C. Isoniazid
16. The drugs possess high bacteriostatic activity only
D. Pyrazinamide
against the agent of the severe long lasting infectious
E. Ethambutol
disease. They are well absorbed from the GIT, penetrate
9. A patient with active tuberculosis is being treated with through haemoatoencephalic barrier, and are excreted
isoniazid and ethambutol as part of the overall regimen. through kidneys.
Which of the following statements is the main reason for In organisms of different patients these drugs are
including the ethambutol? inactivated with different speed due to genetically
A. To facilitate entry of isoniazid into the mycobacteria determined distinct degree of activity of enzymes, effecting
B. To facilitate penetration of the blood-brain barrier their acetylation in the liver.
C. To slow renal excretion of isoniazid These drugs should be administered carefully to
D. To retard the development organism resistance* patients suffering from epilepsy because of their
E. To retard absorption after IM injection stimulating influence on the CNS, which may cause
rapidness of convulsion. - E
10. As a part of a multidrug attack on a patient’s infection with
17. It is the synthetic antituberculous drug, which acts
Mycobacterium tuberculosis, a physician plans to use an
on the mycobacteria stable to streptomycin, preparation of
aminoglycoside antibiotic. Which of the following drugs is the
HINA and PAS. It doesn’t affect the rest pathogenic
most active against the tubercle bacillus and seems to be
microorganisms. It is well absorbed from the GIT. It is
associated with the fewest problems with resistance or typical
taken once a day after breakfast.
aminoglycoside-induced adverse effects?
Its characteristic side effect is affection of the eye:
A. Amikacin
narrowing of peripheral vision, formation of scotomas,
B. Kanamycin
decrease of sharpness of vision and capability of red and
C. Neomycin
green colors differentiation.
D. Streptomycin*
Having stopped taking this drug these disorders go off
E. Tobramycin
independently. - B
11 Amantadine (midantane), used prophylactically against 18. It is the synthetic anti-tuberculous drug, which
influenza A2, is thought to act by: possesses moderate antituberculous activity. Its toxicity is
A. Preventing production of viral capsid protein low, that’s why its daily dose is 9 – 12 g, so it may lead to
B. Preventing uncoating of viral DNA* the development of some complications: stomachache,
C. Causing lysis of infected host cell by release of nausea, loss of appetite, allergic reactions, increase of size
intracellular lysosomal enzymes and pain in the liver, goiter-genic effect. - C
D. Preventing penetration of the virus into the host cell 19. Antibiotics produced by radiant fungi, widely used
E. Preventing virion release for complex treatment of all forms of tuberculosis. They
except expressed effect on Gr(+) and in high concentrations
12. A 30 y.o. man is HIV-positive with a cluster-of-
on Gr(-) bacteria. They are well tolerated by the patients.
differentiation-4 (CD4) count of 200/mm3. Within 2 months
Shortcoming of these drugs is rapid formation of microbial
he develops a peripheral white blood cell count of 1000/mm3
34
resistance; ability to color urine, sputum and tears red; 27. A patient with pulmonary tuberculosis was
affection of the liver, leucopoenia and dyspeptic disorders. administered an agent from the group of antibiotics which
–D belongs to the group of the most effective antituberculous
20. The antibiotic belongs to the group of drugs. Which agent has been administered?
aminoglycosides. It acts on mycobacterial strain resistant A. Isoniazid
to streptomycin, PAS, isoniazid. The drug is used for the B. PAS
treatment of lung tuberculosis and affection of other organs C. Ciprofloxacin
in condition of resistance to other antituberculous drugs. It D. Rifampicin*
is produced in the form of powder in vials for IM injections E. Sodium salt of benzylpenicillin
and in ampoules containing 5-10 ml of 5% solution for IV
28.
injection. - E
A. The hydrazides of isonicotinic acid
B. Ethambutol
C. PAS
D. Rifampicin
E. Kanamycin
17. Anthelmintic, Antiprotozoal, Antimalarial
21. Which antituberculous agent acts as the competitive and Antisyphilitic Drugs
antagonist of para-aminobenzoic acid?
