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1/16/2021 Oxycodone/ Acetaminophen (generic)/ Percocet (brand name) Flashcards | Quizlet

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classification (therapeutic) opioid analgesics
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classification (pharmacologic) opioid agonists, opioid agonists/ nonopioid analgesic


combinations

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indications moderate to severe pain

action binds to opiate receptors in the CNS. Alter the


perception of and response to painful stimuli, while
producing generalized CNS depression.

contraindications/ precautions contraindicated: hypersensitivity to oxicodone


(cross-sensitivity may exist to other opioids);
hypersensitivity to acetaminophen/ aspirin/ ibuprofen
(for combination products); Aspirin- and ibuprofen
containing products should be avoided in pt's with

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bleeding disorders or thrombocytopenia; use


cautiously in: head traume, increased intracranial
pressure, severe renal, hapatic, or pulmonary disease;
cardiovascular disease (ibuprofen- containing
products only); hypothyroidism; adrenal insufficiency;
Alcoholism

adverse reactions/ side effects CNS: confusion, sedation, Resp: respiratory


depression, GI: constipation GU:urinary retention
Misc: physical/psychological dependence, tolerance

interactions drug-drug: use with caution in pt's receiving MAO


inhibitors (may result in unpredictable reactions-
decrease initial dose of oxycodone to 25% of usual
dose), increases CNS depression with alcohol,
antihistamines, and sedative/hypnotics.
Administration of partial-antagonist opiod analgesics
may precipitate withdrawal in physically dependent
pt's. Nalbuphine, buprenorphine, or pentazocine may
decrease analgesia. drug-natural products:
concomital use of kava-kava, valerian, or chamomile
can increase CNS depression

Dosage 5-10 mg q 3-4 hr initially as needed, if using


combination products, acetaminophen or aspirin
dose should not exceed 4g/day and should not
exceed 4 tablets/day if ibuprofen-containing
products.

nursing implications ASSESSMENT: assess blood pressure, pulse and


respirations before and periodically during
administration. If respiratory rate is <10/min, assess

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level of sedation. Assess bowel function routinely. To


minimize constipation increased fluid intake and
laxatives should be instituted. LAB
CONSIDERATIONS: may increase plasma amylase
and lipase levels. TOXICITY AND OVERDOSE: if an
opioid antagonist is required to reverse respiratory
depression or coma, naloxone (Narcan) is the
antidote. dilute the 0,4-mg ampule of naloxone in
10ml of 0.9% NaCl and administer 0.5 ml (0.02mg) by
direct IV push every 2 min. POTENTIAL NURSING
DIAGNOSES: Acut pain (Indications), Disturbed
sensory perception (visual, auditory) (Side Effects),
Risk for injury (side effects) IMPLEMENTATION: high
alert: accidental overdosage of opioid analgesics had
resulted in fatalities. Before administering, clarify all
ambiguous orders; have second practitioner
independently check original order and dose
calculations. Do not confuse oxycodone with
OxyContin. PO: may be administered with food or
milk to minimize GI irritation. Controlled- release
tablets should be swallowed whole, do not crush,
break, or chew. Taking broken, chewed or crushed
controlled- release tablets leads to rapid release and
absorption of a potentially fatal dose of oxycodone.
PT/FAMILY TEACHING: instruct the pt on how to take
the medication. advice pt to avoid concurrent use of
alcohol or other CNS depressants with this
medication. encourage pt to turn, cough, and breath
deeply every 2hr to prevent atelectasis.
EVALUATION/ DESIRED OUTCOME: decrease in
severity of pain without a significant alteration in level
of consciousness or respiratory status.

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