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Objective To demonstrate the efficacy of the balance control trainer (BCT), developed for training patients with
balance problems, as a balance assessment tool in subacute stroke patients.
Methods A prospective cross-sectional study was carried out on 38 subacute stroke patients in their first episode
of a stroke, and having the ability to maintain a standing position without aid for at least 5 minutes. Patients were
assessed using the BCT (BalPro) 43.7±35.7 days after stroke. The balance was assessed using the Berg Balance
Scale (BBS), the Timed Up and Go Test (TUG), a 10-meter walking test (10mWT), a 6-minute walking test (6MWT),
and the Korean version of the Modified Barthel Index. The correlation and validity between the BCT and various
balance assessments were analyzed.
Results Statistically significant linear correlations were observed between the BCT score and the BBS (r=0.698,
p<0.001). A moderate to excellent correlation was seen between the BCT score and 11 of the 14 BBS items. The
BCT scores and other secondary outcome parameters (6MWT r=0.392, p=0.048; TUG r=−0.471, p=0.006; 10mWT
r=−0.437, p=0.012) had a moderate correlation.
Conclusion Balance control training using the BCT (BalPro) showed significant statistical correlation with the
BBS, and could therefore be a useful additional balance assessment tool in subacute stroke patients.
muscle weakness, altered muscular tone, sensory defi- confirm the correlation between the BCT score and other
cits, abnormal postural reactions, and cognitive impair- balance assessment tools, and verify whether the BCT
ments [7]. score could be used as a balance assessment in subacute
Efficient therapeutic approaches based on the ap- stroke patients.
propriate assessment of balance are required; however,
the best tools for balance evaluation in stroke patients MATERIALS AND METHODS
are still under debate [8,9]. Balance can be assessed by
simple questionnaires or instrumented posturography. Participants
Simple questionnaires includes the Berg Balance Scale Between October 2014 and April 2016, a total of 49 sub-
(BBS) [10], the Time Up and Go test (TUG) [11], the Bru- acute stroke patients were recruited from Kyungpook Na-
nel Balance Assessment [12], the Community Balance tional University College of Medicine and Daegu Fatima
and Mobility Scale [13], the Postural Assessment Scale for Hospital, Daegu, Korea.
Stroke patients [14], the 10-meter walking test (10mWT) The inclusion criteria were as follows: the first episode
[15], and the 6-minute walking test (6MWT) [16]. In- of a stroke (an infarction or a hemorrhage), the ability
strumented posturography is a computerized technique to maintain a standing position without aid for at least
which quantifies either the static or dynamic conditions 5 minutes, and the Mini-Mental State Examination ≥24.
[17]. In 1986, the first commercially available testing sys- The exclusion criteria were as follows: cognitive impair-
tem was the EquiTest system of NeuroCom International ment (Mini-Mental State Examination <23), a severe
Inc. [18]. Subsequently, many posturographies have balance dysfunction (BBS <1), vestibular disorders, par-
been developed—the Synapsys Posturography System oxysmal vertigo, visuospatial neglect syndrome, a visual
(Synapsys, Marseille, France), the SMART Balance Mas- disturbance, presence of other neurological conditions,
ter (Natus Medical Inc., Pleasanton, CA, USA), and the any orthopedic disease involving the lower limbs, and a
Tetrax Interactive Static Posturography System (Sunlight high risk of cardiac or other medical problems.
Medical Ltd., Ramat Gan, Israel). These systems assess A total of 38 patients were included in this study (Fig.
the postural stability by measuring the fluctuation of 1). The general characteristics are shown in Table 1. This
body weight distribution on foot plates [19]. The quanti- study was conducted by Kyungpook National Univer-
tative measuring of the center of mass (COM) by utilizing sity, and approved by the Institutional Review Board of
force plates indicates postural sway and weight distribu- Kyungpook National University (IRB No. 2014-01-019-
tions. Postural reactions are quantified while keeping the 001). A written informed consent was obtained from all
feet together and standing on one leg. Sawacha et al. [20] participants in the study.
showed that post-stroke patients could take advantage of
the quantitative posturography in balance assessment. The balance control trainer
However, these instruments measure only the horizon- BalPro (Man&Tel, Gumi, Korea), a lower limb reha-
tal plane movement (such as postural sway, weight dis- bilitation machine, was used for the initial balance as-
tribution, or related measures) rather than vertical move- sessment. The BCT consists of a balance board, two foot
ment (an up-and-down movement of the COM).