A. Isoniazid 1. Pyrantel pamoate is effective in both conditions:
B. Ethambutol A. Amoebiasis and trichuriasis
C. Sodium Paraaminosalicilate (PAS)* B. Taenia solium and ascariasis
D. Rifampicin C. Amoebiasis and strongyloides
E. Kanamycin D. Enterobius and ascariasis *
E. Strongyloides and enterobiasis
22. Hyperuricemia is due to inhibition of uric acid secretion
in kidney: gout can occur as a result of adverse effect of: 2. In malaria, chloroquine (chingamin) acts on:
A. Ethosuxemide A. Erythrocytic cycle*
B. Cyclocerine B. Exoerythrocytic cycle
C. Pyrazinamide * C. Liver
D. Rifampicin D. Schizonts
E. Ampicillin E. All above
3. Flushing occurs after alcohol ingestion in patients taking:
23. A patient was diagnosed with active focal pulmonary A. Chingamin
tuberculosis. What drug should be prescribed in the first B. Penicillin
place? C. Tetracycline
A. Isoniazid * D. Chloramphenicol
B. Cyclocerine E. Metronidazol*
C. Ethionamide
D. Ethoxide 4. Which of the following antimalarial drugs is relatively
E. Sulfalen safe in pregnancy?
A. Primaquine
24. A patient suffers from pulmonary tuberculosis. During B. Co-trimoxazole
treatment neuritis of visual nerve arose. What drug has C. Chloridin
caused this adverse effect? 2012 D. Chingamin*
A. Rifampicin E. Mefloquine
B. Streptomycin
C, Ethambutol 5. Megaloblastic anaemia is a consequence of all drugs except:
D. Isoniazid * A. Trimethoprim
E. Kanamycin B. Methotrexate
C. Amoxicillin *
25. A patient has herpetic rash. What drug should be
D. Pyrimethamine
administered? 2010
E. Co-Trimoxazole
A. Gentamycin
B. Benzylpenicillin sodium salt 6. Intraluminal amoebicide of choice is:
C, Biseptol A. Metronidazol *
D. Clotrimasole B. Emetine
E. Acyclovir * C. Chloroquine
D. Tetracycline
26. After 4 months of treatment for tuberculosis the patient
E. Penicillin
began complaining of toes and fingers numbness, sensation
of creeps. He was diagnosed with polyneuritis. Which 7. A patient with ascariasis was given a drug that also acts
antituberculous might have caused these complications? on the immune system and is used as immunomodulator.
A. Isoniazid * What is the name of this drug?
B. Alcohol iodine solution A. Pyrantel
C. Ciprofloxacin B. Piperazine adipinate
D. Rifampicin C. Naphthammone (Bephenium)
E. Sodium salt of benzylpenicillin D. Levamisole*
E. Phenasalum (Niclosamide)
35
8. A 58 y.o. woman has just returned from a trip to A. Primaquine
Southeast Asia. Over the past 24 hours she developed B. Quinine
shaking, chills, and to of 40.5oC. A blood smear reveals C. Doxycycline
Plasmodium vivax. What drug should be administered to D. Biseptol (Co-trimoxazole)
eradicate the extraerythrocytic phase of the organism? E. Chloridine (Pyrimethamine) *
A. Chloroquine
16. Specify the drug, which is used in amebiasis of any
B. Primaquine*
localization of pathological process.
C. Pyrimethamine
A Metronidazole (Trichopol) *
D. Tetracycline
B. Chingamin
E. Quinacrine (Acrichin)
C. Emetine
9. A young boy presents the infestation with Taenia D. Chiniophon
saginata (tapeworm). Which of the following drugs is the E. Tetracycline
most appropriate drug for him?
A. Mebendazole 17. A woman addressed to a gynecologist in relation to
B. Niclosamide (Phenasal)* large discharge from the vagina with unpleasant smell.
C. Chloroquine After laboratory examination she has been diagnosed with
D. Tetracycline trichomoniasis. Which drug should be administered?
E. Penicillin A Sulfadimezine
10. A patient suffering from syphilis has been treated with B. Metronidazole (Trichopol) *
bismuth preparations. As a result of it, some grey spots turned C. Chingamin
up on the mucous membrane of the oral cavity, and D. Chloridin
nephropathy symptoms appeared. Which drug should be used E. Monomycin
for the treatment of bismuth intoxication? 2012 18. A female patient consulted a doctor about a sense of
A. Nalorphine epigastric discomfort, nausea and anorexia. A duodenal
B. Naloxone content analysis revealed lamblia. What drug should be
C. Bemegride administered? 2011
D. Methylene blue A Rifampicin
E. Unithiol (Dimercaprol)* B. Isoniazid
11. A 23 y.o. patient has been revealed mixed helmintic C. Metronidazol (Trichopol) *
invasion: intestinal cestodes and liver trematodes. Which D. Acyclovir
agent should be administered? E. Chingamin
A. Albendazole 19. During summer vacations a student from tropical
B. Praziquantel* country developed tertian malaria. After recovery he turned
C. Levamisole back to Ukraine for study extension. In January an
D .Pyrantel exacerbation was developed. It is known from past history
E. Piperazine of disease that drug acting on paraerythrocytic
12. Praziquantel is effective in both conditions: plasmodium malariae was prescribed. Indicate the drug:
A. Amoebiasis and trichuriasis A Chingamin (Chloroquine)
B. Taenia solium and Hymenolepis nana * B. Quinidine (Quinine)
C. Amoebiasis and strongyloides C. Hydroxycholoquine
D. Enterobius and ascariasis D. Mefloquine
E. Strongyloides and enterobius E. Primaquine *

13. Mother addressed to the pediatrician with the child who 20. Indicate the drug: it is an alkaloid used for the treatment of
complained of strong itch in the region around the anus, malaria. It possesses other pharmacological properties:
pain intensified at night. After investigation of feaces, the decreases excitabity of the myocardium, stimulates rhythmical
diagnosis of enterobiasis was made. Indicate the drug, contractions of the uterus. Adverse effects include noise and
which should be administered: ringing in the ears, decrease of hearing.
A. Pyrantel pamoate * A. Quinine *
B. Trichlorophen B. Primaquine
C. Phenasal C. Chloridin
D. Ditrazin D. Chingamin
E. Aminoacrichin E. Metronidazol

14. Indicate the antimalarial agent, which is active against 21 Indicate the drug: it is one of the best modern agents for
paraerythrocytic forms of Plasmodium. the prophylaxis and treatment of malaria. It, like quinine,
A. Biseptol decreases excitability of the myocardium and may be used
B. Chingamin as an anti-arrhythmic drug. It also possesses slight immune
C. Quinine suppressive activity, so it is used as a basic drug for
D. Hydroxychlorochin treatment of systemic diseases of connective tissue.
E. Primachin * A. Quinine
B. Primaquine
15. For malaria prevention before journey abroad a doctor C. Chloridin
has got an agent with histoschizontocidic action. What drug D. Chingamin *
did the doctor take? E. Metronidazol
36
22. Indicate the drug: it exerts paralyzing action on analyses enabled to make the following diagnosis: amebic
nematodes, increases tonicity and contractility of the dysentery. Which drug should be used?