A previous study on balance control training using the
Subjects recruited (n=49)
balance control trainer (BCT) shows a remarkable train- Excluded according to
ing effect on improving balance disability [21]. Further- inclusion/exclusion
criteria (n=9)
more, the training effect was measured using several
7 impaired cognition
outcome measurements. The BCT was developed to 2 medical complication
allow training not only in the horizontal plane but also Baseline measurement (n=40)
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Jin Won Song, et al.
Table 1. Demographic factors of the patients enrolled in plates (measures the weight distribution and expresses
this study (n=38) it in the form of a percentage), a tilting sensor (measures
Characteristic Value (%) the thigh inclination during knee flexion and extension
Sex movement, and identifies the subject’s vertical move-
Male 23 (61) ment, i.e., up-and down movement of COM, by the degree
Female 15 (39) of inclination of the thigh), a computer system (includes
Age (yr) 55.32±13.86 the software required to process all the movement data),
Etiology of stroke a display screen (visualizes the input data), and safety
Ischemic 25 (66) bars with a harness (to prevent patients from falling) (Fig.
Hemorrhagic 13 (34) 2A). The height of the display screen is adjusted at the
Lesion location patient’s eye level, and a harness applied to prevent fall-
Supra-tentorial 32 (84) ing. The software translates the pressure on the balance
Infra-tentorial 6 (16) board into a horizontal cursor movement, and the tilting
Mean days from onset 43.7±35.7 movement on the lateral side of the thigh into a verti-
Affected side cal cursor movement on the screen. The cursor moves
Right 22 (58) horizontally and vertically; it then combines both the
Left 15 (39) directional movements, which makes the cursor move di-
Both 1 (3) agonally. By moving a hand-shaped cursor on the screen,
Values are presented as number (%) or mean±standard the patients can pick fruit in a fruit-harvesting electronic
deviation. game (Fig. 2B). The difficulty of the game can be adjusted
by varying the limitation times and the number of fruits.
In our study, the game consisted of 10 repetitive stages,
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Balance Assessment in Subacute Stroke Patients by Balance Control Trainer
and 5 fruits randomly appeared on the screen; this is the ing scales, it is probably the most reliable functional bal-
fifth mode of difficulty among the 7 available modes of ance test [24].
difficulty. An assessment tool of functional mobility measuring
The difficulty level of the BCT differs from ‘1’ being the the time taken to walk a 10-meter distance without as-
simplest mode with one fruit, to ‘7’ being the highest sistance, is the 10mWT [25]. It records the time a patient
difficulty mode with 7 fruits. The limitation time of each takes to walk 10 meters at a normal, comfortable speed.
stage was set to 2 minutes. The game was performed The 6MWT is a one-time measure of the functional sta-
under the supervision of a rehabilitation medicine physi- tus of patients [26]. The patients walk along a 30-meter
cian. After conclusion of the game, the score was auto- hallway for 6 minutes, and the total distance covered is
matically calculated by the computer, as the total sum of recorded.
fruits picked. The score indirectly indicates a side to side The K-MBI scale measures the performance of daily
center of mass shifting ability and vertical movements. living activities. Although the scale is regarded as being
In order for the patients to become familiar with the BCT reliable, its use in stroke medicine clinical trials is vari-
environment, three rounds of the game were played, and able [27]. The scale has demonstrated high inter-rater re-
the best outcome was selected as the result. liability and test-retest reliability. Ten variables are used,
including bowel, urinary, grooming, toilet use, feeding,
The balance assessment transfer, walking, dressing, climbing stairs, and bathing.