smooth muscles of the intestine, so it is used without a A. Furazolidon
purgative agent. It has low toxicity and is used mainly for B. Phthalazol
ascariasis and entrobiasis. C. Metronidazole *
A. Pyrantale pamoate * D. Emetine hydrochloride
B. Mebendazole E. Levomycetin
C. Primaquine
29. After the second abortion a 23 y.o. woman has been
D. Metronidazol
diagnosed with toxoplasmosis. Which drug should be
E. Praziquantel
used for toxoplasmosis treatment? 2012
23. A patient consulted a doctor about bowels dysfunction. A. Co-trimoxazole *
The doctor established symptoms of duodenitis and enteritis. B. Acyclovir
Laboratory examination helped to make the diagnosis of C. Azidothimidine
lambliasis. What drug should be administered? D. Mebendazole
A. Monomycin E. Itraconazole
B. Metronidazol *
C. Chingamin 30. Ascarid eggs have been detected during stool analysis.
D. Tetracycline What drug should be administered? 2016
E. Erythromycin A. Nystatin
B. Chloramphenicol
24. For prevention remote relapses of 4-day malaria a 42 C. Furazolidone
y.o. patient was given primaquine. On the 3rd day of the D. Mebendazole *
treatment with therapeutic doses of the drug patient E. Tetracycline
experienced abdominal pain, cardiac pain, dyspepsia,
generalized cyanosis. What is the reason of these adverse 31. Malaria is treated with structural analogs of vitamin B2
effects of the drug? (riboflavin). These drugs disrupt the synthesis of the
A Cumulation of the therapeutic agent following enzymes in plasmodium: 2016
B. Slowing down of drug’s excretion with urine A. Cytochrome oxidase
C. Decreasing of activity of liver microsomal enzymes B. Peptidase
D. Genetic deficiency of Glucose-6-phosphate C. Aminotransferase
dehydrogenase * D. NAD-dependent dehydrogenase
E. Potentiation of the drug’s action by other therapeutic agent E. FAD-dependent dehydrogenase *
25. A 19 y.o. woman suffers from primary syphilis. Doctor
administered her complex therapy that includes
benzylpenicillin sodium salt. What is the mechanism of
action of this drug? 2010
A. It blocks synthesis of cytoplasm proteins 18. Anticancer Drugs
B. It blocks DNA synthesis
C. It blocks synthesis of peptidoglycan of 1. Methotrexate (structural analogue of the folic acid which is
microbial membrane * competitive inhibitor of the dihydrofolate reductase) is
D. It blocks RNA synthesis prescribed for the treatment of the malignant tumor.
E. It blocks thiol enzymes On which level does methotrexate hinder synthesis of the
nucleic acids?
26. A healthy man is in a region with high risk of catching
A. Replication
malaria. What drug should be administered for individual
B. Reparation
chemoprophylaxis of malaria?
C. Processing
A. Biseptol
D. Transcription
B. Sulfalen
E. Mononucleotide synthesis *
C. Metronidazole
D. Tetracycline 2. Which phase of the cell cycle is resistant to the most
E. Chingamin * chemotherapeutic agents, i.e. those that are classified as
phase-specific?
27. This drug has a destructive effect on erythrocytic forms of
A. Go *
malarial plasmodia and dysenteric amoebae. It is used for the
B. G1
treatment and prevention of such diseases as malaria, amebiasis
C. G2
and interstitial disease. What drug is it?
D. M
A. Erythromycin
E. S
B. Chingamin
3. A cancer man receives prophylactic Allopurinol before a
C. Quinine
course of chemotherapy. Which of the following
D. Emetine hydrochloride
statements is the main purpose of doing this?
E. Tetracycline
A. Facilitate host cell detoxification of the
28. A 30 y.o. patient complains about having abdominal chemotherapeutic drug, thereby reducing host cell
pain and diarrhea for 5 days; body to rise up to 37,5o C along toxicities
with chills. The day before a patient had been in a forest B. Reduce the risk of hyperuricemia and its main
and drunk from an open water reservoir. Laboratory consequences (renal damage, gout) that can occur
with a massive cell kill *
37
C. Inhibit the potential for DNA repair, that otherwise
might lead to chemotherapy failure
D. Potentiate the action of a nitrosourea to bind to purine
moieties in DNA strands
E. Prevent myelosuppression and related blood dyscrasias
4. Which of the following statements is the main
mechanism by which the vincristine exerts its main effects?
A. Alkylating DNA, causing cross-links between
parallel DNA strands
B. Blocking microtubular assembly and mitosis
during M-phase *
C. Inhibiting topoisomerase, preventing repair of DNA
strand breaks
D. Intercalating in DNA strands, thereby preventing
DNA replication by mRNA
E. Stabilizing assembled microtubular arrays, thereby
preventing mitosis
5. Which of the following is the main mechanism by which
the cyclophosphamide exerts its cell killing?
A. Alkylating DNA, causing cross-links between
parallel DNA strands*
B. Blocking microtubular assembly and mitosis during M-
phase
C. Inhibiting topoisomerase, preventing repair of DNA
strand breaks
D. Intercalating in DNA strands, thereby preventing DNA
replication by mRNA
E. Stabilizing assembled microtubular arrays, thereby
preventing mitosis
6. Which condition is the most likely adverse response to
occur as a result of the vincristine action?
A. Nephrotoxicity, renal dysfunction or failure
B. Peripheral sensory and motor neuropathy*
C. Pulmonary damage
D. Agranulocytosis
E. Rhabdomyolysis
7. A patient with advanced Hodgkin’s disease is placed on
combination therapy with vincristine, procarbazine, and
prednisone. Which of the following procedures plays the main
role of the prednisone effects in this therapeutic plan?
A. Preventing opportunistic infections
B. Exerting direct cytotoxic actions, independent of the
other drugs
C. Counteracting fluid overload from chemotherapy-
induced renal dysfunction
D. Counteracting hyperglycemia caused by the other agents
E. Suppressing emesis and vomiting*
8. A 25 y.o. woman with choriocarcinoma is treated with
methotrexate. You anticipate significant host cell toxicity
in response to the high methotrexate dose, and so
immediately after giving the anticancer drug you
administer one of the following drugs:
A. Vitamin K
B. Vitamin B1
C. Vitamin B6
D. Vitamin B12
E. Folic acid *
9. While reviewing charts in a general medicine clinic you
see that a 27 y.o. woman with no history of cancer at all, is
also taking methotrexate. The drug is most likely given to
manage one of the following conditions:
38
A. Hyperthyroidism
B. Asthma or emphysema
C. Clinical gout
D. Myasthenia gravis
E. Rheumatoid arthritis or psoriasis *
10. Allopurinol should be avoided, or reduced doses of the
agent, if the anticancer drug is one of the following:
A. Doxorubicin
B. Cysplatin
C. Mercaptopurine *
D. Cyclophosphamide
E. Vincristine
11. A patient with Wilm’s tumor is receiving a
chemotherapeutic agent that is described as acting by
intercalating into DNA strands, and that is efficacious
regardless of what stage of the cell cycle the tumor cell are
in. Which agent best fits this description?
A. Dactinomycin (Actinomycin) *
B. Cytarabine (Cytosine arabiniside)
C. Mercaptopurine
D. Cyclophosphamide
E. Vincristine
12. A cancer patient develops severe, irreversible
cardiomyopathy because the maximum dose of an
anticancer drug was exceeded. Which drug is most likely
responsible for this patient’s symptoms?
A. Cyclophosphamide
B. Cysplatin
C. Mercaptopurine
D. Doxorubicin *
E. Vincristine
13. A 75 y.o. man complains of progressive difficulty
starting his stream urinating, and having to get up at least
once at night to urinate. Rectal examination reveals a
generally enlarged, smooth-surfaced prostate. Prostatic
serum antigen titers are elevated. Urine flow increases, and
prostate size decreases, in response to finasteride
treatment. What is the main mechanism of its action?
A. Steroid 5-α-reductase inhibition *
B. Competition with dihydrotestosterone for intracellular
androgen receptor and inhibition its binding
C. α1-adrenergic receptor blockade
D. Lowering serum Testosterone levels
E. Testosterone synthesis inhibition
14. A 45 y.o. man complains of progressive difficulty
starting his stream urinating, and having to get up at least
once at night to urinate. Rectal examination reveals an
enlarged, smooth-surfaced prostate. Prostatic serum
antigen (PSA) titers are elevated. Urine flow increases, and
prostate size decreases, in response to cyproterone acetate
(androcur) treatment. This drug’s main mechanism of
action involves one of the following processes. What is it?
A. Steroid 5α-reductase inhibition
B. α1-adrenergic receptor blockade
C. Lowering serum Testosterone levels
D. Competition with dihydrotestosterone for intracellular
androgen receptor and inhibition its binding*
E. Testosterone synthesis inhibition
15. Megaloblastic anaemia is a consequence of all drugs
except:
A. Salazopyridazine
B. Methotrexate
 C. Amoxicillin * A. Dihydrofolate reductase *
D. Sulfalen B. Thioredoxin reductase
E. Co-trimoxazole C. Deaminase
D. -
16. To treat Methotrexate toxicity ___________ is used
E. Thiaminase
A. Folic acid *
B. Folinic acid 24. The main mechanism of Cyproterone acetate
C. Riboflavin (Androcur) action involves one of the following processes:
D. Cyanocobalamin A. Steroid 5-α-reductase inhibition
E. Vicasol B. α1-adrenergic receptor blockade
17. The following drugs are alkylating agents except: C. Lowering serum Testosterone levels
A. Cyclophosphamide D. Blockade of androgen receptors *
B. Methotrexate * E. Testosterone synthesis inhibition
C. Chlorambucil
D. Sarcolysin 19. Basic principles of Acute Poisonings with
E. Myelosan
Drugs Treatment
18. Determine a drug for treatment of lympholeukosis:
1. A patient takes an acute, massive overdose of aspirin
A. Phthoruracil
that, without proper intervention, will be fatal. Which of
B. Embichin *
the following conditions would you expect in the
C. Depostat
advanced (late) stages of aspirin (salicylate poisoning)?