BBS was used as the primary balance outcome measure
for analysis. The TUG, 10mWT, 6MWT, and the Korean The validity and reliability assessment of the BCT
version of the Modified Barthel Index (K-MBI) were used (BalPro)
as the clinical outcome measurements to evaluate the The validity of the BCT was processed by comparing
functional ability of patients. it with the BBS. A total of 38 patients participated in this
A total of 14 items that require the subjects to maintain study, and performed the BCT and BBS tests.
positions or complete movement tasks of varying dif- To evaluate the test-retest reliability, a preliminary
ficulty are easily assessable by BBM. These include: sit- study of 3 normal participants was conducted. These
ting unsupported, sit-to-stand, stand-to-sit, transferring, subjects were measured by BCT, which was repeated the
standing unsupported, standing with the eyes closed, following day.
standing with the feet together, reaching forward with The inter-rater reliability and intra-rater reliability was
an outstretched arm, turning to look behind, picking up not assessed as the BCT score was automatically calcu-
an object from the floor, turning around, placing alter- lated by the computer.
nate feet on a stool, one foot forward, and a single-limb
stance. The degree of success in achieving each task is Statistical analysis
scored from 0 (unable) to 4 (independent), and the final For the statistical analysis, we used the SPSS ver. 20.0
measure is the sum of all the scores. More than 40 points (IBM SPSS, Armonk, NY, USA) for Windows. The nor-
indicate that the subject is independent and has a lesser mal distribution of the variables was confirmed by Kol-
risk of falling [22]. Used frequently in a clinical setting, mogorov–Smirnov tests. The chi-square test was applied
BBS has shown excellent reliability in patients with acute for the nonparametric variables. A paired-sampled t-test
stroke [11], and also showed a moderate to large respon- was computed, and the correlation between both the BCT
siveness at detecting changes within 2–12 weeks [23]. and the BBS was examined using Bland–Altman plots.
TUG is a single-item test that requires the subject to The Pearson correlation coefficient test was applied to
stand up, walk 3 meters, turn back, and sit down again. assess the association between the BCT score, BBS, TUG,
The total time during the sequential movements is re- 10mWT, 6MWT, and K-MBI. A p-value of ≤0.05 was con-
corded. A time of <10 seconds indicates normal mobility, sidered to be statistically significant.
11–20 seconds is the normal limit for disabled patients,
and >20 seconds is considered to be abnormal. Since it
uses agreement in a stop-watch duration rather than rat-
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Jin Won Song, et al.
30
Mean
Table 3. The correlation between BCT score and other
10 balance assessment tools
Pearson correlation
R2 p-value
10 Mean 2SD
coefficient
BBS 0.698 0.487 <0.001
TUG −0.471 0.222 0.006
30
20.0 30.0 40.0 50.0 60.0 10mWT −0.437 0.191 0.012
Mean of the two tests 6MWT 0.392 0.154 0.048
Fig. 3. The Bland and Altman plot for the Berg Balance K-MBI 0.281 0.079 0.087
Scale (BBS) and the BalPro score. The dotted line (the BCT, balance control trainer; BBS, Berg Balance Scale;
middle one) represents the mean difference of the BBS TUG, Timed Up and Go test; 10mWT, 10-meter walking
and the BalPro score. Both extremity lines indicate upper test; 6MWT, 6-minute walking test; K-MBI, Korean ver-
and lower correlations (SD 1.96). sion of Modified Barthel Index.
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Balance Assessment in Subacute Stroke Patients by Balance Control Trainer
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Jin Won Song, et al.