D. Diethylstilbestrol
A. Metabolic alkalosis
E. Phenobolin
B. Respiratory alkalosis
19. A drug belongs to the group of antimetabolites being an C. Respiratory alkalosis plus metabolic acidosis*
antagonist of folic acid. It is able to suppress activity of D. Hypothermia
dihydrofolate-reductase and tymidilsythetase, causes and E. Ventilatory stimulation
thus leads to diminishing of nucleic acids synthesis.
Determine the drug: 2. In addition to providing symptomatic, supportive care, which
A. Mercaptopurine of the following drugs would be a helpful adjunct to manage
B .Methotrexate * severe Paracetamol (Acetaminophen) poisoning?
C. Fluorouracil A. Naloxone
D. Cytarabine B. Acetylcysteine*
E. Cisplatine C. Diazepam
20. Antitumoral drug from the group of antimetabolites is D. Sodium bicarbonate
used for the treatment of leucosis in children and cancer in E. Unitiolum
adults. Determine the drug: 3. Which of the following conditions is the primary cause
A. Methotrexate * of death from massive Paracetamol (Acetaminophen)
B. Sarcolysin overdoses?
C. Colchamine A. Acute nephropathy
D. Rubomycin B. Status epilepticus
E. Prednisolone C. Status asthmaticus
21. In cancer patients who have been continuously D. A-V conduction disturbances
receiving methotrexate, the target cells of tumour with time E. Liver failure *
become insensitive to this drug. In this case, gene
4. A patient has taken a potentially lethal dose of
amplification of the following enzyme is observed: 2016
Acetaminophen (Paracetamol). The current preferred
A. Thiaminase
antidotal therapy involves administration of drug that:
B. Deaminase
A. Inhibits synthesis of superoxide anion radical and
C. Pholate decarboxydase
hydrogen peroxide
D. Thioredoxin reductase
B. Is rich in sulfhydryl (-SH) groups *
E. Dihydrofolate reductase *
C. Alkalinizes the urine to facilitate Acetaminophen
22. Pterin derivatives (aminopterin and methotrexate) are excretion
the inhibitors of dihydrofolate reductase, so that they D. Inhibits hepatic oxidative metabolism to inhibit
inhibit the regeneration of tetrahydrofolic acid from formation of Acetaminophen’s toxic metabolites
dihydrofolate. These drugs inhibit the intermolecular E. Causes metabolic acidosis to combat the toxic
transfer of monocarbon groups, thus suppressing the metabolite’s metabolic alkalosis
synthesis of the following polymer:
A. Gangliosides 5. A patient who receives a rapid IV injection of a drug
B. DNA * develops hypocalcemic tetany. Which of the following
C. Homopolysaccharides drugs is the most likely cause it?
D. Glycosaminoglycans A. Edetate Sodium (Trilon B) *
E. Protein B. Potassium chloride
C. Penicillamine
23. In cancer patients who have been continuously
D. Deferoxamine
receiving methotrexate, the target cells of tumour with
E. Acetylcysteine
time become insensitive to this drug. In this case, gene
amplification of the following enzyme is observed: 2014
39
6. Physostigmine is the antidote against poisoning with D. Ftorotan (Halothane) *
antimuscarinic drugs (e.g., Atropine). Another E. Caffeine
acetylcholinesterase inhibitor, Neostigmine, is less suitable
14. A hypertensive glucose solution was introduced to a
because it cannot overcome the adverse effect of the
patient. It will intensify water movement:
antimuscarinic drug in or on one of the following:
A. From the cells to the intercellular liquid *
A. Smooth muscle
B. From the intercellular liquid to the capillaries
B. Skeletal muscle
C. There will be no changes of water movement
C. Heart
D. From the capillaries to the intercellular liquid
D. Central nervous system *
E. From the intercellular to the cells
E. Exocrine gland
15. A patient suffering with collagenosis has been taking
7. Indicate the measures directed for diminishing of
prednisolone for a long time. Hypokaliemia development
absorption of poisons from the digestive tract:
caused spastic pain of skeletal muscles. What medication
A. Washing of the stomach
should be used in order to correct potassium exchange?
B. Introduction of active carbon*
A. No-spa
C. Drugs stimulating vitally important functions
B. Diphenin
D. Forced diuresis
C. Panangin *
E. Saline purgatives
D. Thyrocalcitonin
8. Indicate the drug that is specific antagonist of opioid E. Diazepam
analgesics.
16. A 35 y.o. patient who often consumes alcohol was
A. Sulfocamfocaine
treated with diuretics. There appeared serious muscle and
B. Atropine
heart weakness, vomiting, diarrhea, BP was 100/60 mm
C. Aceclidine
Hg, depression. This condition is caused by intensified
D. Naloxon *
excretion of:
E. Nalorfin
A. Calcium
9. Indicate the drugs used in poisoning with cholinesterase B. Potassium*
inhibitors: C. Chlorine
A. Aceclidine + Pilocarpine D. Phosphates
B. Atropine + Dipiroxim * E. Sodium
C. Scopolamine + Naloxon
17. A patient underwent appendectomy. In the
D. Caffeine + Atropine
postoperative period he has been taking an antibiotic. The
E. Sulfocamfocaine + Nalorfin
patient complains about hearing impairment and
10. Indicate antidote that should be prescribed in vestibular disorders. What group of antibiotics has such
poisoning with salts of arsenic and other heavy metals. adverse effect?
A. Methylene blue A. Cephalosporins
B. Amyl nitrate B. Tetracyclines
C. Naloxon C. Macrolides
D. Natrium thiosulfate * D. Aminoglycosides*
E. Dipiroxim E. Penicillins
11. A patient with mercury evaporations poisoning has 18. A 35 y.o. female patient has been hospitalized with
been brought from chemical plant into toxicological acute intoxication caused by salts of high-density metals
department. What drug should be used in the given (lead, most probably). As a part of complex therapy the
situation? antidote that contains two active sulfhydric groups has been
A. Unithiol (Dimercaprol) * administered. Specify this antidote: 2016
B. Naloxone A. Metamizole
C. Isonitrozine B. Mannitol
D. Activated carbon (Charcoal) C. Calcium chloride
E. Enterosorbent D. Nalorphine hydrochloride
E. Dimercaprol*
12. A patient with morphine overdosing was admitted into
intensive care unit. What agent from listed drugs is the 19. A 55 y.o. male has been admitted to the resuscitation
most effective in given case? unit unconscious. Relatives reported him to have
A. Camphor mistakenly drunk an alcoholic solution of unknown
B. Naloxone * origin. On examination the patient was diagnosed with
C. Etimizol methanol intoxication. What antidote should be used in
D. Cordiamin this case? 2014
E. Caffeine A. Teturam
13. A patient with cramps, which are consequence of an B. Acetylcysteine
acute poisoning with cocaine, is delivered to emergency C. Ethanol *
room. Choose a pharmacological agent, which has D. Protamine sulfate
anticonvulsant effect: E. Naloxone
A. Aminazine (Chlorpromazine) 20. 14. A 63 y.o. male patient with bladder atony had been
B. Isosorbide administered a medication which he had been arbitrarily
C. Sulfocamphocaine taking at a higher dose. The patient developed,
40
hyperhydration, salivation, diarrhea, muscle spasms. The
administered drug relates to the following group: 2014
salivation,
A. Adrenergic blockers
B. Cholinesterase activator
C. Ganglionic blockers
D. Tocolytics
E. Cholinomimetics*

41