A B C
60 2 40 2 50 2
R =0.487 R =0.222 R =0.191
40
30
50
30
10mWT
TUG
BBS
20
20
40
10
10
30 0 0
0 10 20 30 40 50 60 0 10 20 30 40 50 60 0 10 20 30 40 50 60
Balpro score Balpro score Balpro score
D E
2
2 100 R =0.079
R =0.154
600
80
400
6MWT
K-MBI
60
200
40
0 20
0 10 20 30 40 50 60 0 10 20 30 40 50 60
Balpro score Balpro score
Fig. 4. A scatter plot between the BalPro score and other balance parameters. (A) Berg Balance Scale (BBS), (B) Timed
Up and Go (TUG), (C) 10-meter walking test (10mWT), (D) 6-minute walking test (6MWT), and (E) Korean version of
the Modified Barthel Index (K-MBI).
to-side, with its two foot plate and knee joint sensor. If a patient has trouble passing the easy steps previously
Hence, due to these mechanical causes, results would cleared easily, the test procedure should be stopped, as
differ between the BCT and the BBS. Second, as men- this could indicate distraction. In this ways, assessment
tioned in Material and Methods section, our BCT proto- methods could be improved by modifying the protocol.
col consisted of ten repetitive stages of the fifth difficulty Third, the narrow range of BBS values (33–40) could re-
mode from among seven difficulty modes. The repetitive sult in the poor correlation in low BBS group. Since inclu-
test with the same level of difficulty causes easy distrac- sion criteria of this study required patients with sufficient
tion for the patients, resulting in negative effects on the endurance and strength to follow the BCT training, all
BCT score. To avoid these issues, changing difficulty level BBS points of the patient were 33 and above. In addition,
of the BCT could resolve the issues, by distinguishing age could be another reason for poor correlation between
between patients with balance problem and distracted the BCT and the low BBS. The age of 10 (77%) of the pa-
patients. For instance, BCT should begin with easy level, tients was >65 among the low BBS group. However, the
gradually raising the difficulty level, such that the patient age of 3 (12%) patients was >65 in the high BBS group (BBS
undergoes several levels from moderate to easy to diffi- >40). The mean age of the patients with a low BBS score
cult. Afterward patients will undergo several steps of easy was 65.0±10.5, which is higher than 50.3±12.8 of the high
difficulty level among moderate to high difficulty mode. BBS score group. Also, the mean test time from the di-
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Balance Assessment in Subacute Stroke Patients by Balance Control Trainer
agnosis was shorter in the low BBS group. The mean test sensor, which may result in different conclusions. By ap-
time from the diagnosis was 33.15±19.62 days in the low plying another sensor to measure backward-and-forward
BBS group, which is a shorter duration than 49.20±41.04 movements, the BCT could be a more effective tool as a
days in the high BBS group. three-dimensional balance assessment.
With its unique movement training system, the BCT There are some limitations when using the BCT as a
achieves greater improvements in balance and mobility balance assessment tool. First, the patients should have
in stroke patients [21]. Although other computerized dy- adequate muscle power and cognition to follow detailed
namic posturography measures only the horizontal body instructions. Second, the number of patients in our study
weight distribution, the BalPro training system includes was relatively small compared to other studies. Third, our
not only horizontal movement, but also vertical move- study did not include patients with poor balance control.
ment. By training vertical movement of the center of Fourth, an attached harness of the BCT could have some
gravity, patients learn to control adequate vertical move- influence in assessing the balance of individuals. Patients
ments, which is highly important in a gait cycle. There- with poor trunk control could have a chance to receive a
fore, an improvement of their balance and gait could be higher score by the aid of an attached harness. A further
achieved. Moreover, the BCT score can be easily obtained study should include patients with a severe to mild de-
while patients undergo balance training without the gree of balance problem, in order to evaluate the useful-
assistance of another person. The balance evaluation ness of the BCT as a balance assessment tool.
with simple questionnaires requires additional time and In conclusion, a balance assessment using the BCT
personnel from the training session to assess balance could represent a useful tool for evaluating functional
control. The balance evaluation with an instrument balance control achievement in subacute stroke patients
(computerized posturography) also requires a person due to the significant statistical correlation observed be-
who instructs the patient to get into a specific posture. tween the BCT and the BBS.
Tetrax requires a person who can instruct eight standard
positions for checking balance. However, the BCT score CONFLICT OF INTEREST
can be viewed immediately after the training session and
therefore, it could represent a time-cost effective method No potential conflict of interest relevant to this article
for evaluating balance control. was reported.
In addition, the level of difficulty of the BCT game can
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